| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| T. Rowe Price Investment Management, Inc. | 0 | 1,832,854 | +1,832,854 | 0.00 | 0.03 | +0.03 | buy |
| Polar Capital Holdings Plc | 0 | 1,250,000 | +1,250,000 | 0.00 | 0.17 | +0.17 | buy |
| STATE STREET CORP | 1,532,842 | 2,594,470 | +1,061,628 | 0.00 | 0.00 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 1,132,491 | 2,003,058 | +870,567 | 0.58 | 1.02 | +0.44 | buy |
| Holocene Advisors, LP | 1,183,046 | 1,920,323 | +737,277 | 0.08 | 0.17 | +0.09 | buy |
| VR Adviser, LLC | 1,973,253 | 2,563,952 | +590,699 | 3.16 | 3.99 | +0.83 | buy |
| Invesco Ltd. | 854,043 | 1,397,942 | +543,899 | 0.00 | 0.01 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 15,315 | 527,765 | +512,450 | 0.00 | 0.00 | +0.00 | buy |
| Sofinnova Investments, Inc. | 0 | 429,395 | +429,395 | 0.00 | 0.55 | +0.55 | buy |
| ALKEON CAPITAL MANAGEMENT LLC | 0 | 360,000 | +360,000 | 0.00 | 0.05 | +0.05 | buy |
| Blackstone Inc. | 0 | 347,494 | +347,494 | 0.00 | 0.04 | +0.04 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 66,650 | 403,927 | +337,277 | 0.00 | 0.01 | +0.01 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 246,570 | 539,876 | +293,306 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 0 | 284,666 | +284,666 | 0.00 | 0.02 | +0.02 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 251,615 | +251,615 | 0.00 | 0.05 | +0.05 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 10,762 | 236,400 | +225,638 | 0.00 | 0.02 | +0.02 | buy |
| Ikarian Capital, LLC | 0 | 216,620 | +216,620 | 0.00 | 1.35 | +1.35 | buy |
| JENNISON ASSOCIATES LLC | 1,422,367 | 1,626,628 | +204,261 | 0.02 | 0.03 | +0.01 | buy |
| Integral Health Asset Management, LLC | 330,000 | 520,000 | +190,000 | 0.71 | 1.70 | +0.99 | buy |
| MORGAN STANLEY | 222,017 | 387,383 | +165,366 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 1,968,108 | 2,131,931 | +163,823 | 0.00 | 0.00 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 0 | 118,002 | +118,002 | 0.00 | 0.01 | +0.01 | buy |
| Woodline Partners LP | 134,184 | 241,453 | +107,269 | 0.02 | 0.06 | +0.04 | buy |
| UBS Group AG | 34,983 | 138,645 | +103,662 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 0 | 93,630 | +93,630 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 118,150 | 209,263 | +91,113 | 0.01 | 0.02 | +0.01 | buy |
| JANE STREET GROUP, LLC | 0 | 88,409 | +88,409 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 64,586 | 129,072 | +64,486 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 691,872 | 753,176 | +61,304 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 58,755 | +58,755 | 0.00 | 0.05 | +0.05 | buy |
| Nicholas Investment Partners, LP | 0 | 54,586 | +54,586 | 0.00 | 0.14 | +0.14 | buy |
| Qube Research & Technologies Ltd | 0 | 52,199 | +52,199 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 13,250 | 52,677 | +39,427 | 0.00 | 0.00 | +0.00 | buy |
| Caption Management, LLC | 0 | 38,300 | +38,300 | 0.00 | 0.09 | +0.09 | buy |
| CITIGROUP INC | 49,695 | 86,546 | +36,851 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 0 | 33,880 | +33,880 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 0 | 29,241 | +29,241 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 46,725 | 74,791 | +28,066 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 22,054 | +22,054 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 23,668 | 44,840 | +21,172 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 141,186 | 160,520 | +19,334 | 0.00 | 0.00 | +0.00 | buy |
| BLAIR WILLIAM & CO/IL | 0 | 18,538 | +18,538 | 0.00 | 0.00 | +0.00 | buy |
| ADVISORY RESEARCH INC | 0 | 17,660 | +17,660 | 0.00 | 0.06 | +0.06 | buy |
| DENALI ADVISORS LLC | 0 | 17,300 | +17,300 | 0.00 | 0.12 | +0.12 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 10,363 | 25,191 | +14,828 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 13,958 | +13,958 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 20,121 | 33,858 | +13,737 | 0.02 | 0.03 | +0.02 | buy |
| Bank of New York Mellon Corp | 145,467 | 156,953 | +11,486 | 0.00 | 0.00 | +0.00 | buy |
