| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Frazier Life Sciences Management, L.P. | 19,391,687 | 22,575,851 | +3,184,164 | 2.02 | 1.41 | -0.61 | buy |
| Affinity Asset Advisors, LLC | 2,499,431 | 3,341,519 | +842,088 | 0.98 | 0.72 | -0.26 | buy |
| TANG CAPITAL MANAGEMENT LLC | 602,915 | 1,190,012 | +587,097 | 0.10 | 0.09 | -0.01 | buy |
| T. Rowe Price Investment Management, Inc. | 16,710,347 | 17,292,164 | +581,817 | 0.03 | 0.02 | -0.01 | buy |
| Logos Global Management LP | 12,500,000 | 13,000,000 | +500,000 | 3.67 | 3.17 | -0.51 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 465,672 | 850,147 | +384,475 | 0.00 | 0.00 | +0.00 | buy |
| DAFNA Capital Management LLC | 0 | 340,000 | +340,000 | 0.00 | 0.13 | +0.13 | buy |
| AQR CAPITAL MANAGEMENT LLC | 57,025 | 396,202 | +339,177 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 238,705 | +238,705 | 0.00 | 0.03 | +0.03 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 4,569,819 | 4,757,852 | +188,033 | 0.00 | 0.00 | -0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 115,501 | 236,950 | +121,449 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 98,961 | +98,961 | 0.00 | 0.01 | +0.01 | buy |
| Sofinnova Investments, Inc. | 1,795,880 | 1,877,085 | +81,205 | 0.33 | 0.19 | -0.14 | buy |
| IPG Investment Advisors LLC | 169,978 | 248,108 | +78,130 | 0.10 | 0.08 | -0.02 | buy |
| Walleye Capital LLC | 138,708 | 215,220 | +76,512 | 0.00 | 0.00 | -0.00 | buy |
| XTX Topco Ltd | 55,361 | 123,501 | +68,140 | 0.01 | 0.01 | -0.00 | buy |
| Invesco Ltd. | 48,671 | 113,583 | +64,912 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 0 | 62,421 | +62,421 | 0.00 | 0.02 | +0.02 | buy |
| Squarepoint Ops LLC | 50,308 | 112,465 | +62,157 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 55,585 | 112,524 | +56,939 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 12,673,900 | 12,727,425 | +53,525 | 0.00 | 0.00 | -0.00 | buy |
| FRANKLIN RESOURCES INC | 65,872 | 117,284 | +51,412 | 0.00 | 0.00 | +0.00 | buy |
| Velan Capital Investment Management LP | 0 | 50,000 | +50,000 | 0.00 | 0.07 | +0.07 | buy |
| Paradigm Biocapital Advisors LP | 10,752,354 | 10,802,354 | +50,000 | 0.94 | 0.68 | -0.26 | buy |
| CAPTRUST FINANCIAL ADVISORS | 0 | 47,625 | +47,625 | 0.00 | 0.00 | +0.00 | buy |
| Graham Capital Management, L.P. | 0 | 42,009 | +42,009 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 0 | 40,522 | +40,522 | 0.00 | 0.00 | +0.00 | buy |
| IEQ CAPITAL, LLC | 0 | 40,322 | +40,322 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 320,358 | 359,378 | +39,020 | 0.00 | 0.00 | -0.00 | buy |
| Cerity Partners LLC | 0 | 35,504 | +35,504 | 0.00 | 0.00 | +0.00 | buy |
| Atom Investors LP | 775,417 | 810,455 | +35,038 | 0.24 | 0.14 | -0.11 | buy |
| CWM, LLC | 1,806 | 36,250 | +34,444 | 0.00 | 0.00 | +0.00 | buy |
| Jain Global LLC | 0 | 31,246 | +31,246 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 97,369 | 128,093 | +30,724 | 0.00 | 0.00 | -0.00 | buy |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 0 | 28,139 | +28,139 | 0.00 | 0.00 | +0.00 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 59,384 | 87,251 | +27,867 | 0.00 | 0.00 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 135,770 | 163,052 | +27,282 | 0.00 | 0.00 | -0.00 | buy |
| Aaron Wealth Advisors LLC | 27,735 | 54,658 | +26,923 | 0.01 | 0.01 | +0.00 | buy |
| Creative Planning | 22,684 | 46,695 | +24,011 | 0.00 | 0.00 | +0.00 | buy |
| CIBC WORLD MARKETS CORP | 17,200 | 40,782 | +23,582 | 0.00 | 0.00 | +0.00 | buy |
| ZACKS INVESTMENT MANAGEMENT | 0 | 23,057 | +23,057 | 0.00 | 0.00 | +0.00 | buy |
| Quadrature Capital Ltd | 0 | 20,366 | +20,366 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asia (Singapore) Pte. Ltd. | 0 | 17,500 | +17,500 | 0.00 | 0.01 | +0.01 | buy |
| SIH Partners, LLLP | 0 | 17,067 | +17,067 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 240,746 | 256,032 | +15,286 | 0.00 | 0.00 | -0.00 | buy |
| Palumbo Wealth Management LLC | 28,600 | 43,331 | +14,731 | 0.03 | 0.02 | -0.01 | buy |
| Pallas Capital Advisors LLC | 0 | 11,510 | +11,510 | 0.00 | 0.00 | +0.00 | buy |
| Dynamic Technology Lab Private Ltd | 0 | 10,389 | +10,389 | 0.00 | 0.00 | +0.00 | buy |
| AlphaCore Capital LLC | 0 | 10,000 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 70,037 | 76,273 | +6,236 | 0.00 | 0.00 | -0.00 | buy |
