| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ARCH Venture Management, LLC | 11,055,554 | 11,055,554 | 0 | 14.40 | 28.37 | +13.97 | hold |
| ARMISTICE CAPITAL, LLC | 8,096,000 | 6,172,000 | -1,924,000 | 0.46 | 0.34 | -0.12 | sell |
| Artal Group S.A. | 4,721,194 | 4,721,194 | 0 | 0.34 | 0.25 | -0.09 | hold |
| VANGUARD GROUP INC | 3,792,343 | 4,338,108 | +545,765 | 0.00 | 0.00 | +0.00 | buy |
| Prosight Management, LP | 599,458 | 3,659,755 | +3,060,297 | 0.51 | 2.10 | +1.58 | buy |
| AH Capital Management, L.L.C. | 2,862,500 | 2,862,500 | 0 | 0.38 | 0.43 | +0.05 | hold |
| PFM Health Sciences, LP | 2,575,511 | 2,535,102 | -40,409 | 0.33 | 0.26 | -0.07 | sell |
| Sio Capital Management, LLC | 0 | 2,427,184 | +2,427,184 | 0.00 | 1.74 | +1.74 | buy |
| BANK OF AMERICA CORP /DE/ | 726,751 | 2,199,591 | +1,472,840 | 0.00 | 0.00 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 1,926,000 | 1,926,000 | 0 | 0.01 | 0.00 | -0.00 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 1,811,911 | 1,891,543 | +79,632 | 0.00 | 0.00 | -0.00 | buy |
| STATE STREET CORP | 1,665,304 | 1,670,685 | +5,381 | 0.00 | 0.00 | -0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 2,008,500 | 1,631,600 | -376,900 | 0.01 | 0.01 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 1,297,042 | 1,582,016 | +284,974 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 1,484,608 | 1,154,130 | -330,478 | 0.00 | 0.00 | -0.00 | sell |
| Point72 Asset Management, L.P. | 0 | 1,096,254 | +1,096,254 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 997,419 | 1,071,556 | +74,137 | 0.01 | 0.01 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 626,500 | 1,035,900 | +409,400 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 919,119 | 890,793 | -28,326 | 0.02 | 0.02 | -0.00 | sell |
| CITADEL ADVISORS LLC | 2,147,594 | 837,314 | -1,310,280 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 650,135 | 663,870 | +13,735 | 0.00 | 0.00 | -0.00 | buy |
| NORTHERN TRUST CORP | 700,917 | 662,486 | -38,431 | 0.00 | 0.00 | -0.00 | sell |
| MORGAN STANLEY | 691,814 | 658,225 | -33,589 | 0.00 | 0.00 | -0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 667,849 | 569,039 | -98,810 | 0.12 | 0.09 | -0.03 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 89,779 | 346,953 | +257,174 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 102,243 | 320,724 | +218,481 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 376,188 | 320,261 | -55,927 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 283,080 | 260,661 | -22,419 | 0.00 | 0.00 | -0.00 | sell |
| ExodusPoint Capital Management, LP | 0 | 249,518 | +249,518 | 0.00 | 0.01 | +0.01 | buy |
| REGENTS OF THE UNIVERSITY OF CALIFORNIA | 236,236 | 236,236 | 0 | 0.06 | 0.14 | +0.08 | hold |
| XTX Topco Ltd | 234,645 | 228,327 | -6,318 | 0.11 | 0.06 | -0.05 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 223,845 | +223,845 | 0.00 | 0.13 | +0.13 | buy |
| IPG Investment Advisors LLC | 0 | 207,470 | +207,470 | 0.00 | 0.09 | +0.09 | buy |
| Pennant Investors, LP | 166,200 | 166,200 | 0 | 0.11 | 0.09 | -0.01 | hold |
| Connor, Clark & Lunn Investment Management Ltd. | 145,986 | 148,083 | +2,097 | 0.00 | 0.00 | -0.00 | buy |
| FMR LLC | 57,932 | 138,651 | +80,719 | 0.00 | 0.00 | +0.00 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 54,339 | 136,988 | +82,649 | 0.00 | 0.01 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 0 | 122,162 | +122,162 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 117,606 | 121,509 | +3,903 | 0.00 | 0.00 | -0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 118,310 | 118,310 | 0 | 0.00 | 0.00 | -0.00 | hold |
| JANE STREET GROUP, LLC | 266,454 | 115,242 | -151,212 | 0.00 | 0.00 | -0.00 | sell |
| Pale Fire Capital SE | 186,101 | 111,906 | -74,195 | 0.06 | 0.03 | -0.03 | sell |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 0 | 104,691 | +104,691 | 0.00 | 0.01 | +0.01 | buy |
| TANG CAPITAL MANAGEMENT LLC | 150,000 | 100,000 | -50,000 | 0.03 | 0.02 | -0.01 | sell |
| Walleye Capital LLC | 139,379 | 95,078 | -44,301 | 0.00 | 0.00 | -0.00 | sell |
| DENALI ADVISORS LLC | 91,200 | 91,200 | 0 | 0.06 | 0.06 | -0.00 | hold |
| AMERICAN CENTURY COMPANIES INC | 60,334 | 82,490 | +22,156 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 111,845 | 79,521 | -32,324 | 0.00 | 0.00 | -0.00 | sell |
