| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Frazier Life Sciences Management, L.P. | 6,495,392 | 6,570,392 | +75,000 | 10.39 | 10.27 | -0.12 | buy |
| JANUS HENDERSON GROUP PLC | 4,988,747 | 4,480,284 | -508,463 | 0.09 | 0.09 | -0.00 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 3,614,820 | 3,445,363 | -169,457 | 2.12 | 2.32 | +0.20 | sell |
| BVF INC/IL | 4,370,024 | 3,075,907 | -1,294,117 | 4.19 | 3.51 | -0.68 | sell |
| VANGUARD GROUP INC | 2,446,733 | 2,496,112 | +49,379 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 1,496,217 | 1,793,728 | +297,511 | 0.00 | 0.00 | +0.00 | buy |
| Rock Springs Capital Management LP | 1,772,038 | 1,580,488 | -191,550 | 1.83 | 2.01 | +0.18 | sell |
| Novo Holdings A/S | 1,500,000 | 1,500,000 | 0 | 2.76 | 2.91 | +0.14 | hold |
| CITADEL ADVISORS LLC | 1,585,624 | 1,391,409 | -194,215 | 0.05 | 0.06 | +0.00 | sell |
| TANG CAPITAL MANAGEMENT LLC | 1,287,107 | 1,287,107 | 0 | 4.48 | 3.59 | -0.90 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,199,220 | 1,284,106 | +84,886 | 0.00 | 0.01 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 907,180 | 936,197 | +29,017 | 0.00 | 0.00 | +0.00 | buy |
| Pictet Asset Management Holding SA | 875,113 | 895,690 | +20,577 | 0.03 | 0.04 | +0.00 | buy |
| Clearbridge Investments, LLC | 699,933 | 889,100 | +189,167 | 0.02 | 0.03 | +0.01 | buy |
| LORD, ABBETT & CO. LLC | 0 | 741,368 | +741,368 | 0.00 | 0.09 | +0.09 | buy |
| Avidity Partners Management LP | 731,104 | 731,104 | 0 | 1.06 | 1.45 | +0.39 | hold |
| Polar Capital Holdings Plc | 741,049 | 675,000 | -66,049 | 0.15 | 0.13 | -0.02 | sell |
| First Turn Management, LLC | 703,398 | 647,611 | -55,787 | 3.91 | 4.00 | +0.09 | sell |
| GOLDMAN SACHS GROUP INC | 759,018 | 637,967 | -121,051 | 0.01 | 0.00 | -0.00 | sell |
| MORGAN STANLEY | 541,022 | 625,916 | +84,894 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 941,570 | 592,656 | -348,914 | 0.01 | 0.01 | -0.00 | sell |
| BOONE CAPITAL MANAGEMENT LLC | 523,679 | 543,843 | +20,164 | 4.67 | 5.50 | +0.83 | buy |
| Candriam S.C.A. | 508,475 | 508,475 | 0 | 0.11 | 0.11 | +0.01 | hold |
| LOOMIS SAYLES & CO L P | 0 | 499,316 | +499,316 | 0.00 | 0.03 | +0.03 | buy |
| MPM BioImpact LLC | 492,569 | 492,723 | +154 | 2.62 | 2.88 | +0.27 | buy |
| CADIAN CAPITAL MANAGEMENT, LP | 1,235,121 | 475,714 | -759,407 | 2.10 | 0.95 | -1.15 | sell |
| BANK OF AMERICA CORP /DE/ | 332,101 | 466,209 | +134,108 | 0.00 | 0.00 | +0.00 | buy |
| Prosight Management, LP | 314,800 | 465,825 | +151,025 | 3.22 | 4.61 | +1.39 | buy |
| MILLENNIUM MANAGEMENT LLC | 265,443 | 455,564 | +190,121 | 0.01 | 0.02 | +0.01 | buy |
| AXA S.A. | 425,992 | 426,068 | +76 | 0.04 | 0.05 | +0.01 | buy |
| NORTHERN TRUST CORP | 277,366 | 367,485 | +90,119 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 203,720 | 331,005 | +127,285 | 0.07 | 0.11 | +0.04 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 311,012 | 328,161 | +17,149 | 0.00 | 0.00 | +0.00 | buy |
