| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Frazier Life Sciences Management, L.P. | 22,729,436 | 22,729,436 | 0 | 1.15 | 1.48 | +0.33 | hold |
| T. Rowe Price Investment Management, Inc. | 20,332,161 | 20,231,906 | -100,255 | 0.02 | 0.03 | +0.01 | sell |
| VR Adviser, LLC | 17,857,083 | 17,857,083 | 0 | 1.70 | 2.19 | +0.49 | hold |
| Logos Global Management LP | 15,000,000 | 15,150,000 | +150,000 | 2.54 | 3.26 | +0.72 | buy |
| BlackRock, Inc. | 15,166,198 | 15,071,319 | -94,879 | 0.00 | 0.00 | +0.00 | sell |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 14,502,004 | 14,502,004 | 0 | 0.69 | 0.96 | +0.26 | hold |
| Paradigm Biocapital Advisors LP | 11,907,182 | 13,560,017 | +1,652,835 | 0.65 | 0.87 | +0.23 | buy |
| VANGUARD GROUP INC | 12,695,597 | 12,811,832 | +116,235 | 0.00 | 0.00 | +0.00 | buy |
| ARCH Venture Management, LLC | 11,055,554 | 11,055,554 | 0 | 4.71 | 4.89 | +0.18 | hold |
| Vivo Capital, LLC | 6,756,756 | 9,273,428 | +2,516,672 | 0.88 | 1.63 | +0.75 | buy |
| Siren, L.L.C. | 8,757,249 | 8,757,249 | 0 | 0.58 | 0.75 | +0.17 | hold |
| 5AM Venture Management, LLC | 5,405,404 | 5,405,404 | 0 | 2.64 | 4.32 | +1.68 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 4,835,642 | 4,848,563 | +12,921 | 0.00 | 0.00 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 4,085,787 | 4,285,787 | +200,000 | 0.77 | 0.87 | +0.10 | buy |
| STATE STREET CORP | 4,002,110 | 4,029,256 | +27,146 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 3,797,987 | 2,914,819 | -883,168 | 0.00 | 0.01 | +0.00 | sell |
| AH Capital Management, L.L.C. | 2,862,500 | 2,862,500 | 0 | 1.16 | 0.45 | -0.71 | hold |
| GOLDMAN SACHS GROUP INC | 1,819,849 | 2,517,188 | +697,339 | 0.00 | 0.00 | +0.00 | buy |
| Soleus Capital Management, L.P. | 2,162,162 | 2,162,162 | 0 | 0.19 | 0.25 | +0.06 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,696,593 | 1,725,356 | +28,763 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 2,074,390 | 1,534,390 | -540,000 | 0.01 | 0.02 | +0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 1,571,325 | 1,534,274 | -37,051 | 0.00 | 0.00 | +0.00 | sell |
| TANG CAPITAL MANAGEMENT LLC | 1,502,915 | 1,502,915 | 0 | 0.10 | 0.13 | +0.03 | hold |
| NORTHERN TRUST CORP | 1,411,022 | 1,443,511 | +32,489 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 1,693,423 | 1,371,935 | -321,488 | 0.00 | 0.00 | +0.00 | sell |
| Sio Capital Management, LLC | 1,369,748 | 1,369,748 | 0 | 0.70 | 0.76 | +0.06 | hold |
| SILVERARC CAPITAL MANAGEMENT, LLC | 2,569,591 | 1,368,075 | -1,201,516 | 0.67 | 0.43 | -0.24 | sell |
| JPMORGAN CHASE & CO | 1,372,569 | 1,269,042 | -103,527 | 0.00 | 0.00 | +0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 742,500 | 1,015,005 | +272,505 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 605,390 | 668,756 | +63,366 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 708,060 | 664,339 | -43,721 | 0.00 | 0.00 | +0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 885,651 | 600,580 | -285,071 | 0.00 | 0.00 | +0.00 | sell |
| Bank of New York Mellon Corp | 555,194 | 573,935 | +18,741 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 2,074,425 | 526,009 | -1,548,416 | 0.00 | 0.00 | -0.00 | sell |
| Nuveen, LLC | 450,056 | 450,056 | 0 | 0.00 | 0.00 | +0.00 | hold |
| FMR LLC | 376,976 | 419,554 | +42,578 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 132,269 | 386,069 | +253,800 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 244,332 | 350,314 | +105,982 | 0.00 | 0.00 | +0.00 | buy |
| DAFNA Capital Management LLC | 350,000 | 350,000 | 0 | 0.12 | 0.19 | +0.07 | hold |
| TWO SIGMA INVESTMENTS, LP | 427,603 | 347,767 | -79,836 | 0.00 | 0.00 | +0.00 | sell |
| CITADEL ADVISORS LLC | 0 | 341,799 | +341,799 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 172,226 | 282,025 | +109,799 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 323,480 | 268,252 | -55,228 | 0.00 | 0.00 | +0.00 | sell |
| TD ASSET MANAGEMENT INC | 256,032 | 256,032 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 233,430 | 233,430 | 0 | 0.00 | 0.00 | +0.00 | hold |
| IPG Investment Advisors LLC | 248,108 | 227,994 | -20,114 | 0.06 | 0.09 | +0.03 | sell |
| RHUMBLINE ADVISERS | 201,516 | 201,550 | +34 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 0 | 165,895 | +165,895 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 136,896 | 158,601 | +21,705 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 152,827 | 132,499 | -20,328 | 0.00 | 0.00 | +0.00 | sell |
