| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 2,767,210 | 4,988,747 | +2,221,537 | 0.04 | 0.09 | +0.05 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | 1,951,000 | +1,951,000 | 0.00 | 0.00 | +0.00 | buy |
| Candriam S.C.A. | 0 | 508,475 | +508,475 | 0.00 | 0.11 | +0.11 | buy |
| MPM BioImpact LLC | 0 | 492,569 | +492,569 | 0.00 | 2.62 | +2.62 | buy |
| Clearbridge Investments, LLC | 263,584 | 699,933 | +436,349 | 0.01 | 0.02 | +0.01 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 3,300,400 | 3,614,820 | +314,420 | 1.30 | 2.12 | +0.82 | buy |
| SEI INVESTMENTS CO | 0 | 249,000 | +249,000 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 39,021 | 284,045 | +245,024 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 2,211,685 | 2,446,733 | +235,048 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 697,139 | 907,180 | +210,041 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 1,392,506 | 1,585,624 | +193,118 | 0.03 | 0.05 | +0.02 | buy |
| MORGAN STANLEY | 354,588 | 541,022 | +186,434 | 0.00 | 0.00 | +0.00 | buy |
| Polar Capital Holdings Plc | 625,000 | 741,049 | +116,049 | 0.08 | 0.15 | +0.07 | buy |
| TANG CAPITAL MANAGEMENT LLC | 1,187,107 | 1,287,107 | +100,000 | 3.10 | 4.48 | +1.38 | buy |
| BOONE CAPITAL MANAGEMENT LLC | 451,898 | 523,679 | +71,781 | 2.30 | 4.67 | +2.37 | buy |
| GOLDMAN SACHS GROUP INC | 700,116 | 759,018 | +58,902 | 0.00 | 0.01 | +0.00 | buy |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 162,817 | 220,490 | +57,673 | 0.03 | 0.05 | +0.02 | buy |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 627,272 | 677,939 | +50,667 | 0.04 | 0.06 | +0.02 | buy |
| Bank of New York Mellon Corp | 96,494 | 143,000 | +46,506 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 0 | 45,849 | +45,849 | 0.00 | 0.01 | +0.01 | buy |
| Rhenman & Partners Asset Management AB | 92,250 | 134,250 | +42,000 | 0.22 | 0.44 | +0.22 | buy |
| Hennion & Walsh Asset Management, Inc. | 63,534 | 104,770 | +41,236 | 0.09 | 0.18 | +0.10 | buy |
| PDT Partners, LLC | 0 | 39,363 | +39,363 | 0.00 | 0.13 | +0.13 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 271,654 | 311,012 | +39,358 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 7,875 | 38,114 | +30,239 | 0.00 | 0.00 | +0.00 | buy |
| Penserra Capital Management LLC | 0 | 26,906 | +26,906 | 0.00 | 0.01 | +0.01 | buy |
| Squarepoint Ops LLC | 41,267 | 67,421 | +26,154 | 0.00 | 0.01 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 22,244 | +22,244 | 0.00 | 0.01 | +0.01 | buy |
| Jump Financial, LLC | 0 | 20,478 | +20,478 | 0.00 | 0.01 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 312,613 | 332,101 | +19,488 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 41,105 | 60,019 | +18,914 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 35,637 | 52,916 | +17,279 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 24,100 | 41,050 | +16,950 | 0.00 | 0.00 | +0.00 | buy |
| FIRST TRUST ADVISORS LP | 11,265 | 27,387 | +16,122 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 15,245 | +15,245 | 0.00 | 0.04 | +0.04 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 214,887 | 229,730 | +14,843 | 0.31 | 0.47 | +0.16 | buy |
| Alpine Global Management, LLC | 0 | 14,417 | +14,417 | 0.00 | 0.09 | +0.09 | buy |
| NEOS Investment Management LLC | 27,203 | 41,244 | +14,041 | 0.04 | 0.06 | +0.02 | buy |
| Corton Capital Inc. | 0 | 12,369 | +12,369 | 0.00 | 0.22 | +0.22 | buy |
| Semanteon Capital Management, LP | 0 | 11,252 | +11,252 | 0.00 | 0.27 | +0.27 | buy |
| Ground Swell Capital, LLC | 0 | 10,780 | +10,780 | 0.00 | 0.36 | +0.36 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 45,817 | 56,464 | +10,647 | 0.00 | 0.01 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 24,355 | 34,963 | +10,608 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 10,477 | +10,477 | 0.00 | 0.02 | +0.02 | buy |
| Nan Fung Group Holdings Ltd | 96,100 | 106,100 | +10,000 | 2.24 | 3.87 | +1.63 | buy |
| MetLife Investment Management, LLC | 14,125 | 22,729 | +8,604 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 155,353 | 163,540 | +8,187 | 0.01 | 0.01 | +0.00 | buy |