| Penn Capital Management Company, LLC | 241,151 | 309,244 | +68,093 | 0.78 | 1.11 | +0.33 | buy |
| Invesco Ltd. | 284,045 | 284,532 | +487 | 0.00 | 0.00 | +0.00 | buy |
| Erste Asset Management GmbH | 260,000 | 260,000 | 0 | 0.12 | 0.12 | +0.00 | hold |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 256,779 | +256,779 | 0.00 | 0.04 | +0.04 | buy |
| SEI INVESTMENTS CO | 249,000 | 249,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NORGES BANK | 0 | 248,157 | +248,157 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 235,094 | 245,918 | +10,824 | 0.00 | 0.00 | +0.00 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 229,730 | 242,711 | +12,981 | 0.47 | 0.51 | +0.04 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 190,125 | 228,351 | +38,226 | 0.01 | 0.01 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 163,540 | 227,473 | +63,933 | 0.01 | 0.02 | +0.01 | buy |
| Ensign Peak Advisors, Inc | 222,614 | 220,394 | -2,220 | 0.01 | 0.02 | +0.00 | sell |
| TWO SIGMA ADVISERS, LP | 179,900 | 205,500 | +25,600 | 0.01 | 0.02 | +0.01 | buy |
| BAKER BROS. ADVISORS LP | 190,476 | 190,476 | 0 | 0.08 | 0.08 | -0.01 | hold |
| ARDSLEY ADVISORY PARTNERS LP | 180,000 | 190,000 | +10,000 | 1.11 | 1.40 | +0.29 | buy |
| AMERIPRISE FINANCIAL INC | 15,307 | 183,344 | +168,037 | 0.00 | 0.00 | +0.00 | buy |
| NEXT CENTURY GROWTH INVESTORS LLC | 0 | 164,371 | +164,371 | 0.00 | 0.52 | +0.52 | buy |
| DEUTSCHE BANK AG\ | 249,051 | 157,263 | -91,788 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 212,504 | 151,493 | -61,011 | 0.01 | 0.01 | -0.00 | sell |
| FIRST TRUST ADVISORS LP | 27,387 | 146,411 | +119,024 | 0.00 | 0.01 | +0.00 | buy |
| Nicholas Investment Partners, LP | 0 | 144,479 | +144,479 | 0.00 | 0.52 | +0.52 | buy |
| Atle Fund Management AB | 75,200 | 138,321 | +63,121 | 1.57 | 2.54 | +0.97 | buy |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 220,490 | 138,047 | -82,443 | 0.05 | 0.04 | -0.02 | sell |
| UBS Group AG | 50,743 | 124,390 | +73,647 | 0.00 | 0.00 | +0.00 | buy |
| Highlander Partners, L.P. | 122,980 | 122,980 | 0 | 2.80 | 2.83 | +0.04 | hold |
| WELLINGTON MANAGEMENT GROUP LLP | 75,416 | 122,334 | +46,918 | 0.00 | 0.00 | +0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 104,770 | 116,054 | +11,284 | 0.18 | 0.21 | +0.03 | buy |
| Bank of New York Mellon Corp | 143,000 | 114,699 | -28,301 | 0.00 | 0.00 | -0.00 | sell |
| PDT Partners, LLC | 39,363 | 113,712 | +74,349 | 0.13 | 0.39 | +0.27 | buy |
| WELLS FARGO & COMPANY/MN | 38,114 | 108,027 | +69,913 | 0.00 | 0.00 | +0.00 | buy |
| Nan Fung Group Holdings Ltd | 106,100 | 106,100 | 0 | 3.87 | 3.56 | -0.31 | hold |
| Rhenman & Partners Asset Management AB | 134,250 | 105,000 | -29,250 | 0.44 | 0.33 | -0.11 | sell |
| Cubist Systematic Strategies, LLC | 0 | 98,766 | +98,766 | 0.00 | 0.06 | +0.06 | buy |