| Palumbo Wealth Management LLC | 120,466 | 124,533 | +4,067 | 0.05 | 0.09 | +0.04 | buy |
| SIMPLEX TRADING, LLC | 32,647 | 111,337 | +78,690 | 0.00 | 0.01 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 308,637 | 107,242 | -201,395 | 0.00 | 0.00 | -0.00 | sell |
| PANAGORA ASSET MANAGEMENT INC | 49,606 | 102,379 | +52,773 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 215,220 | 100,931 | -114,289 | 0.00 | 0.00 | -0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 13,052 | 100,459 | +87,407 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 86,468 | 93,580 | +7,112 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 122,671 | 90,746 | -31,925 | 0.00 | 0.00 | +0.00 | sell |
| MetLife Investment Management, LLC | 112,348 | 90,050 | -22,298 | 0.00 | 0.00 | +0.00 | sell |
| Squarepoint Ops LLC | 0 | 84,701 | +84,701 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 94,986 | 81,534 | -13,452 | 0.00 | 0.00 | +0.00 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 132,174 | 79,975 | -52,199 | 0.00 | 0.00 | -0.00 | sell |
| Cresset Asset Management, LLC | 79,913 | 79,913 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Virtus Investment Advisers, LLC | 61,459 | 74,371 | +12,912 | 0.03 | 0.05 | +0.02 | buy |
| TWO SIGMA ADVISERS, LP | 179,200 | 72,400 | -106,800 | 0.00 | 0.00 | -0.00 | sell |
| Velan Capital Investment Management LP | 65,000 | 65,000 | 0 | 0.08 | 0.13 | +0.05 | hold |
| Savant Capital, LLC | 68,221 | 63,754 | -4,467 | 0.00 | 0.00 | +0.00 | sell |
| IEQ CAPITAL, LLC | 61,928 | 63,214 | +1,286 | 0.00 | 0.00 | -0.00 | buy |
| Graham Capital Management, L.P. | 63,824 | 62,705 | -1,119 | 0.00 | 0.01 | +0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 123,120 | 62,678 | -60,442 | 0.01 | 0.01 | +0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 67,901 | 61,801 | -6,100 | 0.00 | 0.00 | +0.00 | sell |
| Cerity Partners LLC | 57,817 | 61,415 | +3,598 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 37,360 | 60,452 | +23,092 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 36,797 | 59,153 | +22,356 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 56,897 | 49,723 | -7,174 | 0.01 | 0.01 | +0.00 | sell |
| ProShare Advisors LLC | 46,175 | 39,786 | -6,389 | 0.00 | 0.00 | +0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 21,579 | 38,161 | +16,582 | 0.00 | 0.00 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 37,300 | 37,300 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AMERICAN CENTURY COMPANIES INC | 0 | 35,454 | +35,454 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 35,075 | 35,075 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Vanguard Personalized Indexing Management, LLC | 36,362 | 34,802 | -1,560 | 0.00 | 0.00 | +0.00 | sell |
| Engineers Gate Manager LP | 0 | 34,523 | +34,523 | 0.00 | 0.00 | +0.00 | buy |
| Qtron Investments LLC | 10,501 | 33,593 | +23,092 | 0.00 | 0.01 | +0.01 | buy |
| CWM, LLC | 41,091 | 33,300 | -7,791 | 0.00 | 0.00 | +0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 52,338 | 33,187 | -19,151 | 0.00 | 0.00 | +0.00 | sell |
| CAPTRUST FINANCIAL ADVISORS | 54,111 | 22,901 | -31,210 | 0.00 | 0.00 | -0.00 | sell |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 21,349 | 22,143 | +794 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 19,151 | 18,532 | -619 | 0.00 | 0.00 | +0.00 | sell |
| PRUDENTIAL FINANCIAL INC | 18,161 | 18,161 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Ameritas Investment Partners, Inc. | 17,980 | 17,980 | 0 | 0.00 | 0.00 | +0.00 | hold |
| QUADRANT CAPITAL GROUP LLC | 17,546 | 17,546 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SEI INVESTMENTS CO | 16,682 | 16,682 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Legal & General Group Plc | 15,428 | 15,428 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CITIGROUP INC | 71,409 | 15,246 | -56,163 | 0.00 | 0.00 | -0.00 | sell |
| CROWLEY WEALTH MANAGEMENT, INC. | 0 | 15,000 | +15,000 | 0.00 | 0.03 | +0.03 | buy |
| SG Americas Securities, LLC | 0 | 14,605 | +14,605 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 0 | 14,378 | +14,378 | 0.00 | 0.00 | +0.00 | buy |
| Ballentine Partners, LLC | 15,769 | 13,996 | -1,773 | 0.00 | 0.00 | +0.00 | sell |
| Pallas Capital Advisors LLC | 12,325 | 13,884 | +1,559 | 0.00 | 0.00 | +0.00 | buy |
| XPONANCE, INC. | 13,490 | 13,490 | 0 | 0.00 | 0.00 | +0.00 | hold |