| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ACADIAN ASSET MANAGEMENT LLC | 474,730 | 882,262 | +407,532 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 179,295 | +179,295 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 585,607 | 664,610 | +79,003 | 0.00 | 0.00 | -0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 16,016 | 94,759 | +78,743 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 0 | 64,600 | +64,600 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 0 | 50,000 | +50,000 | 0.00 | 0.01 | +0.01 | buy |
| NORTHERN TRUST CORP | 110,993 | 156,830 | +45,837 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 0 | 43,021 | +43,021 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 35,600 | +35,600 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 34,870 | +34,870 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 188,646 | 218,446 | +29,800 | 0.00 | 0.00 | +0.00 | buy |
| Tyler-Stone Wealth Management | 38,900 | 47,150 | +8,250 | 0.02 | 0.01 | -0.00 | buy |
| VANGUARD GROUP INC | 2,114,802 | 2,118,416 | +3,614 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 9,631 | 10,451 | +820 | 0.00 | 0.00 | +0.00 | buy |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 0 | 100 | +100 | 0.00 | 0.00 | +0.00 | buy |
| Truvestments Capital LLC | 0 | 25 | +25 | 0.00 | 0.00 | +0.00 | buy |
| Artal Group S.A. | 5,666,410 | 5,666,410 | 0 | 0.16 | 0.10 | -0.05 | hold |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 87,500 | 87,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 337 | 337 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BAKER BROS. ADVISORS LP | 8,128,151 | 8,128,151 | 0 | 0.07 | 0.07 | -0.00 | hold |
| Knoll Capital Management, LLC | 5,517,385 | 5,517,385 | 0 | 3.70 | 2.44 | -1.26 | hold |
| Redmile Group, LLC | 1,063,769 | 1,063,769 | 0 | 0.03 | 0.03 | -0.00 | hold |
| BOOTHBAY FUND MANAGEMENT, LLC | 117,695 | 117,695 | 0 | 0.00 | 0.00 | -0.00 | hold |
| EcoR1 Capital, LLC | 4,595,024 | 4,595,024 | 0 | 0.10 | 0.08 | -0.01 | hold |
| Beacon Pointe Advisors, LLC | 23,400 | 23,400 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Ikarian Capital, LLC | 530,776 | 530,776 | 0 | 0.12 | 0.10 | -0.01 | hold |
| Apella Capital, LLC | 19,783 | 19,783 | 0 | 0.00 | 0.00 | +0.00 | hold |
| INTERNATIONAL ASSETS INVESTMENT MANAGEMENT, LLC | 14,000 | 14,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DLK Investment Management, LLC | 32,000 | 32,000 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Federation des caisses Desjardins du Quebec | 330 | 330 | 0 | 0.00 | 0.00 | -0.00 | hold |
| FMR LLC | 3,358,383 | 3,358,383 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CITIGROUP INC | 74 | 74 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 36,285 | 36,285 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GROUP ONE TRADING LLC | 17,404 | 17,404 | 0 | 0.00 | 0.00 | -0.00 | hold |
| STATE STREET CORP | 160,190 | 160,190 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Advisory Services Network, LLC | 8 | 0 | -8 | 0.00 | 0.00 | -0.00 | sell |
| NBC SECURITIES, INC. | 9,500 | 6,000 | -3,500 | 0.00 | 0.00 | -0.00 | sell |
| ROYAL BANK OF CANADA | 220,331 | 210,297 | -10,034 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 57,635 | 41,173 | -16,462 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 105,761 | 61,109 | -44,652 | 0.02 | 0.01 | -0.01 | sell |
| TWO SIGMA SECURITIES, LLC | 82,141 | 0 | -82,141 | 0.00 | 0.00 | -0.00 | sell |
| BIT Capital GmbH | 228,889 | 0 | -228,889 | 0.02 | 0.00 | -0.02 | sell |
| MORGAN STANLEY | 1,184,072 | 0 | -1,184,072 | 0.00 | 0.00 | -0.00 | sell |