| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Frazier Life Sciences Management, L.P. | 6,795,121 | 6,795,121 | 0 | 13.83 | 14.93 | +1.10 | hold |
| JANUS HENDERSON GROUP PLC | 5,236,277 | 4,997,586 | -238,691 | 0.13 | 0.17 | +0.04 | sell |
| BlackRock, Inc. | 3,577,091 | 3,602,434 | +25,343 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 2,564,869 | 2,545,369 | -19,500 | 0.00 | 0.00 | +0.00 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 2,637,485 | 2,522,563 | -114,922 | 2.35 | 3.04 | +0.69 | sell |
| BVF INC/IL | 2,761,333 | 1,495,290 | -1,266,043 | 5.02 | 4.44 | -0.58 | sell |
| STATE STREET CORP | 1,375,628 | 1,346,904 | -28,724 | 0.00 | 0.00 | +0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,417,215 | 1,283,288 | -133,927 | 0.01 | 0.01 | +0.00 | sell |
| Novo Holdings A/S | 1,500,055 | 1,264,028 | -236,027 | 5.39 | 5.97 | +0.58 | sell |
| TANG CAPITAL MANAGEMENT LLC | 1,236,027 | 1,236,027 | 0 | 3.18 | 3.49 | +0.31 | hold |
| CITADEL ADVISORS LLC | 1,406,352 | 1,040,544 | -365,808 | 0.06 | 0.06 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 1,029,616 | 1,010,022 | -19,594 | 0.00 | 0.00 | +0.00 | sell |
| Clearbridge Investments, LLC | 1,027,527 | 1,003,803 | -23,724 | 0.04 | 0.06 | +0.01 | sell |
| D. E. Shaw & Co., Inc. | 554,957 | 923,509 | +368,552 | 0.03 | 0.05 | +0.03 | buy |
| Polar Capital Holdings Plc | 975,000 | 820,552 | -154,448 | 0.26 | 0.29 | +0.03 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 118,571 | 790,689 | +672,118 | 0.00 | 0.01 | +0.01 | buy |
| Point72 Asset Management, L.P. | 258,866 | 790,675 | +531,809 | 0.03 | 0.13 | +0.09 | buy |
| Rock Springs Capital Management LP | 818,206 | 761,126 | -57,080 | 2.59 | 3.26 | +0.67 | sell |
| MORGAN STANLEY | 566,326 | 670,149 | +103,823 | 0.00 | 0.00 | +0.00 | buy |
| LORD, ABBETT & CO. LLC | 771,146 | 661,940 | -109,206 | 0.13 | 0.14 | +0.02 | sell |
| FMR LLC | 59,441 | 640,218 | +580,777 | 0.00 | 0.00 | +0.00 | buy |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 75,644 | 612,318 | +536,674 | 0.00 | 0.03 | +0.03 | buy |
| Nuveen, LLC | 590,257 | 601,670 | +11,413 | 0.01 | 0.01 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 593,596 | 601,137 | +7,541 | 0.01 | 0.01 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 481,464 | 601,073 | +119,609 | 0.02 | 0.03 | +0.02 | buy |
| First Turn Management, LLC | 527,540 | 570,569 | +43,029 | 5.01 | 6.28 | +1.27 | buy |
| Woodline Partners LP | 567,894 | 567,894 | 0 | 0.15 | 0.20 | +0.04 | hold |
| Pictet Asset Management Holding SA | 701,156 | 541,277 | -159,879 | 0.04 | 0.04 | +0.00 | sell |
| LOOMIS SAYLES & CO L P | 552,957 | 539,040 | -13,917 | 0.04 | 0.05 | +0.01 | sell |
| BOONE CAPITAL MANAGEMENT LLC | 641,448 | 535,732 | -105,716 | 14.00 | 12.88 | -1.12 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 396,348 | 513,448 | +117,100 | 0.03 | 0.05 | +0.02 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 243,000 | 497,468 | +254,468 | 0.02 | 0.06 | +0.04 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 423,744 | 495,976 | +72,232 | 0.08 | 0.11 | +0.04 | buy |
