| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| EcoR1 Capital, LLC | 4,595,024 | 5,717,324 | +1,122,300 | 0.08 | 0.10 | +0.02 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 119,637 | +119,637 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 882,262 | 991,106 | +108,844 | 0.00 | 0.00 | -0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 218,446 | 302,246 | +83,800 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 3,358,383 | 3,404,001 | +45,618 | 0.00 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 664,610 | 707,828 | +43,218 | 0.00 | 0.00 | -0.00 | buy |
| GROUP ONE TRADING LLC | 17,404 | 59,004 | +41,600 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 10,451 | 42,609 | +32,158 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 94,759 | 121,469 | +26,710 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA SECURITIES, LLC | 0 | 16,314 | +16,314 | 0.00 | 0.00 | +0.00 | buy |
| Ground Swell Capital, LLC | 0 | 12,471 | +12,471 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA ADVISERS, LP | 35,600 | 46,900 | +11,300 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 160,190 | 169,690 | +9,500 | 0.00 | 0.00 | -0.00 | buy |
| ROYAL BANK OF CANADA | 210,297 | 215,435 | +5,138 | 0.00 | 0.00 | -0.00 | buy |
| VANGUARD GROUP INC | 2,118,416 | 2,120,473 | +2,057 | 0.00 | 0.00 | -0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 0 | 1,249 | +1,249 | 0.00 | 0.00 | 0.00 | buy |
| Global Retirement Partners, LLC | 0 | 300 | +300 | 0.00 | 0.00 | +0.00 | buy |
| Tyler-Stone Wealth Management | 47,150 | 47,390 | +240 | 0.01 | 0.01 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 36,285 | 36,413 | +128 | 0.00 | 0.00 | -0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 4 | +4 | 0.00 | 0.00 | +0.00 | buy |
| Artal Group S.A. | 5,666,410 | 5,666,410 | 0 | 0.10 | 0.09 | -0.02 | hold |
| PRUDENTIAL FINANCIAL INC | 64,600 | 64,600 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 337 | 337 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Knoll Capital Management, LLC | 5,517,385 | 5,517,385 | 0 | 2.44 | 2.20 | -0.25 | hold |
| Redmile Group, LLC | 1,063,769 | 1,063,769 | 0 | 0.03 | 0.04 | +0.01 | hold |
| INTERNATIONAL ASSETS INVESTMENT MANAGEMENT, LLC | 14,000 | 14,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Federation des caisses Desjardins du Quebec | 330 | 330 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NBC SECURITIES, INC. | 6,000 | 6,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CITIGROUP INC | 74 | 74 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Truvestments Capital LLC | 25 | 0 | -25 | 0.00 | 0.00 | -0.00 | sell |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 100 | 0 | -100 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 156,830 | 156,630 | -200 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 41,173 | 40,137 | -1,036 | 0.00 | 0.00 | -0.00 | sell |
| Apella Capital, LLC | 19,783 | 0 | -19,783 | 0.00 | 0.00 | -0.00 | sell |
| Beacon Pointe Advisors, LLC | 23,400 | 0 | -23,400 | 0.00 | 0.00 | -0.00 | sell |
| DLK Investment Management, LLC | 32,000 | 0 | -32,000 | 0.01 | 0.00 | -0.01 | sell |
| HRT FINANCIAL LP | 34,870 | 0 | -34,870 | 0.00 | 0.00 | -0.00 | sell |
| Virtu Financial LLC | 43,021 | 0 | -43,021 | 0.00 | 0.00 | -0.00 | sell |
| ADAR1 Capital Management, LLC | 50,000 | 0 | -50,000 | 0.01 | 0.00 | -0.01 | sell |
| XTX Topco Ltd | 61,109 | 0 | -61,109 | 0.01 | 0.00 | -0.01 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 87,500 | 0 | -87,500 | 0.00 | 0.00 | -0.00 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 117,695 | 0 | -117,695 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 179,295 | 0 | -179,295 | 0.00 | 0.00 | -0.00 | sell |
| Ikarian Capital, LLC | 530,776 | 0 | -530,776 | 0.10 | 0.00 | -0.10 | sell |
| BAKER BROS. ADVISORS LP | 8,128,151 | 0 | -8,128,151 | 0.07 | 0.00 | -0.07 | sell |