| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Frazier Life Sciences Management, L.P. | 24,675,188 | 24,975,188 | +300,000 | 10.27 | 9.96 | -0.31 | buy |
| T. Rowe Price Investment Management, Inc. | 21,259,646 | 21,185,839 | -73,807 | 0.24 | 0.25 | +0.02 | sell |
| BlackRock, Inc. | 20,151,406 | 21,154,146 | +1,002,740 | 0.01 | 0.01 | +0.00 | buy |
| RTW INVESTMENTS, LP | 16,157,175 | 17,946,754 | +1,789,579 | 2.60 | 2.81 | +0.21 | buy |
| VR Adviser, LLC | 16,382,812 | 17,891,812 | +1,509,000 | 9.89 | 9.94 | +0.04 | buy |
| STATE STREET CORP | 9,300,084 | 12,184,555 | +2,884,471 | 0.01 | 0.01 | +0.00 | buy |
| Logos Global Management LP | 11,150,000 | 12,150,000 | +1,000,000 | 9.29 | 9.58 | +0.29 | buy |
| Siren, L.L.C. | 11,244,246 | 11,397,781 | +153,535 | 5.04 | 4.24 | -0.80 | buy |
| Paradigm Biocapital Advisors LP | 10,392,702 | 9,550,000 | -842,702 | 3.44 | 3.28 | -0.16 | sell |
| ARCH Venture Management, LLC | 7,091,557 | 7,091,557 | 0 | 16.95 | 11.81 | -5.14 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 5,996,149 | 6,501,426 | +505,277 | 0.01 | 0.01 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,815,340 | 6,272,508 | +4,457,168 | 0.00 | 0.01 | +0.01 | buy |
| Cormorant Asset Management, LP | 5,800,000 | 6,000,000 | +200,000 | 4.73 | 5.63 | +0.90 | buy |
| Affinity Asset Advisors, LLC | 5,350,000 | 5,250,000 | -100,000 | 5.08 | 4.70 | -0.37 | sell |
| Vivo Capital, LLC | 12,151,480 | 4,127,412 | -8,024,068 | 16.34 | 6.90 | -9.44 | sell |
| ALLIANCEBERNSTEIN L.P. | 2,644,920 | 4,118,614 | +1,473,694 | 0.00 | 0.02 | +0.02 | buy |
| GOLDMAN SACHS GROUP INC | 4,875,186 | 3,822,113 | -1,053,073 | 0.01 | 0.01 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 3,055,897 | 3,048,737 | -7,160 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 1,490,080 | 2,883,417 | +1,393,337 | 0.00 | 0.00 | +0.00 | buy |
| AH Capital Management, L.L.C. | 2,862,500 | 2,862,500 | 0 | 3.59 | 0.37 | -3.22 | hold |
| Woodline Partners LP | 2,831,538 | 2,831,867 | +329 | 0.17 | 0.16 | -0.01 | buy |
| JENNISON ASSOCIATES LLC | 0 | 2,788,412 | +2,788,412 | 0.00 | 0.03 | +0.03 | buy |
| Soleus Capital Management, L.P. | 0 | 2,700,000 | +2,700,000 | 0.00 | 1.70 | +1.70 | buy |
| SAMLYN CAPITAL, LLC | 0 | 2,256,986 | +2,256,986 | 0.00 | 0.69 | +0.69 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 1,087,301 | 2,042,034 | +954,733 | 0.01 | 0.02 | +0.01 | buy |
| NORTHERN TRUST CORP | 1,701,623 | 1,958,120 | +256,497 | 0.00 | 0.00 | +0.00 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 1,944,790 | +1,944,790 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,898,224 | 1,944,790 | +46,566 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 1,654,497 | 1,936,462 | +281,965 | 0.02 | 0.02 | +0.00 | buy |
| Nuveen, LLC | 543,021 | 1,841,735 | +1,298,714 | 0.00 | 0.01 | +0.01 | buy |
| DIMENSIONAL FUND ADVISORS LP | 1,786,389 | 1,763,980 | -22,409 | 0.01 | 0.01 | -0.00 | sell |
| UBS Group AG | 1,848,580 | 1,596,662 | -251,918 | 0.01 | 0.00 | -0.00 | sell |