| GOLDMAN SACHS GROUP INC | 395,008 | 450,838 | +55,830 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 496,061 | 445,527 | -50,534 | 0.00 | 0.01 | +0.00 | sell |
| Candriam S.C.A. | 373,005 | 403,026 | +30,021 | 0.11 | 0.15 | +0.05 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 383,160 | 394,489 | +11,329 | 0.00 | 0.00 | +0.00 | buy |
| MACQUARIE GROUP LTD | 435,717 | 393,212 | -42,505 | 0.03 | 0.03 | +0.01 | sell |
| BANK OF AMERICA CORP /DE/ | 389,270 | 390,474 | +1,204 | 0.00 | 0.00 | +0.00 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 17,575 | 389,574 | +371,999 | 0.00 | 0.10 | +0.09 | buy |
| NORTHERN TRUST CORP | 402,396 | 385,336 | -17,060 | 0.00 | 0.00 | +0.00 | sell |
| EMERALD ADVISERS, LLC | 305,766 | 369,600 | +63,834 | 0.57 | 0.87 | +0.30 | buy |
| NEXT CENTURY GROWTH INVESTORS LLC | 190,325 | 360,934 | +170,609 | 0.75 | 1.93 | +1.18 | buy |
| FEDERATED HERMES, INC. | 344,304 | 346,522 | +2,218 | 0.03 | 0.04 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 171,814 | 343,126 | +171,312 | 0.02 | 0.04 | +0.02 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 317,150 | +317,150 | 0.00 | 0.05 | +0.05 | buy |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 0 | 313,259 | +313,259 | 0.00 | 0.06 | +0.06 | buy |
| MILLENNIUM MANAGEMENT LLC | 288,159 | 309,031 | +20,872 | 0.01 | 0.02 | +0.00 | buy |
| Penn Capital Management Company, LLC | 342,256 | 307,991 | -34,265 | 1.51 | 1.74 | +0.23 | sell |
| TimesSquare Capital Management, LLC | 0 | 300,649 | +300,649 | 0.00 | 0.32 | +0.32 | buy |
| Russell Investments Group, Ltd. | 247,733 | 278,763 | +31,030 | 0.02 | 0.02 | +0.01 | buy |
| TWO SIGMA ADVISERS, LP | 171,400 | 276,400 | +105,000 | 0.02 | 0.04 | +0.02 | buy |
| UBS Group AG | 182,456 | 275,842 | +93,386 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 21,438 | 254,485 | +233,047 | 0.00 | 0.02 | +0.02 | buy |
| RAYMOND JAMES FINANCIAL INC | 264,118 | 251,733 | -12,385 | 0.00 | 0.01 | +0.00 | sell |
| Erste Asset Management GmbH | 260,000 | 250,000 | -10,000 | 0.11 | 0.18 | +0.06 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 249,857 | 243,387 | -6,470 | 0.02 | 0.02 | +0.01 | sell |
| SEI INVESTMENTS CO | 228,000 | 228,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| EMERALD MUTUAL FUND ADVISERS TRUST | 217,542 | 219,038 | +1,496 | 0.67 | 0.83 | +0.15 | buy |
| Nicholas Investment Partners, LP | 184,483 | 217,068 | +32,585 | 0.84 | 1.22 | +0.38 | buy |
| AMERIPRISE FINANCIAL INC | 242,760 | 203,068 | -39,692 | 0.00 | 0.00 | +0.00 | sell |
| ALGERT GLOBAL LLC | 159,349 | 190,599 | +31,250 | 0.17 | 0.23 | +0.06 | buy |
| DEUTSCHE BANK AG\ | 155,627 | 184,330 | +28,703 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 43,010 | 167,230 | +124,220 | 0.00 | 0.00 | +0.00 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 231,993 | 164,746 | -67,247 | 0.64 | 0.66 | +0.02 | sell |
