| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Frazier Life Sciences Management, L.P. | 19,391,687 | 22,575,851 | +3,184,164 | 2.02 | 1.41 | -0.61 | buy |
| Affinity Asset Advisors, LLC | 2,499,431 | 3,341,519 | +842,088 | 0.98 | 0.72 | -0.26 | buy |
| TANG CAPITAL MANAGEMENT LLC | 602,915 | 1,190,012 | +587,097 | 0.10 | 0.09 | -0.01 | buy |
| T. Rowe Price Investment Management, Inc. | 16,710,347 | 17,292,164 | +581,817 | 0.03 | 0.02 | -0.01 | buy |
| Logos Global Management LP | 12,500,000 | 13,000,000 | +500,000 | 3.67 | 3.17 | -0.51 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 229,600 | 75,627 | +153,973 | 0.05 | 0.01 | 0.00 | sell |
| Sofinnova Investments, Inc. | 1,795,880 | 1,877,085 | +81,205 | 0.33 | 0.17 | -0.16 | buy |
| IPG Investment Advisors LLC | 169,978 | 248,108 | +78,130 | 0.10 | 0.08 | -0.02 | buy |
| Paradigm Biocapital Advisors LP | 10,752,354 | 10,802,354 | +50,000 | 0.94 | 0.68 | -0.26 | buy |
| Atom Investors LP | 775,417 | 810,455 | +35,038 | 0.24 | 0.14 | -0.11 | buy |
| Aaron Wealth Advisors LLC | 27,735 | 54,658 | +26,923 | 0.01 | 0.01 | +0.00 | buy |
| Palumbo Wealth Management LLC | 28,600 | 43,331 | +14,731 | 0.03 | 0.02 | -0.01 | buy |
| GF FUND MANAGEMENT CO. LTD. | 5,936 | 7,240 | +1,304 | 0.00 | 0.00 | -0.00 | buy |
| Woodline Partners LP | 4,147,275 | 4,147,433 | +158 | 0.07 | 0.04 | -0.03 | buy |
| China Universal Asset Management Co., Ltd. | 59,949 | 56,710 | -3,239 | 0.01 | 0.01 | -0.01 | sell |
| ALPS ADVISORS INC | 228,619 | 210,283 | -18,336 | 0.00 | 0.00 | -0.00 | sell |
| Siren, L.L.C. | 8,857,179 | 8,757,249 | -99,930 | 0.98 | 0.68 | -0.31 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 7,543,901 | 7,367,996 | -175,905 | 4.23 | 2.11 | -2.13 | sell |
| PFM Health Sciences, LP | 4,390,427 | 3,489,559 | -900,868 | 0.68 | 0.35 | -0.34 | sell |