| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Frazier Life Sciences Management, L.P. | 6,795,121 | 7,679,684 | +884,563 | 14.42 | 18.25 | +3.84 | buy |
| JANUS HENDERSON GROUP PLC | 6,065,308 | 6,945,813 | +880,505 | 0.21 | 0.31 | +0.09 | buy |
| BlackRock, Inc. | 3,645,286 | 3,846,530 | +201,244 | 0.00 | 0.01 | +0.00 | buy |
| SSI INVESTMENT MANAGEMENT LLC | 0 | 3,255,000 | +3,255,000 | 0.72 | 0.67 | -0.05 | buy |
| FMR LLC | 646,466 | 1,965,375 | +1,318,909 | 0.00 | 0.01 | +0.01 | buy |
| STATE STREET CORP | 2,143,992 | 1,944,281 | -199,711 | 0.01 | 0.01 | +0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,420,375 | 1,717,421 | +297,046 | 0.01 | 0.02 | +0.01 | buy |
| BVF INC/IL | 1,495,290 | 1,584,727 | +89,437 | 3.98 | 4.66 | +0.69 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 2,093,582 | 1,408,871 | -684,711 | 2.58 | 2.15 | -0.43 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 1,237,830 | 1,334,809 | +96,979 | 0.02 | 0.02 | +0.01 | buy |
| Novo Holdings A/S | 1,264,028 | 1,325,000 | +60,972 | 7.75 | 9.92 | +2.16 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,062,926 | 1,260,003 | +197,077 | 0.01 | 0.01 | +0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 1,236,027 | 1,236,027 | 0 | 4.82 | 5.80 | +0.98 | hold |
| TCG Crossover Management, LLC | 62,049 | 1,062,049 | +1,000,000 | 0.16 | 2.81 | +2.64 | buy |
| CITADEL ADVISORS LLC | 840,220 | 1,052,048 | +211,828 | 0.05 | 0.07 | +0.02 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 655,778 | 911,419 | +255,641 | 0.03 | 0.06 | +0.02 | buy |
| Rock Springs Capital Management LP | 762,294 | 811,294 | +49,000 | 3.09 | 4.42 | +1.33 | buy |
| TWO SIGMA INVESTMENTS, LP | 388,542 | 774,841 | +386,299 | 0.05 | 0.06 | +0.01 | buy |
| Capital World Investors | 0 | 724,415 | +724,415 | 0.00 | 0.01 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 713,452 | 722,177 | +8,725 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 650,715 | 714,804 | +64,089 | 0.01 | 0.02 | +0.00 | buy |
| Clearbridge Investments, LLC | 865,967 | 671,870 | -194,097 | 0.05 | 0.05 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 724,317 | 662,306 | -62,011 | 0.01 | 0.01 | -0.00 | sell |
| Paradigm Biocapital Advisors LP | 0 | 625,000 | +625,000 | 0.00 | 1.18 | +1.18 | buy |
| LORD, ABBETT & CO. LLC | 579,983 | 617,064 | +37,081 | 0.14 | 0.19 | +0.05 | buy |
| Bank of New York Mellon Corp | 565,579 | 584,523 | +18,944 | 0.01 | 0.01 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 439,085 | 582,085 | +143,000 | 0.05 | 0.08 | +0.03 | buy |
| Woodline Partners LP | 567,894 | 567,894 | 0 | 0.17 | 0.20 | +0.02 | hold |
| BALYASNY ASSET MANAGEMENT L.P. | 285,870 | 539,031 | +253,161 | 0.04 | 0.10 | +0.06 | buy |
| MORGAN STANLEY | 425,685 | 524,566 | +98,881 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 481,961 | 506,211 | +24,250 | 0.06 | 0.08 | +0.01 | buy |
| UBS Group AG | 320,783 | 494,994 | +174,211 | 0.01 | 0.01 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 521,652 | 479,476 | -42,176 | 0.11 | 0.10 | -0.01 | sell |
