| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Frazier Life Sciences Management, L.P. | 7,679,684 | 7,679,684 | 0 | 18.25 | 19.58 | +1.32 | hold |
| BlackRock, Inc. | 3,846,530 | 4,390,063 | +543,533 | 0.01 | 0.01 | +0.00 | buy |
| FMR LLC | 1,965,375 | 3,670,314 | +1,704,939 | 0.01 | 0.02 | +0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,717,421 | 2,655,607 | +938,186 | 0.02 | 0.03 | +0.01 | buy |
| STATE STREET CORP | 1,944,281 | 2,170,689 | +226,408 | 0.01 | 0.01 | +0.00 | buy |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 335,669 | 1,404,741 | +1,069,072 | 0.10 | 0.49 | +0.39 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,260,003 | 1,393,908 | +133,905 | 0.01 | 0.01 | +0.00 | buy |
| Invesco Ltd. | 285,236 | 1,364,084 | +1,078,848 | 0.00 | 0.01 | +0.01 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 1,334,809 | 1,309,987 | -24,822 | 0.02 | 0.03 | +0.00 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 1,408,871 | 1,248,389 | -160,482 | 2.15 | 1.95 | -0.20 | sell |
| TANG CAPITAL MANAGEMENT LLC | 1,236,027 | 1,236,027 | 0 | 5.80 | 6.57 | +0.77 | hold |
| Capital World Investors | 724,415 | 1,153,480 | +429,065 | 0.01 | 0.02 | +0.01 | buy |
| FRANKLIN RESOURCES INC | 714,804 | 1,152,770 | +437,966 | 0.02 | 0.03 | +0.01 | buy |
| Novo Holdings A/S | 1,325,000 | 1,125,000 | -200,000 | 9.92 | 7.65 | -2.27 | sell |
| TCG Crossover Management, LLC | 1,062,049 | 1,062,049 | 0 | 2.81 | 2.99 | +0.18 | hold |
| BVF INC/IL | 1,584,727 | 1,056,027 | -528,700 | 4.66 | 3.16 | -1.50 | sell |
| Polar Capital Holdings Plc | 283,484 | 845,524 | +562,040 | 0.11 | 0.28 | +0.17 | buy |
| Rock Springs Capital Management LP | 811,294 | 798,145 | -13,149 | 4.42 | 4.56 | +0.14 | sell |
| AMERIPRISE FINANCIAL INC | 219,255 | 726,694 | +507,439 | 0.00 | 0.02 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 774,841 | 690,318 | -84,523 | 0.06 | 0.06 | +0.00 | sell |
| Bank of New York Mellon Corp | 584,523 | 669,974 | +85,451 | 0.01 | 0.01 | +0.00 | buy |
| Clearbridge Investments, LLC | 671,870 | 639,734 | -32,136 | 0.05 | 0.06 | +0.01 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 911,419 | 606,427 | -304,992 | 0.06 | 0.04 | -0.02 | sell |
| Woodline Partners LP | 567,894 | 567,894 | 0 | 0.20 | 0.21 | +0.01 | hold |
| BANK OF AMERICA CORP /DE/ | 722,177 | 561,724 | -160,453 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 662,306 | 549,874 | -112,432 | 0.01 | 0.01 | -0.00 | sell |
| LORD, ABBETT & CO. LLC | 617,064 | 540,977 | -76,087 | 0.19 | 0.18 | -0.00 | sell |
| Pictet Asset Management Holding SA | 423,511 | 526,443 | +102,932 | 0.04 | 0.06 | +0.02 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 539,031 | 489,170 | -49,861 | 0.10 | 0.10 | +0.01 | sell |
| EMERALD ADVISERS, LLC | 397,263 | 468,295 | +71,032 | 1.16 | 1.29 | +0.13 | buy |
| NORTHERN TRUST CORP | 394,920 | 452,036 | +57,116 | 0.00 | 0.01 | +0.00 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 449,429 | +449,429 | 0.00 | 0.01 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 427,090 | 449,429 | +22,339 | 0.01 | 0.01 | +0.00 | buy |
