| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Frazier Life Sciences Management, L.P. | 16,216,216 | 19,391,687 | +3,175,471 | 1.79 | 2.12 | +0.33 | buy |
| T. Rowe Price Investment Management, Inc. | 7,374,359 | 16,830,856 | +9,456,497 | 0.01 | 0.03 | +0.02 | buy |
| VR Adviser, LLC | 16,216,216 | 16,216,216 | 0 | 2.44 | 2.32 | -0.12 | hold |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 13,768,039 | 13,768,039 | 0 | 1.33 | 1.35 | +0.02 | hold |
| VANGUARD GROUP INC | 10,351,746 | 13,288,740 | +2,936,994 | 0.00 | 0.00 | +0.00 | buy |
| ARCH Venture Management, LLC | 11,055,554 | 11,055,554 | 0 | 9.81 | 11.58 | +1.78 | hold |
| Logos Global Management LP | 5,900,000 | 10,900,000 | +5,000,000 | 1.60 | 3.33 | +1.73 | buy |
| Paradigm Biocapital Advisors LP | 7,250,000 | 10,668,141 | +3,418,141 | 0.65 | 1.02 | +0.36 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 7,816,926 | 6,946,488 | -870,438 | 4.55 | 4.27 | -0.28 | sell |
| Vivo Capital, LLC | 6,756,756 | 6,756,756 | 0 | 1.47 | 1.53 | +0.05 | hold |
| STATE STREET CORP | 2,458,180 | 6,027,620 | +3,569,440 | 0.00 | 0.00 | +0.00 | buy |
| 5AM Venture Management, LLC | 5,405,404 | 5,405,404 | 0 | 2.85 | 3.05 | +0.20 | hold |
| PFM Health Sciences, LP | 4,671,774 | 4,876,911 | +205,137 | 0.60 | 0.76 | +0.16 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 3,311,891 | 4,502,698 | +1,190,807 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 3,293,371 | 4,315,673 | +1,022,302 | 0.01 | 0.01 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 1,721,710 | 4,220,671 | +2,498,961 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 4,134,036 | 4,138,849 | +4,813 | 0.09 | 0.10 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 8,178,092 | 4,109,548 | -4,068,544 | 0.01 | 0.01 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 2,192,636 | 3,230,356 | +1,037,720 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 3,672,375 | 3,027,727 | -644,648 | 0.01 | 0.01 | -0.00 | sell |
| AH Capital Management, L.L.C. | 2,862,500 | 2,862,500 | 0 | 0.58 | 0.69 | +0.11 | hold |
| Affinity Asset Advisors, LLC | 2,499,431 | 2,499,431 | 0 | 0.93 | 1.06 | +0.13 | hold |
| MILLENNIUM MANAGEMENT LLC | 814,773 | 2,410,550 | +1,595,777 | 0.00 | 0.01 | +0.00 | buy |
| Sio Capital Management, LLC | 2,874,536 | 2,219,186 | -655,350 | 2.56 | 2.71 | +0.16 | sell |
| Soleus Capital Management, L.P. | 2,162,162 | 2,162,162 | 0 | 0.45 | 0.49 | +0.04 | hold |
| JPMORGAN CHASE & CO | 2,037,614 | 2,024,514 | -13,100 | 0.00 | 0.00 | +0.00 | sell |
| Prosight Management, LP | 2,750,000 | 1,984,010 | -765,990 | 1.94 | 1.37 | -0.57 | sell |
| Sofinnova Investments, Inc. | 1,699,528 | 1,842,668 | +143,140 | 0.25 | 0.42 | +0.16 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,333,421 | 1,723,630 | +390,209 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 853,641 | 1,537,949 | +684,308 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 804,482 | 1,344,913 | +540,431 | 0.00 | 0.01 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 1,575,100 | 1,291,000 | -284,100 | 0.01 | 0.01 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 500,058 | 1,208,299 | +708,241 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,000,000 | 1,000,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Walleye Capital LLC | 672,119 | 949,557 | +277,438 | 0.02 | 0.03 | +0.01 | buy |
| MORGAN STANLEY | 1,722,525 | 873,141 | -849,384 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 843,300 | 793,200 | -50,100 | 0.00 | 0.01 | +0.00 | sell |
| Bank of New York Mellon Corp | 392,490 | 509,551 | +117,061 | 0.00 | 0.00 | +0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 550,000 | 502,915 | -47,085 | 0.13 | 0.10 | -0.03 | sell |
| D. E. Shaw & Co., Inc. | 315,553 | 483,826 | +168,273 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0 | 364,085 | +364,085 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 47,273 | 343,930 | +296,657 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 0 | 329,700 | +329,700 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 230,487 | 306,129 | +75,642 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 130,407 | 284,206 | +153,799 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 0 | 240,746 | +240,746 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 0 | 232,170 | +232,170 | 0.00 | 0.00 | +0.00 | buy |
