| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| LORD, ABBETT & CO. LLC | 0 | 741,368 | +741,368 | 0.00 | 0.09 | +0.09 | buy |
| LOOMIS SAYLES & CO L P | 0 | 499,316 | +499,316 | 0.00 | 0.03 | +0.03 | buy |
| STATE STREET CORP | 1,496,217 | 1,793,728 | +297,511 | 0.00 | 0.00 | +0.00 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 256,779 | +256,779 | 0.00 | 0.04 | +0.04 | buy |
| NORGES BANK | 0 | 248,157 | +248,157 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 265,443 | 455,564 | +190,121 | 0.01 | 0.02 | +0.01 | buy |
| Clearbridge Investments, LLC | 699,933 | 889,100 | +189,167 | 0.02 | 0.03 | +0.01 | buy |
| AMERIPRISE FINANCIAL INC | 15,307 | 183,344 | +168,037 | 0.00 | 0.00 | +0.00 | buy |
| NEXT CENTURY GROWTH INVESTORS LLC | 0 | 164,371 | +164,371 | 0.00 | 0.52 | +0.52 | buy |
| Prosight Management, LP | 314,800 | 465,825 | +151,025 | 3.22 | 4.61 | +1.39 | buy |
| Nicholas Investment Partners, LP | 0 | 144,479 | +144,479 | 0.00 | 0.52 | +0.52 | buy |
| BANK OF AMERICA CORP /DE/ | 332,101 | 466,209 | +134,108 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 203,720 | 331,005 | +127,285 | 0.07 | 0.11 | +0.04 | buy |
| FIRST TRUST ADVISORS LP | 27,387 | 146,411 | +119,024 | 0.00 | 0.01 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 0 | 98,766 | +98,766 | 0.00 | 0.06 | +0.06 | buy |
| Informed Momentum Co LLC | 0 | 95,421 | +95,421 | 0.00 | 0.56 | +0.56 | buy |
| NORTHERN TRUST CORP | 277,366 | 367,485 | +90,119 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 541,022 | 625,916 | +84,894 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,199,220 | 1,284,106 | +84,886 | 0.00 | 0.01 | +0.00 | buy |
| Frazier Life Sciences Management, L.P. | 6,495,392 | 6,570,392 | +75,000 | 10.39 | 10.27 | -0.12 | buy |
| PDT Partners, LLC | 39,363 | 113,712 | +74,349 | 0.13 | 0.39 | +0.27 | buy |
| UBS Group AG | 50,743 | 124,390 | +73,647 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 38,114 | 108,027 | +69,913 | 0.00 | 0.00 | +0.00 | buy |
| Penn Capital Management Company, LLC | 241,151 | 309,244 | +68,093 | 0.78 | 1.11 | +0.33 | buy |
| OPPENHEIMER ASSET MANAGEMENT INC. | 0 | 67,000 | +67,000 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 163,540 | 227,473 | +63,933 | 0.01 | 0.02 | +0.01 | buy |
| Atle Fund Management AB | 75,200 | 138,321 | +63,121 | 1.57 | 2.54 | +0.97 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 60,448 | +60,448 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 6,503 | 57,985 | +51,482 | 0.02 | 0.17 | +0.16 | buy |
| VANGUARD GROUP INC | 2,446,733 | 2,496,112 | +49,379 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 75,416 | 122,334 | +46,918 | 0.00 | 0.00 | +0.00 | buy |
| TWINBEECH CAPITAL LP | 0 | 45,720 | +45,720 | 0.00 | 0.03 | +0.03 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 190,125 | 228,351 | +38,226 | 0.01 | 0.01 | +0.00 | buy |
| STEPHENS INC /AR/ | 0 | 36,000 | +36,000 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 907,180 | 936,197 | +29,017 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 20,478 | 46,768 | +26,290 | 0.01 | 0.04 | +0.02 | buy |
| OSAIC HOLDINGS, INC. | 1,178 | 27,285 | +26,107 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 179,900 | 205,500 | +25,600 | 0.01 | 0.02 | +0.01 | buy |
| ADAR1 Capital Management, LLC | 0 | 24,100 | +24,100 | 0.00 | 0.16 | +0.16 | buy |
| ROYAL BANK OF CANADA | 4,824 | 27,216 | +22,392 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 45,849 | 67,375 | +21,526 | 0.01 | 0.01 | +0.01 | buy |
| Pictet Asset Management Holding SA | 875,113 | 895,690 | +20,577 | 0.03 | 0.04 | +0.00 | buy |
| BOONE CAPITAL MANAGEMENT LLC | 523,679 | 543,843 | +20,164 | 4.67 | 5.50 | +0.83 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 311,012 | 328,161 | +17,149 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 0 | 16,690 | +16,690 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 68,858 | 85,457 | +16,599 | 0.01 | 0.01 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 13,203 | 28,518 | +15,315 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 0 | 13,015 | +13,015 | 0.00 | 0.00 | +0.00 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 229,730 | 242,711 | +12,981 | 0.47 | 0.51 | +0.04 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 12,733 | +12,733 | 0.00 | 0.01 | +0.01 | buy |
