| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Frazier Life Sciences Management, L.P. | 22,575,851 | 22,729,436 | +153,585 | 1.41 | 1.15 | -0.26 | buy |
| T. Rowe Price Investment Management, Inc. | 17,292,164 | 20,332,161 | +3,039,997 | 0.02 | 0.02 | +0.00 | buy |
| VR Adviser, LLC | 16,216,216 | 17,857,083 | +1,640,867 | 1.89 | 1.70 | -0.19 | buy |
| BlackRock, Inc. | 15,598,808 | 15,166,198 | -432,610 | 0.00 | 0.00 | -0.00 | sell |
| Logos Global Management LP | 13,000,000 | 15,000,000 | +2,000,000 | 3.17 | 2.54 | -0.62 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 12,315,004 | 14,502,004 | +2,187,000 | 0.68 | 0.69 | +0.01 | buy |
| VANGUARD GROUP INC | 12,727,425 | 12,695,597 | -31,828 | 0.00 | 0.00 | -0.00 | sell |
| Paradigm Biocapital Advisors LP | 10,802,354 | 11,907,182 | +1,104,828 | 0.68 | 0.65 | -0.04 | buy |
| ARCH Venture Management, LLC | 11,055,554 | 11,055,554 | 0 | 7.34 | 4.71 | -2.63 | hold |
| Siren, L.L.C. | 8,757,249 | 8,757,249 | 0 | 0.68 | 0.58 | -0.10 | hold |
| Vivo Capital, LLC | 6,756,756 | 6,756,756 | 0 | 1.23 | 0.88 | -0.35 | hold |
| 5AM Venture Management, LLC | 5,405,404 | 5,405,404 | 0 | 2.80 | 2.64 | -0.16 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 4,757,852 | 4,835,642 | +77,790 | 0.00 | 0.00 | -0.00 | buy |
| Affinity Asset Advisors, LLC | 3,341,519 | 4,085,787 | +744,268 | 0.72 | 0.77 | +0.05 | buy |
| STATE STREET CORP | 4,177,885 | 4,002,110 | -175,775 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 3,224,518 | 3,797,987 | +573,469 | 0.00 | 0.00 | +0.00 | buy |
| AH Capital Management, L.L.C. | 2,862,500 | 2,862,500 | 0 | 0.56 | 1.16 | +0.60 | hold |
| SILVERARC CAPITAL MANAGEMENT, LLC | 7,367,996 | 2,569,591 | -4,798,405 | 2.11 | 0.67 | -1.44 | sell |
| Soleus Capital Management, L.P. | 2,162,162 | 2,162,162 | 0 | 0.23 | 0.19 | -0.04 | hold |
| MARSHALL WACE, LLP | 2,027,027 | 2,074,425 | +47,398 | 0.00 | 0.00 | -0.00 | buy |
| Woodline Partners LP | 4,147,433 | 2,074,390 | -2,073,043 | 0.04 | 0.01 | -0.02 | sell |
| GOLDMAN SACHS GROUP INC | 1,936,257 | 1,819,849 | -116,408 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,441,656 | 1,696,593 | +254,937 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 1,838,128 | 1,693,423 | -144,705 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 1,948,825 | 1,571,325 | -377,500 | 0.00 | 0.00 | -0.00 | sell |
| TANG CAPITAL MANAGEMENT LLC | 1,190,012 | 1,502,915 | +312,903 | 0.09 | 0.10 | +0.01 | buy |
| NORTHERN TRUST CORP | 1,665,809 | 1,411,022 | -254,787 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 1,415,244 | 1,372,569 | -42,675 | 0.00 | 0.00 | -0.00 | sell |
| Sio Capital Management, LLC | 1,356,186 | 1,369,748 | +13,562 | 0.56 | 0.70 | +0.14 | buy |
| PFM Health Sciences, LP | 3,489,559 | 1,072,224 | -2,417,335 | 0.37 | 0.12 | -0.25 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 850,147 | 885,651 | +35,504 | 0.00 | 0.00 | -0.00 | buy |
| Jain Global LLC | 31,246 | 774,340 | +743,094 | 0.00 | 0.02 | +0.01 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 956,507 | 742,500 | -214,007 | 0.00 | 0.00 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 396,202 | 708,060 | +311,858 | 0.00 | 0.00 | +0.00 | buy |
| Octagon Capital Advisors LP | 2,250,000 | 700,000 | -1,550,000 | 0.65 | 0.20 | -0.46 | sell |
| ROYAL BANK OF CANADA | 0 | 605,390 | +605,390 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 548,269 | 555,194 | +6,925 | 0.00 | 0.00 | -0.00 | buy |
| Atom Investors LP | 810,455 | 549,959 | -260,496 | 0.14 | 0.06 | -0.07 | sell |
| UBS Group AG | 0 | 495,647 | +495,647 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 483,583 | 450,056 | -33,527 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 591,637 | 427,603 | -164,034 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 359,378 | 376,976 | +17,598 | 0.00 | 0.00 | -0.00 | buy |
| DAFNA Capital Management LLC | 340,000 | 350,000 | +10,000 | 0.13 | 0.12 | -0.01 | buy |
| BARCLAYS PLC | 249,594 | 323,480 | +73,886 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 236,950 | 308,637 | +71,687 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 256,032 | 256,032 | 0 | 0.00 | 0.00 | -0.00 | hold |
| IPG Investment Advisors LLC | 248,108 | 248,108 | 0 | 0.08 | 0.06 | -0.02 | hold |
| Creative Planning | 46,695 | 244,332 | +197,637 | 0.00 | 0.00 | +0.00 | buy |
| Prosight Management, LP | 947,110 | 240,295 | -706,815 | 0.43 | 0.07 | -0.35 | sell |
