| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 4,766,109 | 5,236,277 | +470,168 | 0.12 | 0.13 | 0.00 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 2,527,000 | 2,637,485 | +110,485 | 2.27 | 2.35 | +0.08 | buy |
| ALGERT GLOBAL LLC | 66,761 | 159,349 | +92,588 | 0.07 | 0.17 | 0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 356,276 | 423,744 | +67,468 | 0.07 | 0.08 | +0.01 | buy |
| Clearbridge Investments, LLC | 978,067 | 1,027,527 | +49,460 | 0.04 | 0.04 | +0.00 | buy |
| BOONE CAPITAL MANAGEMENT LLC | 603,318 | 641,448 | +38,130 | 9.25 | 14.00 | +4.75 | buy |
| Atle Fund Management AB | 77,263 | 106,912 | +29,649 | 1.54 | 2.33 | +0.79 | buy |
| First Turn Management, LLC | 503,014 | 527,540 | +24,526 | 4.57 | 5.01 | +0.44 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 499,183 | 481,464 | +17,719 | 0.02 | 0.02 | 0.00 | sell |
| Legato Capital Management LLC | 16,552 | 31,763 | +15,211 | 0.10 | 0.19 | +0.09 | buy |
| GSA CAPITAL PARTNERS LLP | 40,459 | 27,051 | +13,408 | 0.19 | 0.11 | 0.00 | sell |
| AlphaQuest LLC | 22,580 | 9,783 | +12,797 | 0.12 | 0.05 | 0.00 | sell |
| D. E. Shaw & Co., Inc. | 543,277 | 554,957 | +11,680 | 0.03 | 0.03 | 0.00 | buy |
| Nicholas Investment Partners, LP | 173,043 | 184,483 | +11,440 | 0.80 | 0.84 | +0.03 | buy |
| ALPS ADVISORS INC | 35,516 | 26,636 | +8,880 | 0.01 | 0.01 | 0.00 | sell |
| PDT Partners, LLC | 137,495 | 145,379 | +7,884 | 0.44 | 0.42 | -0.02 | buy |
| TWO SIGMA INVESTMENTS, LP | 175,126 | 171,814 | +3,312 | 0.02 | 0.02 | 0.00 | sell |
| ExodusPoint Capital Management, LP | 36,262 | 34,175 | +2,087 | 0.02 | 0.02 | 0.00 | sell |
| Secure Asset Management, LLC | 48,910 | 50,997 | +2,087 | 0.44 | 0.48 | +0.04 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,415,137 | 1,417,215 | +2,078 | 0.01 | 0.01 | +0.00 | buy |
| Woodline Partners LP | 566,271 | 567,894 | +1,623 | 0.17 | 0.15 | -0.01 | buy |
| Values First Advisors, Inc. | 18,118 | 19,632 | +1,514 | 0.48 | 0.54 | +0.07 | buy |
| Avanza Fonder AB | 2,878 | 4,154 | +1,276 | 0.00 | 0.01 | +0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 22,560 | 21,409 | +1,151 | 0.08 | 0.06 | 0.00 | sell |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 136,700 | 135,915 | +785 | 0.04 | 0.05 | 0.00 | sell |
| Virtus Investment Advisers, LLC | 8,492 | 9,066 | +574 | 0.10 | 0.16 | +0.05 | buy |
| Palumbo Wealth Management LLC | 5,376 | 5,604 | +228 | 0.08 | 0.09 | +0.01 | buy |
| China Universal Asset Management Co., Ltd. | 9,831 | 9,949 | +118 | 0.04 | 0.05 | +0.01 | buy |
| Novo Holdings A/S | 1,500,000 | 1,500,055 | +55 | 5.14 | 5.39 | +0.25 | buy |