| BAKER BROS. ADVISORS LP | 445,975 | 445,975 | 0 | 0.24 | 0.26 | +0.03 | hold |
| LOOMIS SAYLES & CO L P | 475,324 | 443,636 | -31,688 | 0.06 | 0.07 | +0.01 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 582,085 | 442,185 | -139,900 | 0.08 | 0.07 | -0.01 | sell |
| FEDERATED HERMES, INC. | 506,211 | 436,635 | -69,576 | 0.08 | 0.07 | -0.00 | sell |
| NEXT CENTURY GROWTH INVESTORS LLC | 385,539 | 420,213 | +34,674 | 2.58 | 2.61 | +0.03 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 479,476 | 420,063 | -59,413 | 0.10 | 0.09 | -0.01 | sell |
| BOONE CAPITAL MANAGEMENT LLC | 421,236 | 415,641 | -5,595 | 11.92 | 11.38 | -0.54 | sell |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 286,406 | 384,570 | +98,164 | 0.01 | 0.01 | +0.01 | buy |
| UBS Group AG | 494,994 | 379,760 | -115,234 | 0.01 | 0.01 | -0.00 | sell |
| Candriam S.C.A. | 464,216 | 376,143 | -88,073 | 0.22 | 0.20 | -0.02 | sell |
| TimesSquare Capital Management, LLC | 376,473 | 367,281 | -9,192 | 0.59 | 0.63 | +0.04 | sell |
| MORGAN STANLEY | 524,566 | 351,404 | -173,162 | 0.00 | 0.00 | -0.00 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 375,000 | 350,000 | -25,000 | 0.05 | 0.06 | +0.00 | sell |
| Palo Alto Investors LP | 325,175 | 348,808 | +23,633 | 4.59 | 5.64 | +1.05 | buy |
| Octagon Capital Advisors LP | 338,900 | 338,900 | 0 | 3.46 | 3.64 | +0.18 | hold |
| PANAGORA ASSET MANAGEMENT INC | 129,114 | 337,461 | +208,347 | 0.04 | 0.12 | +0.08 | buy |
| Nuveen, LLC | 474,227 | 329,282 | -144,945 | 0.01 | 0.01 | -0.00 | sell |
| RA CAPITAL MANAGEMENT, L.P. | 318,554 | 318,554 | 0 | 0.31 | 0.32 | +0.01 | hold |
| Hood River Capital Management LLC | 285,384 | 306,439 | +21,055 | 0.26 | 0.26 | -0.00 | buy |
| Penn Capital Management Company, LLC | 256,767 | 298,914 | +42,147 | 1.84 | 2.22 | +0.38 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 250,399 | 289,372 | +38,973 | 1.12 | 1.19 | +0.07 | buy |
| Patient Square Capital LP | 230,000 | 260,500 | +30,500 | 3.77 | 4.72 | +0.95 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 201,145 | 250,558 | +49,413 | 0.03 | 0.04 | +0.01 | buy |
| BNP Paribas Asset Management Holding S.A. | 265,631 | 248,963 | -16,668 | 0.03 | 0.03 | +0.00 | sell |
| RAYMOND JAMES FINANCIAL INC | 228,174 | 233,311 | +5,137 | 0.01 | 0.01 | +0.00 | buy |
| NAN FUNG TRINITY (HK) Ltd | 232,679 | 232,679 | 0 | 2.36 | 2.69 | +0.33 | hold |
| Russell Investments Group, Ltd. | 197,093 | 219,341 | +22,248 | 0.02 | 0.02 | +0.00 | buy |
| First Turn Management, LLC | 400,464 | 218,051 | -182,413 | 4.13 | 2.73 | -1.40 | sell |
| Erste Asset Management GmbH | 210,000 | 205,000 | -5,000 | 0.17 | 0.20 | +0.02 | sell |
| Handelsbanken Fonder AB | 194,000 | 197,179 | +3,179 | 0.06 | 0.07 | +0.01 | buy |
| SEGALL BRYANT & HAMILL, LLC | 175,898 | 178,980 | +3,082 | 0.17 | 0.25 | +0.08 | buy |
| Ensign Peak Advisors, Inc | 202,473 | 175,598 | -26,875 | 0.03 | 0.03 | -0.00 | sell |
| Nicholas Investment Partners, LP | 131,303 | 172,695 | +41,392 | 0.88 | 1.14 | +0.26 | buy |
