| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| PRICE T ROWE ASSOCIATES INC /MD/ | 31,959 | 1,164,682 | +1,132,723 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 1,693,343 | 2,476,244 | +782,901 | 0.00 | 0.00 | +0.00 | buy |
| CADIAN CAPITAL MANAGEMENT, LP | 1,434,922 | 1,934,922 | +500,000 | 1.83 | 2.28 | +0.45 | buy |
| Sofinnova Investments, Inc. | 9,089 | 352,397 | +343,308 | 0.02 | 0.58 | +0.56 | buy |
| Clearbridge Investments, LLC | 16,164 | 264,097 | +247,933 | 0.00 | 0.01 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 240,776 | 456,318 | +215,542 | 0.00 | 0.00 | +0.00 | buy |
| PATHWAY CAPITAL MANAGEMENT, LP | 0 | 190,286 | +190,286 | 0.00 | 6.28 | +6.28 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 27,313 | 211,111 | +183,798 | 0.00 | 0.01 | +0.01 | buy |
| FRANKLIN RESOURCES INC | 744,622 | 913,068 | +168,446 | 0.01 | 0.01 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 14,364 | 171,526 | +157,162 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 1,923,760 | 2,062,551 | +138,791 | 0.04 | 0.04 | -0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 7,006 | 137,216 | +130,210 | 0.00 | 0.03 | +0.03 | buy |
| ARDSLEY ADVISORY PARTNERS LP | 100,000 | 225,000 | +125,000 | 0.86 | 1.43 | +0.57 | buy |
| Qube Research & Technologies Ltd | 0 | 124,641 | +124,641 | 0.00 | 0.01 | +0.01 | buy |
| UBS Group AG | 0 | 118,541 | +118,541 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 1,620,910 | 1,734,775 | +113,865 | 0.00 | 0.00 | -0.00 | buy |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 100,000 | 211,949 | +111,949 | 0.01 | 0.02 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 575,080 | 681,180 | +106,100 | 0.00 | 0.00 | -0.00 | buy |
| BOONE CAPITAL MANAGEMENT LLC | 389,791 | 490,139 | +100,348 | 3.89 | 3.38 | -0.51 | buy |
| MORGAN STANLEY | 146,916 | 244,691 | +97,775 | 0.00 | 0.00 | +0.00 | buy |
| Nan Fung Group Holdings Ltd | 0 | 96,100 | +96,100 | 0.00 | 1.77 | +1.77 | buy |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 533,693 | 621,778 | +88,085 | 0.06 | 0.05 | -0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 136,403 | 224,376 | +87,973 | 0.00 | 0.01 | +0.00 | buy |
| JPMORGAN CHASE & CO | 99,776 | 186,583 | +86,807 | 0.00 | 0.00 | +0.00 | buy |
| OBERWEIS ASSET MANAGEMENT INC/ | 0 | 77,400 | +77,400 | 0.00 | 0.21 | +0.21 | buy |
| Lexington Partners L.P. | 0 | 68,519 | +68,519 | 0.00 | 1.33 | +1.33 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 0 | 67,500 | +67,500 | 0.00 | 0.00 | +0.00 | buy |
| Knights of Columbus Asset Advisors LLC | 57,871 | 116,644 | +58,773 | 0.17 | 0.22 | +0.05 | buy |
| Pictet Asset Management Holding SA | 739,010 | 793,655 | +54,645 | 0.03 | 0.03 | -0.00 | buy |
| BANK OF MONTREAL /CAN/ | 0 | 49,791 | +49,791 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 0 | 47,000 | +47,000 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 224,571 | 266,681 | +42,110 | 0.00 | 0.00 | -0.00 | buy |
