| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Vivo Capital, LLC | 6,756,756 | 9,273,428 | +2,516,672 | 0.88 | 1.63 | +0.75 | buy |
| Paradigm Biocapital Advisors LP | 11,907,182 | 13,560,017 | +1,652,835 | 0.65 | 0.87 | +0.23 | buy |
| GOLDMAN SACHS GROUP INC | 1,819,849 | 2,517,188 | +697,339 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 0 | 341,799 | +341,799 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 742,500 | 1,015,005 | +272,505 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 132,269 | 386,069 | +253,800 | 0.00 | 0.00 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 4,085,787 | 4,285,787 | +200,000 | 0.77 | 0.87 | +0.10 | buy |
| DEUTSCHE BANK AG\ | 0 | 165,895 | +165,895 | 0.00 | 0.00 | +0.00 | buy |
| Logos Global Management LP | 15,000,000 | 15,150,000 | +150,000 | 2.54 | 3.26 | +0.72 | buy |
| VANGUARD GROUP INC | 12,695,597 | 12,811,832 | +116,235 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 172,226 | 282,025 | +109,799 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 244,332 | 350,314 | +105,982 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 13,052 | 100,459 | +87,407 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 84,701 | +84,701 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 32,647 | 111,337 | +78,690 | 0.00 | 0.01 | +0.00 | buy |
| ROYAL BANK OF CANADA | 605,390 | 668,756 | +63,366 | 0.00 | 0.00 | +0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 49,606 | 102,379 | +52,773 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 376,976 | 419,554 | +42,578 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 0 | 35,454 | +35,454 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 0 | 34,523 | +34,523 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 1,411,022 | 1,443,511 | +32,489 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,696,593 | 1,725,356 | +28,763 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 4,002,110 | 4,029,256 | +27,146 | 0.00 | 0.00 | +0.00 | buy |
| Qtron Investments LLC | 10,501 | 33,593 | +23,092 | 0.00 | 0.01 | +0.01 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 37,360 | 60,452 | +23,092 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 36,797 | 59,153 | +22,356 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 136,896 | 158,601 | +21,705 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 555,194 | 573,935 | +18,741 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 21,579 | 38,161 | +16,582 | 0.00 | 0.00 | +0.00 | buy |
| CROWLEY WEALTH MANAGEMENT, INC. | 0 | 15,000 | +15,000 | 0.00 | 0.03 | +0.03 | buy |
| SG Americas Securities, LLC | 0 | 14,605 | +14,605 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 0 | 14,378 | +14,378 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 4,835,642 | 4,848,563 | +12,921 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 61,459 | 74,371 | +12,912 | 0.03 | 0.05 | +0.02 | buy |
| GTS SECURITIES LLC | 0 | 10,775 | +10,775 | 0.00 | 0.00 | +0.00 | buy |
| Arax Advisory Partners | 0 | 7,681 | +7,681 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 86,468 | 93,580 | +7,112 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 5,192 | 11,977 | +6,785 | 0.00 | 0.00 | +0.00 | buy |
| Palumbo Wealth Management LLC | 120,466 | 124,533 | +4,067 | 0.05 | 0.09 | +0.04 | buy |
| Cerity Partners LLC | 57,817 | 61,415 | +3,598 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 10,070 | 13,176 | +3,106 | 0.00 | 0.00 | +0.00 | buy |
| Pallas Capital Advisors LLC | 12,325 | 13,884 | +1,559 | 0.00 | 0.00 | +0.00 | buy |
| Optiver Holding B.V. | 0 | 1,424 | +1,424 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 1,700 | 3,054 | +1,354 | 0.00 | 0.00 | +0.00 | buy |
| IEQ CAPITAL, LLC | 61,928 | 63,214 | +1,286 | 0.00 | 0.00 | -0.00 | buy |
| SUMMIT SECURITIES GROUP LLC | 0 | 1,072 | +1,072 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 12,496 | 13,380 | +884 | 0.00 | 0.00 | +0.00 | buy |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 21,349 | 22,143 | +794 | 0.00 | 0.00 | +0.00 | buy |
| Wilmington Savings Fund Society, FSB | 0 | 431 | +431 | 0.00 | 0.00 | +0.00 | buy |
