| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| T. Rowe Price Investment Management, Inc. | 17,292,164 | 20,332,161 | +3,039,997 | 0.02 | 0.02 | +0.00 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 12,315,004 | 14,502,004 | +2,187,000 | 0.63 | 0.56 | -0.07 | buy |
| Logos Global Management LP | 13,000,000 | 15,000,000 | +2,000,000 | 3.17 | 2.54 | -0.62 | buy |
| VR Adviser, LLC | 16,216,216 | 17,857,083 | +1,640,867 | 1.89 | 1.70 | -0.19 | buy |
| Paradigm Biocapital Advisors LP | 10,802,354 | 11,907,182 | +1,104,828 | 0.68 | 0.65 | -0.04 | buy |
| Affinity Asset Advisors, LLC | 3,341,519 | 4,085,787 | +744,268 | 0.72 | 0.77 | +0.05 | buy |
| TANG CAPITAL MANAGEMENT LLC | 1,190,012 | 1,502,915 | +312,903 | 0.09 | 0.10 | +0.01 | buy |
| Frazier Life Sciences Management, L.P. | 22,575,851 | 22,729,436 | +153,585 | 1.41 | 1.15 | -0.26 | buy |
| Palumbo Wealth Management LLC | 43,331 | 120,466 | +77,135 | 0.02 | 0.05 | +0.03 | buy |
| Dynamic Technology Lab Private Ltd | 10,389 | 29,177 | +18,788 | 0.00 | 0.01 | +0.00 | buy |
| Velan Capital Investment Management LP | 50,000 | 65,000 | +15,000 | 0.07 | 0.08 | +0.01 | buy |
| Sio Capital Management, LLC | 1,356,186 | 1,369,748 | +13,562 | 0.55 | 0.66 | +0.11 | buy |
| DAFNA Capital Management LLC | 340,000 | 350,000 | +10,000 | 0.13 | 0.12 | -0.01 | buy |
| Pallas Capital Advisors LLC | 11,510 | 12,325 | +815 | 0.00 | 0.00 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 56,710 | 56,897 | +187 | 0.01 | 0.01 | -0.00 | buy |
| Virtus Investment Advisers, LLC | 62,421 | 61,459 | -962 | 0.02 | 0.03 | +0.00 | sell |
| Atom Investors LP | 810,455 | 549,959 | -260,496 | 0.14 | 0.06 | -0.07 | sell |
| Prosight Management, LP | 947,110 | 240,295 | -706,815 | 0.43 | 0.07 | -0.35 | sell |
| Woodline Partners LP | 4,147,433 | 2,074,390 | -2,073,043 | 0.04 | 0.01 | -0.02 | sell |
| PFM Health Sciences, LP | 3,489,559 | 1,072,224 | -2,417,335 | 0.35 | 0.12 | -0.23 | sell |
| Octagon Capital Advisors LP | 5,136,795 | 700,000 | -4,436,795 | 1.38 | 0.20 | -1.19 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 7,367,996 | 2,569,591 | -4,798,405 | 2.11 | 0.67 | -1.44 | sell |