| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| T. Rowe Price Investment Management, Inc. | 17,292,164 | 20,332,161 | +3,039,997 | 0.02 | 0.02 | +0.00 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 12,315,004 | 14,502,004 | +2,187,000 | 0.68 | 0.69 | +0.01 | buy |
| Logos Global Management LP | 13,000,000 | 15,000,000 | +2,000,000 | 3.17 | 2.54 | -0.62 | buy |
| VR Adviser, LLC | 16,216,216 | 17,857,083 | +1,640,867 | 1.89 | 1.70 | -0.19 | buy |
| Paradigm Biocapital Advisors LP | 10,802,354 | 11,907,182 | +1,104,828 | 0.68 | 0.65 | -0.04 | buy |
| Affinity Asset Advisors, LLC | 3,341,519 | 4,085,787 | +744,268 | 0.72 | 0.77 | +0.05 | buy |
| Jain Global LLC | 31,246 | 774,340 | +743,094 | 0.00 | 0.02 | +0.01 | buy |
| ROYAL BANK OF CANADA | 0 | 605,390 | +605,390 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 3,224,518 | 3,797,987 | +573,469 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 0 | 495,647 | +495,647 | 0.00 | 0.00 | +0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 1,190,012 | 1,502,915 | +312,903 | 0.09 | 0.10 | +0.01 | buy |
| AQR CAPITAL MANAGEMENT LLC | 396,202 | 708,060 | +311,858 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,441,656 | 1,696,593 | +254,937 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 46,695 | 244,332 | +197,637 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 156,160 | +156,160 | 0.00 | 0.00 | +0.00 | buy |
| Frazier Life Sciences Management, L.P. | 22,575,851 | 22,729,436 | +153,585 | 1.41 | 1.15 | -0.26 | buy |
| JANE STREET GROUP, LLC | 0 | 132,269 | +132,269 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 122,671 | +122,671 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 154,490 | 233,430 | +78,940 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 4,757,852 | 4,835,642 | +77,790 | 0.00 | 0.00 | -0.00 | buy |
| Palumbo Wealth Management LLC | 43,331 | 120,466 | +77,135 | 0.02 | 0.05 | +0.03 | buy |
| BARCLAYS PLC | 249,594 | 323,480 | +73,886 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 236,950 | 308,637 | +71,687 | 0.00 | 0.00 | +0.00 | buy |
| Savant Capital, LLC | 0 | 68,221 | +68,221 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 113,583 | 172,226 | +58,643 | 0.00 | 0.00 | +0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 0 | 49,606 | +49,606 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 2,027,027 | 2,074,425 | +47,398 | 0.00 | 0.00 | -0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 0 | 37,300 | +37,300 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 850,147 | 885,651 | +35,504 | 0.00 | 0.00 | -0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 35,075 | +35,075 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 258 | 32,647 | +32,389 | 0.00 | 0.00 | +0.00 | buy |
| EP Wealth Advisors, LLC | 0 | 23,000 | +23,000 | 0.00 | 0.00 | +0.00 | buy |
| Cerity Partners LLC | 35,504 | 57,817 | +22,313 | 0.00 | 0.00 | +0.00 | buy |
| Graham Capital Management, L.P. | 42,009 | 63,824 | +21,815 | 0.00 | 0.00 | +0.00 | buy |
| IEQ CAPITAL, LLC | 40,322 | 61,928 | +21,606 | 0.00 | 0.00 | +0.00 | buy |
| Vanguard Personalized Indexing Management, LLC | 15,804 | 36,362 | +20,558 | 0.00 | 0.00 | +0.00 | buy |
| Dynamic Technology Lab Private Ltd | 10,389 | 29,177 | +18,788 | 0.00 | 0.01 | +0.00 | buy |
| MetLife Investment Management, LLC | 93,594 | 112,348 | +18,754 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 359,378 | 376,976 | +17,598 | 0.00 | 0.00 | -0.00 | buy |
| QUADRANT CAPITAL GROUP LLC | 1,030 | 17,546 | +16,516 | 0.00 | 0.00 | +0.00 | buy |
| Ballentine Partners, LLC | 0 | 15,769 | +15,769 | 0.00 | 0.00 | +0.00 | buy |
| Velan Capital Investment Management LP | 50,000 | 65,000 | +15,000 | 0.07 | 0.08 | +0.01 | buy |
| Sio Capital Management, LLC | 1,356,186 | 1,369,748 | +13,562 | 0.56 | 0.70 | +0.14 | buy |
| Catalyst Funds Management Pty Ltd | 0 | 13,061 | +13,061 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 13,052 | +13,052 | 0.00 | 0.00 | +0.00 | buy |
| Qtron Investments LLC | 0 | 10,501 | +10,501 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 26,859 | 37,360 | +10,501 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 76,273 | 86,468 | +10,195 | 0.00 | 0.00 | -0.00 | buy |
| Mariner, LLC | 0 | 10,092 | +10,092 | 0.00 | 0.00 | +0.00 | buy |
