| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Frazier Life Sciences Management, L.P. | 22,729,436 | 24,675,188 | +1,945,752 | 2.27 | 10.27 | +8.00 | buy |
| T. Rowe Price Investment Management, Inc. | 16,111,414 | 21,259,646 | +5,148,232 | 0.04 | 0.24 | +0.20 | buy |
| BlackRock, Inc. | 15,597,330 | 20,151,406 | +4,554,076 | 0.00 | 0.01 | +0.00 | buy |
| VR Adviser, LLC | 17,857,083 | 16,382,812 | -1,474,271 | 3.28 | 9.89 | +6.61 | sell |
| RTW INVESTMENTS, LP | 146,651 | 16,157,175 | +16,010,524 | 0.01 | 2.60 | +2.60 | buy |
| Vivo Capital, LLC | 9,273,428 | 12,151,480 | +2,878,052 | 2.23 | 16.34 | +14.11 | buy |
| Siren, L.L.C. | 8,757,249 | 11,244,246 | +2,486,997 | 0.97 | 5.04 | +4.07 | buy |
| Logos Global Management LP | 13,000,000 | 11,150,000 | -1,850,000 | 3.22 | 9.29 | +6.07 | sell |
| Paradigm Biocapital Advisors LP | 14,159,095 | 10,392,702 | -3,766,393 | 1.41 | 3.44 | +2.03 | sell |
| STATE STREET CORP | 6,174,642 | 9,300,084 | +3,125,442 | 0.00 | 0.01 | +0.00 | buy |
| ARCH Venture Management, LLC | 11,055,554 | 7,091,557 | -3,963,997 | 6.31 | 16.95 | +10.64 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 4,926,335 | 5,996,149 | +1,069,814 | 0.00 | 0.01 | +0.00 | buy |
| Cormorant Asset Management, LP | 0 | 5,800,000 | +5,800,000 | 0.00 | 4.73 | +4.73 | buy |
| Affinity Asset Advisors, LLC | 3,900,000 | 5,350,000 | +1,450,000 | 1.04 | 5.08 | +4.03 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 98,073 | 5,143,985 | +5,045,912 | 0.00 | 0.16 | +0.16 | buy |
| GOLDMAN SACHS GROUP INC | 3,331,418 | 4,875,186 | +1,543,768 | 0.00 | 0.01 | +0.01 | buy |
| JANUS HENDERSON GROUP PLC | 0 | 3,710,966 | +3,710,966 | 0.00 | 0.03 | +0.03 | buy |
| 5AM Venture Management, LLC | 5,405,404 | 3,485,971 | -1,919,433 | 6.32 | 15.66 | +9.34 | sell |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 14,502,004 | 3,434,967 | -11,067,037 | 1.34 | 1.51 | +0.16 | sell |
| Commodore Capital LP | 0 | 3,175,000 | +3,175,000 | 0.00 | 2.97 | +2.97 | buy |
| BANK OF AMERICA CORP /DE/ | 1,611,850 | 3,055,897 | +1,444,047 | 0.00 | 0.00 | +0.00 | buy |
| AH Capital Management, L.L.C. | 2,862,500 | 2,862,500 | 0 | 0.67 | 3.59 | +2.91 | hold |
| Woodline Partners LP | 1,930,642 | 2,831,538 | +900,896 | 0.03 | 0.17 | +0.15 | buy |
| ALLIANCEBERNSTEIN L.P. | 208,810 | 2,644,920 | +2,436,110 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 2,100,000 | +2,100,000 | 0.00 | 0.05 | +0.05 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,673,404 | 1,898,224 | +224,820 | 0.00 | 0.00 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 1,317,584 | 1,851,812 | +534,228 | 0.71 | 3.53 | +2.82 | buy |
| UBS Group AG | 170,531 | 1,848,580 | +1,678,049 | 0.00 | 0.01 | +0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 103,503 | 1,815,340 | +1,711,837 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 1,775,685 | 1,786,389 | +10,704 | 0.00 | 0.01 | +0.00 | buy |
