| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Bain Capital Life Sciences Investors, LLC | 2,760,888 | 9,677,125 | +6,916,237 | 0.57 | 1.84 | +1.27 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 3,634,473 | 8,829,758 | +5,195,285 | 0.01 | 0.02 | +0.01 | buy |
| T. Rowe Price Investment Management, Inc. | 3,970,026 | 6,793,788 | +2,823,762 | 0.00 | 0.01 | +0.00 | buy |
| JENNISON ASSOCIATES LLC | 2,433,728 | 6,020,167 | +3,586,439 | 0.00 | 0.01 | +0.00 | buy |
| Cormorant Asset Management, LP | 0 | 5,000,000 | +5,000,000 | 0.00 | 0.57 | +0.57 | buy |
| Alyeska Investment Group, L.P. | 0 | 4,800,000 | +4,800,000 | 0.00 | 0.03 | +0.03 | buy |
| VANGUARD GROUP INC | 2,844,239 | 3,450,727 | +606,488 | 0.00 | 0.00 | +0.00 | buy |
| HEIGHTS CAPITAL MANAGEMENT, INC | 0 | 3,144,106 | +3,144,106 | 0.00 | 1.50 | +1.50 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 489,321 | 2,187,039 | +1,697,718 | 0.00 | 0.00 | +0.00 | buy |
| Jefferies Financial Group Inc. | 0 | 1,997,208 | +1,997,208 | 0.00 | 0.05 | +0.05 | buy |
| Burkehill Global Management, LP | 0 | 1,900,000 | +1,900,000 | 0.00 | 0.21 | +0.21 | buy |
| Anson Funds Management LP | 0 | 1,822,830 | +1,822,830 | 0.00 | 0.51 | +0.51 | buy |
| CITADEL ADVISORS LLC | 0 | 1,687,980 | +1,687,980 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 1,662,401 | 1,484,836 | -177,565 | 0.02 | 0.02 | +0.00 | sell |
| MORGAN STANLEY | 1,708,888 | 1,324,806 | -384,082 | 0.00 | 0.00 | -0.00 | sell |
| Woodline Partners LP | 0 | 1,218,464 | +1,218,464 | 0.00 | 0.01 | +0.01 | buy |
| Blue Owl Capital Holdings LP | 0 | 1,125,000 | +1,125,000 | 0.00 | 0.55 | +0.55 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 458,972 | 1,060,764 | +601,792 | 0.76 | 2.01 | +1.25 | buy |
| BlackRock, Inc. | 3,452,147 | 970,601 | -2,481,546 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 168,899 | 855,330 | +686,431 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,141,297 | 553,462 | -587,835 | 0.00 | 0.00 | -0.00 | sell |
| CANTOR FITZGERALD, L. P. | 1,484,585 | 532,500 | -952,085 | 0.08 | 0.02 | -0.06 | sell |
| BANK OF AMERICA CORP /DE/ | 984,095 | 498,243 | -485,852 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 490,200 | 472,042 | -18,158 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 471,500 | 413,600 | -57,900 | 0.00 | 0.00 | -0.00 | sell |
| Almitas Capital LLC | 367,491 | 367,491 | 0 | 0.17 | 0.14 | -0.03 | hold |
| GOLDMAN SACHS GROUP INC | 330,541 | 353,307 | +22,766 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 343,411 | 344,540 | +1,129 | 0.00 | 0.00 | -0.00 | buy |
| Raiffeisen Bank International AG | 300,000 | 300,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| PRUDENTIAL FINANCIAL INC | 287,490 | 284,000 | -3,490 | 0.00 | 0.00 | -0.00 | sell |
| AXA S.A. | 270,077 | 270,516 | +439 | 0.00 | 0.00 | -0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 321,411 | 252,357 | -69,054 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 0 | 238,325 | +238,325 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 0 | 235,270 | +235,270 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 938,718 | 217,967 | -720,751 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 33,460 | 190,957 | +157,497 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 399,766 | 133,020 | -266,746 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 10,900 | 126,100 | +115,200 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 124,395 | +124,395 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 97,260 | +97,260 | 0.00 | 0.01 | +0.01 | buy |
| THRIVENT FINANCIAL FOR LUTHERANS | 95,327 | 95,327 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TD ASSET MANAGEMENT INC | 88,600 | 88,600 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TCG Crossover Management, LLC | 86,795 | 86,795 | 0 | 0.02 | 0.02 | -0.00 | hold |
| Invesco Ltd. | 61,675 | 84,831 | +23,156 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 251,437 | 80,796 | -170,641 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 0 | 71,441 | +71,441 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 31,462 | 62,499 | +31,037 | 0.00 | 0.00 | +0.00 | buy |
| FRED ALGER MANAGEMENT, LLC | 477,210 | 59,813 | -417,397 | 0.00 | 0.00 | -0.00 | sell |
