| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VR Adviser, LLC | 0 | 16,216,216 | +16,216,216 | 0.00 | 2.44 | +2.44 | buy |
| Frazier Life Sciences Management, L.P. | 0 | 16,216,216 | +16,216,216 | 0.00 | 1.79 | +1.79 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 0 | 13,768,039 | +13,768,039 | 0.00 | 1.33 | +1.33 | buy |
| JANUS HENDERSON GROUP PLC | 0 | 8,178,092 | +8,178,092 | 0.00 | 0.01 | +0.01 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 223,845 | 7,816,926 | +7,593,081 | 0.13 | 4.55 | +4.42 | buy |
| T. Rowe Price Investment Management, Inc. | 0 | 7,374,359 | +7,374,359 | 0.00 | 0.01 | +0.01 | buy |
| Paradigm Biocapital Advisors LP | 0 | 7,250,000 | +7,250,000 | 0.00 | 0.65 | +0.65 | buy |
| Vivo Capital, LLC | 0 | 6,756,756 | +6,756,756 | 0.00 | 1.47 | +1.47 | buy |
| VANGUARD GROUP INC | 4,338,108 | 10,351,746 | +6,013,638 | 0.00 | 0.00 | +0.00 | buy |
| Logos Global Management LP | 0 | 5,900,000 | +5,900,000 | 0.00 | 1.60 | +1.60 | buy |
| 5AM Venture Management, LLC | 0 | 5,405,404 | +5,405,404 | 0.00 | 2.85 | +2.85 | buy |
| Artal Group S.A. | 4,721,194 | 9,630,810 | +4,909,616 | 0.25 | 0.58 | +0.33 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 4,319,484 | +4,319,484 | 0.00 | 0.03 | +0.03 | buy |
| MARSHALL WACE, LLP | 0 | 3,672,375 | +3,672,375 | 0.00 | 0.01 | +0.01 | buy |
| Woodline Partners LP | 890,793 | 4,134,036 | +3,243,243 | 0.02 | 0.09 | +0.08 | buy |
| Affinity Asset Advisors, LLC | 0 | 2,499,431 | +2,499,431 | 0.00 | 0.93 | +0.93 | buy |
| CITADEL ADVISORS LLC | 837,314 | 3,293,371 | +2,456,057 | 0.00 | 0.01 | +0.01 | buy |
| Soleus Capital Management, L.P. | 0 | 2,162,162 | +2,162,162 | 0.00 | 0.45 | +0.45 | buy |
| PFM Health Sciences, LP | 2,535,102 | 4,671,774 | +2,136,672 | 0.26 | 0.60 | +0.34 | buy |
| JPMORGAN CHASE & CO | 66,154 | 2,037,614 | +1,971,460 | 0.00 | 0.00 | +0.00 | buy |
| Sofinnova Investments, Inc. | 0 | 1,699,528 | +1,699,528 | 0.00 | 0.25 | +0.25 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,891,543 | 3,311,891 | +1,420,348 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 658,225 | 1,722,525 | +1,064,300 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 1,000,000 | +1,000,000 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 249,518 | 1,185,758 | +936,240 | 0.01 | 0.03 | +0.02 | buy |
| STATE STREET CORP | 1,670,685 | 2,458,180 | +787,495 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 663,870 | 1,333,421 | +669,551 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 1,582,016 | 2,192,636 | +610,620 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 95,078 | 672,119 | +577,041 | 0.00 | 0.02 | +0.01 | buy |
| TANG CAPITAL MANAGEMENT LLC | 100,000 | 550,000 | +450,000 | 0.02 | 0.13 | +0.11 | buy |
| Sio Capital Management, LLC | 2,427,184 | 2,874,536 | +447,352 | 1.74 | 2.56 | +0.82 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 0 | 324,248 | +324,248 | 0.00 | 0.00 | +0.00 | buy |
| Polar Asset Management Partners Inc. | 0 | 263,500 | +263,500 | 0.00 | 0.02 | +0.02 | buy |
| ROYAL BANK OF CANADA | 0 | 209,612 | +209,612 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 0 | 202,715 | +202,715 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 662,486 | 853,641 | +191,155 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 320,261 | 500,058 | +179,797 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 173,803 | +173,803 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 260,661 | 392,490 | +131,829 | 0.00 | 0.00 | +0.00 | buy |
| THRIVENT FINANCIAL FOR LUTHERANS | 0 | 101,756 | +101,756 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 55,997 | 150,826 | +94,829 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 138,651 | 230,487 | +91,836 | 0.00 | 0.00 | +0.00 | buy |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 0 | 68,300 | +68,300 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 115,242 | 168,412 | +53,170 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 82,490 | 130,407 | +47,917 | 0.00 | 0.00 | +0.00 | buy |
| EntryPoint Capital, LLC | 32,087 | 77,566 | +45,479 | 0.06 | 0.09 | +0.03 | buy |
| VIRTUS ADVISERS, LLC | 0 | 41,526 | +41,526 | 0.00 | 0.05 | +0.05 | buy |
