| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| MORGAN STANLEY | 0 | 1,184,072 | +1,184,072 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 1,817,492 | 2,114,802 | +297,310 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA SECURITIES, LLC | 0 | 82,141 | +82,141 | 0.00 | 0.00 | +0.00 | buy |
| BAKER BROS. ADVISORS LP | 8,065,398 | 8,128,151 | +62,753 | 0.03 | 0.07 | +0.05 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 533,113 | 585,607 | +52,494 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 428,353 | 474,730 | +46,377 | 0.00 | 0.00 | +0.00 | buy |
| BIT Capital GmbH | 187,472 | 228,889 | +41,417 | 0.02 | 0.02 | +0.00 | buy |
| Tyler-Stone Wealth Management | 0 | 38,900 | +38,900 | 0.00 | 0.02 | +0.02 | buy |
| Apella Capital, LLC | 0 | 19,783 | +19,783 | 0.00 | 0.00 | +0.00 | buy |
| INTERNATIONAL ASSETS INVESTMENT MANAGEMENT, LLC | 0 | 14,000 | +14,000 | 0.00 | 0.00 | +0.00 | buy |
| NBC SECURITIES, INC. | 7,500 | 9,500 | +2,000 | 0.00 | 0.00 | +0.00 | buy |
| Advisory Services Network, LLC | 0 | 8 | +8 | 0.00 | 0.00 | +0.00 | buy |
| Artal Group S.A. | 5,666,410 | 5,666,410 | 0 | 0.15 | 0.16 | +0.00 | hold |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 87,500 | 87,500 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 337 | 337 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Knoll Capital Management, LLC | 5,517,385 | 5,517,385 | 0 | 3.53 | 3.70 | +0.17 | hold |
| Redmile Group, LLC | 1,063,769 | 1,063,769 | 0 | 0.03 | 0.03 | -0.00 | hold |
| BOOTHBAY FUND MANAGEMENT, LLC | 117,695 | 117,695 | 0 | 0.00 | 0.00 | +0.00 | hold |
| EcoR1 Capital, LLC | 4,595,024 | 4,595,024 | 0 | 0.10 | 0.10 | +0.00 | hold |
| Ikarian Capital, LLC | 530,776 | 530,776 | 0 | 0.12 | 0.12 | -0.00 | hold |
| Federation des caisses Desjardins du Quebec | 330 | 330 | 0 | 0.00 | 0.00 | +0.00 | hold |
| FMR LLC | 3,358,383 | 3,358,383 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NORTHERN TRUST CORP | 110,993 | 110,993 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CITIGROUP INC | 74 | 74 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 36,285 | 36,285 | 0 | 0.00 | 0.00 | +0.00 | hold |
| STATE STREET CORP | 160,190 | 160,190 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Qube Research & Technologies Ltd | 4 | 0 | -4 | 0.00 | 0.00 | -0.00 | sell |
| Authentikos Wealth Advisory, LLC | 34 | 0 | -34 | 0.00 | 0.00 | -0.00 | sell |
| Beaird Harris Wealth Management, LLC | 92 | 0 | -92 | 0.00 | 0.00 | -0.00 | sell |
| FEDERATED HERMES, INC. | 708 | 0 | -708 | 0.00 | 0.00 | -0.00 | sell |
| US BANCORP \DE\ | 1,500 | 0 | -1,500 | 0.00 | 0.00 | -0.00 | sell |
| Beacon Pointe Advisors, LLC | 25,000 | 23,400 | -1,600 | 0.00 | 0.00 | +0.00 | sell |
| Tower Research Capital LLC (TRC) | 14,333 | 9,631 | -4,702 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 8,003 | 0 | -8,003 | 0.00 | 0.00 | -0.00 | sell |
| Bayesian Capital Management, LP | 14,462 | 0 | -14,462 | 0.00 | 0.00 | -0.00 | sell |
| GROUP ONE TRADING LLC | 52,084 | 17,404 | -34,680 | 0.00 | 0.00 | -0.00 | sell |
| Vontobel Holding Ltd. | 45,000 | 0 | -45,000 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 111,797 | 57,635 | -54,162 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 162,744 | 105,761 | -56,983 | 0.02 | 0.02 | +0.00 | sell |
| ROYAL BANK OF CANADA | 419,973 | 220,331 | -199,642 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 260,306 | 16,016 | -244,290 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 555,636 | 188,646 | -366,990 | 0.00 | 0.00 | -0.00 | sell |
| Alyeska Investment Group, L.P. | 3,109,436 | 0 | -3,109,436 | 0.01 | 0.00 | -0.01 | sell |
| ARMISTICE CAPITAL, LLC | 3,712,000 | 0 | -3,712,000 | 0.07 | 0.00 | -0.07 | sell |