| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JENNISON ASSOCIATES LLC | 5,546,467 | 5,632,681 | +86,214 | 0.03 | 0.02 | -0.01 | buy |
| FRED ALGER MANAGEMENT, LLC | 2,522,882 | 4,119,394 | +1,596,512 | 0.09 | 0.09 | +0.00 | buy |
| T. Rowe Price Investment Management, Inc. | 3,878,210 | 3,673,724 | -204,486 | 0.02 | 0.01 | -0.01 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 3,036,645 | 3,036,645 | 0 | 0.04 | 0.03 | -0.02 | hold |
| Bain Capital Life Sciences Investors, LLC | 1,649,964 | 2,760,888 | +1,110,924 | 1.35 | 1.36 | +0.00 | buy |
| VANGUARD GROUP INC | 2,366,057 | 2,553,710 | +187,653 | 0.00 | 0.00 | -0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 698,317 | 1,628,913 | +930,596 | 0.00 | 0.01 | +0.00 | buy |
| VR Adviser, LLC | 1,563,952 | 1,563,952 | 0 | 0.75 | 0.39 | -0.36 | hold |
| Sofinnova Investments, Inc. | 1,220,400 | 1,533,883 | +313,483 | 0.58 | 0.60 | +0.02 | buy |
| STEMPOINT CAPITAL LP | 1,178,105 | 1,278,444 | +100,339 | 2.59 | 1.81 | -0.78 | buy |
| Commodore Capital LP | 1,100,000 | 1,100,000 | 0 | 0.56 | 0.32 | -0.24 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 970,573 | 1,094,644 | +124,071 | 0.00 | 0.00 | -0.00 | buy |
| STATE STREET CORP | 2,005,801 | 896,123 | -1,109,678 | 0.00 | 0.00 | -0.00 | sell |
| MORGAN STANLEY | 295,509 | 828,829 | +533,320 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 0 | 667,275 | +667,275 | 0.00 | 0.01 | +0.01 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 634,217 | 629,087 | -5,130 | 0.00 | 0.00 | -0.00 | sell |
| Cubist Systematic Strategies, LLC | 0 | 573,180 | +573,180 | 0.00 | 0.04 | +0.04 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 582,275 | 552,792 | -29,483 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 169,105 | 478,674 | +309,569 | 0.00 | 0.00 | +0.00 | buy |
| Integral Health Asset Management, LLC | 425,000 | 450,000 | +25,000 | 0.32 | 0.25 | -0.07 | buy |
| Redmile Group, LLC | 442,826 | 442,826 | 0 | 0.20 | 0.12 | -0.08 | hold |
| TWO SIGMA INVESTMENTS, LP | 395,437 | 420,477 | +25,040 | 0.01 | 0.00 | -0.00 | buy |
| Walleye Capital LLC | 189,957 | 401,982 | +212,025 | 0.01 | 0.02 | +0.01 | buy |
| NORTHERN TRUST CORP | 306,408 | 388,004 | +81,596 | 0.00 | 0.00 | -0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 403,136 | 331,260 | -71,876 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 395,823 | 321,359 | -74,464 | 0.00 | 0.00 | -0.00 | sell |
| PANAGORA ASSET MANAGEMENT INC | 299,801 | 319,371 | +19,570 | 0.01 | 0.01 | -0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 286,810 | 286,810 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MARSHALL WACE, LLP | 330,187 | 283,806 | -46,381 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 72,500 | 281,200 | +208,700 | 0.00 | 0.00 | +0.00 | buy |
| E Fund Management Co., Ltd. | 286,424 | 280,133 | -6,291 | 0.12 | 0.07 | -0.05 | sell |
| JPMORGAN CHASE & CO | 956,689 | 279,954 | -676,735 | 0.00 | 0.00 | -0.00 | sell |
| AXA S.A. | 270,778 | 270,854 | +76 | 0.01 | 0.00 | -0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 257,421 | +257,421 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 303,326 | 230,293 | -73,033 | 0.00 | 0.00 | -0.00 | sell |
| Atle Fund Management AB | 64,321 | 168,522 | +104,201 | 0.29 | 0.37 | +0.08 | buy |
| Bank of New York Mellon Corp | 190,217 | 158,093 | -32,124 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 296,615 | 157,702 | -138,913 | 0.00 | 0.00 | -0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 158,809 | 157,051 | -1,758 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 315,379 | 156,995 | -158,384 | 0.01 | 0.00 | -0.01 | sell |
| Trexquant Investment LP | 28,233 | 144,584 | +116,351 | 0.00 | 0.01 | +0.01 | buy |
| Crestline Management, LP | 104,705 | 143,575 | +38,870 | 0.06 | 0.04 | -0.02 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 139,895 | 131,795 | -8,100 | 1.32 | 0.56 | -0.76 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 118,327 | 125,845 | +7,518 | 0.00 | 0.00 | -0.00 | buy |
| Jump Financial, LLC | 182,135 | 109,786 | -72,349 | 0.03 | 0.01 | -0.02 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 56,828 | 98,673 | +41,845 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 134,030 | 88,600 | -45,430 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 14,817 | 87,455 | +72,638 | 0.01 | 0.03 | +0.02 | buy |
