| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Logos Global Management LP | 10,900,000 | 12,500,000 | +1,600,000 | 3.33 | 3.67 | +0.34 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 6,946,488 | 7,543,901 | +597,413 | 4.27 | 4.23 | -0.04 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 70,000 | 229,600 | +159,600 | 0.02 | 0.05 | 0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 502,915 | 602,915 | +100,000 | 0.10 | 0.10 | +0.00 | buy |
| Paradigm Biocapital Advisors LP | 10,668,141 | 10,752,354 | +84,213 | 1.02 | 0.94 | -0.08 | buy |
| ALPS ADVISORS INC | 217,178 | 228,619 | +11,441 | 0.00 | 0.00 | -0.00 | buy |
| Woodline Partners LP | 4,138,849 | 4,147,275 | +8,426 | 0.10 | 0.07 | -0.03 | buy |
| China Universal Asset Management Co., Ltd. | 54,335 | 59,949 | +5,614 | 0.02 | 0.01 | -0.00 | buy |
| E Fund Management Co., Ltd. | 14,917 | 14,838 | -79 | 0.00 | 0.00 | -0.00 | sell |
| Palumbo Wealth Management LLC | 39,723 | 28,600 | -11,123 | 0.04 | 0.03 | -0.02 | sell |
| VIRTUS ADVISERS, LLC | 42,275 | 27,031 | -15,244 | 0.05 | 0.03 | -0.03 | sell |
| Rafferty Asset Management, LLC | 232,170 | 209,751 | -22,419 | 0.00 | 0.00 | -0.00 | sell |
| Sofinnova Investments, Inc. | 1,842,668 | 1,795,880 | -46,788 | 0.40 | 0.33 | -0.07 | sell |
| T. Rowe Price Investment Management, Inc. | 16,830,856 | 16,710,347 | -120,509 | 0.03 | 0.03 | -0.00 | sell |
| PFM Health Sciences, LP | 4,876,911 | 4,390,427 | -486,484 | 0.75 | 0.68 | -0.07 | sell |
| Sio Capital Management, LLC | 2,219,186 | 1,356,186 | -863,000 | 2.40 | 0.96 | -1.44 | sell |
| Prosight Management, LP | 1,984,010 | 947,110 | -1,036,900 | 1.33 | 0.66 | -0.68 | sell |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 13,768,039 | 12,315,004 | -1,453,035 | 1.20 | 1.05 | -0.15 | sell |