| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| PERCEPTIVE ADVISORS LLC | 1,132,491 | 2,003,058 | +870,567 | 0.57 | 1.01 | +0.44 | buy |
| Holocene Advisors, LP | 1,183,046 | 1,920,323 | +737,277 | 0.08 | 0.17 | +0.09 | buy |
| VR Adviser, LLC | 1,973,253 | 2,563,952 | +590,699 | 3.16 | 3.99 | +0.83 | buy |
| JENNISON ASSOCIATES LLC | 1,422,367 | 1,626,628 | +204,261 | 0.02 | 0.03 | +0.01 | buy |
| Integral Health Asset Management, LLC | 330,000 | 520,000 | +190,000 | 0.71 | 1.70 | +0.99 | buy |
| Woodline Partners LP | 134,184 | 241,453 | +107,269 | 0.02 | 0.06 | +0.04 | buy |
| Rafferty Asset Management, LLC | 118,150 | 209,263 | +91,113 | 0.01 | 0.02 | +0.01 | buy |
| PROFUND ADVISORS LLC | 20,121 | 33,858 | +13,737 | 0.02 | 0.03 | 0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 50,621 | 46,021 | +4,600 | 0.02 | 0.02 | 0.00 | sell |
| Lynx1 Capital Management LP | 2,106,000 | 2,110,401 | +4,401 | 21.20 | 18.84 | -2.36 | buy |
| CHURCHILL MANAGEMENT Corp | 57,047 | 49,356 | -7,691 | 0.01 | 0.02 | +0.00 | sell |
| Rokos Capital Management LLP | 173,850 | 80,335 | -93,515 | 0.02 | 0.02 | -0.00 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 2,340,118 | 2,007,729 | -332,389 | 0.78 | 0.84 | +0.06 | sell |
| Redmile Group, LLC | 1,774,252 | 1,374,189 | -400,063 | 1.28 | 1.12 | -0.17 | sell |
| Commodore Capital LP | 2,525,753 | 1,900,000 | -625,753 | 4.49 | 3.77 | -0.72 | sell |
| FRED ALGER MANAGEMENT, LLC | 4,259,455 | 3,327,132 | -932,323 | 0.37 | 0.41 | +0.03 | sell |
| BAKER BROS. ADVISORS LP | 1,594,000 | 13,331 | -1,580,669 | 0.14 | 0.00 | -0.14 | sell |