| Sunbelt Securities, Inc. | 0 | 162 | +162 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 0 | 100 | +100 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 201,516 | 201,550 | +34 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 10,943 | 10,967 | +24 | 0.00 | 0.00 | +0.00 | buy |
| Cloud Capital Management, LLC | 0 | 21 | +21 | 0.00 | 0.00 | 0.00 | buy |
| IFP Advisors, Inc | 86 | 94 | +8 | 0.00 | 0.00 | +0.00 | buy |
| Clearstead Advisors, LLC | 0 | 2 | +2 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 1,817 | 1,818 | +1 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 17,980 | 17,980 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TD ASSET MANAGEMENT INC | 256,032 | 256,032 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 233,430 | 233,430 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PRUDENTIAL FINANCIAL INC | 18,161 | 18,161 | 0 | 0.00 | 0.00 | +0.00 | hold |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 35,075 | 35,075 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TANG CAPITAL MANAGEMENT LLC | 1,502,915 | 1,502,915 | 0 | 0.10 | 0.13 | +0.03 | hold |
| ARCH Venture Management, LLC | 11,055,554 | 11,055,554 | 0 | 4.71 | 4.89 | +0.18 | hold |
| DAFNA Capital Management LLC | 350,000 | 350,000 | 0 | 0.12 | 0.19 | +0.07 | hold |
| Daiwa Securities Group Inc. | 1,074 | 1,074 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Sio Capital Management, LLC | 1,369,748 | 1,369,748 | 0 | 0.70 | 0.76 | +0.06 | hold |
| AH Capital Management, L.L.C. | 2,862,500 | 2,862,500 | 0 | 1.16 | 0.45 | -0.71 | hold |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 14,502,004 | 14,502,004 | 0 | 0.69 | 0.96 | +0.26 | hold |
| VR Adviser, LLC | 17,857,083 | 17,857,083 | 0 | 1.70 | 2.19 | +0.49 | hold |
| XPONANCE, INC. | 13,490 | 13,490 | 0 | 0.00 | 0.00 | +0.00 | hold |
| QUADRANT CAPITAL GROUP LLC | 17,546 | 17,546 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Parallel Advisors, LLC | 4,227 | 4,227 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AlphaCore Capital LLC | 10,000 | 10,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Steward Partners Investment Advisory, LLC | 200 | 200 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Cresset Asset Management, LLC | 79,913 | 79,913 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Physician Wealth Advisors, Inc. | 1,192 | 1,192 | 0 | 0.00 | 0.00 | +0.00 | hold |
| 5AM Venture Management, LLC | 5,405,404 | 5,405,404 | 0 | 2.64 | 4.32 | +1.68 | hold |
| Soleus Capital Management, L.P. | 2,162,162 | 2,162,162 | 0 | 0.19 | 0.25 | +0.06 | hold |
| Rise Advisors, LLC | 365 | 365 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Velan Capital Investment Management LP | 65,000 | 65,000 | 0 | 0.08 | 0.13 | +0.05 | hold |
| SBI Securities Co., Ltd. | 508 | 508 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Nuveen, LLC | 450,056 | 450,056 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Frazier Life Sciences Management, L.P. | 22,729,436 | 22,729,436 | 0 | 1.15 | 1.48 | +0.33 | hold |
| Covestor Ltd | 40 | 40 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Susquehanna Portfolio Strategies, LLC | 37,300 | 37,300 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Siren, L.L.C. | 8,757,249 | 8,757,249 | 0 | 0.58 | 0.75 | +0.17 | hold |
| Hughes Financial Services, LLC | 490 | 490 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Rialto Wealth Management, LLC | 413 | 413 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SEI INVESTMENTS CO | 16,682 | 16,682 | 0 | 0.00 | 0.00 | +0.00 | hold |
| US BANCORP \DE\ | 1,587 | 1,587 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Legal & General Group Plc | 15,428 | 15,428 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ROTHSCHILD INVESTMENT LLC | 385 | 385 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AMALGAMATED BANK | 6,343 | 6,343 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MACKENZIE FINANCIAL CORP | 11,141 | 11,141 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 2,038 | 2,038 | 0 | 0.00 | 0.00 | +0.00 | hold |
| True Wealth Design, LLC | 1,158 | 1,116 | -42 | 0.00 | 0.00 | +0.00 | sell |
| EverSource Wealth Advisors, LLC | 2,442 | 2,390 | -52 | 0.00 | 0.00 | +0.00 | sell |
| Fortitude Family Office, LLC | 360 | 0 | -360 | 0.00 | 0.00 | -0.00 | sell |
| Brooklyn Investment Group | 408 | 0 | -408 | 0.00 | 0.00 | -0.00 | sell |