| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JENNISON ASSOCIATES LLC | 8,970,578 | 20,033,730 | +11,063,152 | 0.02 | 0.04 | +0.02 | buy |
| T. Rowe Price Investment Management, Inc. | 11,080,005 | 18,869,907 | +7,789,902 | 0.02 | 0.04 | +0.02 | buy |
| Bain Capital Life Sciences Investors, LLC | 9,677,125 | 17,241,445 | +7,564,320 | 2.35 | 3.19 | +0.84 | buy |
| BlackRock, Inc. | 2,373,003 | 10,754,701 | +8,381,698 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 8,829,758 | 9,174,758 | +345,000 | 0.04 | 0.04 | +0.00 | buy |
| STATE STREET CORP | 469,978 | 7,839,305 | +7,369,327 | 0.00 | 0.00 | +0.00 | buy |
| Cormorant Asset Management, LP | 5,500,000 | 5,000,000 | -500,000 | 0.75 | 0.80 | +0.05 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 442,277 | 4,418,674 | +3,976,397 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 1,250,242 | 4,200,142 | +2,949,900 | 0.01 | 0.04 | +0.03 | buy |
| NORGES BANK | 0 | 4,112,401 | +4,112,401 | 0.00 | 0.00 | +0.00 | buy |
| Opaleye Management Inc. | 1,380,000 | 3,863,800 | +2,483,800 | 0.49 | 1.09 | +0.60 | buy |
| CITADEL ADVISORS LLC | 0 | 3,522,112 | +3,522,112 | 0.00 | 0.01 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,133,245 | 3,459,464 | +2,326,219 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 0 | 2,413,937 | +2,413,937 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 783,220 | 2,211,825 | +1,428,605 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 5,903,281 | 2,068,491 | -3,834,790 | 0.01 | 0.00 | -0.01 | sell |
| MARSHALL WACE, LLP | 2,179,818 | 1,565,939 | -613,879 | 0.01 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 2,036,663 | 1,535,300 | -501,363 | 0.01 | 0.01 | -0.00 | sell |
| UBS Group AG | 606,664 | 1,471,895 | +865,231 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 1,934,990 | 1,426,840 | -508,150 | 0.01 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 2,497,917 | 1,410,931 | -1,086,986 | 0.01 | 0.00 | -0.00 | sell |
| MORGAN STANLEY | 1,408,152 | 1,345,526 | -62,626 | 0.00 | 0.00 | -0.00 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 0 | 1,329,012 | +1,329,012 | 0.00 | 0.59 | +0.59 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 1,066,239 | 1,278,652 | +212,413 | 2.05 | 2.20 | +0.15 | buy |
| NORTHERN TRUST CORP | 238,442 | 1,007,102 | +768,660 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 740,648 | 967,195 | +226,547 | 0.00 | 0.00 | +0.00 | buy |
| Stonepine Capital Management, LLC | 50,000 | 917,100 | +867,100 | 0.12 | 2.17 | +2.05 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 756,637 | 856,637 | +100,000 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 828,145 | +828,145 | 0.00 | 0.00 | +0.00 | buy |
| CANTOR FITZGERALD, L. P. | 765,000 | 800,001 | +35,001 | 0.07 | 0.05 | -0.03 | buy |
| HEIGHTS CAPITAL MANAGEMENT, INC | 0 | 755,626 | +755,626 | 0.00 | 0.54 | +0.54 | buy |
| Blue Owl Capital Holdings LP | 0 | 714,710 | +714,710 | 0.00 | 0.34 | +0.34 | buy |
| Ikarian Capital, LLC | 900,000 | 700,000 | -200,000 | 0.35 | 0.36 | +0.01 | sell |
| Burkehill Global Management, LP | 700,000 | 700,000 | 0 | 0.09 | 0.08 | -0.01 | hold |
| GSA CAPITAL PARTNERS LLP | 561,726 | 668,563 | +106,837 | 0.09 | 0.13 | +0.04 | buy |
| Nuveen, LLC | 0 | 646,345 | +646,345 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 269,257 | 493,314 | +224,057 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 16,700 | 488,775 | +472,075 | 0.00 | 0.01 | +0.01 | buy |
| Raiffeisen Bank International AG | 450,000 | 430,000 | -20,000 | 0.02 | 0.02 | -0.00 | sell |
| TD ASSET MANAGEMENT INC | 66,924 | 391,472 | +324,548 | 0.00 | 0.00 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 17,595 | 383,294 | +365,699 | 0.00 | 0.02 | +0.02 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 374,886 | +374,886 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 50,824 | 374,886 | +324,062 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 54,299 | 304,819 | +250,520 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 247,659 | 286,212 | +38,553 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 267,372 | 267,372 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Invesco Ltd. | 192,383 | 241,565 | +49,182 | 0.00 | 0.00 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 0 | 196,872 | +196,872 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 27,473 | 184,232 | +156,759 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 243,445 | 182,455 | -60,990 | 0.02 | 0.01 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 182,055 | +182,055 | 0.00 | 0.00 | +0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 0 | 161,916 | +161,916 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 0 | 152,964 | +152,964 | 0.00 | 0.01 | +0.01 | buy |
