| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 4,988,747 | 4,480,284 | +508,463 | 0.09 | 0.09 | 0.00 | sell |
| Clearbridge Investments, LLC | 699,933 | 889,100 | +189,167 | 0.02 | 0.03 | +0.01 | buy |
| Prosight Management, LP | 314,800 | 465,825 | +151,025 | 3.22 | 4.47 | +1.25 | buy |
| Woodline Partners LP | 203,720 | 331,005 | +127,285 | 0.07 | 0.11 | +0.04 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,199,220 | 1,284,106 | +84,886 | 0.00 | 0.01 | +0.00 | buy |
| Frazier Life Sciences Management, L.P. | 6,495,392 | 6,570,392 | +75,000 | 10.39 | 10.27 | -0.12 | buy |
| PDT Partners, LLC | 39,363 | 113,712 | +74,349 | 0.13 | 0.39 | +0.27 | buy |
| Penn Capital Management Company, LLC | 241,151 | 309,244 | +68,093 | 0.78 | 1.11 | +0.33 | buy |
| TWO SIGMA INVESTMENTS, LP | 163,540 | 227,473 | +63,933 | 0.01 | 0.02 | 0.00 | buy |
| Atle Fund Management AB | 75,200 | 138,321 | +63,121 | 1.57 | 2.54 | +0.97 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 190,125 | 228,351 | +38,226 | 0.01 | 0.01 | +0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 38,088 | 16,538 | +21,550 | 0.08 | 0.05 | 0.00 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 45,849 | 67,375 | +21,526 | 0.01 | 0.01 | +0.01 | buy |
| BOONE CAPITAL MANAGEMENT LLC | 523,679 | 543,843 | +20,164 | 4.67 | 5.50 | +0.83 | buy |
| Rafferty Asset Management, LLC | 68,858 | 85,457 | +16,599 | 0.01 | 0.01 | +0.00 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 229,730 | 242,711 | +12,981 | 0.47 | 0.51 | +0.04 | buy |
| Hennion & Walsh Asset Management, Inc. | 104,770 | 116,054 | +11,284 | 0.18 | 0.21 | +0.03 | buy |
| ARDSLEY ADVISORY PARTNERS LP | 180,000 | 190,000 | +10,000 | 1.11 | 1.40 | +0.29 | buy |
| PROFUND ADVISORS LLC | 13,008 | 16,984 | +3,976 | 0.02 | 0.03 | 0.00 | buy |
| Values First Advisors, Inc. | 19,754 | 23,725 | +3,971 | 0.40 | 0.50 | +0.10 | buy |
| China Universal Asset Management Co., Ltd. | 5,537 | 9,176 | +3,639 | 0.03 | 0.04 | +0.01 | buy |
| NEOS Investment Management LLC | 41,244 | 44,683 | +3,439 | 0.06 | 0.05 | -0.01 | buy |
| ALPS ADVISORS INC | 36,759 | 37,245 | +486 | 0.01 | 0.01 | +0.00 | buy |
| MPM BioImpact LLC | 492,569 | 492,723 | +154 | 2.62 | 2.88 | +0.27 | buy |
| HighMark Wealth Management LLC | 265 | 180 | -85 | 0.01 | 0.00 | -0.00 | sell |
| GREAT LAKES ADVISORS, LLC | 8,308 | 6,465 | -1,843 | 0.00 | 0.00 | -0.00 | sell |
| HighVista Strategies LLC | 20,208 | 13,571 | -6,637 | 0.25 | 0.18 | -0.07 | sell |
| Secure Asset Management, LLC | 45,904 | 36,514 | -9,390 | 0.30 | 0.24 | -0.06 | sell |
| Golden State Equity Partners | 19,930 | 1,300 | -18,630 | 0.14 | 0.03 | -0.12 | sell |
| Phocas Financial Corp. | 60,399 | 37,889 | -22,510 | 0.01 | 0.01 | -0.00 | sell |
| CenterBook Partners LP | 34,885 | 11,530 | -23,355 | 0.07 | 0.03 | -0.05 | sell |
| Rhenman & Partners Asset Management AB | 134,250 | 105,000 | -29,250 | 0.44 | 0.33 | -0.11 | sell |
| First Turn Management, LLC | 703,398 | 647,611 | -55,787 | 3.91 | 4.00 | +0.09 | sell |
| Knights of Columbus Asset Advisors LLC | 104,865 | 45,886 | -58,979 | 0.23 | 0.12 | -0.12 | sell |
| Polar Capital Holdings Plc | 741,049 | 675,000 | -66,049 | 0.15 | 0.13 | -0.02 | sell |
| Affinity Asset Advisors, LLC | 155,000 | 75,000 | -80,000 | 0.83 | 0.45 | -0.38 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 160,000 | 80,000 | -80,000 | 0.01 | 0.01 | -0.00 | sell |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 220,490 | 138,047 | -82,443 | 0.05 | 0.04 | -0.02 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 3,614,820 | 3,445,363 | -169,457 | 2.12 | 2.32 | +0.20 | sell |
| Rock Springs Capital Management LP | 1,772,038 | 1,580,488 | -191,550 | 1.82 | 2.01 | +0.18 | sell |
| CADIAN CAPITAL MANAGEMENT, LP | 1,235,121 | 475,714 | -759,407 | 2.10 | 0.95 | -1.15 | sell |
| BVF INC/IL | 4,370,024 | 3,075,907 | -1,294,117 | 4.19 | 3.51 | -0.68 | sell |