| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Frazier Life Sciences Management, L.P. | 6,495,392 | 6,495,392 | 0 | 10.25 | 6.88 | -3.37 | hold |
| BVF INC/IL | 4,370,024 | 4,370,024 | 0 | 3.23 | 3.02 | -0.21 | hold |
| EVENTIDE ASSET MANAGEMENT, LLC | 2,663,649 | 3,300,400 | +636,751 | 1.28 | 1.30 | +0.02 | buy |
| STATE STREET CORP | 1,734,775 | 2,822,472 | +1,087,697 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 2,062,551 | 2,767,210 | +704,659 | 0.04 | 0.04 | +0.00 | buy |
| CADIAN CAPITAL MANAGEMENT, LP | 1,934,922 | 2,292,567 | +357,645 | 2.28 | 2.05 | -0.23 | buy |
| VANGUARD GROUP INC | 2,476,244 | 2,211,685 | -264,559 | 0.00 | 0.00 | -0.00 | sell |
| Rock Springs Capital Management LP | 1,851,464 | 1,856,564 | +5,100 | 1.35 | 1.19 | -0.16 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,164,682 | 1,597,506 | +432,824 | 0.00 | 0.00 | +0.00 | buy |
| Novo Holdings A/S | 1,500,000 | 1,500,000 | 0 | 2.73 | 2.60 | -0.14 | hold |
| CITADEL ADVISORS LLC | 1,442,812 | 1,392,506 | -50,306 | 0.04 | 0.03 | -0.01 | sell |
| TANG CAPITAL MANAGEMENT LLC | 1,137,107 | 1,187,107 | +50,000 | 3.10 | 3.10 | +0.00 | buy |
| Avidity Partners Management LP | 1,142,850 | 1,142,850 | 0 | 1.29 | 1.02 | -0.27 | hold |
| First Turn Management, LLC | 836,302 | 958,654 | +122,352 | 3.55 | 3.60 | +0.06 | buy |
| Pictet Asset Management Holding SA | 793,655 | 955,914 | +162,259 | 0.03 | 0.03 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 913,068 | 941,374 | +28,306 | 0.01 | 0.01 | -0.01 | buy |
| GOLDMAN SACHS GROUP INC | 456,318 | 700,116 | +243,798 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 681,180 | 697,139 | +15,959 | 0.00 | 0.00 | -0.00 | buy |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 621,778 | 627,272 | +5,494 | 0.05 | 0.04 | -0.01 | buy |
| Polar Capital Holdings Plc | 625,000 | 625,000 | 0 | 0.11 | 0.08 | -0.03 | hold |
| AXA S.A. | 593,713 | 593,786 | +73 | 0.06 | 0.04 | -0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 224,376 | 539,666 | +315,290 | 0.01 | 0.01 | +0.01 | buy |
| Prosight Management, LP | 293,301 | 465,000 | +171,699 | 3.48 | 3.25 | -0.23 | buy |
| BOONE CAPITAL MANAGEMENT LLC | 490,139 | 451,898 | -38,241 | 3.38 | 2.30 | -1.08 | sell |
| CITIGROUP INC | 85,231 | 371,051 | +285,820 | 0.00 | 0.01 | +0.01 | buy |
| Checkpoint Capital L.P. | 233,659 | 362,193 | +128,534 | 4.81 | 6.08 | +1.27 | buy |
| MORGAN STANLEY | 244,691 | 354,588 | +109,897 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 150,824 | 312,613 | +161,789 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 288,035 | 281,079 | -6,956 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 99,922 | 274,866 | +174,944 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 266,681 | 271,654 | +4,973 | 0.00 | 0.00 | -0.00 | buy |
| Rafferty Asset Management, LLC | 130,346 | 266,262 | +135,916 | 0.02 | 0.02 | +0.01 | buy |
| Clearbridge Investments, LLC | 264,097 | 263,584 | -513 | 0.01 | 0.01 | -0.00 | sell |
