| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| SSI INVESTMENT MANAGEMENT LLC | 0 | 3,255,000 | +3,255,000 | 0.72 | 0.67 | -0.05 | buy |
| FMR LLC | 646,466 | 1,965,375 | +1,318,909 | 0.00 | 0.01 | +0.01 | buy |
| TCG Crossover Management, LLC | 62,049 | 1,062,049 | +1,000,000 | 0.16 | 2.81 | +2.64 | buy |
| Frazier Life Sciences Management, L.P. | 6,795,121 | 7,679,684 | +884,563 | 14.42 | 18.25 | +3.84 | buy |
| JANUS HENDERSON GROUP PLC | 6,065,308 | 6,945,813 | +880,505 | 0.21 | 0.31 | +0.09 | buy |
| Capital World Investors | 0 | 724,415 | +724,415 | 0.00 | 0.01 | +0.01 | buy |
| Paradigm Biocapital Advisors LP | 0 | 625,000 | +625,000 | 0.00 | 1.18 | +1.18 | buy |
| BAKER BROS. ADVISORS LP | 0 | 445,975 | +445,975 | 0.00 | 0.24 | +0.24 | buy |
| TWO SIGMA INVESTMENTS, LP | 388,542 | 774,841 | +386,299 | 0.05 | 0.06 | +0.01 | buy |
| Octagon Capital Advisors LP | 0 | 338,900 | +338,900 | 0.00 | 3.46 | +3.46 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 0 | 318,554 | +318,554 | 0.00 | 0.31 | +0.31 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,420,375 | 1,717,421 | +297,046 | 0.01 | 0.02 | +0.01 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 0 | 286,406 | +286,406 | 0.00 | 0.01 | +0.01 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 655,778 | 911,419 | +255,641 | 0.03 | 0.06 | +0.02 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 285,870 | 539,031 | +253,161 | 0.04 | 0.10 | +0.06 | buy |
| Invesco Ltd. | 64,951 | 285,236 | +220,285 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 840,220 | 1,052,048 | +211,828 | 0.05 | 0.07 | +0.02 | buy |
| BlackRock, Inc. | 3,645,286 | 3,846,530 | +201,244 | 0.00 | 0.01 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,062,926 | 1,260,003 | +197,077 | 0.01 | 0.01 | +0.00 | buy |
| UBS Group AG | 320,783 | 494,994 | +174,211 | 0.01 | 0.01 | +0.00 | buy |
| Palo Alto Investors LP | 156,421 | 325,175 | +168,754 | 1.72 | 4.59 | +2.87 | buy |
| Point72 Asset Management, L.P. | 190,638 | 346,991 | +156,353 | 0.02 | 0.06 | +0.03 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 439,085 | 582,085 | +143,000 | 0.05 | 0.08 | +0.03 | buy |
| PANAGORA ASSET MANAGEMENT INC | 0 | 129,114 | +129,114 | 0.00 | 0.04 | +0.04 | buy |
| MILLENNIUM MANAGEMENT LLC | 244,273 | 368,575 | +124,302 | 0.01 | 0.03 | +0.01 | buy |
| Atle Fund Management AB | 89,685 | 195,768 | +106,083 | 2.26 | 3.03 | +0.77 | buy |
| MORGAN STANLEY | 425,685 | 524,566 | +98,881 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 1,237,830 | 1,334,809 | +96,979 | 0.02 | 0.02 | +0.01 | buy |
| BVF INC/IL | 1,495,290 | 1,584,727 | +89,437 | 3.98 | 4.66 | +0.69 | buy |
| ExodusPoint Capital Management, LP | 0 | 87,373 | +87,373 | 0.00 | 0.08 | +0.08 | buy |
| Neuberger Berman Group LLC | 0 | 80,549 | +80,549 | 0.00 | 0.01 | +0.01 | buy |
| Fisher Asset Management, LLC | 14,089 | 93,109 | +79,020 | 0.00 | 0.00 | +0.00 | buy |