| Informed Momentum Co LLC | 0 | 95,421 | +95,421 | 0.00 | 0.56 | +0.56 | buy |
| JANE STREET GROUP, LLC | 122,664 | 91,084 | -31,580 | 0.00 | 0.01 | +0.00 | sell |
| Rafferty Asset Management, LLC | 68,858 | 85,457 | +16,599 | 0.01 | 0.01 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 160,000 | 80,000 | -80,000 | 0.01 | 0.01 | -0.00 | sell |
| Affinity Asset Advisors, LLC | 155,000 | 75,000 | -80,000 | 0.83 | 0.45 | -0.38 | sell |
| Swiss National Bank | 64,800 | 69,000 | +4,200 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 45,849 | 67,375 | +21,526 | 0.01 | 0.01 | +0.01 | buy |
| OPPENHEIMER ASSET MANAGEMENT INC. | 0 | 67,000 | +67,000 | 0.00 | 0.00 | +0.00 | buy |
| Palo Alto Investors LP | 64,700 | 64,700 | 0 | 0.26 | 0.33 | +0.07 | hold |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 60,019 | 63,461 | +3,442 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 60,448 | +60,448 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 6,503 | 57,985 | +51,482 | 0.02 | 0.17 | +0.16 | buy |
| RHUMBLINE ADVISERS | 52,916 | 51,877 | -1,039 | 0.00 | 0.00 | +0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 56,464 | 49,734 | -6,730 | 0.01 | 0.00 | -0.00 | sell |
| Jump Financial, LLC | 20,478 | 46,768 | +26,290 | 0.01 | 0.04 | +0.02 | buy |
| Knights of Columbus Asset Advisors LLC | 104,865 | 45,886 | -58,979 | 0.23 | 0.12 | -0.12 | sell |
| TWINBEECH CAPITAL LP | 0 | 45,720 | +45,720 | 0.00 | 0.03 | +0.03 | buy |
| NEOS Investment Management LLC | 41,244 | 44,683 | +3,439 | 0.06 | 0.05 | -0.01 | buy |
| BANK OF MONTREAL /CAN/ | 42,998 | 42,998 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 41,050 | 41,050 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Phocas Financial Corp. | 60,399 | 37,889 | -22,510 | 0.01 | 0.01 | -0.00 | sell |
| ALPS ADVISORS INC | 36,759 | 37,245 | +486 | 0.01 | 0.01 | +0.00 | buy |
| Secure Asset Management, LLC | 45,904 | 36,514 | -9,390 | 0.30 | 0.24 | -0.06 | sell |
| Legal & General Group Plc | 34,185 | 36,198 | +2,013 | 0.00 | 0.00 | +0.00 | buy |
| STEPHENS INC /AR/ | 0 | 36,000 | +36,000 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 32,656 | 33,729 | +1,073 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 13,203 | 28,518 | +15,315 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 23,832 | 27,761 | +3,929 | 0.00 | 0.00 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 1,178 | 27,285 | +26,107 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 4,824 | 27,216 | +22,392 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 15,608 | 24,825 | +9,217 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 0 | 24,100 | +24,100 | 0.00 | 0.16 | +0.16 | buy |
| Russell Investments Group, Ltd. | 17,497 | 24,015 | +6,518 | 0.00 | 0.00 | +0.00 | buy |
| Values First Advisors, Inc. | 19,754 | 23,725 | +3,971 | 0.40 | 0.50 | +0.10 | buy |
| MARSHALL WACE, LLP | 20,520 | 23,722 | +3,202 | 0.00 | 0.00 | +0.00 | buy |