| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| MILLENNIUM MANAGEMENT LLC | 686,813 | 2,736,912 | +2,050,099 | 0.00 | 0.00 | +0.00 | buy |
| T. Rowe Price Investment Management, Inc. | 8,362,489 | 9,858,257 | +1,495,768 | 0.01 | 0.01 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 470,475 | 1,839,799 | +1,369,324 | 0.00 | 0.01 | +0.00 | buy |
| Ikarian Capital, LLC | 0 | 900,000 | +900,000 | 0.00 | 0.26 | +0.26 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 0 | 756,637 | +756,637 | 0.00 | 0.00 | +0.00 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 1,544,525 | 2,253,550 | +709,025 | 3.56 | 2.64 | -0.92 | buy |
| BlackRock, Inc. | 1,620,872 | 2,328,470 | +707,598 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 662,149 | +662,149 | 0.00 | 0.00 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 0 | 550,000 | +550,000 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 0 | 452,039 | +452,039 | 0.00 | 0.00 | +0.00 | buy |
| JENNISON ASSOCIATES LLC | 8,497,537 | 8,905,699 | +408,162 | 0.01 | 0.01 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 331,000 | 737,900 | +406,900 | 0.00 | 0.00 | +0.00 | buy |
| 683 Capital Management, LLC | 0 | 388,562 | +388,562 | 0.00 | 0.07 | +0.07 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 303,992 | +303,992 | 0.00 | 0.06 | +0.06 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 243,445 | +243,445 | 0.00 | 0.01 | +0.01 | buy |
| Qube Research & Technologies Ltd | 89,157 | 331,225 | +242,068 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 4,190,759 | 4,419,458 | +228,699 | 0.00 | 0.00 | -0.00 | buy |
| BARCLAYS PLC | 3,083 | 220,696 | +217,613 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 1,339,423 | 1,522,583 | +183,160 | 0.00 | 0.01 | +0.00 | buy |
| Stonepine Capital Management, LLC | 0 | 171,100 | +171,100 | 0.00 | 0.30 | +0.30 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 920,340 | 1,085,816 | +165,476 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 1,044,169 | 1,204,070 | +159,901 | 0.02 | 0.01 | -0.00 | buy |
| GOLDMAN SACHS GROUP INC | 272,596 | 430,674 | +158,078 | 0.00 | 0.00 | +0.00 | buy |
| Graham Capital Management, L.P. | 0 | 151,451 | +151,451 | 0.00 | 0.01 | +0.01 | buy |
| Hudson Bay Capital Management LP | 0 | 138,729 | +138,729 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 11,868 | 149,094 | +137,226 | 0.00 | 0.00 | +0.00 | buy |
| Raiffeisen Bank International AG | 350,000 | 450,000 | +100,000 | 0.01 | 0.01 | +0.00 | buy |
| OMERS ADMINISTRATION Corp | 0 | 95,400 | +95,400 | 0.00 | 0.00 | +0.00 | buy |
| Opaleye Management Inc. | 808,882 | 900,000 | +91,118 | 0.27 | 0.26 | -0.01 | buy |
| LETKO, BROSSEAU & ASSOCIATES INC | 0 | 90,475 | +90,475 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 352 | 73,774 | +73,422 | 0.00 | 0.00 | +0.00 | buy |
| Dynamic Technology Lab Private Ltd | 0 | 66,789 | +66,789 | 0.00 | 0.03 | +0.03 | buy |
| Invesco Ltd. | 122,800 | 189,195 | +66,395 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 0 | 56,648 | +56,648 | 0.00 | 0.00 | +0.00 | buy |
| MATAURO, LLC | 0 | 55,108 | +55,108 | 0.00 | 0.02 | +0.02 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 51,552 | +51,552 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 376,800 | 425,478 | +48,678 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 12,032 | 58,777 | +46,745 | 0.00 | 0.00 | +0.00 | buy |
| Lighthouse Investment Partners, LLC | 0 | 38,880 | +38,880 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 95,675 | 130,675 | +35,000 | 0.00 | 0.01 | +0.00 | buy |
| MERCER GLOBAL ADVISORS INC /ADV | 0 | 26,510 | +26,510 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 4,367 | 30,345 | +25,978 | 0.00 | 0.00 | +0.00 | buy |
| Quadrature Capital Ltd | 42,912 | 66,377 | +23,465 | 0.00 | 0.00 | +0.00 | buy |
| Callan Family Office, LLC | 0 | 22,575 | +22,575 | 0.00 | 0.00 | +0.00 | buy |
| Clear Harbor Asset Management, LLC | 0 | 19,500 | +19,500 | 0.00 | 0.00 | +0.00 | buy |
| ANTIPODES PARTNERS Ltd | 0 | 17,187 | +17,187 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 0 | 15,686 | +15,686 | 0.00 | 0.00 | +0.00 | buy |
| Private Advisor Group, LLC | 0 | 14,725 | +14,725 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 226,987 | 238,442 | +11,455 | 0.00 | 0.00 | -0.00 | buy |