| PICTON MAHONEY ASSET MANAGEMENT | 1,420 | 74,118 | +72,698 | 0.00 | 0.07 | +0.07 | buy |
| Ensign Peak Advisors, Inc | 133,973 | 202,473 | +68,500 | 0.02 | 0.03 | +0.02 | buy |
| FRANKLIN RESOURCES INC | 650,715 | 714,804 | +64,089 | 0.01 | 0.02 | +0.00 | buy |
| Novo Holdings A/S | 1,264,028 | 1,325,000 | +60,972 | 7.75 | 9.92 | +2.16 | buy |
| Rock Springs Capital Management LP | 762,294 | 811,294 | +49,000 | 3.09 | 4.42 | +1.33 | buy |
| Lisanti Capital Growth, LLC | 0 | 39,005 | +39,005 | 0.00 | 0.91 | +0.91 | buy |
| Cinctive Capital Management LP | 0 | 38,518 | +38,518 | 0.00 | 0.23 | +0.23 | buy |
| LORD, ABBETT & CO. LLC | 579,983 | 617,064 | +37,081 | 0.14 | 0.19 | +0.05 | buy |
| SEI INVESTMENTS CO | 46,078 | 81,109 | +35,031 | 0.00 | 0.01 | +0.00 | buy |
| Alyeska Investment Group, L.P. | 0 | 34,051 | +34,051 | 0.00 | 0.01 | +0.01 | buy |
| EMERALD ADVISERS, LLC | 367,134 | 397,263 | +30,129 | 0.89 | 1.16 | +0.27 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 31,659 | 57,369 | +25,710 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 481,961 | 506,211 | +24,250 | 0.06 | 0.08 | +0.01 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 72,194 | 95,555 | +23,361 | 0.00 | 0.01 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 34,114 | 55,693 | +21,579 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 3,160 | 24,317 | +21,157 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 374,864 | 394,920 | +20,056 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 565,579 | 584,523 | +18,944 | 0.01 | 0.01 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 409,286 | 427,090 | +17,804 | 0.01 | 0.01 | +0.00 | buy |
| NEXT CENTURY GROWTH INVESTORS LLC | 368,035 | 385,539 | +17,504 | 2.02 | 2.58 | +0.56 | buy |
| Aquatic Capital Management LLC | 0 | 16,983 | +16,983 | 0.00 | 0.05 | +0.05 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 24,126 | 40,025 | +15,899 | 0.00 | 0.01 | +0.00 | buy |
| HighVista Strategies LLC | 0 | 15,563 | +15,563 | 0.00 | 0.40 | +0.40 | buy |
| THRIVENT FINANCIAL FOR LUTHERANS | 41,857 | 57,061 | +15,204 | 0.01 | 0.01 | +0.00 | buy |
| FIRST TRUST ADVISORS LP | 137,700 | 151,272 | +13,572 | 0.01 | 0.01 | +0.00 | buy |
| Hillsdale Investment Management Inc. | 47,630 | 59,730 | +12,100 | 0.10 | 0.15 | +0.05 | buy |
| Diversified Trust Co | 0 | 10,745 | +10,745 | 0.00 | 0.02 | +0.02 | buy |
| Ellsworth Advisors, LLC | 0 | 10,629 | +10,629 | 0.00 | 0.18 | +0.18 | buy |
| SIERRA SUMMIT ADVISORS LLC | 0 | 10,457 | +10,457 | 0.00 | 0.14 | +0.14 | buy |
| TD ASSET MANAGEMENT INC | 23,276 | 33,688 | +10,412 | 0.00 | 0.00 | +0.00 | buy |
| MANGROVE PARTNERS IM, LLC | 0 | 9,916 | +9,916 | 0.00 | 0.07 | +0.07 | buy |
| NOMURA HOLDINGS INC | 9,876 | 19,598 | +9,722 | 0.00 | 0.02 | +0.01 | buy |
| AMI ASSET MANAGEMENT CORP | 0 | 8,859 | +8,859 | 0.00 | 0.05 | +0.05 | buy |
| BANK OF AMERICA CORP /DE/ | 713,452 | 722,177 | +8,725 | 0.00 | 0.00 | +0.00 | buy |
