| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Frazier Life Sciences Management, L.P. | 6,795,121 | 6,795,121 | 0 | 13.99 | 13.83 | -0.16 | hold |
| JANUS HENDERSON GROUP PLC | 4,766,109 | 5,236,277 | +470,168 | 0.12 | 0.13 | +0.01 | buy |
| BlackRock, Inc. | 3,339,557 | 3,577,091 | +237,534 | 0.00 | 0.00 | +0.00 | buy |
| BVF INC/IL | 2,796,513 | 2,761,333 | -35,180 | 5.13 | 5.02 | -0.11 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 2,527,000 | 2,637,485 | +110,485 | 2.27 | 2.35 | +0.08 | buy |
| VANGUARD GROUP INC | 2,540,061 | 2,564,869 | +24,808 | 0.00 | 0.00 | +0.00 | buy |
| Novo Holdings A/S | 1,500,000 | 1,500,055 | +55 | 5.14 | 5.39 | +0.25 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,415,137 | 1,417,215 | +2,078 | 0.01 | 0.01 | +0.00 | buy |
| CITADEL ADVISORS LLC | 1,445,995 | 1,406,352 | -39,643 | 0.06 | 0.06 | -0.00 | sell |
| STATE STREET CORP | 1,494,566 | 1,375,628 | -118,938 | 0.00 | 0.00 | -0.00 | sell |
| TANG CAPITAL MANAGEMENT LLC | 1,237,107 | 1,236,027 | -1,080 | 3.08 | 3.18 | +0.10 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 963,665 | 1,029,616 | +65,951 | 0.00 | 0.00 | +0.00 | buy |
| Clearbridge Investments, LLC | 978,067 | 1,027,527 | +49,460 | 0.04 | 0.04 | +0.00 | buy |
| Polar Capital Holdings Plc | 1,175,000 | 975,000 | -200,000 | 0.32 | 0.26 | -0.06 | sell |
| Rock Springs Capital Management LP | 951,765 | 818,206 | -133,559 | 2.45 | 2.59 | +0.14 | sell |
| LORD, ABBETT & CO. LLC | 813,398 | 771,146 | -42,252 | 0.13 | 0.13 | -0.00 | sell |
| Pictet Asset Management Holding SA | 778,244 | 701,156 | -77,088 | 0.04 | 0.04 | -0.00 | sell |
| BOONE CAPITAL MANAGEMENT LLC | 603,318 | 641,448 | +38,130 | 9.25 | 14.00 | +4.75 | buy |
| FRANKLIN RESOURCES INC | 593,355 | 593,596 | +241 | 0.01 | 0.01 | +0.00 | buy |
| Nuveen, LLC | 654,722 | 590,257 | -64,465 | 0.01 | 0.01 | -0.00 | sell |
| Woodline Partners LP | 566,271 | 567,894 | +1,623 | 0.17 | 0.15 | -0.01 | buy |
| MORGAN STANLEY | 606,431 | 566,326 | -40,105 | 0.00 | 0.00 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 543,277 | 554,957 | +11,680 | 0.03 | 0.03 | -0.00 | buy |
| LOOMIS SAYLES & CO L P | 566,155 | 552,957 | -13,198 | 0.04 | 0.04 | -0.00 | sell |
| First Turn Management, LLC | 503,014 | 527,540 | +24,526 | 4.57 | 5.01 | +0.44 | buy |
| Bank of New York Mellon Corp | 246,730 | 496,061 | +249,331 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 499,183 | 481,464 | -17,719 | 0.02 | 0.02 | +0.00 | sell |
| JPMORGAN CHASE & CO | 287,936 | 480,276 | +192,340 | 0.00 | 0.00 | +0.00 | buy |
| MACQUARIE GROUP LTD | 366,751 | 435,717 | +68,966 | 0.02 | 0.03 | +0.01 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 356,276 | 423,744 | +67,468 | 0.07 | 0.08 | +0.01 | buy |
| NORTHERN TRUST CORP | 388,921 | 402,396 | +13,475 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 188,500 | 396,348 | +207,848 | 0.01 | 0.03 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 477,651 | 395,008 | -82,643 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 378,622 | 389,270 | +10,648 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 327,878 | 383,160 | +55,282 | 0.00 | 0.00 | +0.00 | buy |