| State of Tennessee, Department of Treasury | 0 | 39,154 | +39,154 | 0.00 | 0.00 | +0.00 | buy |
| CenterBook Partners LP | 15,138 | 51,837 | +36,699 | 0.06 | 0.19 | +0.13 | buy |
| ExodusPoint Capital Management, LP | 0 | 33,182 | +33,182 | 0.00 | 0.01 | +0.01 | buy |
| MetLife Investment Management, LLC | 14,125 | 46,753 | +32,628 | 0.00 | 0.01 | +0.01 | buy |
| ADAMS STREET PARTNERS LLC | 0 | 32,627 | +32,627 | 0.00 | 0.30 | +0.30 | buy |
| Squarepoint Ops LLC | 99,657 | 132,212 | +32,555 | 0.02 | 0.02 | +0.00 | buy |
| ALPS ADVISORS INC | 0 | 31,679 | +31,679 | 0.00 | 0.01 | +0.01 | buy |
| Rock Springs Capital Management LP | 1,820,733 | 1,851,464 | +30,731 | 1.54 | 1.35 | -0.19 | buy |
| BANK OF AMERICA CORP /DE/ | 122,649 | 150,824 | +28,175 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 10,694 | 38,524 | +27,830 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 58,723 | 85,231 | +26,508 | 0.00 | 0.00 | +0.00 | buy |
| Jasper Ridge Partners, L.P. | 0 | 25,825 | +25,825 | 0.00 | 0.03 | +0.03 | buy |
| Octagon Capital Advisors LP | 0 | 25,000 | +25,000 | 0.00 | 0.12 | +0.12 | buy |
| Frazier Life Sciences Management, L.P. | 6,470,392 | 6,495,392 | +25,000 | 13.59 | 10.25 | -3.34 | buy |
| TWINBEECH CAPITAL LP | 0 | 22,459 | +22,459 | 0.00 | 0.01 | +0.01 | buy |
| Hennion & Walsh Asset Management, Inc. | 26,493 | 48,512 | +22,019 | 0.05 | 0.08 | +0.03 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 0 | 20,120 | +20,120 | 0.00 | 0.00 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 30,000 | 50,000 | +20,000 | 0.31 | 0.29 | -0.02 | buy |
| Utah Retirement Systems | 0 | 19,577 | +19,577 | 0.00 | 0.01 | +0.01 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 114,109 | 133,527 | +19,418 | 0.02 | 0.02 | -0.00 | buy |
| FMR LLC | 1,573 | 20,777 | +19,204 | 0.00 | 0.00 | +0.00 | buy |
| Partners Group Holding AG | 0 | 18,271 | +18,271 | 0.00 | 0.05 | +0.05 | buy |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 0 | 17,874 | +17,874 | 0.00 | 0.00 | +0.00 | buy |
| ADVENT CAPITAL MANAGEMENT /DE/ | 0 | 17,200 | +17,200 | 0.00 | 0.01 | +0.01 | buy |
| Mission Creek Capital Partners, Inc. | 0 | 16,315 | +16,315 | 0.00 | 0.12 | +0.12 | buy |
| Dynamic Technology Lab Private Ltd | 0 | 16,282 | +16,282 | 0.00 | 0.05 | +0.05 | buy |
| Engineers Gate Manager LP | 0 | 16,045 | +16,045 | 0.00 | 0.01 | +0.01 | buy |
| GENWORTH FINANCIAL INC | 0 | 13,051 | +13,051 | 0.00 | 0.12 | +0.12 | buy |
| TOKIO MARINE ASSET MANAGEMENT CO LTD | 0 | 13,051 | +13,051 | 0.00 | 0.02 | +0.02 | buy |
| NORTHERN TRUST CORP | 275,234 | 288,035 | +12,801 | 0.00 | 0.00 | -0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 17,886 | 28,728 | +10,842 | 0.00 | 0.00 | +0.00 | buy |
| Erste Asset Management GmbH | 225,000 | 235,000 | +10,000 | 0.12 | 0.10 | -0.02 | buy |
| GREAT LAKES ADVISORS, LLC | 0 | 9,500 | +9,500 | 0.00 | 0.00 | +0.00 | buy |