| ALLIANCEBERNSTEIN L.P. | 154,490 | 233,430 | +78,940 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 215,220 | 215,220 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RHUMBLINE ADVISERS | 209,443 | 201,516 | -7,927 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 343,100 | 179,200 | -163,900 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 113,583 | 172,226 | +58,643 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 156,160 | +156,160 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 210,283 | 152,827 | -57,456 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 135,816 | 136,896 | +1,080 | 0.00 | 0.00 | -0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 132,269 | +132,269 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 128,093 | 132,174 | +4,081 | 0.00 | 0.00 | -0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 238,705 | 123,120 | -115,585 | 0.03 | 0.01 | -0.02 | sell |
| Brevan Howard Capital Management LP | 0 | 122,671 | +122,671 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 117,284 | 122,128 | +4,844 | 0.00 | 0.00 | -0.00 | buy |
| Palumbo Wealth Management LLC | 43,331 | 120,466 | +77,135 | 0.02 | 0.05 | +0.03 | buy |
| MetLife Investment Management, LLC | 93,594 | 112,348 | +18,754 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 123,501 | 106,779 | -16,722 | 0.01 | 0.01 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 108,788 | 94,986 | -13,802 | 0.00 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 76,273 | 86,468 | +10,195 | 0.00 | 0.00 | -0.00 | buy |
| Cresset Asset Management, LLC | 81,569 | 79,913 | -1,656 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 152,229 | 71,409 | -80,820 | 0.00 | 0.00 | -0.00 | sell |
| Savant Capital, LLC | 0 | 68,221 | +68,221 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 69,427 | 67,901 | -1,526 | 0.00 | 0.00 | -0.00 | sell |
| Velan Capital Investment Management LP | 50,000 | 65,000 | +15,000 | 0.07 | 0.08 | +0.01 | buy |
| Graham Capital Management, L.P. | 42,009 | 63,824 | +21,815 | 0.00 | 0.00 | +0.00 | buy |
| IEQ CAPITAL, LLC | 40,322 | 61,928 | +21,606 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 62,421 | 61,459 | -962 | 0.02 | 0.03 | +0.00 | sell |
| Cerity Partners LLC | 35,504 | 57,817 | +22,313 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 56,710 | 56,897 | +187 | 0.01 | 0.01 | -0.00 | buy |
| CAPTRUST FINANCIAL ADVISORS | 47,625 | 54,111 | +6,486 | 0.00 | 0.00 | -0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 52,338 | 52,338 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PANAGORA ASSET MANAGEMENT INC | 0 | 49,606 | +49,606 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 52,541 | 46,175 | -6,366 | 0.00 | 0.00 | -0.00 | sell |
| CWM, LLC | 36,250 | 41,091 | +4,841 | 0.00 | 0.00 | -0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 26,859 | 37,360 | +10,501 | 0.00 | 0.00 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 0 | 37,300 | +37,300 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 36,797 | 36,797 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Vanguard Personalized Indexing Management, LLC | 15,804 | 36,362 | +20,558 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 35,075 | +35,075 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 258 | 32,647 | +32,389 | 0.00 | 0.00 | +0.00 | buy |
| Dynamic Technology Lab Private Ltd | 10,389 | 29,177 | +18,788 | 0.00 | 0.01 | +0.00 | buy |
| EP Wealth Advisors, LLC | 0 | 23,000 | +23,000 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 13,656 | 21,579 | +7,923 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 14,182 | 21,533 | +7,351 | 0.00 | 0.00 | +0.00 | buy |
| CIBC WORLD MARKETS CORP | 40,782 | 21,388 | -19,394 | 0.00 | 0.00 | -0.00 | sell |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 28,139 | 21,349 | -6,790 | 0.00 | 0.00 | -0.00 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 19,710 | 19,151 | -559 | 0.00 | 0.00 | -0.00 | sell |
| PRUDENTIAL FINANCIAL INC | 10,951 | 18,161 | +7,210 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 17,980 | 17,980 | 0 | 0.00 | 0.00 | -0.00 | hold |
| QUADRANT CAPITAL GROUP LLC | 1,030 | 17,546 | +16,516 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 16,682 | 16,682 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Ballentine Partners, LLC | 0 | 15,769 | +15,769 | 0.00 | 0.00 | +0.00 | buy |