| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Frazier Life Sciences Management, L.P. | 4,360,107 | 6,470,392 | +2,110,285 | 6.74 | 13.59 | +6.86 | buy |
| JANUS HENDERSON GROUP PLC | 265,612 | 1,923,760 | +1,658,148 | 0.00 | 0.04 | 0.00 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 3,459,201 | 3,958,579 | +499,378 | 1.51 | 2.25 | +0.74 | buy |
| Nicholas Investment Partners, LP | 915,119 | 1,199,366 | +284,247 | 1.62 | 2.83 | +1.21 | buy |
| Polar Capital Holdings Plc | 925,000 | 1,175,000 | +250,000 | 0.16 | 0.28 | +0.11 | buy |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 337,414 | 533,693 | +196,279 | 0.03 | 0.06 | +0.03 | buy |
| CADIAN CAPITAL MANAGEMENT, LP | 1,264,922 | 1,434,922 | +170,000 | 1.55 | 1.83 | +0.28 | buy |
| Woodline Partners LP | 327,818 | 452,707 | +124,889 | 0.10 | 0.17 | +0.07 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 37,740 | 114,109 | +76,369 | 0.00 | 0.02 | +0.01 | buy |
| PERCEPTIVE ADVISORS LLC | 601,566 | 672,042 | +70,476 | 0.45 | 0.71 | +0.26 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 24,000 | 61,000 | +37,000 | 0.02 | 0.05 | 0.00 | buy |
| Rafferty Asset Management, LLC | 115,893 | 137,205 | +21,312 | 0.02 | 0.03 | +0.01 | buy |
| Campbell & CO Investment Adviser LLC | 14,974 | 28,556 | +13,582 | 0.07 | 0.11 | +0.04 | buy |
| Hennion & Walsh Asset Management, Inc. | 13,977 | 26,493 | +12,516 | 0.02 | 0.05 | +0.03 | buy |
| Legato Capital Management LLC | 25,997 | 36,317 | +10,320 | 0.09 | 0.17 | +0.08 | buy |
| Penn Capital Management Company, LLC | 239,274 | 245,970 | +6,696 | 0.60 | 0.80 | +0.20 | buy |
| Atom Investors LP | 8,624 | 13,142 | +4,518 | 0.08 | 0.09 | +0.01 | buy |
| Secure Asset Management, LLC | 35,554 | 39,698 | +4,144 | 0.28 | 0.38 | +0.10 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 106,375 | 110,114 | +3,739 | 0.93 | 1.30 | +0.37 | buy |
| Parkman Healthcare Partners LLC | 62,410 | 65,050 | +2,640 | 0.28 | 0.38 | +0.10 | buy |
| PROFUND ADVISORS LLC | 21,116 | 23,056 | +1,940 | 0.03 | 0.04 | +0.01 | buy |
| Knights of Columbus Asset Advisors LLC | 57,054 | 57,871 | +817 | 0.13 | 0.17 | +0.03 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 41,950 | 42,444 | +494 | 0.00 | 0.01 | 0.00 | buy |
| China Universal Asset Management Co., Ltd. | 498 | 986 | +488 | 0.00 | 0.01 | +0.01 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 54,454 | 53,379 | -1,075 | 0.08 | 0.11 | +0.03 | sell |
| VIRTUS ADVISERS, LLC | 12,129 | 10,739 | -1,390 | 0.19 | 0.21 | +0.02 | sell |
| Clearbridge Investments, LLC | 20,564 | 16,164 | -4,400 | 0.00 | 0.00 | +0.00 | sell |
| CenterBook Partners LP | 28,122 | 15,138 | -12,984 | 0.09 | 0.06 | -0.03 | sell |
| Soleus Capital Management, L.P. | 176,000 | 103,000 | -73,000 | 0.51 | 0.33 | -0.18 | sell |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 234,268 | 152,410 | -81,858 | 0.04 | 0.04 | -0.01 | sell |
| Novo Holdings A/S | 1,684,193 | 1,500,000 | -184,193 | 3.37 | 3.50 | +0.14 | sell |
| Prosight Management, LP | 675,000 | 353,508 | -321,492 | 5.11 | 3.54 | -1.57 | sell |