| Phocas Financial Corp. | 35,556 | 35,561 | +5 | 0.25 | 0.26 | +0.01 | buy |
| Knights of Columbus Asset Advisors LLC | 19,757 | 19,268 | -489 | 0.06 | 0.06 | -0.00 | sell |
| BOSUN ASSET MANAGEMENT, LLC | 10,126 | 9,530 | -596 | 0.22 | 0.17 | -0.05 | sell |
| E Fund Management Co., Ltd. | 4,847 | 4,143 | -704 | 0.01 | 0.01 | -0.00 | sell |
| TANG CAPITAL MANAGEMENT LLC | 1,237,107 | 1,236,027 | -1,080 | 3.08 | 3.18 | +0.10 | sell |
| NEOS Investment Management LLC | 11,432 | 9,947 | -1,485 | 0.01 | 0.01 | -0.00 | sell |
| TEMA ETFS LLC | 11,432 | 9,947 | -1,485 | 0.15 | 0.13 | -0.02 | sell |
| EntryPoint Capital, LLC | 9,675 | 7,266 | -2,409 | 0.20 | 0.19 | -0.01 | sell |
| RICE HALL JAMES & ASSOCIATES, LLC | 234,696 | 231,993 | -2,703 | 0.62 | 0.64 | +0.01 | sell |
| PROFUND ADVISORS LLC | 11,002 | 8,187 | -2,815 | 0.02 | 0.01 | -0.01 | sell |
| Patient Square Capital LP | 116,362 | 113,462 | -2,900 | 2.17 | 2.08 | -0.09 | sell |
| Calamos Advisors LLC | 36,654 | 33,265 | -3,389 | 0.01 | 0.01 | -0.00 | sell |
| AIGEN INVESTMENT MANAGEMENT, LP | 9,929 | 6,504 | -3,425 | 0.07 | 0.05 | -0.03 | sell |
| NEXT CENTURY GROWTH INVESTORS LLC | 195,341 | 190,325 | -5,016 | 0.78 | 0.75 | -0.03 | sell |
| Rhenman & Partners Asset Management AB | 73,755 | 65,755 | -8,000 | 0.38 | 0.42 | +0.04 | sell |
| Candriam S.C.A. | 382,979 | 373,005 | -9,974 | 0.11 | 0.11 | +0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 260,366 | 249,857 | -10,509 | 0.02 | 0.02 | -0.00 | sell |
| LOOMIS SAYLES & CO L P | 566,155 | 552,957 | -13,198 | 0.04 | 0.04 | -0.00 | sell |
| Rafferty Asset Management, LLC | 51,857 | 37,207 | -14,650 | 0.01 | 0.01 | -0.00 | sell |
| Hennion & Walsh Asset Management, Inc. | 147,193 | 122,769 | -24,424 | 0.29 | 0.25 | -0.04 | sell |
| Affinity Asset Advisors, LLC | 49,692 | 24,692 | -25,000 | 0.21 | 0.17 | -0.04 | sell |
| Penn Capital Management Company, LLC | 373,519 | 342,256 | -31,263 | 1.64 | 1.51 | -0.13 | sell |
| BVF INC/IL | 2,796,513 | 2,761,333 | -35,180 | 5.13 | 5.02 | -0.11 | sell |
| CITADEL ADVISORS LLC | 1,445,995 | 1,406,352 | -39,643 | 0.09 | 0.09 | -0.00 | sell |
| LORD, ABBETT & CO. LLC | 813,398 | 771,146 | -42,252 | 0.13 | 0.13 | -0.00 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 345,000 | 243,000 | -102,000 | 0.03 | 0.02 | -0.01 | sell |
| Rock Springs Capital Management LP | 951,765 | 818,206 | -133,559 | 2.45 | 2.59 | +0.14 | sell |
| Prosight Management, LP | 343,326 | 200,000 | -143,326 | 5.08 | 2.48 | -2.60 | sell |
| Polar Capital Holdings Plc | 1,175,000 | 975,000 | -200,000 | 0.32 | 0.26 | -0.06 | sell |