| Steward Partners Investment Advisory, LLC | 30,050 | 39,550 | +9,500 | 0.01 | 0.02 | +0.00 | buy |
| NEOS Investment Management LLC | 0 | 7,442 | +7,442 | 0.00 | 0.02 | +0.02 | buy |
| ProShare Advisors LLC | 0 | 7,074 | +7,074 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 22,644 | 28,701 | +6,057 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 6,027 | +6,027 | 0.00 | 0.01 | +0.01 | buy |
| Blue Owl Capital Holdings LP | 4,784 | 10,013 | +5,229 | 0.12 | 0.07 | -0.05 | buy |
| Janney Montgomery Scott LLC | 18,925 | 24,100 | +5,175 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 54,400 | 59,300 | +4,900 | 0.00 | 0.00 | -0.00 | buy |
| StepStone Group LP | 0 | 4,568 | +4,568 | 0.00 | 0.02 | +0.02 | buy |
| China Universal Asset Management Co., Ltd. | 986 | 5,394 | +4,408 | 0.01 | 0.03 | +0.02 | buy |
| ROYAL BANK OF CANADA | 3,490 | 7,847 | +4,357 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 4,934 | 8,601 | +3,667 | 0.00 | 0.00 | +0.00 | buy |
| Legato Capital Management LLC | 36,317 | 39,807 | +3,490 | 0.17 | 0.15 | -0.01 | buy |
| Tower Research Capital LLC (TRC) | 1,593 | 4,235 | +2,642 | 0.00 | 0.00 | -0.00 | buy |
| Point72 Middle East FZE | 463 | 2,728 | +2,265 | 0.00 | 0.01 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 38,810 | 40,805 | +1,995 | 0.00 | 0.00 | -0.00 | buy |
| Arizona State Retirement System | 7,038 | 8,413 | +1,375 | 0.00 | 0.00 | -0.00 | buy |
| Golden State Equity Partners | 17,980 | 18,930 | +950 | 0.16 | 0.14 | -0.02 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 221,946 | 222,864 | +918 | 0.01 | 0.01 | -0.00 | buy |
| West Tower Group, LLC | 0 | 364 | +364 | 0.00 | 0.02 | +0.02 | buy |
| Mirae Asset Global Investments Co., Ltd. | 17,106 | 17,395 | +289 | 0.00 | 0.00 | -0.00 | buy |
| AMERIPRISE FINANCIAL INC | 30,397 | 30,577 | +180 | 0.00 | 0.00 | -0.00 | buy |
| AMALGAMATED BANK | 3,369 | 3,504 | +135 | 0.00 | 0.00 | -0.00 | buy |
| COMERICA BANK | 0 | 95 | +95 | 0.00 | 0.00 | +0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 2,442 | 2,516 | +74 | 0.00 | 0.00 | -0.00 | buy |
| Cape Investment Advisory, Inc. | 0 | 50 | +50 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 72 | 115 | +43 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 240 | 270 | +30 | 0.00 | 0.00 | -0.00 | buy |
| Allspring Global Investments Holdings, LLC | 23,033 | 23,058 | +25 | 0.00 | 0.00 | -0.00 | buy |
| SIGNATUREFD, LLC | 170 | 174 | +4 | 0.00 | 0.00 | -0.00 | buy |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 32,348 | 32,351 | +3 | 0.00 | 0.00 | -0.00 | buy |
| NOMURA ASSET MANAGEMENT CO LTD | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Ameritas Investment Partners, Inc. | 2,637 | 2,637 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BVF INC/IL | 4,370,024 | 4,370,024 | 0 | 3.72 | 3.23 | -0.50 | hold |
| HANTZ FINANCIAL SERVICES, INC. | 5 | 5 | 0 | 0.00 | 0.00 | 0.00 | hold |