| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Polar Capital Holdings Plc | 675,000 | 1,175,000 | +500,000 | 0.16 | 0.32 | +0.17 | buy |
| D. E. Shaw & Co., Inc. | 157,352 | 543,277 | +385,925 | 0.01 | 0.03 | +0.02 | buy |
| MACQUARIE GROUP LTD | 0 | 366,751 | +366,751 | 0.00 | 0.02 | +0.02 | buy |
| FEDERATED HERMES, INC. | 3,641 | 347,366 | +343,725 | 0.00 | 0.03 | +0.03 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 261,644 | 499,183 | +237,539 | 0.01 | 0.02 | +0.01 | buy |
| Point72 Asset Management, L.P. | 0 | 232,098 | +232,098 | 0.00 | 0.03 | +0.03 | buy |
| Frazier Life Sciences Management, L.P. | 6,570,392 | 6,795,121 | +224,729 | 11.28 | 13.99 | +2.71 | buy |
| Cubist Systematic Strategies, LLC | 83,969 | 296,887 | +212,918 | 0.06 | 0.18 | +0.12 | buy |
| Russell Investments Group, Ltd. | 25,960 | 229,449 | +203,489 | 0.00 | 0.01 | +0.01 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 150,000 | 345,000 | +195,000 | 0.01 | 0.03 | +0.02 | buy |
| JANUS HENDERSON GROUP PLC | 4,581,642 | 4,766,109 | +184,467 | 0.10 | 0.12 | +0.02 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 176,960 | 356,276 | +179,316 | 0.03 | 0.07 | +0.04 | buy |
| Woodline Partners LP | 404,404 | 566,271 | +161,867 | 0.11 | 0.17 | +0.05 | buy |
| Qube Research & Technologies Ltd | 0 | 139,434 | +139,434 | 0.00 | 0.01 | +0.01 | buy |
| Bank of New York Mellon Corp | 124,328 | 246,730 | +122,402 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 2,424,734 | 2,540,061 | +115,327 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 1,381,627 | 1,494,566 | +112,939 | 0.00 | 0.00 | +0.00 | buy |
| Penn Capital Management Company, LLC | 278,427 | 373,519 | +95,092 | 1.13 | 1.64 | +0.51 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 101,248 | 188,500 | +87,252 | 0.01 | 0.01 | +0.01 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 73,888 | 149,518 | +75,630 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 169,323 | 240,744 | +71,421 | 0.00 | 0.00 | +0.00 | buy |
| Clearbridge Investments, LLC | 907,317 | 978,067 | +70,750 | 0.03 | 0.04 | +0.01 | buy |
| Patient Square Capital LP | 64,900 | 116,362 | +51,462 | 1.00 | 2.17 | +1.16 | buy |
| UBS Group AG | 184,589 | 235,957 | +51,368 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 4,815 | 54,327 | +49,512 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 126,446 | 175,126 | +48,680 | 0.01 | 0.02 | +0.01 | buy |
| State of New Jersey Common Pension Fund D | 0 | 37,969 | +37,969 | 0.00 | 0.01 | +0.01 | buy |
| AQR CAPITAL MANAGEMENT LLC | 12,048 | 49,076 | +37,028 | 0.00 | 0.00 | +0.00 | buy |
| Calamos Advisors LLC | 0 | 36,654 | +36,654 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA ADVISERS, LP | 174,400 | 206,600 | +32,200 | 0.02 | 0.02 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 228,351 | 260,366 | +32,015 | 0.01 | 0.02 | +0.00 | buy |
| Semanteon Capital Management, LP | 0 | 31,478 | +31,478 | 0.00 | 0.77 | +0.77 | buy |
| NEXT CENTURY GROWTH INVESTORS LLC | 164,252 | 195,341 | +31,089 | 0.51 | 0.78 | +0.27 | buy |
| LORD, ABBETT & CO. LLC | 782,354 | 813,398 | +31,044 | 0.10 | 0.13 | +0.03 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 25,744 | 56,605 | +30,861 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 6,989 | 31,625 | +24,636 | 0.00 | 0.00 | +0.00 | buy |
| Nicholas Investment Partners, LP | 148,843 | 173,043 | +24,200 | 0.54 | 0.80 | +0.26 | buy |
| PDT Partners, LLC | 113,713 | 137,495 | +23,782 | 0.42 | 0.44 | +0.02 | buy |
| Aquatic Capital Management LLC | 22,589 | 46,310 | +23,721 | 0.03 | 0.05 | +0.03 | buy |
| Jefferies Financial Group Inc. | 0 | 23,500 | +23,500 | 0.00 | 0.02 | +0.02 | buy |
| BOONE CAPITAL MANAGEMENT LLC | 581,843 | 603,318 | +21,475 | 8.12 | 9.25 | +1.13 | buy |
| Nan Fung Group Holdings Ltd | 125,330 | 146,765 | +21,435 | 4.43 | 5.39 | +0.96 | buy |
| AlphaQuest LLC | 1,829 | 22,580 | +20,751 | 0.01 | 0.11 | +0.10 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 943,344 | 963,665 | +20,321 | 0.00 | 0.00 | +0.00 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 7,460 | 25,493 | +18,033 | 0.05 | 0.05 | +0.01 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 15,691 | +15,691 | 0.00 | 0.11 | +0.11 | buy |
| Invesco Ltd. | 299,279 | 313,423 | +14,144 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 22,153 | 36,262 | +14,109 | 0.01 | 0.02 | +0.01 | buy |
