| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| CADIAN CAPITAL MANAGEMENT, LP | 1,434,922 | 1,934,922 | +500,000 | 1.83 | 2.28 | +0.45 | buy |
| Sofinnova Investments, Inc. | 9,089 | 352,397 | +343,308 | 0.02 | 0.58 | +0.56 | buy |
| Clearbridge Investments, LLC | 16,164 | 264,097 | +247,933 | 0.00 | 0.01 | +0.01 | buy |
| JANUS HENDERSON GROUP PLC | 1,923,760 | 2,062,551 | +138,791 | 0.04 | 0.04 | 0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 328,784 | 196,128 | +132,656 | 0.03 | 0.02 | 0.00 | sell |
| ARDSLEY ADVISORY PARTNERS LP | 100,000 | 225,000 | +125,000 | 0.86 | 1.43 | +0.57 | buy |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 100,000 | 211,949 | +111,949 | 0.01 | 0.02 | +0.01 | buy |
| BOONE CAPITAL MANAGEMENT LLC | 389,791 | 490,139 | +100,348 | 3.89 | 3.38 | -0.51 | buy |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 533,693 | 621,778 | +88,085 | 0.06 | 0.05 | -0.00 | buy |
| Knights of Columbus Asset Advisors LLC | 57,871 | 116,644 | +58,773 | 0.17 | 0.22 | +0.05 | buy |
| CenterBook Partners LP | 15,138 | 51,837 | +36,699 | 0.06 | 0.19 | +0.13 | buy |
| Rock Springs Capital Management LP | 1,820,733 | 1,851,464 | +30,731 | 1.54 | 1.35 | -0.20 | buy |
| Frazier Life Sciences Management, L.P. | 6,470,392 | 6,495,392 | +25,000 | 13.59 | 10.25 | -3.34 | buy |
| Hennion & Walsh Asset Management, Inc. | 26,493 | 48,512 | +22,019 | 0.05 | 0.08 | +0.03 | buy |
| Affinity Asset Advisors, LLC | 30,000 | 50,000 | +20,000 | 0.31 | 0.29 | -0.02 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 114,109 | 133,527 | +19,418 | 0.02 | 0.02 | -0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 61,000 | 49,912 | +11,088 | 0.05 | 0.11 | 0.00 | sell |
| Erste Asset Management GmbH | 225,000 | 235,000 | +10,000 | 0.12 | 0.10 | -0.02 | buy |
| Blue Owl Capital Holdings LP | 4,784 | 10,013 | +5,229 | 0.12 | 0.07 | -0.05 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 42,444 | 37,767 | +4,677 | 0.01 | 0.00 | 0.00 | sell |
| China Universal Asset Management Co., Ltd. | 986 | 5,394 | +4,408 | 0.01 | 0.03 | +0.02 | buy |
| Legato Capital Management LLC | 36,317 | 39,807 | +3,490 | 0.17 | 0.15 | -0.01 | buy |
| ADAMS STREET PARTNERS LLC | 29,849 | 32,627 | +2,778 | 0.20 | 0.30 | 0.00 | buy |
| PROFUND ADVISORS LLC | 23,056 | 21,170 | +1,886 | 0.04 | 0.03 | 0.00 | sell |
| Golden State Equity Partners | 17,980 | 18,930 | +950 | 0.16 | 0.14 | -0.02 | buy |
| Elequin Capital, LP | 106 | 93 | -13 | 0.00 | 0.00 | +0.00 | sell |
| E Fund Management Co., Ltd. | 7,050 | 7,001 | -49 | 0.02 | 0.01 | -0.00 | sell |
| Penn Capital Management Company, LLC | 245,970 | 245,728 | -242 | 0.80 | 0.67 | -0.13 | sell |
| Secure Asset Management, LLC | 39,698 | 39,203 | -495 | 0.38 | 0.31 | -0.06 | sell |
| VIRTUS ADVISERS, LLC | 10,739 | 9,430 | -1,309 | 0.21 | 0.18 | -0.03 | sell |
| Atom Investors LP | 13,142 | 10,453 | -2,689 | 0.09 | 0.05 | -0.04 | sell |
| Rafferty Asset Management, LLC | 137,205 | 130,346 | -6,859 | 0.03 | 0.02 | -0.01 | sell |
| RICE HALL JAMES & ASSOCIATES, LLC | 53,379 | 42,840 | -10,539 | 0.11 | 0.07 | -0.03 | sell |
| Lion Point Capital, LP | 27,000 | 13,500 | -13,500 | 0.38 | 0.20 | -0.18 | sell |
| Values First Advisors, Inc. | 37,919 | 16,740 | -21,179 | 0.77 | 0.30 | -0.48 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 110,114 | 80,811 | -29,303 | 1.30 | 0.74 | -0.56 | sell |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 152,410 | 98,946 | -53,464 | 0.04 | 0.02 | -0.02 | sell |
| Prosight Management, LP | 353,508 | 293,301 | -60,207 | 3.54 | 3.48 | -0.06 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 665,000 | 575,000 | -90,000 | 0.05 | 0.04 | -0.01 | sell |
| PERCEPTIVE ADVISORS LLC | 672,042 | 534,942 | -137,100 | 0.71 | 0.35 | -0.36 | sell |
| Woodline Partners LP | 452,707 | 253,263 | -199,444 | 0.17 | 0.08 | -0.09 | sell |
| Polar Capital Holdings Plc | 1,175,000 | 625,000 | -550,000 | 0.28 | 0.11 | -0.16 | sell |
| Nicholas Investment Partners, LP | 1,199,366 | 398,883 | -800,483 | 2.83 | 1.38 | -1.45 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 3,958,579 | 2,663,649 | -1,294,930 | 2.25 | 1.28 | -0.96 | sell |