| Erste Asset Management GmbH | 235,000 | 260,000 | +25,000 | 0.10 | 0.09 | -0.01 | buy |
| Penn Capital Management Company, LLC | 245,728 | 245,696 | -32 | 0.67 | 0.55 | -0.12 | sell |
| ARDSLEY ADVISORY PARTNERS LP | 225,000 | 245,000 | +20,000 | 1.43 | 0.88 | -0.54 | buy |
| DEUTSCHE BANK AG\ | 171,526 | 244,151 | +72,625 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 124,641 | 241,498 | +116,857 | 0.01 | 0.01 | +0.00 | buy |
| Woodline Partners LP | 253,263 | 233,267 | -19,996 | 0.08 | 0.05 | -0.03 | sell |
| Ensign Peak Advisors, Inc | 222,614 | 222,614 | 0 | 0.01 | 0.01 | -0.00 | hold |
| RICE HALL JAMES & ASSOCIATES, LLC | 42,840 | 214,887 | +172,047 | 0.07 | 0.31 | +0.23 | buy |
| Altium Capital Management LLC | 0 | 208,000 | +208,000 | 0.00 | 2.33 | +2.33 | buy |
| TWO SIGMA ADVISERS, LP | 336,300 | 197,000 | -139,300 | 0.02 | 0.01 | -0.01 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 222,864 | 196,679 | -26,185 | 0.01 | 0.01 | -0.00 | sell |
| BAKER BROS. ADVISORS LP | 190,476 | 190,476 | 0 | 0.06 | 0.06 | -0.00 | hold |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 98,946 | 162,817 | +63,871 | 0.02 | 0.03 | +0.01 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 575,000 | 160,000 | -415,000 | 0.04 | 0.01 | -0.03 | sell |
| Affinity Asset Advisors, LLC | 50,000 | 160,000 | +110,000 | 0.29 | 0.65 | +0.36 | buy |
| UBS Group AG | 118,541 | 156,911 | +38,370 | 0.00 | 0.00 | -0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 196,128 | 155,353 | -40,775 | 0.01 | 0.01 | -0.00 | sell |
| Nicholas Investment Partners, LP | 398,883 | 151,002 | -247,881 | 1.38 | 0.39 | -0.99 | sell |
| JPMORGAN CHASE & CO | 186,583 | 145,560 | -41,023 | 0.00 | 0.00 | -0.00 | sell |
| Atle Fund Management AB | 0 | 123,000 | +123,000 | 0.00 | 1.88 | +1.88 | buy |
| Highlander Partners, L.P. | 122,980 | 122,980 | 0 | 2.90 | 2.14 | -0.76 | hold |
| CenterBook Partners LP | 51,837 | 122,457 | +70,620 | 0.19 | 0.21 | +0.03 | buy |
| JANE STREET GROUP, LLC | 31,709 | 114,605 | +82,896 | 0.00 | 0.00 | +0.00 | buy |
| Aberdeen Group plc | 0 | 109,758 | +109,758 | 0.00 | 0.01 | +0.01 | buy |
| Knights of Columbus Asset Advisors LLC | 116,644 | 102,278 | -14,366 | 0.22 | 0.19 | -0.04 | sell |
| Bank of New York Mellon Corp | 117,284 | 96,494 | -20,790 | 0.00 | 0.00 | -0.00 | sell |
| Nan Fung Group Holdings Ltd | 96,100 | 96,100 | 0 | 1.77 | 2.24 | +0.47 | hold |
| Rhenman & Partners Asset Management AB | 0 | 92,250 | +92,250 | 0.00 | 0.22 | +0.22 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 211,111 | 86,992 | -124,119 | 0.01 | 0.00 | -0.01 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 80,811 | 79,194 | -1,617 | 0.74 | 0.56 | -0.18 | sell |
| TWINBEECH CAPITAL LP | 22,459 | 79,018 | +56,559 | 0.01 | 0.04 | +0.03 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 70,442 | +70,442 | 0.00 | 0.00 | +0.00 | buy |
| Simplify Asset Management Inc. | 70,000 | 70,000 | 0 | 0.32 | 0.17 | -0.15 | hold |
