| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| STATE STREET CORP | 1,734,775 | 2,822,472 | +1,087,697 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 2,062,551 | 2,767,210 | +704,659 | 0.04 | 0.04 | +0.00 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 2,663,649 | 3,300,400 | +636,751 | 1.28 | 1.30 | +0.02 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,164,682 | 1,597,506 | +432,824 | 0.00 | 0.00 | +0.00 | buy |
| CADIAN CAPITAL MANAGEMENT, LP | 1,934,922 | 2,292,567 | +357,645 | 2.28 | 2.05 | -0.23 | buy |
| MILLENNIUM MANAGEMENT LLC | 224,376 | 539,666 | +315,290 | 0.01 | 0.01 | +0.01 | buy |
| CITIGROUP INC | 85,231 | 371,051 | +285,820 | 0.00 | 0.01 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 456,318 | 700,116 | +243,798 | 0.00 | 0.00 | +0.00 | buy |
| Altium Capital Management LLC | 0 | 208,000 | +208,000 | 0.00 | 2.33 | +2.33 | buy |
| BARCLAYS PLC | 99,922 | 274,866 | +174,944 | 0.00 | 0.00 | +0.00 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 42,840 | 214,887 | +172,047 | 0.07 | 0.31 | +0.23 | buy |
| Prosight Management, LP | 293,301 | 465,000 | +171,699 | 3.48 | 3.25 | -0.23 | buy |
| Pictet Asset Management Holding SA | 793,655 | 955,914 | +162,259 | 0.03 | 0.03 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 150,824 | 312,613 | +161,789 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 130,346 | 266,262 | +135,916 | 0.02 | 0.02 | +0.01 | buy |
| Checkpoint Capital L.P. | 233,659 | 362,193 | +128,534 | 4.81 | 6.08 | +1.27 | buy |
| Atle Fund Management AB | 0 | 123,000 | +123,000 | 0.00 | 1.88 | +1.88 | buy |
| First Turn Management, LLC | 836,302 | 958,654 | +122,352 | 3.55 | 3.60 | +0.06 | buy |
| Qube Research & Technologies Ltd | 124,641 | 241,498 | +116,857 | 0.01 | 0.01 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 50,000 | 160,000 | +110,000 | 0.29 | 0.65 | +0.36 | buy |
| MORGAN STANLEY | 244,691 | 354,588 | +109,897 | 0.00 | 0.00 | +0.00 | buy |
| Aberdeen Group plc | 0 | 109,758 | +109,758 | 0.00 | 0.01 | +0.01 | buy |
| Rhenman & Partners Asset Management AB | 0 | 92,250 | +92,250 | 0.00 | 0.22 | +0.22 | buy |
| JANE STREET GROUP, LLC | 31,709 | 114,605 | +82,896 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 171,526 | 244,151 | +72,625 | 0.00 | 0.00 | +0.00 | buy |
| CenterBook Partners LP | 51,837 | 122,457 | +70,620 | 0.19 | 0.21 | +0.03 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 70,442 | +70,442 | 0.00 | 0.00 | +0.00 | buy |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 98,946 | 162,817 | +63,871 | 0.02 | 0.03 | +0.01 | buy |
| Phocas Financial Corp. | 0 | 61,536 | +61,536 | 0.00 | 0.01 | +0.01 | buy |
| TWINBEECH CAPITAL LP | 22,459 | 79,018 | +56,559 | 0.01 | 0.04 | +0.03 | buy |
| TANG CAPITAL MANAGEMENT LLC | 1,137,107 | 1,187,107 | +50,000 | 3.10 | 3.10 | +0.00 | buy |
| UBS Group AG | 118,541 | 156,911 | +38,370 | 0.00 | 0.00 | -0.00 | buy |
| ExodusPoint Capital Management, LP | 33,182 | 64,419 | +31,237 | 0.01 | 0.02 | +0.01 | buy |
| FRANKLIN RESOURCES INC | 913,068 | 941,374 | +28,306 | 0.01 | 0.01 | -0.01 | buy |
| Erste Asset Management GmbH | 235,000 | 260,000 | +25,000 | 0.10 | 0.09 | -0.01 | buy |
| HighVista Strategies LLC | 0 | 20,208 | +20,208 | 0.00 | 0.18 | +0.18 | buy |
| ARDSLEY ADVISORY PARTNERS LP | 225,000 | 245,000 | +20,000 | 1.43 | 0.88 | -0.54 | buy |
| NEOS Investment Management LLC | 7,442 | 27,203 | +19,761 | 0.02 | 0.04 | +0.02 | buy |
| PROFUND ADVISORS LLC | 21,170 | 40,864 | +19,694 | 0.03 | 0.04 | +0.01 | buy |
| AQR CAPITAL MANAGEMENT LLC | 12,876 | 32,015 | +19,139 | 0.00 | 0.00 | +0.00 | buy |
| Steward Partners Investment Advisory, LLC | 39,550 | 56,700 | +17,150 | 0.02 | 0.02 | -0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 28,728 | 45,817 | +17,089 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 681,180 | 697,139 | +15,959 | 0.00 | 0.00 | -0.00 | buy |
| Aquatic Capital Management LLC | 0 | 15,700 | +15,700 | 0.00 | 0.01 | +0.01 | buy |
| MARSHALL WACE, LLP | 0 | 15,100 | +15,100 | 0.00 | 0.00 | +0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 48,512 | 63,534 | +15,022 | 0.08 | 0.09 | +0.00 | buy |
| NEW YORK LIFE INVESTMENT MANAGEMENT LLC | 0 | 14,309 | +14,309 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 47,000 | 59,800 | +12,800 | 0.00 | 0.00 | +0.00 | buy |