| CITIGROUP INC | 153,470 | 165,136 | +11,666 | 0.01 | 0.01 | -0.00 | buy |
| Legal & General Group Plc | 153,870 | 159,231 | +5,361 | 0.00 | 0.00 | +0.00 | buy |
| Neuberger Berman Group LLC | 80,549 | 139,447 | +58,898 | 0.01 | 0.01 | +0.01 | buy |
| Rhenman & Partners Asset Management AB | 92,605 | 139,205 | +46,600 | 1.06 | 1.54 | +0.48 | buy |
| FIRST TRUST ADVISORS LP | 151,272 | 136,141 | -15,131 | 0.01 | 0.01 | -0.00 | sell |
| Highlander Partners, L.P. | 122,980 | 122,980 | 0 | 4.45 | 4.83 | +0.38 | hold |
| PDT Partners, LLC | 145,379 | 122,041 | -23,338 | 0.79 | 0.75 | -0.04 | sell |
| PERCEPTIVE ADVISORS LLC | 0 | 115,391 | +115,391 | 0.00 | 0.21 | +0.21 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 147,037 | 110,673 | -36,364 | 0.76 | 0.63 | -0.13 | sell |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 108,338 | 105,669 | -2,669 | 1.58 | 1.62 | +0.04 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 57,369 | 101,900 | +44,531 | 0.00 | 0.01 | +0.00 | buy |
| Capricorn Fund Managers Ltd | 0 | 101,240 | +101,240 | 0.00 | 0.95 | +0.95 | buy |
| Atle Fund Management AB | 195,768 | 100,807 | -94,961 | 3.03 | 3.17 | +0.14 | sell |
| MILLENNIUM MANAGEMENT LLC | 368,575 | 96,213 | -272,362 | 0.03 | 0.01 | -0.02 | sell |
| PEREGRINE CAPITAL MANAGEMENT LLC | 0 | 88,820 | +88,820 | 0.00 | 0.34 | +0.34 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 68,815 | 86,257 | +17,442 | 0.01 | 0.01 | +0.00 | buy |
| Swiss National Bank | 74,300 | 84,800 | +10,500 | 0.00 | 0.01 | +0.00 | buy |
| Voleon Capital Management LP | 150,513 | 82,877 | -67,636 | 0.30 | 0.18 | -0.12 | sell |
| Fisher Asset Management, LLC | 93,109 | 82,476 | -10,633 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 50,045 | 81,586 | +31,541 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 90,664 | 81,001 | -9,663 | 0.00 | 0.00 | +0.00 | sell |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 80,991 | 77,278 | -3,713 | 0.05 | 0.06 | +0.01 | sell |
| Soleus Capital Management, L.P. | 400,306 | 75,000 | -325,306 | 1.50 | 0.30 | -1.20 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 55,693 | 74,750 | +19,057 | 0.00 | 0.01 | +0.00 | buy |
| Alyeska Investment Group, L.P. | 34,051 | 73,959 | +39,908 | 0.01 | 0.02 | +0.01 | buy |
| SEI INVESTMENTS CO | 81,109 | 71,412 | -9,697 | 0.01 | 0.01 | +0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 66,629 | 68,725 | +2,096 | 0.00 | 0.00 | +0.00 | buy |
| ARISTEIA CAPITAL, L.L.C. | 0 | 64,475 | +64,475 | 0.00 | 0.12 | +0.12 | buy |
| Lisanti Capital Growth, LLC | 39,005 | 63,295 | +24,290 | 0.91 | 1.63 | +0.72 | buy |
| OPPENHEIMER ASSET MANAGEMENT INC. | 63,000 | 62,000 | -1,000 | 0.00 | 0.00 | +0.00 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 95,555 | 60,861 | -34,694 | 0.01 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 51,942 | 59,380 | +7,438 | 0.00 | 0.01 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 49,180 | 58,787 | +9,607 | 0.00 | 0.00 | +0.00 | buy |
| Hillsdale Investment Management Inc. | 59,730 | 58,630 | -1,100 | 0.15 | 0.16 | +0.01 | sell |