| Jain Global LLC | 0 | 56,160 | +56,160 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 6,415 | 51,036 | +44,621 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 159,866 | 50,621 | -109,245 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 61,405 | 49,066 | -12,339 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 155,174 | 47,810 | -107,364 | 0.00 | 0.00 | -0.00 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 45,675 | 45,675 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MYDA Advisors LLC | 0 | 40,000 | +40,000 | 0.00 | 0.02 | +0.02 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 57,036 | 39,770 | -17,266 | 0.00 | 0.00 | -0.00 | sell |
| Point72 Asia (Singapore) Pte. Ltd. | 0 | 34,767 | +34,767 | 0.00 | 0.01 | +0.01 | buy |
| AQR CAPITAL MANAGEMENT LLC | 73,956 | 32,129 | -41,827 | 0.00 | 0.00 | -0.00 | sell |
| Vanguard Personalized Indexing Management, LLC | 19,379 | 24,948 | +5,569 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 36,276 | 24,048 | -12,228 | 0.00 | 0.00 | -0.00 | sell |
| Catalyst Funds Management Pty Ltd | 0 | 21,000 | +21,000 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA SECURITIES, LLC | 0 | 16,491 | +16,491 | 0.00 | 0.00 | +0.00 | buy |
| Rangeley Capital, LLC | 0 | 16,000 | +16,000 | 0.00 | 0.03 | +0.03 | buy |
| FMR LLC | 4,161 | 15,456 | +11,295 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 682,670 | 15,141 | -667,529 | 0.00 | 0.00 | -0.00 | sell |
| Hudson Bay Capital Management LP | 0 | 13,070 | +13,070 | 0.00 | 0.00 | +0.00 | buy |
| DRW Securities, LLC | 0 | 12,840 | +12,840 | 0.00 | 0.00 | +0.00 | buy |
| Savant Capital, LLC | 0 | 12,471 | +12,471 | 0.00 | 0.00 | +0.00 | buy |
| CRA Financial Services, LLC | 11,000 | 11,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BARCLAYS PLC | 56,438 | 9,737 | -46,701 | 0.00 | 0.00 | -0.00 | sell |
| SBI Securities Co., Ltd. | 2,916 | 6,516 | +3,600 | 0.00 | 0.00 | +0.00 | buy |
| SUMMIT SECURITIES GROUP LLC | 0 | 4,824 | +4,824 | 0.00 | 0.00 | +0.00 | buy |
| Point72 (DIFC) Ltd | 0 | 2,432 | +2,432 | 0.00 | 0.00 | +0.00 | buy |
| Truvestments Capital LLC | 1,973 | 1,973 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CWM, LLC | 6,191 | 1,597 | -4,594 | 0.00 | 0.00 | -0.00 | sell |
| Rise Advisors, LLC | 0 | 1,083 | +1,083 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 0 | 939 | +939 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 194 | 912 | +718 | 0.00 | 0.00 | +0.00 | buy |
| Federation des caisses Desjardins du Quebec | 340 | 340 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Mid-American Wealth Advisory Group, Inc. | 0 | 91 | +91 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 90 | 41 | -49 | 0.00 | 0.00 | -0.00 | sell |
| Covestor Ltd | 37 | 34 | -3 | 0.00 | 0.00 | 0.00 | sell |
| True Wealth Design, LLC | 63 | 17 | -46 | 0.00 | 0.00 | -0.00 | sell |
| Ameritas Investment Partners, Inc. | 3,452 | 0 | -3,452 | 0.00 | 0.00 | -0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 12,981 | 0 | -12,981 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 3,338 | 0 | -3,338 | 0.00 | 0.00 | -0.00 | sell |
| COLDSTREAM CAPITAL MANAGEMENT INC | 280 | 0 | -280 | 0.00 | 0.00 | -0.00 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 31,148 | 0 | -31,148 | 0.00 | 0.00 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 64,630 | 0 | -64,630 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 61,388 | 0 | -61,388 | 0.00 | 0.00 | -0.00 | sell |
| Sterling Capital Management LLC | 636 | 0 | -636 | 0.00 | 0.00 | -0.00 | sell |
| Atle Fund Management AB | 182,354 | 0 | -182,354 | 0.11 | 0.00 | -0.11 | sell |
| ENVESTNET ASSET MANAGEMENT INC | 25,540 | 0 | -25,540 | 0.00 | 0.00 | -0.00 | sell |
| OXFORD ASSET MANAGEMENT LLP | 15,405 | 0 | -15,405 | 0.01 | 0.00 | -0.01 | sell |
| Neuberger Berman Group LLC | 10,565 | 0 | -10,565 | 0.00 | 0.00 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 26,622 | 0 | -26,622 | 0.00 | 0.00 | -0.00 | sell |
| Integral Health Asset Management, LLC | 850,000 | 0 | -850,000 | 0.13 | 0.00 | -0.13 | sell |
| Nuveen, LLC | 434,389 | 0 | -434,389 | 0.00 | 0.00 | -0.00 | sell |
| Corebridge Financial, Inc. | 21,981 | 0 | -21,981 | 0.00 | 0.00 | -0.00 | sell |
| CoreCap Advisors, LLC | 151 | 0 | -151 | 0.00 | 0.00 | -0.00 | sell |