| UBS Group AG | 405,120 | 415,677 | +10,557 | 0.00 | 0.00 | -0.00 | buy |
| HB Wealth Management, LLC | 0 | 10,000 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 21,264 | 30,629 | +9,365 | 0.00 | 0.00 | -0.00 | buy |
| Bank of New York Mellon Corp | 47,810 | 54,047 | +6,237 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 0 | 4,678 | +4,678 | 0.00 | 0.00 | +0.00 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 0 | 3,500 | +3,500 | 0.00 | 0.00 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 0 | 1,891 | +1,891 | 0.00 | 0.00 | +0.00 | buy |
| FLAGSHIP HARBOR ADVISORS, LLC | 0 | 1,000 | +1,000 | 0.00 | 0.00 | +0.00 | buy |
| JONES FINANCIAL COMPANIES LLLP | 20,007 | 20,660 | +653 | 0.00 | 0.00 | -0.00 | buy |
| Vanguard Personalized Indexing Management, LLC | 22,151 | 22,384 | +233 | 0.00 | 0.00 | -0.00 | buy |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 2 | 60 | +58 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 88,600 | 88,600 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 8,829,758 | 8,829,758 | 0 | 0.03 | 0.03 | -0.00 | hold |
| Arax Advisory Partners | 10 | 10 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Almitas Capital LLC | 387,491 | 387,491 | 0 | 0.21 | 0.19 | -0.02 | hold |
| Russell Investments Group, Ltd. | 939 | 939 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Bain Capital Life Sciences Investors, LLC | 9,677,125 | 9,677,125 | 0 | 1.50 | 1.62 | +0.12 | hold |
| Truvestments Capital LLC | 680 | 680 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CRA Financial Services, LLC | 15,000 | 15,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Optiver Holding B.V. | 24 | 24 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Burkehill Global Management, LP | 700,000 | 700,000 | 0 | 0.09 | 0.10 | +0.01 | hold |
| Covestor Ltd | 34 | 34 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Federation des caisses Desjardins du Quebec | 340 | 340 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 50,824 | 50,824 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 811 | 811 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 13,084 | 13,011 | -73 | 0.00 | 0.00 | -0.00 | sell |
| SBI Securities Co., Ltd. | 456 | 316 | -140 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 1,831 | 1,640 | -191 | 0.00 | 0.00 | -0.00 | sell |
| Wilmington Savings Fund Society, FSB | 450 | 0 | -450 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 14,064 | 13,045 | -1,019 | 0.00 | 0.00 | -0.00 | sell |
| Rise Advisors, LLC | 1,083 | 0 | -1,083 | 0.00 | 0.00 | -0.00 | sell |
| Jefferies Financial Group Inc. | 47,500 | 45,125 | -2,375 | 0.00 | 0.00 | -0.00 | sell |
| Caitong International Asset Management Co., Ltd | 8,983 | 0 | -8,983 | 0.01 | 0.00 | -0.01 | sell |
| Rangeley Capital, LLC | 11,300 | 0 | -11,300 | 0.02 | 0.00 | -0.02 | sell |
| FRED ALGER MANAGEMENT, LLC | 59,813 | 28,021 | -31,792 | 0.00 | 0.00 | -0.00 | sell |
| Susquehanna Portfolio Strategies, LLC | 33,937 | 0 | -33,937 | 0.00 | 0.00 | -0.00 | sell |
| ROYAL BANK OF CANADA | 91,723 | 0 | -91,723 | 0.00 | 0.00 | -0.00 | sell |
| FEDERATED HERMES, INC. | 112,028 | 0 | -112,028 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 284,299 | 155,387 | -128,912 | 0.03 | 0.01 | -0.03 | sell |
| MORGAN STANLEY | 1,474,676 | 1,343,708 | -130,968 | 0.00 | 0.00 | -0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 186,521 | 0 | -186,521 | 0.00 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,294,949 | 1,093,959 | -200,990 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 372,108 | 138,281 | -233,827 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 268,058 | 0 | -268,058 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 1,326,043 | 959,076 | -366,967 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 537,649 | 0 | -537,649 | 0.00 | 0.00 | -0.00 | sell |
| Cormorant Asset Management, LP | 5,000,000 | 4,400,000 | -600,000 | 0.81 | 0.55 | -0.26 | sell |
| CITADEL ADVISORS LLC | 705,465 | 0 | -705,465 | 0.00 | 0.00 | -0.00 | sell |
| Woodline Partners LP | 2,135,348 | 1,250,242 | -885,106 | 0.02 | 0.01 | -0.01 | sell |
| Alyeska Investment Group, L.P. | 1,300,000 | 0 | -1,300,000 | 0.01 | 0.00 | -0.01 | sell |
| HEIGHTS CAPITAL MANAGEMENT, INC | 2,084,202 | 0 | -2,084,202 | 1.55 | 0.00 | -1.55 | sell |