| NORTHERN TRUST CORP | 1,331,508 | 1,701,623 | +370,115 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 18,391 | 1,654,497 | +1,636,106 | 0.00 | 0.02 | +0.02 | buy |
| FMR LLC | 521,455 | 1,490,080 | +968,625 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 850,100 | 1,398,869 | +548,769 | 0.00 | 0.04 | +0.03 | buy |
| D. E. Shaw & Co., Inc. | 201,938 | 1,219,534 | +1,017,596 | 0.00 | 0.02 | +0.01 | buy |
| Rock Springs Capital Management LP | 951,710 | 1,103,469 | +151,759 | 0.18 | 1.05 | +0.87 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 32,486 | 1,087,301 | +1,054,815 | 0.00 | 0.01 | +0.01 | buy |
| MORGAN STANLEY | 810,385 | 989,210 | +178,825 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 1,153,090 | 924,405 | -228,685 | 0.00 | 0.00 | +0.00 | sell |
| EcoR1 Capital, LLC | 0 | 900,000 | +900,000 | 0.00 | 0.62 | +0.62 | buy |
| First Turn Management, LLC | 0 | 867,639 | +867,639 | 0.00 | 1.57 | +1.57 | buy |
| Holocene Advisors, LP | 0 | 760,722 | +760,722 | 0.00 | 0.03 | +0.03 | buy |
| Invesco Ltd. | 329,795 | 759,932 | +430,137 | 0.00 | 0.00 | +0.00 | buy |
| Integral Health Asset Management, LLC | 0 | 700,000 | +700,000 | 0.00 | 0.60 | +0.60 | buy |
| Point72 Asset Management, L.P. | 0 | 693,309 | +693,309 | 0.00 | 0.02 | +0.02 | buy |
| AQR CAPITAL MANAGEMENT LLC | 669,876 | 691,205 | +21,329 | 0.00 | 0.01 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 670,597 | +670,597 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 543,196 | 595,379 | +52,183 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 2,237,951 | 575,996 | -1,661,955 | 0.01 | 0.01 | +0.00 | sell |
| ExodusPoint Capital Management, LP | 1,490,967 | 575,715 | -915,252 | 0.06 | 0.09 | +0.03 | sell |
| Bank of New York Mellon Corp | 546,776 | 559,629 | +12,853 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 424,713 | 543,021 | +118,308 | 0.00 | 0.00 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 0 | 500,723 | +500,723 | 0.00 | 0.02 | +0.02 | buy |
| CITADEL ADVISORS LLC | 1,030,345 | 498,381 | -531,964 | 0.00 | 0.01 | +0.00 | sell |
| JANE STREET GROUP, LLC | 912,519 | 455,019 | -457,500 | 0.00 | 0.01 | +0.00 | sell |
| MARSHALL WACE, LLP | 61,960 | 426,526 | +364,566 | 0.00 | 0.01 | +0.01 | buy |
| Creative Planning | 381,695 | 418,834 | +37,139 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 12,755 | 416,715 | +403,960 | 0.00 | 0.01 | +0.01 | buy |
| Parkman Healthcare Partners LLC | 0 | 406,702 | +406,702 | 0.00 | 0.68 | +0.68 | buy |
| TD ASSET MANAGEMENT INC | 229,840 | 394,260 | +164,420 | 0.00 | 0.01 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 165,359 | 380,977 | +215,618 | 0.00 | 0.00 | +0.00 | buy |
| Polymer Capital Management (HK) LTD | 0 | 357,670 | +357,670 | 0.00 | 0.81 | +0.81 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 0 | 354,575 | +354,575 | 0.00 | 4.08 | +4.08 | buy |
| Atom Investors LP | 0 | 345,587 | +345,587 | 0.00 | 0.40 | +0.40 | buy |