| Squarepoint Ops LLC | 21,682 | 34,462 | +12,780 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 6,978 | 19,182 | +12,204 | 0.00 | 0.00 | +0.00 | buy |
| Campbell & CO Investment Adviser LLC | 16,167 | 25,944 | +9,777 | 0.05 | 0.09 | +0.04 | buy |
| EntryPoint Capital, LLC | 0 | 9,675 | +9,675 | 0.00 | 0.20 | +0.20 | buy |
| Secure Asset Management, LLC | 39,920 | 48,910 | +8,990 | 0.25 | 0.44 | +0.19 | buy |
| CIBC WORLD MARKETS CORP | 0 | 8,813 | +8,813 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 0 | 8,492 | +8,492 | 0.00 | 0.10 | +0.10 | buy |
| JANE STREET GROUP, LLC | 172,633 | 180,784 | +8,151 | 0.01 | 0.01 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 18,733 | 26,816 | +8,083 | 0.00 | 0.00 | +0.00 | buy |
| CAPITAL FUND MANAGEMENT S.A. | 27,322 | 35,127 | +7,805 | 0.01 | 0.02 | +0.01 | buy |
| Rafferty Asset Management, LLC | 45,160 | 51,857 | +6,697 | 0.01 | 0.01 | +0.00 | buy |
| Gotham Asset Management, LLC | 0 | 6,043 | +6,043 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 6,200 | 12,200 | +6,000 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 17,214 | 23,120 | +5,906 | 0.01 | 0.02 | +0.01 | buy |
| Palumbo Wealth Management LLC | 0 | 5,376 | +5,376 | 0.00 | 0.08 | +0.08 | buy |
| Tidal Investments LLC | 0 | 5,260 | +5,260 | 0.00 | 0.00 | +0.00 | buy |
| Empowered Funds, LLC | 33,266 | 38,386 | +5,120 | 0.02 | 0.02 | +0.00 | buy |
| E Fund Management Co., Ltd. | 0 | 4,847 | +4,847 | 0.00 | 0.01 | +0.01 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 0 | 4,720 | +4,720 | 0.00 | 0.00 | +0.00 | buy |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 0 | 4,700 | +4,700 | 0.00 | 0.00 | +0.00 | buy |
| Mariner, LLC | 0 | 4,464 | +4,464 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 23,150 | 27,548 | +4,398 | 0.01 | 0.01 | +0.00 | buy |
| BANK OF MONTREAL /CAN/ | 52,498 | 56,340 | +3,842 | 0.00 | 0.00 | +0.00 | buy |
| Legato Capital Management LLC | 13,395 | 16,552 | +3,157 | 0.07 | 0.10 | +0.03 | buy |
| FRANKLIN RESOURCES INC | 590,662 | 593,355 | +2,693 | 0.01 | 0.01 | +0.00 | buy |
| RHUMBLINE ADVISERS | 53,113 | 55,434 | +2,321 | 0.00 | 0.00 | +0.00 | buy |
| AIGEN INVESTMENT MANAGEMENT, LP | 7,742 | 9,929 | +2,187 | 0.06 | 0.07 | +0.01 | buy |
| Legal & General Group Plc | 40,820 | 42,834 | +2,014 | 0.00 | 0.00 | +0.00 | buy |
| KBC Group NV | 0 | 1,967 | +1,967 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 9,182 | 11,002 | +1,820 | 0.01 | 0.02 | +0.01 | buy |
| AMERIPRISE FINANCIAL INC | 194,076 | 195,883 | +1,807 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 12,114 | 13,911 | +1,797 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 24,327 | 26,047 | +1,720 | 0.00 | 0.00 | +0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 145,599 | 147,193 | +1,594 | 0.27 | 0.29 | +0.02 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 14,050 | 15,500 | +1,450 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 0 | 1,250 | +1,250 | 0.00 | 0.01 | +0.01 | buy |
| Schonfeld Strategic Advisors LLC | 17,200 | 18,425 | +1,225 | 0.00 | 0.01 | +0.00 | buy |
| Creative Planning | 8,130 | 9,351 | +1,221 | 0.00 | 0.00 | +0.00 | buy |
| STEPHENS INC /AR/ | 19,000 | 20,000 | +1,000 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 41,050 | 41,850 | +800 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 21,625 | 22,353 | +728 | 0.00 | 0.00 | +0.00 | buy |
| BI Asset Management Fondsmaeglerselskab A/S | 0 | 727 | +727 | 0.00 | 0.00 | +0.00 | buy |
| Allianz Asset Management GmbH | 5,800 | 6,500 | +700 | 0.00 | 0.00 | +0.00 | buy |
| Aster Capital Management (DIFC) Ltd | 84 | 694 | +610 | 0.00 | 0.01 | +0.00 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 0 | 442 | +442 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 165 | 593 | +428 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 10,600 | 10,998 | +398 | 0.00 | 0.00 | +0.00 | buy |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 16,346 | 16,685 | +339 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Hong Kong Ltd | 0 | 296 | +296 | 0.00 | 0.00 | +0.00 | buy |
| COMERICA BANK | 617 | 895 | +278 | 0.00 | 0.00 | +0.00 | buy |
| FIFTH THIRD BANCORP | 0 | 263 | +263 | 0.00 | 0.00 | +0.00 | buy |
| Brooklyn Investment Group | 0 | 235 | +235 | 0.00 | 0.00 | +0.00 | buy |