| LOOMIS SAYLES & CO L P | 514,981 | 475,324 | -39,657 | 0.05 | 0.06 | +0.01 | sell |
| Nuveen, LLC | 503,045 | 474,227 | -28,818 | 0.01 | 0.01 | +0.00 | sell |
| Candriam S.C.A. | 569,590 | 464,216 | -105,374 | 0.22 | 0.22 | -0.00 | sell |
| BAKER BROS. ADVISORS LP | 0 | 445,975 | +445,975 | 0.00 | 0.24 | +0.24 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 409,286 | 427,090 | +17,804 | 0.01 | 0.01 | +0.00 | buy |
| Pictet Asset Management Holding SA | 577,274 | 423,511 | -153,763 | 0.04 | 0.04 | -0.00 | sell |
| BOONE CAPITAL MANAGEMENT LLC | 421,236 | 421,236 | 0 | 10.44 | 11.92 | +1.48 | hold |
| First Turn Management, LLC | 481,564 | 400,464 | -81,100 | 4.35 | 4.13 | -0.21 | sell |
| Soleus Capital Management, L.P. | 573,614 | 400,306 | -173,308 | 1.92 | 1.50 | -0.42 | sell |
| EMERALD ADVISERS, LLC | 367,134 | 397,263 | +30,129 | 0.89 | 1.16 | +0.27 | buy |
| NORTHERN TRUST CORP | 374,864 | 394,920 | +20,056 | 0.00 | 0.00 | +0.00 | buy |
| NEXT CENTURY GROWTH INVESTORS LLC | 368,035 | 385,539 | +17,504 | 2.02 | 2.58 | +0.56 | buy |
| TimesSquare Capital Management, LLC | 395,827 | 376,473 | -19,354 | 0.47 | 0.59 | +0.12 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 467,468 | 375,000 | -92,468 | 0.06 | 0.05 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 244,273 | 368,575 | +124,302 | 0.01 | 0.03 | +0.01 | buy |
| Point72 Asset Management, L.P. | 190,638 | 346,991 | +156,353 | 0.02 | 0.06 | +0.03 | buy |
| Octagon Capital Advisors LP | 0 | 338,900 | +338,900 | 0.00 | 3.46 | +3.46 | buy |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 336,701 | 335,669 | -1,032 | 0.07 | 0.10 | +0.03 | sell |
| Palo Alto Investors LP | 156,421 | 325,175 | +168,754 | 1.72 | 4.59 | +2.87 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 0 | 318,554 | +318,554 | 0.00 | 0.31 | +0.31 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 0 | 286,406 | +286,406 | 0.00 | 0.01 | +0.01 | buy |
| Hood River Capital Management LLC | 280,028 | 285,384 | +5,356 | 0.24 | 0.26 | +0.02 | buy |
| Invesco Ltd. | 64,951 | 285,236 | +220,285 | 0.00 | 0.00 | +0.00 | buy |
| Polar Capital Holdings Plc | 793,642 | 283,484 | -510,158 | 0.29 | 0.11 | -0.17 | sell |
| BNP Paribas Asset Management Holding S.A. | 257,228 | 265,631 | +8,403 | 0.02 | 0.03 | +0.01 | buy |
| Penn Capital Management Company, LLC | 281,918 | 256,767 | -25,151 | 1.78 | 1.84 | +0.06 | sell |
| EMERALD MUTUAL FUND ADVISERS TRUST | 242,320 | 250,399 | +8,079 | 0.93 | 1.12 | +0.19 | buy |
| NAN FUNG TRINITY (HK) Ltd | 227,479 | 232,679 | +5,200 | 1.42 | 2.36 | +0.94 | buy |
| Patient Square Capital LP | 298,682 | 230,000 | -68,682 | 5.05 | 3.77 | -1.28 | sell |
| RAYMOND JAMES FINANCIAL INC | 246,418 | 228,174 | -18,244 | 0.01 | 0.01 | +0.00 | sell |
| SEI INVESTMENTS CO | 228,000 | 228,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AMERIPRISE FINANCIAL INC | 271,480 | 219,255 | -52,225 | 0.00 | 0.00 | -0.00 | sell |
| Erste Asset Management GmbH | 250,000 | 210,000 | -40,000 | 0.17 | 0.17 | +0.00 | sell |