| Point72 (DIFC) Ltd | 0 | 5,216 | +5,216 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 2,251 | 6,343 | +4,092 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 544,819 | 548,269 | +3,450 | 0.00 | 0.00 | -0.00 | buy |
| Vanguard Personalized Indexing Management, LLC | 12,525 | 15,804 | +3,279 | 0.00 | 0.00 | -0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 66,319 | 69,427 | +3,108 | 0.00 | 0.00 | -0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 1,945,773 | 1,948,825 | +3,052 | 0.00 | 0.00 | -0.00 | buy |
| SIGNATUREFD, LLC | 0 | 2,740 | +2,740 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 133,377 | 135,816 | +2,439 | 0.00 | 0.00 | -0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 10,136 | 12,522 | +2,386 | 0.00 | 0.00 | -0.00 | buy |
| Cresset Asset Management, LLC | 79,913 | 81,569 | +1,656 | 0.00 | 0.00 | -0.00 | buy |
| EverSource Wealth Advisors, LLC | 6 | 1,515 | +1,509 | 0.00 | 0.00 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 5,936 | 7,240 | +1,304 | 0.00 | 0.00 | -0.00 | buy |
| True Wealth Design, LLC | 0 | 1,094 | +1,094 | 0.00 | 0.00 | +0.00 | buy |
| QUADRANT CAPITAL GROUP LLC | 0 | 1,030 | +1,030 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 444,769 | 445,580 | +811 | 0.00 | 0.00 | -0.00 | buy |
| XPONANCE, INC. | 12,393 | 13,116 | +723 | 0.00 | 0.00 | -0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 10,371 | 10,951 | +580 | 0.00 | 0.00 | -0.00 | buy |
| Parkside Financial Bank & Trust | 0 | 285 | +285 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 868 | 1,104 | +236 | 0.00 | 0.00 | -0.00 | buy |
| Allworth Financial LP | 0 | 213 | +213 | 0.00 | 0.00 | +0.00 | buy |
| Steward Partners Investment Advisory, LLC | 0 | 200 | +200 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 4,147,275 | 4,147,433 | +158 | 0.07 | 0.04 | -0.03 | buy |
| Mirae Asset Global Investments Co., Ltd. | 9,421 | 9,460 | +39 | 0.00 | 0.00 | -0.00 | buy |
| Ameritas Investment Partners, Inc. | 17,980 | 17,980 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 171,821 | 171,821 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 154,490 | 154,490 | 0 | 0.00 | 0.00 | -0.00 | hold |
| JANUS HENDERSON GROUP PLC | 73,200 | 73,200 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ARCH Venture Management, LLC | 11,055,554 | 11,055,554 | 0 | 12.05 | 7.34 | -4.71 | hold |
| ALGERT GLOBAL LLC | 51,364 | 51,364 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MARSHALL WACE, LLP | 2,027,027 | 2,027,027 | 0 | 0.01 | 0.00 | -0.00 | hold |
| HighVista Strategies LLC | 135,667 | 135,667 | 0 | 0.13 | 0.07 | -0.06 | hold |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 39,963 | 39,963 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Neuberger Berman Group LLC | 13,158 | 13,158 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Daiwa Securities Group Inc. | 1,074 | 1,074 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Sio Capital Management, LLC | 1,356,186 | 1,356,186 | 0 | 0.96 | 0.56 | -0.40 | hold |
| AH Capital Management, L.L.C. | 2,862,500 | 2,862,500 | 0 | 0.96 | 0.56 | -0.40 | hold |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 12,315,004 | 12,315,004 | 0 | 1.15 | 0.68 | -0.46 | hold |
| VR Adviser, LLC | 16,216,216 | 16,216,216 | 0 | 2.79 | 1.89 | -0.90 | hold |
| Prosight Management, LP | 947,110 | 947,110 | 0 | 0.67 | 0.43 | -0.24 | hold |
| Vivo Capital, LLC | 6,756,756 | 6,756,756 | 0 | 1.90 | 1.23 | -0.67 | hold |
| KLP KAPITALFORVALTNING AS | 27,400 | 27,400 | 0 | 0.00 | 0.00 | -0.00 | hold |
| 5AM Venture Management, LLC | 5,405,404 | 5,405,404 | 0 | 3.24 | 2.80 | -0.44 | hold |
| Soleus Capital Management, L.P. | 2,162,162 | 2,162,162 | 0 | 0.41 | 0.23 | -0.18 | hold |
| Octagon Capital Advisors LP | 5,136,795 | 5,136,795 | 0 | 2.19 | 0.96 | -1.23 | hold |
| SBI Securities Co., Ltd. | 388 | 388 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Covestor Ltd | 43 | 43 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Pictet Asset Management Holding SA | 17,302 | 17,302 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Smartleaf Asset Management LLC | 108 | 108 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Police & Firemen's Retirement System of New Jersey | 36,797 | 36,797 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO | 11,916 | 11,916 | 0 | 0.00 | 0.00 | -0.00 | hold |