| DAFNA Capital Management LLC | 340,000 | 350,000 | +10,000 | 0.13 | 0.12 | -0.01 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 13,656 | 21,579 | +7,923 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 14,182 | 21,533 | +7,351 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 10,951 | 18,161 | +7,210 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 548,269 | 555,194 | +6,925 | 0.00 | 0.00 | -0.00 | buy |
| CAPTRUST FINANCIAL ADVISORS | 47,625 | 54,111 | +6,486 | 0.00 | 0.00 | -0.00 | buy |
| SIGNATUREFD, LLC | 2,740 | 7,879 | +5,139 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 117,284 | 122,128 | +4,844 | 0.00 | 0.00 | -0.00 | buy |
| CWM, LLC | 36,250 | 41,091 | +4,841 | 0.00 | 0.00 | -0.00 | buy |
| Parallel Advisors, LLC | 0 | 4,227 | +4,227 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 128,093 | 132,174 | +4,081 | 0.00 | 0.00 | -0.00 | buy |
| Sterling Capital Management LLC | 3,171 | 5,192 | +2,021 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 1,700 | +1,700 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 213 | 1,817 | +1,604 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 0 | 1,587 | +1,587 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 9,460 | 10,943 | +1,483 | 0.00 | 0.00 | -0.00 | buy |
| Physician Wealth Advisors, Inc. | 0 | 1,192 | +1,192 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 135,816 | 136,896 | +1,080 | 0.00 | 0.00 | -0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 1,104 | 2,038 | +934 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 1,515 | 2,442 | +927 | 0.00 | 0.00 | +0.00 | buy |
| Pallas Capital Advisors LLC | 11,510 | 12,325 | +815 | 0.00 | 0.00 | -0.00 | buy |
| Hughes Financial Services, LLC | 0 | 490 | +490 | 0.00 | 0.00 | +0.00 | buy |
| MAI Capital Management | 0 | 467 | +467 | 0.00 | 0.00 | +0.00 | buy |
| Rialto Wealth Management, LLC | 0 | 413 | +413 | 0.00 | 0.00 | +0.00 | buy |
| Brooklyn Investment Group | 0 | 408 | +408 | 0.00 | 0.00 | +0.00 | buy |
| XPONANCE, INC. | 13,116 | 13,490 | +374 | 0.00 | 0.00 | -0.00 | buy |
| Rise Advisors, LLC | 0 | 365 | +365 | 0.00 | 0.00 | +0.00 | buy |
| Fortitude Family Office, LLC | 0 | 360 | +360 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 56,710 | 56,897 | +187 | 0.01 | 0.01 | -0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 245 | 385 | +140 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 388 | 508 | +120 | 0.00 | 0.00 | +0.00 | buy |
| IFP Advisors, Inc | 0 | 86 | +86 | 0.00 | 0.00 | +0.00 | buy |
| True Wealth Design, LLC | 1,094 | 1,158 | +64 | 0.00 | 0.00 | -0.00 | buy |
| Ameritas Investment Partners, Inc. | 17,980 | 17,980 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TD ASSET MANAGEMENT INC | 256,032 | 256,032 | 0 | 0.00 | 0.00 | -0.00 | hold |
| VOYA INVESTMENT MANAGEMENT LLC | 52,338 | 52,338 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ARCH Venture Management, LLC | 11,055,554 | 11,055,554 | 0 | 7.34 | 4.71 | -2.63 | hold |
| Neuberger Berman Group LLC | 13,158 | 13,158 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Daiwa Securities Group Inc. | 1,074 | 1,074 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AH Capital Management, L.L.C. | 2,862,500 | 2,862,500 | 0 | 0.56 | 1.16 | +0.60 | hold |
| IPG Investment Advisors LLC | 248,108 | 248,108 | 0 | 0.08 | 0.06 | -0.02 | hold |
| Vivo Capital, LLC | 6,756,756 | 6,756,756 | 0 | 1.23 | 0.88 | -0.35 | hold |
| AlphaCore Capital LLC | 10,000 | 10,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Steward Partners Investment Advisory, LLC | 200 | 200 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Walleye Capital LLC | 215,220 | 215,220 | 0 | 0.00 | 0.00 | -0.00 | hold |
| 5AM Venture Management, LLC | 5,405,404 | 5,405,404 | 0 | 2.80 | 2.64 | -0.16 | hold |
| Soleus Capital Management, L.P. | 2,162,162 | 2,162,162 | 0 | 0.23 | 0.19 | -0.04 | hold |
| Siren, L.L.C. | 8,757,249 | 8,757,249 | 0 | 0.68 | 0.58 | -0.10 | hold |
| Police & Firemen's Retirement System of New Jersey | 36,797 | 36,797 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GF FUND MANAGEMENT CO. LTD. | 7,240 | 7,240 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SEI INVESTMENTS CO | 16,682 | 16,682 | 0 | 0.00 | 0.00 | -0.00 | hold |