| Ensign Peak Advisors, Inc | 133,973 | 202,473 | +68,500 | 0.02 | 0.03 | +0.02 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 217,606 | 201,145 | -16,461 | 0.02 | 0.03 | +0.00 | sell |
| Logos Global Management LP | 225,000 | 200,000 | -25,000 | 1.18 | 0.95 | -0.23 | sell |
| Russell Investments Group, Ltd. | 209,174 | 197,093 | -12,081 | 0.02 | 0.02 | +0.00 | sell |
| Atle Fund Management AB | 89,685 | 195,768 | +106,083 | 2.26 | 3.03 | +0.77 | buy |
| Handelsbanken Fonder AB | 213,500 | 194,000 | -19,500 | 0.05 | 0.06 | +0.01 | sell |
| SEGALL BRYANT & HAMILL, LLC | 185,024 | 175,898 | -9,126 | 0.20 | 0.17 | -0.03 | sell |
| D. E. Shaw & Co., Inc. | 948,161 | 167,489 | -780,672 | 0.06 | 0.01 | -0.04 | sell |
| Legal & General Group Plc | 168,393 | 153,870 | -14,523 | 0.00 | 0.00 | +0.00 | sell |
| CITIGROUP INC | 145,992 | 153,470 | +7,478 | 0.01 | 0.01 | +0.00 | buy |
| FIRST TRUST ADVISORS LP | 137,700 | 151,272 | +13,572 | 0.01 | 0.01 | +0.00 | buy |
| Voleon Capital Management LP | 173,067 | 150,513 | -22,554 | 0.29 | 0.30 | +0.01 | sell |
| RICE HALL JAMES & ASSOCIATES, LLC | 164,449 | 147,037 | -17,412 | 0.72 | 0.76 | +0.04 | sell |
| PDT Partners, LLC | 145,379 | 145,379 | 0 | 0.74 | 0.79 | +0.05 | hold |
| Nicholas Investment Partners, LP | 213,391 | 131,303 | -82,088 | 1.23 | 0.88 | -0.35 | sell |
| PANAGORA ASSET MANAGEMENT INC | 0 | 129,114 | +129,114 | 0.00 | 0.04 | +0.04 | buy |
| Highlander Partners, L.P. | 122,980 | 122,980 | 0 | 3.49 | 4.45 | +0.96 | hold |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 111,310 | 108,338 | -2,972 | 1.34 | 1.58 | +0.24 | sell |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 297,950 | 104,099 | -193,851 | 0.08 | 0.04 | -0.04 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 72,194 | 95,555 | +23,361 | 0.00 | 0.01 | +0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 98,294 | 93,592 | -4,702 | 0.27 | 0.29 | +0.02 | sell |
| Fisher Asset Management, LLC | 14,089 | 93,109 | +79,020 | 0.00 | 0.00 | +0.00 | buy |
| Rhenman & Partners Asset Management AB | 106,255 | 92,605 | -13,650 | 0.78 | 1.06 | +0.27 | sell |
| JPMORGAN CHASE & CO | 97,386 | 90,664 | -6,722 | 0.00 | 0.00 | +0.00 | sell |
| ExodusPoint Capital Management, LP | 0 | 87,373 | +87,373 | 0.00 | 0.08 | +0.08 | buy |
| SEI INVESTMENTS CO | 46,078 | 81,109 | +35,031 | 0.00 | 0.01 | +0.00 | buy |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 90,056 | 80,991 | -9,065 | 0.05 | 0.05 | +0.01 | sell |
| Neuberger Berman Group LLC | 0 | 80,549 | +80,549 | 0.00 | 0.01 | +0.01 | buy |
| Swiss National Bank | 74,300 | 74,300 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PICTON MAHONEY ASSET MANAGEMENT | 1,420 | 74,118 | +72,698 | 0.00 | 0.07 | +0.07 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 67,749 | 68,815 | +1,066 | 0.01 | 0.01 | +0.00 | buy |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 372,511 | 67,885 | -304,626 | 0.02 | 0.00 | -0.01 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 59,201 | 66,629 | +7,428 | 0.00 | 0.00 | +0.00 | buy |
| OPPENHEIMER ASSET MANAGEMENT INC. | 64,000 | 63,000 | -1,000 | 0.00 | 0.00 | +0.00 | sell |