| Palumbo Wealth Management LLC | 0 | 78,436 | +78,436 | 0.00 | 0.07 | +0.07 | buy |
| JPMORGAN CHASE & CO | 86,835 | 66,154 | -20,681 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 133,688 | 64,319 | -69,369 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 60,506 | +60,506 | 0.00 | 0.00 | +0.00 | buy |
| CORNERCAP INVESTMENT COUNSEL INC | 58,045 | 58,045 | 0 | 0.02 | 0.02 | -0.00 | hold |
| Squarepoint Ops LLC | 88,464 | 55,997 | -32,467 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 48,694 | 52,355 | +3,661 | 0.00 | 0.00 | -0.00 | buy |
| Atom Investors LP | 0 | 50,533 | +50,533 | 0.00 | 0.01 | +0.01 | buy |
| MetLife Investment Management, LLC | 37,277 | 42,040 | +4,763 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN INTERNATIONAL GROUP, INC. | 40,110 | 39,768 | -342 | 0.00 | 0.00 | -0.00 | sell |
| PRUDENTIAL FINANCIAL INC | 0 | 37,976 | +37,976 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 37,034 | 37,697 | +663 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 47,912 | 36,997 | -10,915 | 0.00 | 0.00 | -0.00 | sell |
| Graham Capital Management, L.P. | 24,955 | 36,410 | +11,455 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 36,682 | 34,811 | -1,871 | 0.00 | 0.00 | -0.00 | sell |
| EntryPoint Capital, LLC | 80,546 | 32,087 | -48,459 | 0.16 | 0.06 | -0.11 | sell |
| Invesco Ltd. | 31,798 | 29,254 | -2,544 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 17,472 | 29,013 | +11,541 | 0.01 | 0.01 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 34,299 | 28,371 | -5,928 | 0.00 | 0.00 | -0.00 | sell |
| Aaron Wealth Advisors LLC | 13,368 | 27,735 | +14,367 | 0.00 | 0.01 | +0.00 | buy |
| ALGERT GLOBAL LLC | 327,095 | 27,640 | -299,455 | 0.03 | 0.00 | -0.03 | sell |
| DEUTSCHE BANK AG\ | 27,310 | 25,603 | -1,707 | 0.00 | 0.00 | -0.00 | sell |
| ProShare Advisors LLC | 23,009 | 25,087 | +2,078 | 0.00 | 0.00 | -0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 19,931 | 24,684 | +4,753 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 18,638 | +18,638 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 18,829 | 18,417 | -412 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 14,228 | 15,786 | +1,558 | 0.00 | 0.00 | -0.00 | buy |
| HSBC HOLDINGS PLC | 0 | 15,619 | +15,619 | 0.00 | 0.00 | +0.00 | buy |
| Corient Private Wealth LLC | 0 | 14,555 | +14,555 | 0.00 | 0.00 | +0.00 | buy |
| Vanguard Personalized Indexing Management, LLC | 16,504 | 14,252 | -2,252 | 0.00 | 0.00 | -0.00 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 13,600 | 13,300 | -300 | 0.00 | 0.00 | -0.00 | sell |
| SANDERS MORRIS HARRIS LLC | 575,189 | 12,000 | -563,189 | 0.62 | 0.00 | -0.61 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 12,616 | 11,790 | -826 | 0.00 | 0.00 | -0.00 | sell |
| Cubist Systematic Strategies, LLC | 74,270 | 10,407 | -63,863 | 0.00 | 0.00 | -0.00 | sell |
| Point72 Asia (Singapore) Pte. Ltd. | 0 | 9,565 | +9,565 | 0.00 | 0.01 | +0.01 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 80,364 | 8,113 | -72,251 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 95,160 | 6,494 | -88,666 | 0.00 | 0.00 | -0.00 | sell |
| Ameritas Investment Partners, Inc. | 4,957 | 4,957 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SIMPLEX TRADING, LLC | 1,570 | 4,632 | +3,062 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 18,140 | 2,945 | -15,195 | 0.00 | 0.00 | -0.00 | sell |
| AMALGAMATED BANK | 6,474 | 2,251 | -4,223 | 0.00 | 0.00 | -0.00 | sell |
| GROUP ONE TRADING LLC | 0 | 2,161 | +2,161 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 2,668 | 1,551 | -1,117 | 0.00 | 0.00 | -0.00 | sell |
| METROPOLITAN LIFE INSURANCE CO/NY | 786 | 1,528 | +742 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 290 | 1,251 | +961 | 0.00 | 0.00 | +0.00 | buy |
| Daiwa Securities Group Inc. | 354 | 354 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GPS Wealth Strategies Group, LLC | 350 | 350 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MassMutual Private Wealth & Trust, FSB | 0 | 333 | +333 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 365 | 314 | -51 | 0.00 | 0.00 | -0.00 | sell |
| SHELL ASSET MANAGEMENT CO | 25,996 | 52 | -25,944 | 0.00 | 0.00 | -0.00 | sell |
| Covestor Ltd | 23 | 43 | +20 | 0.00 | 0.00 | 0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 0 | 22 | +22 | 0.00 | 0.00 | +0.00 | buy |