| Candriam S.C.A. | 382,979 | 373,005 | -9,974 | 0.11 | 0.11 | +0.00 | sell |
| AXA S.A. | 351,372 | 351,682 | +310 | 0.05 | 0.05 | -0.00 | buy |
| FEDERATED HERMES, INC. | 347,366 | 344,304 | -3,062 | 0.03 | 0.03 | -0.00 | sell |
| Penn Capital Management Company, LLC | 373,519 | 342,256 | -31,263 | 1.64 | 1.51 | -0.13 | sell |
| EMERALD ADVISERS, LLC | 0 | 305,766 | +305,766 | 0.00 | 0.57 | +0.57 | buy |
| Soleus Capital Management, L.P. | 0 | 298,696 | +298,696 | 0.00 | 1.05 | +1.05 | buy |
| MILLENNIUM MANAGEMENT LLC | 479,299 | 288,159 | -191,140 | 0.02 | 0.01 | -0.01 | sell |
| RAYMOND JAMES FINANCIAL INC | 249,318 | 264,118 | +14,800 | 0.00 | 0.00 | +0.00 | buy |
| Erste Asset Management GmbH | 260,000 | 260,000 | 0 | 0.15 | 0.11 | -0.04 | hold |
| Point72 Asset Management, L.P. | 232,098 | 258,866 | +26,768 | 0.03 | 0.03 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 260,366 | 249,857 | -10,509 | 0.02 | 0.02 | -0.00 | sell |
| Russell Investments Group, Ltd. | 229,449 | 247,733 | +18,284 | 0.01 | 0.02 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 345,000 | 243,000 | -102,000 | 0.03 | 0.02 | -0.01 | sell |
| AMERIPRISE FINANCIAL INC | 195,883 | 242,760 | +46,877 | 0.00 | 0.00 | +0.00 | buy |
| Eversept Partners, LP | 0 | 232,175 | +232,175 | 0.00 | 1.19 | +1.19 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 234,696 | 231,993 | -2,703 | 0.62 | 0.64 | +0.01 | sell |
| SEI INVESTMENTS CO | 228,000 | 228,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| EMERALD MUTUAL FUND ADVISERS TRUST | 0 | 217,542 | +217,542 | 0.00 | 0.67 | +0.67 | buy |
| Prosight Management, LP | 343,326 | 200,000 | -143,326 | 5.08 | 2.48 | -2.60 | sell |
| WELLS FARGO & COMPANY/MN | 33,668 | 198,160 | +164,492 | 0.00 | 0.00 | +0.00 | buy |
| NEXT CENTURY GROWTH INVESTORS LLC | 195,341 | 190,325 | -5,016 | 0.78 | 0.75 | -0.03 | sell |
| Nicholas Investment Partners, LP | 173,043 | 184,483 | +11,440 | 0.80 | 0.84 | +0.03 | buy |
| UBS Group AG | 235,957 | 182,456 | -53,501 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 175,126 | 171,814 | -3,312 | 0.02 | 0.02 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 206,600 | 171,400 | -35,200 | 0.02 | 0.02 | -0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 149,518 | 161,490 | +11,972 | 0.00 | 0.00 | -0.00 | buy |
| ALGERT GLOBAL LLC | 66,761 | 159,349 | +92,588 | 0.07 | 0.17 | +0.10 | buy |
| Qube Research & Technologies Ltd | 139,434 | 159,028 | +19,594 | 0.01 | 0.01 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 240,744 | 155,627 | -85,117 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 81,304 | 154,871 | +73,567 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 15,823 | 148,689 | +132,866 | 0.01 | 0.10 | +0.09 | buy |