| FRED ALGER MANAGEMENT, LLC | 0 | 230,854 | +230,854 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 45,126 | 230,622 | +185,496 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 202,715 | 217,178 | +14,463 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 154,615 | 212,488 | +57,873 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 73,358 | 206,639 | +133,281 | 0.00 | 0.00 | +0.00 | buy |
| Polar Asset Management Partners Inc. | 263,500 | 200,300 | -63,200 | 0.02 | 0.01 | -0.00 | sell |
| Verition Fund Management LLC | 22,606 | 169,460 | +146,854 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 8,172 | 160,436 | +152,264 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 154,490 | 154,490 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CITIGROUP INC | 48,701 | 134,367 | +85,666 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 9,748 | 122,251 | +112,503 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 0 | 121,719 | +121,719 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 40,675 | 106,221 | +65,546 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 68,331 | 103,686 | +35,355 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 55,722 | 101,924 | +46,202 | 0.00 | 0.00 | +0.00 | buy |
| THRIVENT FINANCIAL FOR LUTHERANS | 101,756 | 101,756 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Corebridge Financial, Inc. | 60,677 | 94,904 | +34,227 | 0.00 | 0.00 | +0.00 | buy |
| EntryPoint Capital, LLC | 77,566 | 75,647 | -1,919 | 0.09 | 0.12 | +0.03 | sell |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 0 | 70,000 | +70,000 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 47,861 | 67,661 | +19,800 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 0 | 65,872 | +65,872 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 22,890 | 64,946 | +42,056 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 1,035,227 | 63,599 | -971,628 | 0.01 | 0.00 | -0.01 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 63,286 | +63,286 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 113,383 | 60,848 | -52,535 | 0.02 | 0.01 | -0.01 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 59,499 | +59,499 | 0.00 | 0.00 | +0.00 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 104,481 | 59,384 | -45,097 | 0.01 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 36,145 | 59,138 | +22,993 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 30,527 | 54,335 | +23,808 | 0.01 | 0.02 | +0.01 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 39,026 | 53,795 | +14,769 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 32,053 | 51,599 | +19,546 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 26,849 | 50,234 | +23,385 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 0 | 48,632 | +48,632 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 47,830 | +47,830 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 0 | 47,626 | +47,626 | 0.00 | 0.00 | +0.00 | buy |
| Valence8 US LP | 0 | 46,923 | +46,923 | 0.00 | 0.06 | +0.06 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 0 | 42,361 | +42,361 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 41,526 | 42,275 | +749 | 0.05 | 0.05 | +0.01 | buy |
| Palumbo Wealth Management LLC | 68,345 | 39,723 | -28,622 | 0.07 | 0.04 | -0.03 | sell |
| Invesco Ltd. | 32,811 | 37,381 | +4,570 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 0 | 35,960 | +35,960 | 0.00 | 0.00 | +0.00 | buy |
| BROWN WEALTH MANAGEMENT, LLC | 30,000 | 30,000 | 0 | 0.03 | 0.03 | +0.00 | hold |
| Aaron Wealth Advisors LLC | 27,735 | 27,735 | 0 | 0.01 | 0.01 | -0.00 | hold |
| VICTORY CAPITAL MANAGEMENT INC | 21,479 | 21,079 | -400 | 0.00 | 0.00 | +0.00 | sell |
| AMERIPRISE FINANCIAL INC | 173,803 | 20,928 | -152,875 | 0.00 | 0.00 | -0.00 | sell |
| Creative Planning | 16,277 | 20,014 | +3,737 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 18,859 | 18,859 | 0 | 0.00 | 0.00 | +0.00 | hold |
| HSBC HOLDINGS PLC | 15,653 | 18,256 | +2,603 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 11,050 | 17,980 | +6,930 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 13,288 | 17,665 | +4,377 | 0.00 | 0.00 | +0.00 | buy |
| Pictet Asset Management Holding SA | 0 | 17,302 | +17,302 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 16,682 | 16,682 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Virtu Financial LLC | 36,135 | 15,685 | -20,450 | 0.01 | 0.00 | -0.00 | sell |