| STEMPOINT CAPITAL LP | 239,861 | 1,565,913 | +1,326,052 | 0.75 | 4.96 | +4.22 | buy |
| Rock Springs Capital Management LP | 1,103,469 | 1,402,150 | +298,681 | 1.05 | 1.25 | +0.20 | buy |
| Evergreen Quality Fund GP, Ltd. | 0 | 1,375,300 | +1,375,300 | 0.00 | 0.41 | +0.41 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 1,398,869 | 1,368,918 | -29,951 | 0.04 | 0.03 | -0.00 | sell |
| FRED ALGER MANAGEMENT, LLC | 236,824 | 1,308,455 | +1,071,631 | 0.02 | 0.08 | +0.06 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 1,851,812 | 1,263,026 | -588,786 | 3.53 | 2.58 | -0.96 | sell |
| Point72 Asset Management, L.P. | 693,309 | 1,247,203 | +553,894 | 0.02 | 0.03 | +0.02 | buy |
| First Turn Management, LLC | 867,639 | 1,221,721 | +354,082 | 1.57 | 2.39 | +0.83 | buy |
| FEDERATED HERMES, INC. | 1,005 | 1,082,262 | +1,081,257 | 0.00 | 0.03 | +0.03 | buy |
| Caption Management, LLC | 0 | 1,041,225 | +1,041,225 | 0.00 | 0.67 | +0.67 | buy |
| Integral Health Asset Management, LLC | 700,000 | 1,000,000 | +300,000 | 0.60 | 0.75 | +0.15 | buy |
| D. E. Shaw & Co., Inc. | 1,219,534 | 949,590 | -269,944 | 0.02 | 0.01 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 575,996 | 909,814 | +333,818 | 0.01 | 0.01 | +0.00 | buy |
| Invesco Ltd. | 759,932 | 864,527 | +104,595 | 0.00 | 0.00 | -0.00 | buy |
| Assenagon Asset Management S.A. | 0 | 812,876 | +812,876 | 0.00 | 0.02 | +0.02 | buy |
| MARSHALL WACE, LLP | 426,526 | 756,991 | +330,465 | 0.01 | 0.01 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 0 | 719,725 | +719,725 | 0.00 | 0.01 | +0.01 | buy |
| CITIGROUP INC | 49,110 | 713,534 | +664,424 | 0.00 | 0.01 | +0.01 | buy |
| Capital World Investors | 0 | 704,602 | +704,602 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 691,205 | 681,481 | -9,724 | 0.01 | 0.00 | -0.00 | sell |
| TD ASSET MANAGEMENT INC | 394,260 | 661,152 | +266,892 | 0.01 | 0.01 | +0.01 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 5,143,985 | 658,175 | -4,485,810 | 0.16 | 0.02 | -0.14 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 595,379 | 655,298 | +59,919 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 455,019 | 624,107 | +169,088 | 0.01 | 0.01 | -0.00 | buy |
| MORGAN STANLEY | 989,210 | 615,976 | -373,234 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 559,629 | 567,973 | +8,344 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 670,597 | 547,935 | -122,662 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 924,405 | 500,604 | -423,801 | 0.00 | 0.00 | -0.00 | sell |
| ORBIMED ADVISORS LLC | 0 | 495,900 | +495,900 | 0.00 | 0.17 | +0.17 | buy |
| Polymer Capital Management (HK) LTD | 357,670 | 478,020 | +120,350 | 0.81 | 0.89 | +0.08 | buy |
| Creative Planning | 418,834 | 405,879 | -12,955 | 0.00 | 0.00 | -0.00 | sell |
| Pictet Asset Management Holding SA | 208,273 | 393,288 | +185,015 | 0.00 | 0.01 | +0.00 | buy |
| Cinctive Capital Management LP | 171,920 | 391,642 | +219,722 | 0.18 | 0.29 | +0.10 | buy |