| E Fund Management Co., Ltd. | 0 | 11,239 | +11,239 | 0.00 | 0.02 | +0.02 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0 | 11,201 | +11,201 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 11,100 | +11,100 | 0.00 | 0.02 | +0.02 | buy |
| NORTHERN TRUST CORP | 299,769 | 310,672 | +10,903 | 0.00 | 0.00 | +0.00 | buy |
| Birchview Capital, LP | 0 | 10,000 | +10,000 | 0.00 | 0.18 | +0.18 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 0 | 9,830 | +9,830 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 9,740 | +9,740 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 16,798 | 23,689 | +6,891 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 0 | 4,962 | +4,962 | 0.00 | 0.02 | +0.02 | buy |
| VIRTUS ADVISERS, LLC | 0 | 4,507 | +4,507 | 0.00 | 0.06 | +0.06 | buy |
| Lynx1 Capital Management LP | 2,106,000 | 2,110,401 | +4,401 | 21.20 | 18.84 | -2.36 | buy |
| Squarepoint Ops LLC | 19,292 | 23,633 | +4,341 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 3,397 | +3,397 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 42,602 | 44,147 | +1,545 | 0.00 | 0.00 | +0.00 | buy |
| Quantbot Technologies LP | 0 | 1,500 | +1,500 | 0.00 | 0.00 | +0.00 | buy |
| MACROVIEW INVESTMENT MANAGEMENT LLC | 0 | 1,131 | +1,131 | 0.00 | 0.03 | +0.03 | buy |
| Tower Research Capital LLC (TRC) | 1,581 | 2,623 | +1,042 | 0.00 | 0.00 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 96,005 | 96,310 | +305 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 0 | 274 | +274 | 0.00 | 0.00 | +0.00 | buy |
| Daiwa Securities Group Inc. | 0 | 175 | +175 | 0.00 | 0.00 | +0.00 | buy |
| PRIVATE TRUST CO NA | 497 | 653 | +156 | 0.00 | 0.00 | +0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 3,285 | 3,403 | +118 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 58 | 132 | +74 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 4,648 | 4,704 | +56 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 3,452 | 3,452 | 0 | 0.00 | 0.00 | +0.00 | hold |
| VOYA INVESTMENT MANAGEMENT LLC | 13,929 | 13,929 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 3,266,645 | 3,266,645 | 0 | 0.11 | 0.15 | +0.04 | hold |
| MetLife Investment Management, LLC | 18,315 | 18,315 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Capital Advisors, Ltd. LLC | 81 | 81 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Bain Capital Life Sciences Investors, LLC | 2,000,000 | 2,000,000 | 0 | 3.40 | 4.35 | +0.95 | hold |
| Bogart Wealth, LLC | 50 | 50 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Nan Fung Group Holdings Ltd | 47,150 | 47,150 | 0 | 0.58 | 0.67 | +0.09 | hold |
| TCG Crossover Management, LLC | 486,795 | 486,795 | 0 | 1.09 | 1.23 | +0.13 | hold |
| Beaird Harris Wealth Management, LLC | 79 | 79 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Federation des caisses Desjardins du Quebec | 340 | 340 | 0 | 0.00 | 0.00 | +0.00 | hold |
| FRANKLIN RESOURCES INC | 12,065 | 12,065 | 0 | 0.00 | 0.00 | +0.00 | hold |
| METROPOLITAN LIFE INSURANCE CO/NY | 2,021 | 2,021 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 23 | 23 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Russell Investments Group, Ltd. | 14 | 0 | -14 | 0.00 | 0.00 | -0.00 | sell |
| PNC FINANCIAL SERVICES GROUP, INC. | 719 | 690 | -29 | 0.00 | 0.00 | +0.00 | sell |
| Authentikos Wealth Advisory, LLC | 33 | 0 | -33 | 0.00 | 0.00 | -0.00 | sell |
| JANUS HENDERSON GROUP PLC | 19,597 | 19,559 | -38 | 0.00 | 0.00 | +0.00 | sell |
| AMERICAN INTERNATIONAL GROUP, INC. | 17,186 | 17,118 | -68 | 0.00 | 0.00 | -0.00 | sell |
| COMERICA BANK | 2,028 | 1,943 | -85 | 0.00 | 0.00 | +0.00 | sell |
| LPL Financial LLC | 37,861 | 37,638 | -223 | 0.00 | 0.00 | +0.00 | sell |
| FMR LLC | 792 | 405 | -387 | 0.00 | 0.00 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 14,546 | 13,761 | -785 | 0.00 | 0.00 | +0.00 | sell |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 7,539 | 4,739 | -2,800 | 0.00 | 0.00 | -0.00 | sell |
| Allspring Global Investments Holdings, LLC | 4,136 | 1,164 | -2,972 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 32,161 | 28,717 | -3,444 | 0.00 | 0.00 | +0.00 | sell |
| DEUTSCHE BANK AG\ | 21,135 | 17,329 | -3,806 | 0.00 | 0.00 | -0.00 | sell |