| ALLIANCEBERNSTEIN L.P. | 118,310 | 154,490 | +36,180 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 0 | 36,135 | +36,135 | 0.00 | 0.01 | +0.01 | buy |
| RHUMBLINE ADVISERS | 121,509 | 154,615 | +33,106 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 15,786 | 48,701 | +32,915 | 0.00 | 0.00 | +0.00 | buy |
| BROWN WEALTH MANAGEMENT, LLC | 0 | 30,000 | +30,000 | 0.00 | 0.03 | +0.03 | buy |
| Atom Investors LP | 50,533 | 79,529 | +28,996 | 0.01 | 0.02 | +0.01 | buy |
| MetLife Investment Management, LLC | 42,040 | 68,331 | +26,291 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 0 | 22,606 | +22,606 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 52,355 | 73,358 | +21,003 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 37,976 | 58,836 | +20,860 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 0 | 16,682 | +16,682 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 0 | 16,277 | +16,277 | 0.00 | 0.00 | +0.00 | buy |
| ZACKS INVESTMENT MANAGEMENT | 0 | 14,188 | +14,188 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 0 | 13,288 | +13,288 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 24,684 | 36,145 | +11,461 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 28,371 | 39,026 | +10,655 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 37,697 | 47,861 | +10,164 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 2,945 | 12,649 | +9,704 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 11,790 | 21,479 | +9,689 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 0 | 7,758 | +7,758 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 25,603 | 32,053 | +6,450 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 4,957 | 11,050 | +6,093 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 29,254 | 32,811 | +3,557 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 6,494 | 9,748 | +3,254 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 0 | 3,100 | +3,100 | 0.00 | 0.00 | +0.00 | buy |
| COMERICA BANK | 0 | 2,861 | +2,861 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 4,632 | 6,688 | +2,056 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 0 | 1,868 | +1,868 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 25,087 | 26,849 | +1,762 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 29,013 | 30,527 | +1,514 | 0.01 | 0.01 | +0.00 | buy |
| Arax Advisory Partners | 0 | 846 | +846 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 314 | 786 | +472 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 18,417 | 18,859 | +442 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 22 | 354 | +332 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 0 | 125 | +125 | 0.00 | 0.00 | +0.00 | buy |
| Smartleaf Asset Management LLC | 0 | 108 | +108 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 8,113 | 8,172 | +59 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 15,619 | 15,653 | +34 | 0.00 | 0.00 | -0.00 | buy |
| SANDERS MORRIS HARRIS LLC | 12,000 | 12,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MassMutual Private Wealth & Trust, FSB | 333 | 333 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ARCH Venture Management, LLC | 11,055,554 | 11,055,554 | 0 | 28.37 | 9.81 | -18.56 | hold |
| Daiwa Securities Group Inc. | 354 | 354 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AH Capital Management, L.L.C. | 2,862,500 | 2,862,500 | 0 | 0.43 | 0.58 | +0.15 | hold |
| Pennant Investors, LP | 166,200 | 166,200 | 0 | 0.09 | 0.11 | +0.01 | hold |
| Aaron Wealth Advisors LLC | 27,735 | 27,735 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Covestor Ltd | 43 | 43 | 0 | 0.00 | 0.00 | 0.00 | hold |
| REGENTS OF THE UNIVERSITY OF CALIFORNIA | 236,236 | 236,236 | 0 | 0.14 | 0.30 | +0.16 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| AMALGAMATED BANK | 2,251 | 2,251 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GROUP ONE TRADING LLC | 2,161 | 2,161 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Avior Wealth Management, LLC | 18 | 0 | -18 | 0.00 | 0.00 | -0.00 | sell |
| GPS Wealth Strategies Group, LLC | 350 | 0 | -350 | 0.00 | 0.00 | -0.00 | sell |
| CORNERCAP INVESTMENT COUNSEL INC | 58,045 | 57,504 | -541 | 0.02 | 0.02 | +0.00 | sell |