| ROYAL BANK OF CANADA | 67,062 | 87,157 | +20,095 | 0.00 | 0.00 | -0.00 | buy |
| TCG Crossover Management, LLC | 86,795 | 86,795 | 0 | 0.07 | 0.03 | -0.03 | hold |
| Corton Capital Inc. | 31,931 | 66,741 | +34,810 | 0.13 | 0.15 | +0.03 | buy |
| ALLIANCEBERNSTEIN L.P. | 64,630 | 64,630 | 0 | 0.00 | 0.00 | -0.00 | hold |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 76,513 | 61,842 | -14,671 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 41,239 | 61,130 | +19,891 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 61,880 | 60,570 | -1,310 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 56,424 | 55,864 | -560 | 0.00 | 0.00 | -0.00 | sell |
| ENVESTNET ASSET MANAGEMENT INC | 30,026 | 48,070 | +18,044 | 0.00 | 0.00 | -0.00 | buy |
| Ensign Peak Advisors, Inc | 19,373 | 36,873 | +17,500 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 29,441 | 36,670 | +7,229 | 0.00 | 0.00 | -0.00 | buy |
| SG Americas Securities, LLC | 0 | 35,098 | +35,098 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 22,894 | 34,566 | +11,672 | 0.00 | 0.00 | -0.00 | buy |
| D. E. Shaw & Co., Inc. | 0 | 33,963 | +33,963 | 0.00 | 0.00 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 33,548 | 33,251 | -297 | 0.00 | 0.00 | -0.00 | sell |
| MetLife Investment Management, LLC | 27,714 | 27,714 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GSA CAPITAL PARTNERS LLP | 0 | 26,976 | +26,976 | 0.00 | 0.01 | +0.01 | buy |
| WELLS FARGO & COMPANY/MN | 19,309 | 24,162 | +4,853 | 0.00 | 0.00 | -0.00 | buy |
| Corebridge Financial, Inc. | 23,129 | 23,709 | +580 | 0.00 | 0.00 | -0.00 | buy |
| Graham Capital Management, L.P. | 17,966 | 23,571 | +5,605 | 0.00 | 0.00 | -0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 21,797 | 23,559 | +1,762 | 0.00 | 0.00 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 14,018 | 22,361 | +8,343 | 0.00 | 0.00 | -0.00 | buy |
| KEYBANK NATIONAL ASSOCIATION/OH | 21,506 | 21,506 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Engineers Gate Manager LP | 22,969 | 19,662 | -3,307 | 0.00 | 0.00 | -0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 14,293 | 14,904 | +611 | 0.00 | 0.00 | -0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 14,204 | +14,204 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 15,324 | 13,865 | -1,459 | 0.00 | 0.00 | -0.00 | sell |
| Bridgefront Capital, LLC | 11,876 | 12,229 | +353 | 0.04 | 0.02 | -0.01 | buy |
| SEI INVESTMENTS CO | 0 | 12,206 | +12,206 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 0 | 11,265 | +11,265 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 11,603 | 11,098 | -505 | 0.00 | 0.00 | -0.00 | sell |
| Vanguard Personalized Indexing Management, LLC | 0 | 10,173 | +10,173 | 0.00 | 0.00 | +0.00 | buy |
| Birchview Capital, LP | 10,000 | 10,000 | 0 | 0.07 | 0.04 | -0.03 | hold |
| China Universal Asset Management Co., Ltd. | 5,671 | 9,395 | +3,724 | 0.01 | 0.00 | -0.00 | buy |
| SIMPLEX TRADING, LLC | 6,204 | 7,638 | +1,434 | 0.00 | 0.00 | -0.00 | buy |
| VIRTUS ADVISERS, LLC | 7,207 | 7,338 | +131 | 0.03 | 0.02 | -0.01 | buy |
| Point72 (DIFC) Ltd | 0 | 6,987 | +6,987 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asia (Singapore) Pte. Ltd. | 0 | 6,680 | +6,680 | 0.00 | 0.01 | +0.01 | buy |
| Legal & General Group Plc | 26,720 | 3,961 | -22,759 | 0.00 | 0.00 | -0.00 | sell |
| Ameritas Investment Partners, Inc. | 3,452 | 3,452 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 33,825 | 3,338 | -30,487 | 0.00 | 0.00 | -0.00 | sell |
| nVerses Capital, LLC | 0 | 3,000 | +3,000 | 0.00 | 0.01 | +0.01 | buy |
| FMR LLC | 1,077 | 2,758 | +1,681 | 0.00 | 0.00 | +0.00 | buy |
| CIBC Private Wealth Group LLC | 0 | 2,000 | +2,000 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 1,441 | 1,767 | +326 | 0.00 | 0.00 | -0.00 | buy |
| AMALGAMATED BANK | 1,175 | 1,175 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MACROVIEW INVESTMENT MANAGEMENT LLC | 1,131 | 1,131 | 0 | 0.01 | 0.01 | -0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 82,160 | 990 | -81,170 | 0.00 | 0.00 | -0.00 | sell |
| PRIVATE TRUST CO NA | 538 | 872 | +334 | 0.00 | 0.00 | -0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 1,562 | 811 | -751 | 0.00 | 0.00 | -0.00 | sell |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 4,263 | 798 | -3,465 | 0.00 | 0.00 | -0.00 | sell |
| Truvestments Capital LLC | 0 | 766 | +766 | 0.00 | 0.00 | +0.00 | buy |