| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Polar Capital Holdings Plc | 675,000 | 1,175,000 | +500,000 | 0.16 | 0.32 | +0.17 | buy |
| Frazier Life Sciences Management, L.P. | 6,570,392 | 6,795,121 | +224,729 | 11.28 | 13.99 | +2.71 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 150,000 | 345,000 | +195,000 | 0.01 | 0.03 | +0.02 | buy |
| JANUS HENDERSON GROUP PLC | 4,581,642 | 4,766,109 | +184,467 | 0.10 | 0.12 | 0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 176,960 | 356,276 | +179,316 | 0.03 | 0.07 | +0.04 | buy |
| Woodline Partners LP | 404,404 | 566,271 | +161,867 | 0.11 | 0.17 | +0.05 | buy |
| Penn Capital Management Company, LLC | 278,427 | 373,519 | +95,092 | 1.13 | 1.64 | +0.51 | buy |
| Clearbridge Investments, LLC | 907,317 | 978,067 | +70,750 | 0.03 | 0.04 | +0.01 | buy |
| Patient Square Capital LP | 64,900 | 116,362 | +51,462 | 1.00 | 2.17 | +1.16 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 228,351 | 260,366 | +32,015 | 0.01 | 0.02 | +0.00 | buy |
| NEXT CENTURY GROWTH INVESTORS LLC | 164,252 | 195,341 | +31,089 | 0.51 | 0.78 | +0.27 | buy |
| LORD, ABBETT & CO. LLC | 782,354 | 813,398 | +31,044 | 0.10 | 0.13 | +0.03 | buy |
| Nicholas Investment Partners, LP | 148,843 | 173,043 | +24,200 | 0.54 | 0.80 | +0.26 | buy |
| PDT Partners, LLC | 113,713 | 137,495 | +23,782 | 0.42 | 0.44 | +0.02 | buy |
| BOONE CAPITAL MANAGEMENT LLC | 581,843 | 603,318 | +21,475 | 8.12 | 9.25 | +1.13 | buy |
| Nan Fung Group Holdings Ltd | 125,330 | 146,765 | +21,435 | 4.43 | 5.39 | +0.96 | buy |
| ExodusPoint Capital Management, LP | 22,153 | 36,262 | +14,109 | 0.01 | 0.02 | 0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 54,123 | 40,459 | +13,664 | 0.19 | 0.19 | 0.00 | sell |
| Campbell & CO Investment Adviser LLC | 16,167 | 25,944 | +9,777 | 0.05 | 0.09 | +0.04 | buy |
| Secure Asset Management, LLC | 39,920 | 48,910 | +8,990 | 0.25 | 0.44 | +0.19 | buy |
| Rafferty Asset Management, LLC | 45,160 | 51,857 | +6,697 | 0.01 | 0.01 | +0.00 | buy |
| Empowered Funds, LLC | 33,266 | 38,386 | +5,120 | 0.02 | 0.03 | +0.00 | buy |
| Legato Capital Management LLC | 13,395 | 16,552 | +3,157 | 0.07 | 0.10 | +0.03 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 25,059 | 22,560 | +2,499 | 0.08 | 0.08 | 0.00 | sell |
| AIGEN INVESTMENT MANAGEMENT, LP | 7,742 | 9,929 | +2,187 | 0.06 | 0.07 | +0.01 | buy |
| PROFUND ADVISORS LLC | 9,182 | 11,002 | +1,820 | 0.01 | 0.02 | +0.01 | buy |
| Hennion & Walsh Asset Management, Inc. | 145,599 | 147,193 | +1,594 | 0.27 | 0.29 | +0.02 | buy |
| ALGERT GLOBAL LLC | 68,291 | 66,761 | +1,530 | 0.07 | 0.07 | 0.00 | sell |
| GF FUND MANAGEMENT CO. LTD. | 1,008 | 1,228 | +220 | 0.00 | 0.00 | +0.00 | buy |
| MCF Advisors LLC | 203 | 242 | +39 | 0.00 | 0.00 | +0.00 | buy |
| Informed Momentum Co LLC | 72,956 | 72,678 | -278 | 0.43 | 0.57 | +0.14 | sell |
| BOSUN ASSET MANAGEMENT, LLC | 10,413 | 10,126 | -287 | 0.19 | 0.22 | +0.03 | sell |
| China Universal Asset Management Co., Ltd. | 10,179 | 9,831 | -348 | 0.04 | 0.04 | +0.00 | sell |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 136,700 | 135,915 | -785 | 0.04 | 0.04 | +0.01 | sell |
| Avanza Fonder AB | 4,564 | 2,878 | -1,686 | 0.01 | 0.00 | -0.00 | sell |
| Values First Advisors, Inc. | 19,840 | 18,118 | -1,722 | 0.45 | 0.48 | +0.03 | sell |
| Phocas Financial Corp. | 37,585 | 35,556 | -2,029 | 0.21 | 0.25 | +0.04 | sell |
| ALPS ADVISORS INC | 38,822 | 35,516 | -3,306 | 0.01 | 0.01 | -0.00 | sell |
| First Turn Management, LLC | 506,908 | 503,014 | -3,894 | 3.75 | 4.57 | +0.81 | sell |
| RICE HALL JAMES & ASSOCIATES, LLC | 238,999 | 234,696 | -4,303 | 0.54 | 0.62 | +0.08 | sell |
| NEOS Investment Management LLC | 17,693 | 11,432 | -6,261 | 0.02 | 0.01 | -0.01 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,422,729 | 1,415,137 | -7,592 | 0.01 | 0.01 | +0.00 | sell |
| LOOMIS SAYLES & CO L P | 578,024 | 566,155 | -11,869 | 0.03 | 0.04 | +0.01 | sell |
| Affinity Asset Advisors, LLC | 70,742 | 49,692 | -21,050 | 0.46 | 0.35 | -0.11 | sell |
| Knights of Columbus Asset Advisors LLC | 46,002 | 19,757 | -26,245 | 0.13 | 0.06 | -0.06 | sell |
| TEMA ETFS LLC | 41,968 | 11,432 | -30,536 | 0.72 | 0.15 | -0.57 | sell |
| Atle Fund Management AB | 116,692 | 77,263 | -39,429 | 2.28 | 1.54 | -0.74 | sell |
| Candriam S.C.A. | 429,731 | 382,979 | -46,752 | 0.10 | 0.11 | +0.01 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 2,606,938 | 2,527,000 | -79,938 | 1.96 | 2.27 | +0.31 | sell |
| Prosight Management, LP | 451,127 | 343,326 | -107,801 | 5.16 | 5.08 | -0.07 | sell |
| Rock Springs Capital Management LP | 1,471,564 | 951,765 | -519,799 | 2.32 | 2.45 | +0.14 | sell |
| Avidity Partners Management LP | 666,200 | 40,000 | -626,200 | 2.75 | 0.37 | -2.37 | sell |