| Jump Financial, LLC | 148,689 | 162,100 | +13,411 | 0.10 | 0.18 | +0.08 | buy |
| NAN FUNG TRINITY (HK) Ltd | 146,765 | 156,265 | +9,500 | 0.89 | 1.14 | +0.25 | buy |
| Soleus Capital Management, L.P. | 298,696 | 148,696 | -150,000 | 1.05 | 0.58 | -0.47 | sell |
| CITIGROUP INC | 70,707 | 147,252 | +76,545 | 0.00 | 0.01 | +0.00 | buy |
| PDT Partners, LLC | 145,379 | 145,379 | 0 | 0.42 | 0.67 | +0.25 | hold |
| FIRST TRUST ADVISORS LP | 129,794 | 144,248 | +14,454 | 0.01 | 0.01 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 144,950 | 144,184 | -766 | 0.08 | 0.15 | +0.07 | sell |
| Ensign Peak Advisors, Inc | 133,973 | 133,973 | 0 | 0.01 | 0.02 | +0.00 | hold |
| Squarepoint Ops LLC | 18,277 | 127,903 | +109,626 | 0.00 | 0.02 | +0.02 | buy |
| Highlander Partners, L.P. | 122,980 | 122,980 | 0 | 2.40 | 3.14 | +0.74 | hold |
| Hennion & Walsh Asset Management, Inc. | 122,769 | 115,854 | -6,915 | 0.25 | 0.31 | +0.06 | sell |
| BARCLAYS PLC | 154,871 | 115,771 | -39,100 | 0.00 | 0.00 | -0.00 | sell |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 112,731 | 113,458 | +727 | 1.04 | 1.27 | +0.23 | buy |
| Trexquant Investment LP | 104,303 | 109,959 | +5,656 | 0.06 | 0.08 | +0.02 | buy |
| Patient Square Capital LP | 113,462 | 104,262 | -9,200 | 2.08 | 2.04 | -0.04 | sell |
| Invesco Ltd. | 64,653 | 101,471 | +36,818 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 480,276 | 100,209 | -380,067 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 0 | 100,000 | +100,000 | 0.00 | 0.00 | +0.00 | buy |
| NOMURA HOLDINGS INC | 0 | 96,341 | +96,341 | 0.00 | 0.03 | +0.03 | buy |
| Atle Fund Management AB | 106,912 | 93,605 | -13,307 | 2.33 | 2.70 | +0.37 | sell |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 135,915 | 90,056 | -45,859 | 0.05 | 0.04 | -0.00 | sell |
| Voleon Capital Management LP | 0 | 86,529 | +86,529 | 0.00 | 0.15 | +0.15 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 66,791 | 78,897 | +12,106 | 0.00 | 0.01 | +0.00 | buy |
| 1832 Asset Management L.P. | 0 | 75,800 | +75,800 | 0.00 | 0.01 | +0.01 | buy |
| Swiss National Bank | 70,200 | 72,000 | +1,800 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 31,142 | 64,999 | +33,857 | 0.00 | 0.01 | +0.01 | buy |
| Palo Alto Investors LP | 64,700 | 64,700 | 0 | 0.70 | 0.88 | +0.18 | hold |
| OPPENHEIMER ASSET MANAGEMENT INC. | 62,000 | 64,000 | +2,000 | 0.00 | 0.00 | +0.00 | buy |
| Aquatic Capital Management LLC | 36,897 | 63,946 | +27,049 | 0.04 | 0.09 | +0.05 | buy |
| Informed Momentum Co LLC | 0 | 63,077 | +63,077 | 0.00 | 0.52 | +0.52 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 161,490 | 60,699 | -100,791 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 64,593 | 59,065 | -5,528 | 0.00 | 0.00 | +0.00 | sell |
| BANK OF MONTREAL /CAN/ | 57,043 | 57,043 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Rhenman & Partners Asset Management AB | 65,755 | 56,255 | -9,500 | 0.42 | 0.46 | +0.03 | sell |
| Jain Global LLC | 0 | 55,601 | +55,601 | 0.00 | 0.05 | +0.05 | buy |