| NAN FUNG TRINITY (HK) Ltd | 0 | 146,765 | +146,765 | 0.00 | 0.89 | +0.89 | buy |
| PDT Partners, LLC | 137,495 | 145,379 | +7,884 | 0.44 | 0.42 | -0.02 | buy |
| Cubist Systematic Strategies, LLC | 296,887 | 144,950 | -151,937 | 0.18 | 0.08 | -0.10 | sell |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 135,915 | 135,915 | 0 | 0.04 | 0.05 | +0.00 | hold |
| Ensign Peak Advisors, Inc | 133,973 | 133,973 | 0 | 0.01 | 0.01 | +0.00 | hold |
| FIRST TRUST ADVISORS LP | 129,634 | 129,794 | +160 | 0.01 | 0.01 | +0.00 | buy |
| Highlander Partners, L.P. | 122,980 | 122,980 | 0 | 3.43 | 2.40 | -1.02 | hold |
| Hennion & Walsh Asset Management, Inc. | 147,193 | 122,769 | -24,424 | 0.29 | 0.25 | -0.04 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 112,924 | 118,571 | +5,647 | 0.00 | 0.00 | +0.00 | buy |
| Patient Square Capital LP | 116,362 | 113,462 | -2,900 | 2.17 | 2.08 | -0.09 | sell |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 0 | 112,731 | +112,731 | 0.00 | 1.04 | +1.04 | buy |
| Atle Fund Management AB | 77,263 | 106,912 | +29,649 | 1.54 | 2.33 | +0.79 | buy |
| Trexquant Investment LP | 0 | 104,303 | +104,303 | 0.00 | 0.06 | +0.06 | buy |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 0 | 75,644 | +75,644 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 133,721 | 70,707 | -63,014 | 0.00 | 0.00 | -0.00 | sell |
| Swiss National Bank | 69,800 | 70,200 | +400 | 0.00 | 0.00 | -0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 19,815 | 66,791 | +46,976 | 0.00 | 0.00 | +0.00 | buy |
| Rhenman & Partners Asset Management AB | 73,755 | 65,755 | -8,000 | 0.38 | 0.42 | +0.04 | sell |
| Palo Alto Investors LP | 64,700 | 64,700 | 0 | 0.56 | 0.70 | +0.15 | hold |
| Invesco Ltd. | 313,423 | 64,653 | -248,770 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 55,434 | 64,593 | +9,159 | 0.00 | 0.00 | +0.00 | buy |
| OPPENHEIMER ASSET MANAGEMENT INC. | 62,000 | 62,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| FMR LLC | 54,327 | 59,441 | +5,114 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF MONTREAL /CAN/ | 56,340 | 57,043 | +703 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 56,605 | 52,410 | -4,195 | 0.00 | 0.00 | -0.00 | sell |
| Secure Asset Management, LLC | 48,910 | 50,997 | +2,087 | 0.44 | 0.48 | +0.04 | buy |
| AQR CAPITAL MANAGEMENT LLC | 49,076 | 47,516 | -1,560 | 0.00 | 0.00 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 41,850 | 43,450 | +1,600 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 42,834 | 43,010 | +176 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 51,857 | 37,207 | -14,650 | 0.01 | 0.01 | -0.00 | sell |
| Aquatic Capital Management LLC | 46,310 | 36,897 | -9,413 | 0.05 | 0.04 | -0.02 | sell |
| Phocas Financial Corp. | 35,556 | 35,561 | +5 | 0.25 | 0.26 | +0.01 | buy |
| ExodusPoint Capital Management, LP | 36,262 | 34,175 | -2,087 | 0.02 | 0.02 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 32,808 | 33,574 | +766 | 0.00 | 0.00 | +0.00 | buy |