| Swiss National Bank | 0 | 336,800 | +336,800 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 0 | 301,066 | +301,066 | 0.00 | 0.04 | +0.04 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0 | 259,007 | +259,007 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 33,187 | 253,554 | +220,367 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 346,072 | 252,747 | -93,325 | 0.04 | 0.13 | +0.09 | sell |
| Rafferty Asset Management, LLC | 131,019 | 251,963 | +120,944 | 0.00 | 0.02 | +0.01 | buy |
| RHUMBLINE ADVISERS | 189,012 | 242,636 | +53,624 | 0.00 | 0.00 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 0 | 239,861 | +239,861 | 0.00 | 0.75 | +0.75 | buy |
| FRED ALGER MANAGEMENT, LLC | 0 | 236,824 | +236,824 | 0.00 | 0.02 | +0.02 | buy |
| Tidal Investments LLC | 0 | 226,877 | +226,877 | 0.00 | 0.01 | +0.01 | buy |
| TEMA ETFS LLC | 0 | 226,877 | +226,877 | 0.00 | 0.25 | +0.25 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 54,769 | 216,614 | +161,845 | 0.00 | 0.00 | +0.00 | buy |
| Pictet Asset Management Holding SA | 0 | 208,273 | +208,273 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 10,689 | 204,449 | +193,760 | 0.00 | 0.00 | +0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 900,000 | 200,000 | -700,000 | 0.17 | 0.16 | -0.00 | sell |
| HighVista Strategies LLC | 0 | 181,069 | +181,069 | 0.00 | 0.81 | +0.81 | buy |
| Cinctive Capital Management LP | 0 | 171,920 | +171,920 | 0.00 | 0.18 | +0.18 | buy |
| Longaeva Partners L.P. | 0 | 171,233 | +171,233 | 0.00 | 0.13 | +0.13 | buy |
| DEUTSCHE BANK AG\ | 121,977 | 163,326 | +41,349 | 0.00 | 0.00 | +0.00 | buy |
| NATIXIS | 0 | 163,192 | +163,192 | 0.00 | 0.01 | +0.01 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 199,788 | 153,647 | -46,141 | 0.00 | 0.00 | +0.00 | sell |
| XTX Topco Ltd | 10,798 | 147,618 | +136,820 | 0.00 | 0.04 | +0.04 | buy |
| Informed Momentum Co LLC | 0 | 137,925 | +137,925 | 0.00 | 0.26 | +0.26 | buy |
| Legal & General Group Plc | 15,428 | 133,444 | +118,016 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 50,605 | 113,216 | +62,611 | 0.01 | 0.07 | +0.06 | buy |
| WELLS FARGO & COMPANY/MN | 220,132 | 107,176 | -112,956 | 0.00 | 0.00 | +0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 88,232 | 106,830 | +18,598 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 80,368 | 103,644 | +23,276 | 0.00 | 0.01 | +0.01 | buy |
| FRANKLIN RESOURCES INC | 0 | 101,827 | +101,827 | 0.00 | 0.00 | +0.00 | buy |
| Burkehill Global Management, LP | 0 | 100,000 | +100,000 | 0.00 | 0.08 | +0.08 | buy |
| SEVEN GRAND MANAGERS, LLC | 0 | 100,000 | +100,000 | 0.00 | 0.11 | +0.11 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 0 | 98,609 | +98,609 | 0.00 | 0.00 | +0.00 | buy |
| J. Goldman & Co LP | 0 | 98,033 | +98,033 | 0.00 | 0.07 | +0.07 | buy |
| Squarepoint Ops LLC | 258,275 | 94,685 | -163,590 | 0.00 | 0.00 | +0.00 | sell |
| ALGERT GLOBAL LLC | 0 | 88,030 | +88,030 | 0.00 | 0.02 | +0.02 | buy |
| RAYMOND JAMES FINANCIAL INC | 0 | 82,678 | +82,678 | 0.00 | 0.00 | +0.00 | buy |