| EntryPoint Capital, LLC | 1,668 | 9,758 | +8,090 | 0.04 | 0.15 | +0.12 | buy |
| JANE STREET GROUP, LLC | 114,605 | 122,664 | +8,059 | 0.00 | 0.00 | +0.00 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 0 | 7,947 | +7,947 | 0.00 | 0.00 | +0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 0 | 7,218 | +7,218 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 6,503 | +6,503 | 0.00 | 0.02 | +0.02 | buy |
| Campbell & CO Investment Adviser LLC | 0 | 6,439 | +6,439 | 0.00 | 0.02 | +0.02 | buy |
| ProShare Advisors LLC | 0 | 6,224 | +6,224 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 28,645 | 34,185 | +5,540 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 59,300 | 64,800 | +5,500 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 15,100 | 20,520 | +5,420 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 8,201 | 13,203 | +5,002 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 70,442 | 75,416 | +4,974 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 244,151 | 249,051 | +4,900 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 0 | 4,824 | +4,824 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 32,883 | 36,759 | +3,876 | 0.01 | 0.01 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 3,353 | 7,197 | +3,844 | 0.00 | 0.00 | +0.00 | buy |
| Secure Asset Management, LLC | 42,274 | 45,904 | +3,630 | 0.25 | 0.30 | +0.05 | buy |
| Knights of Columbus Asset Advisors LLC | 102,278 | 104,865 | +2,587 | 0.19 | 0.23 | +0.05 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 12,000 | 14,050 | +2,050 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 11,015 | 12,344 | +1,329 | 0.15 | 0.21 | +0.06 | buy |
| Ameritas Investment Partners, Inc. | 2,637 | 3,843 | +1,206 | 0.00 | 0.00 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 0 | 1,178 | +1,178 | 0.00 | 0.00 | +0.00 | buy |
| AlphaQuest LLC | 15 | 1,142 | +1,127 | 0.00 | 0.01 | +0.01 | buy |
| Golden State Equity Partners | 18,930 | 19,930 | +1,000 | 0.14 | 0.14 | +0.01 | buy |
| Arizona State Retirement System | 8,327 | 9,210 | +883 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 844 | 1,357 | +513 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 54 | 359 | +305 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 941,374 | 941,570 | +196 | 0.01 | 0.01 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 270 | 365 | +95 | 0.00 | 0.00 | +0.00 | buy |
| Pathway Financial Advisers, LLC | 0 | 87 | +87 | 0.00 | 0.00 | +0.00 | buy |
| MassMutual Private Wealth & Trust, FSB | 0 | 74 | +74 | 0.00 | 0.00 | +0.00 | buy |
| COMERICA BANK | 100 | 162 | +62 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 8 | 48 | +40 | 0.00 | 0.00 | +0.00 | buy |
| Covestor Ltd | 3 | 23 | +20 | 0.00 | 0.00 | +0.00 | buy |
| NATIONAL BANK OF CANADA /FI/ | 0 | 20 | +20 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 17,481 | 17,497 | +16 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 170 | 180 | +10 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 5 | 15 | +10 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 0 | 3 | +3 | 0.00 | 0.00 | +0.00 | buy |
| AGF MANAGEMENT LTD | 0 | 0 | 0 | 0.00 | 0.01 | +0.01 | hold |
| ZAZOVE ASSOCIATES LLC | 0 | 0 | 0 | 0.00 | 0.12 | +0.12 | hold |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 0 | 0 | 0 | 0.00 | 1.56 | +1.56 | hold |
| NOMURA ASSET MANAGEMENT CO LTD | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| BVF INC/IL | 4,370,024 | 4,370,024 | 0 | 3.02 | 4.19 | +1.17 | hold |
| GREAT LAKES ADVISORS, LLC | 8,308 | 8,308 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ADVENT CAPITAL MANAGEMENT /DE/ | 0 | 0 | 0 | 0.00 | 0.65 | +0.65 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 160,000 | 160,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 0 | 0 | 0.00 | 0.00 | +0.00 | hold |
| LAZARD ASSET MANAGEMENT LLC | 0 | 0 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TANG CAPITAL MANAGEMENT LLC | 0 | 0 | 0 | 0.00 | 0.29 | +0.29 | hold |
| BAKER BROS. ADVISORS LP | 190,476 | 190,476 | 0 | 0.06 | 0.08 | +0.02 | hold |
| SHENKMAN CAPITAL MANAGEMENT INC | 0 | 0 | 0 | 0.00 | 0.09 | +0.09 | hold |
| WOLVERINE ASSET MANAGEMENT LLC | 0 | 0 | 0 | 0.00 | 1.13 | +1.13 | hold |