| Propel Bio Management, LLC | 70,000 | 70,000 | 0 | 1.71 | 1.02 | -0.69 | hold |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 67,500 | 67,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Palo Alto Investors LP | 64,700 | 64,700 | 0 | 0.17 | 0.18 | +0.01 | hold |
| ExodusPoint Capital Management, LP | 33,182 | 64,419 | +31,237 | 0.01 | 0.02 | +0.01 | buy |
| Hennion & Walsh Asset Management, Inc. | 48,512 | 63,534 | +15,022 | 0.08 | 0.09 | +0.00 | buy |
| Phocas Financial Corp. | 0 | 61,536 | +61,536 | 0.00 | 0.01 | +0.01 | buy |
| TD ASSET MANAGEMENT INC | 47,000 | 59,800 | +12,800 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 59,300 | 59,300 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Steward Partners Investment Advisory, LLC | 39,550 | 56,700 | +17,150 | 0.02 | 0.02 | -0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 49,912 | 49,857 | -55 | 0.05 | 0.04 | -0.01 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 28,728 | 45,817 | +17,089 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF MONTREAL /CAN/ | 49,791 | 45,272 | -4,519 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 38,524 | 44,191 | +5,667 | 0.00 | 0.00 | +0.00 | buy |
| Secure Asset Management, LLC | 39,203 | 42,274 | +3,071 | 0.31 | 0.25 | -0.06 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 37,767 | 41,836 | +4,069 | 0.00 | 0.00 | -0.00 | buy |
| Squarepoint Ops LLC | 132,212 | 41,267 | -90,945 | 0.02 | 0.00 | -0.01 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 40,805 | 41,105 | +300 | 0.00 | 0.00 | -0.00 | buy |
| PROFUND ADVISORS LLC | 21,170 | 40,864 | +19,694 | 0.03 | 0.04 | +0.01 | buy |
| Invesco Ltd. | 84,867 | 39,021 | -45,846 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 35,824 | 35,637 | -187 | 0.00 | 0.00 | -0.00 | sell |
| ALPS ADVISORS INC | 31,679 | 32,883 | +1,204 | 0.01 | 0.01 | -0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 12,876 | 32,015 | +19,139 | 0.00 | 0.00 | +0.00 | buy |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 32,351 | 31,489 | -862 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 28,701 | 28,645 | -56 | 0.00 | 0.00 | -0.00 | sell |
| NEOS Investment Management LLC | 7,442 | 27,203 | +19,761 | 0.02 | 0.04 | +0.02 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 24,339 | 24,355 | +16 | 0.00 | 0.00 | -0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 32,202 | 24,100 | -8,102 | 0.00 | 0.00 | -0.00 | sell |
| Values First Advisors, Inc. | 16,740 | 21,408 | +4,668 | 0.30 | 0.32 | +0.02 | buy |
| FMR LLC | 20,777 | 20,321 | -456 | 0.00 | 0.00 | -0.00 | sell |
| HighVista Strategies LLC | 0 | 20,208 | +20,208 | 0.00 | 0.18 | +0.18 | buy |
| Utah Retirement Systems | 19,577 | 19,577 | 0 | 0.01 | 0.01 | -0.00 | hold |
| AMERIPRISE FINANCIAL INC | 30,577 | 19,027 | -11,550 | 0.00 | 0.00 | -0.00 | sell |
| Mirae Asset Global Investments Co., Ltd. | 17,395 | 18,641 | +1,246 | 0.00 | 0.00 | -0.00 | buy |
| Allspring Global Investments Holdings, LLC | 23,058 | 18,455 | -4,603 | 0.00 | 0.00 | -0.00 | sell |