| Calamos Advisors LLC | 0 | 8,535 | +8,535 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 0 | 8,530 | +8,530 | 0.00 | 0.00 | +0.00 | buy |
| Jefferies Financial Group Inc. | 0 | 8,500 | +8,500 | 0.00 | 0.01 | +0.01 | buy |
| BNP Paribas Asset Management Holding S.A. | 257,228 | 265,631 | +8,403 | 0.02 | 0.03 | +0.01 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 242,320 | 250,399 | +8,079 | 0.93 | 1.12 | +0.19 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 36,411 | 44,476 | +8,065 | 0.00 | 0.00 | +0.00 | buy |
| Fieldview Capital Management, LLC | 0 | 7,832 | +7,832 | 0.00 | 0.21 | +0.21 | buy |
| MACKENZIE FINANCIAL CORP | 19,889 | 27,588 | +7,699 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 145,992 | 153,470 | +7,478 | 0.01 | 0.01 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 59,201 | 66,629 | +7,428 | 0.00 | 0.00 | +0.00 | buy |
| POLEN CAPITAL MANAGEMENT LLC | 13,360 | 20,531 | +7,171 | 0.00 | 0.01 | +0.01 | buy |
| ALPS ADVISORS INC | 42,097 | 49,128 | +7,031 | 0.02 | 0.02 | +0.00 | buy |
| Financiere des Professionnels - Fonds d,investissement inc. | 0 | 6,700 | +6,700 | 0.00 | 0.04 | +0.04 | buy |
| ZACKS INVESTMENT MANAGEMENT | 30,398 | 36,889 | +6,491 | 0.02 | 0.03 | +0.01 | buy |
| ADAR1 Capital Management, LLC | 0 | 6,200 | +6,200 | 0.00 | 0.03 | +0.03 | buy |
| Corient Private Wealth LLC | 0 | 5,770 | +5,770 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 43,450 | 49,180 | +5,730 | 0.00 | 0.00 | +0.00 | buy |
| JONES FINANCIAL COMPANIES LLLP | 945 | 6,419 | +5,474 | 0.00 | 0.00 | +0.00 | buy |
| Hood River Capital Management LLC | 280,028 | 285,384 | +5,356 | 0.24 | 0.26 | +0.02 | buy |
| Quantinno Capital Management LP | 3,192 | 8,497 | +5,305 | 0.00 | 0.00 | +0.00 | buy |
| NAN FUNG TRINITY (HK) Ltd | 227,479 | 232,679 | +5,200 | 1.42 | 2.36 | +0.94 | buy |
| GUGGENHEIM CAPITAL LLC | 9,772 | 14,488 | +4,716 | 0.01 | 0.01 | +0.00 | buy |
| Cynosure Group, LLC | 0 | 4,694 | +4,694 | 0.00 | 0.05 | +0.05 | buy |
| Vident Advisory, LLC | 0 | 4,633 | +4,633 | 0.00 | 0.00 | +0.00 | buy |
| INCEPTIONR LLC | 0 | 4,558 | +4,558 | 0.00 | 0.10 | +0.10 | buy |
| MARTINGALE ASSET MANAGEMENT L P | 18,226 | 22,727 | +4,501 | 0.04 | 0.05 | +0.02 | buy |
| Sofinnova Investments, Inc. | 23,100 | 27,591 | +4,491 | 0.08 | 0.13 | +0.05 | buy |
| Knights of Columbus Asset Advisors LLC | 19,499 | 23,824 | +4,325 | 0.09 | 0.12 | +0.04 | buy |
| Marex Group plc | 0 | 4,176 | +4,176 | 0.00 | 0.00 | +0.00 | buy |
| SummitTX Capital, L.P. | 0 | 4,170 | +4,170 | 0.00 | 0.01 | +0.01 | buy |
| Pathstone Holdings, LLC | 21,676 | 25,575 | +3,899 | 0.01 | 0.01 | +0.00 | buy |
| Jain Global LLC | 0 | 3,857 | +3,857 | 0.00 | 0.00 | +0.00 | buy |
| Allianz Asset Management GmbH | 27,444 | 31,255 | +3,811 | 0.00 | 0.00 | +0.00 | buy |
| Northwest & Ethical Investments L.P. | 0 | 3,600 | +3,600 | 0.00 | 0.01 | +0.01 | buy |