| Rhenman & Partners Asset Management AB | 0 | 349,000 | +349,000 | 0.00 | 0.60 | +0.60 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 216,614 | 347,656 | +131,042 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 253,554 | 340,847 | +87,293 | 0.00 | 0.01 | +0.00 | buy |
| EcoR1 Capital, LLC | 900,000 | 330,000 | -570,000 | 0.62 | 0.30 | -0.32 | sell |
| ROYAL BANK OF CANADA | 0 | 313,397 | +313,397 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 336,800 | 311,900 | -24,900 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 107,176 | 290,523 | +183,347 | 0.00 | 0.00 | +0.00 | buy |
| Longaeva Partners L.P. | 171,233 | 286,322 | +115,089 | 0.13 | 0.15 | +0.02 | buy |
| SIMPLEX TRADING, LLC | 252,747 | 276,988 | +24,241 | 0.13 | 0.13 | +0.01 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 259,007 | 266,140 | +7,133 | 0.00 | 0.00 | +0.00 | buy |
| E Fund Management Co., Ltd. | 32,605 | 265,381 | +232,776 | 0.02 | 0.11 | +0.09 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 354,575 | 265,199 | -89,376 | 4.08 | 3.39 | -0.69 | sell |
| Parkman Healthcare Partners LLC | 406,702 | 258,684 | -148,018 | 0.68 | 0.49 | -0.20 | sell |
| RHUMBLINE ADVISERS | 242,636 | 256,367 | +13,731 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 163,326 | 222,306 | +58,980 | 0.00 | 0.00 | +0.00 | buy |
| ArrowMark Colorado Holdings LLC | 79,052 | 210,927 | +131,875 | 0.03 | 0.16 | +0.13 | buy |
| Rafferty Asset Management, LLC | 251,963 | 206,463 | -45,500 | 0.02 | 0.01 | -0.01 | sell |
| Man Group plc | 0 | 202,553 | +202,553 | 0.00 | 0.01 | +0.01 | buy |
| Tidal Investments LLC | 226,877 | 182,438 | -44,439 | 0.01 | 0.01 | -0.00 | sell |
| TEMA ETFS LLC | 226,877 | 182,438 | -44,439 | 0.25 | 0.11 | -0.14 | sell |
| MOODY ALDRICH PARTNERS LLC | 0 | 177,939 | +177,939 | 0.00 | 0.59 | +0.59 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 204,449 | 176,273 | -28,176 | 0.00 | 0.00 | -0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 98,609 | 172,006 | +73,397 | 0.00 | 0.01 | +0.00 | buy |
| HighVista Strategies LLC | 181,069 | 160,328 | -20,741 | 0.81 | 0.67 | -0.14 | sell |
| Atom Investors LP | 345,587 | 159,811 | -185,776 | 0.40 | 0.26 | -0.14 | sell |
| Russell Investments Group, Ltd. | 14,296 | 155,553 | +141,257 | 0.00 | 0.00 | +0.00 | buy |
| Quantinno Capital Management LP | 0 | 149,297 | +149,297 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 133,444 | 148,195 | +14,751 | 0.00 | 0.00 | +0.00 | buy |
| NOMURA HOLDINGS INC | 0 | 142,500 | +142,500 | 0.00 | 0.01 | +0.01 | buy |
| Squarepoint Ops LLC | 94,685 | 135,233 | +40,548 | 0.00 | 0.00 | +0.00 | buy |
| PFM Health Sciences, LP | 0 | 134,088 | +134,088 | 0.00 | 0.21 | +0.21 | buy |
| BARCLAYS PLC | 45,079 | 127,843 | +82,764 | 0.00 | 0.00 | +0.00 | buy |
| Holocene Advisors, LP | 760,722 | 126,550 | -634,172 | 0.03 | 0.01 | -0.02 | sell |
| Corient Private Wealth LLC | 0 | 117,377 | +117,377 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 103,644 | 116,992 | +13,348 | 0.01 | 0.01 | +0.00 | buy |