| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| T. Rowe Price Investment Management, Inc. | 7,374,359 | 16,830,856 | +9,456,497 | 0.01 | 0.03 | +0.02 | buy |
| Logos Global Management LP | 5,900,000 | 10,900,000 | +5,000,000 | 1.60 | 3.33 | +1.73 | buy |
| JANUS HENDERSON GROUP PLC | 8,178,092 | 4,109,548 | +4,068,544 | 0.01 | 0.01 | 0.00 | sell |
| Paradigm Biocapital Advisors LP | 7,250,000 | 10,668,141 | +3,418,141 | 0.65 | 1.02 | +0.36 | buy |
| Frazier Life Sciences Management, L.P. | 16,216,216 | 19,391,687 | +3,175,471 | 1.79 | 2.12 | +0.33 | buy |
| PFM Health Sciences, LP | 4,671,774 | 4,876,911 | +205,137 | 0.55 | 0.75 | +0.21 | buy |
| Sofinnova Investments, Inc. | 1,699,528 | 1,842,668 | +143,140 | 0.21 | 0.40 | +0.19 | buy |
| China Universal Asset Management Co., Ltd. | 30,527 | 54,335 | +23,808 | 0.01 | 0.02 | +0.01 | buy |
| ALPS ADVISORS INC | 202,715 | 217,178 | +14,463 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 4,134,036 | 4,138,849 | +4,813 | 0.09 | 0.10 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 41,526 | 42,275 | +749 | 0.05 | 0.05 | +0.01 | buy |
| Palumbo Wealth Management LLC | 68,345 | 39,723 | -28,622 | 0.07 | 0.04 | -0.03 | sell |
| TANG CAPITAL MANAGEMENT LLC | 550,000 | 502,915 | -47,085 | 0.13 | 0.10 | -0.03 | sell |
| Polar Asset Management Partners Inc. | 263,500 | 200,300 | -63,200 | 0.01 | 0.01 | -0.00 | sell |
| Sio Capital Management, LLC | 2,874,536 | 2,219,186 | -655,350 | 1.84 | 2.40 | +0.57 | sell |
| Prosight Management, LP | 2,750,000 | 1,984,010 | -765,990 | 1.94 | 1.33 | -0.61 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 7,816,926 | 6,946,488 | -870,438 | 4.55 | 4.27 | -0.28 | sell |