| Legato Capital Management LLC | 0 | 12,418 | +12,418 | 0.00 | 0.06 | +0.06 | buy |
| Aquatic Capital Management LLC | 5,700 | 17,600 | +11,900 | 0.01 | 0.02 | +0.01 | buy |
| Hennion & Walsh Asset Management, Inc. | 104,770 | 116,054 | +11,284 | 0.18 | 0.21 | +0.03 | buy |
| SG Americas Securities, LLC | 0 | 11,253 | +11,253 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 235,094 | 245,918 | +10,824 | 0.00 | 0.00 | +0.00 | buy |
| FORA Capital, LLC | 0 | 10,226 | +10,226 | 0.00 | 0.05 | +0.05 | buy |
| ARDSLEY ADVISORY PARTNERS LP | 180,000 | 190,000 | +10,000 | 1.11 | 1.40 | +0.29 | buy |
| Engineers Gate Manager LP | 0 | 9,580 | +9,580 | 0.00 | 0.01 | +0.01 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 15,608 | 24,825 | +9,217 | 0.00 | 0.00 | +0.00 | buy |
| BOSUN ASSET MANAGEMENT, LLC | 0 | 7,157 | +7,157 | 0.00 | 0.13 | +0.13 | buy |
| SHERBROOKE PARK ADVISERS LLC | 0 | 6,779 | +6,779 | 0.00 | 0.06 | +0.06 | buy |
| Russell Investments Group, Ltd. | 17,497 | 24,015 | +6,518 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 0 | 6,382 | +6,382 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 5,516 | +5,516 | 0.00 | 0.01 | +0.01 | buy |
| E Fund Management Co., Ltd. | 0 | 5,491 | +5,491 | 0.00 | 0.01 | +0.01 | buy |
| AQR CAPITAL MANAGEMENT LLC | 8,294 | 12,545 | +4,251 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 64,800 | 69,000 | +4,200 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 6,224 | 10,230 | +4,006 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 13,008 | 16,984 | +3,976 | 0.02 | 0.03 | +0.01 | buy |
| Values First Advisors, Inc. | 19,754 | 23,725 | +3,971 | 0.40 | 0.50 | +0.10 | buy |
| JPMORGAN CHASE & CO | 23,832 | 27,761 | +3,929 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 5,537 | 9,176 | +3,639 | 0.03 | 0.04 | +0.01 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 60,019 | 63,461 | +3,442 | 0.00 | 0.00 | +0.00 | buy |
| NEOS Investment Management LLC | 41,244 | 44,683 | +3,439 | 0.06 | 0.05 | -0.01 | buy |
| MARSHALL WACE, LLP | 20,520 | 23,722 | +3,202 | 0.00 | 0.00 | +0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 0 | 2,333 | +2,333 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 34,185 | 36,198 | +2,013 | 0.00 | 0.00 | +0.00 | buy |
| COMERICA BANK | 0 | 2,000 | +2,000 | 0.00 | 0.00 | +0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 7,218 | 8,865 | +1,647 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 1,504 | +1,504 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 32,656 | 33,729 | +1,073 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 147 | 1,177 | +1,030 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 9,210 | 10,178 | +968 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 284,045 | 284,532 | +487 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 36,759 | 37,245 | +486 | 0.01 | 0.01 | +0.00 | buy |
| FMR LLC | 886 | 1,317 | +431 | 0.00 | 0.00 | +0.00 | buy |
| COMERICA BANK | 162 | 588 | +426 | 0.00 | 0.00 | +0.00 | buy |
| JONES FINANCIAL COMPANIES LLLP | 0 | 357 | +357 | 0.00 | 0.00 | +0.00 | buy |
| NATIONAL BANK OF CANADA /FI/ | 20 | 343 | +323 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 1,407 | 1,725 | +318 | 0.00 | 0.00 | +0.00 | buy |
| MCF Advisors LLC | 0 | 203 | +203 | 0.00 | 0.00 | +0.00 | buy |
| MPM BioImpact LLC | 492,569 | 492,723 | +154 | 2.62 | 2.88 | +0.27 | buy |
| NISA INVESTMENT ADVISORS, LLC | 359 | 471 | +112 | 0.00 | 0.00 | +0.00 | buy |
| TD Waterhouse Canada Inc. | 0 | 78 | +78 | 0.00 | 0.00 | +0.00 | buy |
| AXA S.A. | 425,992 | 426,068 | +76 | 0.04 | 0.05 | +0.01 | buy |
| CWM, LLC | 48 | 122 | +74 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 10 | 59 | +49 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 180 | 221 | +41 | 0.00 | 0.00 | +0.00 | buy |
| Daiwa Securities Group Inc. | 148 | 188 | +40 | 0.00 | 0.00 | +0.00 | buy |
| BESSEMER GROUP INC | 0 | 30 | +30 | 0.00 | 0.00 | +0.00 | buy |