| Rafferty Asset Management, LLC | 0 | 146,107 | +146,107 | 0.00 | 0.00 | +0.00 | buy |
| Diametric Capital, LP | 262,831 | 135,598 | -127,233 | 0.19 | 0.04 | -0.14 | sell |
| RHUMBLINE ADVISERS | 0 | 131,640 | +131,640 | 0.00 | 0.00 | +0.00 | buy |
| Almitas Capital LLC | 337,391 | 125,900 | -211,491 | 0.21 | 0.09 | -0.11 | sell |
| DEUTSCHE BANK AG\ | 0 | 110,962 | +110,962 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 0 | 108,703 | +108,703 | 0.00 | 0.08 | +0.08 | buy |
| ALLIANCEBERNSTEIN L.P. | 0 | 108,410 | +108,410 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 98,500 | 98,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| D. E. Shaw & Co., Inc. | 189,412 | 90,652 | -98,760 | 0.00 | 0.00 | -0.00 | sell |
| LETKO, BROSSEAU & ASSOCIATES INC | 90,475 | 90,475 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Graham Capital Management, L.P. | 101,688 | 81,279 | -20,409 | 0.01 | 0.01 | -0.00 | sell |
| PROFUND ADVISORS LLC | 0 | 73,409 | +73,409 | 0.00 | 0.01 | +0.01 | buy |
| Virtu Financial LLC | 38,703 | 69,511 | +30,808 | 0.00 | 0.01 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0 | 68,592 | +68,592 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 0 | 66,749 | +66,749 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 0 | 60,289 | +60,289 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 0 | 59,368 | +59,368 | 0.00 | 0.00 | +0.00 | buy |
| MATAURO, LLC | 55,108 | 55,108 | 0 | 0.02 | 0.02 | +0.00 | hold |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 0 | 54,086 | +54,086 | 0.00 | 0.00 | +0.00 | buy |
| EntryPoint Capital, LLC | 0 | 50,927 | +50,927 | 0.00 | 0.04 | +0.04 | buy |
| ADAR1 Capital Management, LLC | 0 | 50,000 | +50,000 | 0.00 | 0.01 | +0.01 | buy |
| XTX Topco Ltd | 12,512 | 45,702 | +33,190 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 97,792 | 44,701 | -53,091 | 0.00 | 0.00 | -0.00 | sell |
| KEYBANK NATIONAL ASSOCIATION/OH | 0 | 39,005 | +39,005 | 0.00 | 0.00 | +0.00 | buy |
| Quantbot Technologies LP | 0 | 37,208 | +37,208 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 34,419 | +34,419 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 0 | 33,203 | +33,203 | 0.00 | 0.00 | +0.00 | buy |
| GSB Wealth Management, LLC | 20,000 | 30,000 | +10,000 | 0.01 | 0.02 | +0.01 | buy |
| WINTON GROUP Ltd | 15,300 | 27,000 | +11,700 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA SECURITIES, LLC | 0 | 26,663 | +26,663 | 0.00 | 0.01 | +0.01 | buy |
| China Universal Asset Management Co., Ltd. | 17,083 | 25,950 | +8,867 | 0.00 | 0.00 | +0.00 | buy |
| RITHOLTZ WEALTH MANAGEMENT | 0 | 25,000 | +25,000 | 0.00 | 0.00 | +0.00 | buy |
| Wealthfront Advisers LLC | 0 | 24,389 | +24,389 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | 23,400 | +23,400 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 23,035 | +23,035 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 0 | 21,377 | +21,377 | 0.00 | 0.00 | +0.00 | buy |
| E Fund Management Co., Ltd. | 0 | 20,601 | +20,601 | 0.00 | 0.00 | +0.00 | buy |
| nVerses Capital, LLC | 0 | 20,286 | +20,286 | 0.00 | 0.10 | +0.10 | buy |
| ProShare Advisors LLC | 0 | 20,086 | +20,086 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 1,569 | 19,609 | +18,040 | 0.00 | 0.00 | +0.00 | buy |
| Clear Harbor Asset Management, LLC | 19,500 | 19,500 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Callan Family Office, LLC | 17,434 | 17,434 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PRUDENTIAL FINANCIAL INC | 0 | 16,985 | +16,985 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 0 | 16,493 | +16,493 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 0 | 16,490 | +16,490 | 0.00 | 0.00 | +0.00 | buy |
| &PARTNERS | 0 | 16,200 | +16,200 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 12,991 | 15,928 | +2,937 | 0.00 | 0.00 | +0.00 | buy |