| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RTW INVESTMENTS, LP | 16,157,175 | 17,946,754 | +1,789,579 | 2.60 | 2.81 | +0.21 | buy |
| VR Adviser, LLC | 16,382,812 | 17,891,812 | +1,509,000 | 9.89 | 9.94 | +0.04 | buy |
| Rock Springs Capital Management LP | 1,103,469 | 1,402,150 | +298,681 | 1.05 | 1.25 | +0.20 | buy |
| Cormorant Asset Management, LP | 5,800,000 | 6,000,000 | +200,000 | 4.71 | 5.63 | +0.92 | buy |
| ArrowMark Colorado Holdings LLC | 79,052 | 210,927 | +131,875 | 0.03 | 0.16 | +0.13 | buy |
| Longaeva Partners L.P. | 171,233 | 286,322 | +115,089 | 0.10 | 0.11 | +0.01 | buy |
| China Universal Asset Management Co., Ltd. | 54,939 | 59,493 | +4,554 | 0.07 | 0.07 | -0.00 | buy |
| E Fund Management (Hong Kong) Co., Ltd. | 932 | 1,312 | +380 | 0.01 | 0.01 | +0.00 | buy |
| Abel Hall, LLC | 16,947 | 16,724 | -223 | 0.06 | 0.05 | -0.01 | sell |
| Harvest Investment Services, LLC | 73,744 | 65,939 | -7,805 | 0.22 | 0.19 | -0.03 | sell |
| HighVista Strategies LLC | 181,069 | 160,328 | -20,741 | 0.81 | 0.67 | -0.14 | sell |
| TEMA ETFS LLC | 226,877 | 182,438 | -44,439 | 0.25 | 0.11 | -0.14 | sell |
| ACUTA CAPITAL PARTNERS, LLC | 354,575 | 265,199 | -89,376 | 4.05 | 3.39 | -0.66 | sell |
| EcoR1 Capital, LLC | 900,000 | 330,000 | -570,000 | 0.62 | 0.29 | -0.32 | sell |
| Holocene Advisors, LP | 760,722 | 126,550 | -634,172 | 0.03 | 0.01 | -0.02 | sell |
| Vivo Capital, LLC | 12,151,480 | 4,127,412 | -8,024,068 | 16.34 | 6.90 | -9.44 | sell |