| FIRST TRUST ADVISORS LP | 0 | 11,265 | +11,265 | 0.00 | 0.00 | +0.00 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 0 | 10,764 | +10,764 | 0.00 | 0.05 | +0.05 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 10,016 | +10,016 | 0.00 | 0.00 | +0.00 | buy |
| Jefferies Financial Group Inc. | 0 | 9,330 | +9,330 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 38,524 | 44,191 | +5,667 | 0.00 | 0.00 | +0.00 | buy |
| E Fund Management Co., Ltd. | 7,001 | 12,583 | +5,582 | 0.01 | 0.02 | +0.01 | buy |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 621,778 | 627,272 | +5,494 | 0.05 | 0.04 | -0.01 | buy |
| Rock Springs Capital Management LP | 1,851,464 | 1,856,564 | +5,100 | 1.35 | 1.19 | -0.16 | buy |
| Atom Investors LP | 10,453 | 15,430 | +4,977 | 0.05 | 0.05 | -0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 266,681 | 271,654 | +4,973 | 0.00 | 0.00 | -0.00 | buy |
| Values First Advisors, Inc. | 16,740 | 21,408 | +4,668 | 0.30 | 0.32 | +0.02 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 37,767 | 41,836 | +4,069 | 0.00 | 0.00 | -0.00 | buy |
| FEDERATED HERMES, INC. | 5,000 | 9,000 | +4,000 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 5,394 | 8,952 | +3,558 | 0.03 | 0.03 | -0.00 | buy |
| Secure Asset Management, LLC | 39,203 | 42,274 | +3,071 | 0.31 | 0.25 | -0.06 | buy |
| Russell Investments Group, Ltd. | 15,656 | 17,481 | +1,825 | 0.00 | 0.00 | -0.00 | buy |
| VIRTUS ADVISERS, LLC | 9,430 | 11,015 | +1,585 | 0.18 | 0.15 | -0.03 | buy |
| BROWN BROTHERS HARRIMAN & CO | 1,194 | 2,499 | +1,305 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 17,395 | 18,641 | +1,246 | 0.00 | 0.00 | -0.00 | buy |
| Pacer Advisors, Inc. | 0 | 1,240 | +1,240 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 31,679 | 32,883 | +1,204 | 0.01 | 0.01 | -0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 8,601 | 9,709 | +1,108 | 0.00 | 0.00 | -0.00 | buy |
| Engineers Gate Manager LP | 16,045 | 17,122 | +1,077 | 0.01 | 0.01 | -0.00 | buy |
| WETZEL INVESTMENT ADVISORS, INC. | 1,400 | 2,400 | +1,000 | 0.03 | 0.03 | +0.01 | buy |
| WELLS FARGO & COMPANY/MN | 7,006 | 7,875 | +869 | 0.00 | 0.00 | -0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 40,805 | 41,105 | +300 | 0.00 | 0.00 | -0.00 | buy |
| Elequin Capital, LP | 93 | 355 | +262 | 0.00 | 0.00 | -0.00 | buy |
| OLD POINT TRUST & FINANCIAL SERVICES N A | 0 | 250 | +250 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 8,223 | 8,327 | +104 | 0.00 | 0.00 | -0.00 | buy |
| AXA S.A. | 593,713 | 593,786 | +73 | 0.06 | 0.04 | -0.01 | buy |
| US BANCORP \DE\ | 115 | 156 | +41 | 0.00 | 0.00 | +0.00 | buy |
| Private Wealth Management Group, LLC | 0 | 35 | +35 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 23 | 54 | +31 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 0 | 17 | +17 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 24,339 | 24,355 | +16 | 0.00 | 0.00 | -0.00 | buy |
| CIBC Private Wealth Group LLC | 0 | 10 | +10 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 0 | 8 | +8 | 0.00 | 0.00 | 0.00 | buy |
| Avior Wealth Management, LLC | 0 | 5 | +5 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 0 | 5 | +5 | 0.00 | 0.00 | +0.00 | buy |
| COMERICA BANK | 95 | 100 | +5 | 0.00 | 0.00 | -0.00 | buy |
| NOMURA ASSET MANAGEMENT CO LTD | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Ameritas Investment Partners, Inc. | 2,637 | 2,637 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BVF INC/IL | 4,370,024 | 4,370,024 | 0 | 3.23 | 3.02 | -0.21 | hold |
| HANTZ FINANCIAL SERVICES, INC. | 5 | 5 | 0 | 0.00 | 0.00 | 0.00 | hold |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 67,500 | 67,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BAKER BROS. ADVISORS LP | 190,476 | 190,476 | 0 | 0.06 | 0.06 | -0.00 | hold |
| Palo Alto Investors LP | 64,700 | 64,700 | 0 | 0.17 | 0.18 | +0.01 | hold |
| Novo Holdings A/S | 1,500,000 | 1,500,000 | 0 | 2.73 | 2.60 | -0.14 | hold |
| Ensign Peak Advisors, Inc | 222,614 | 222,614 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Daiwa Securities Group Inc. | 148 | 148 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Utah Retirement Systems | 19,577 | 19,577 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Allworth Financial LP | 630 | 630 | 0 | 0.00 | 0.00 | -0.00 | hold |