| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Octagon Capital Advisors LP | 0 | 5,136,795 | +5,136,795 | 0.00 | 2.19 | +2.19 | buy |
| MILLENNIUM MANAGEMENT LLC | 2,410,550 | 4,177,900 | +1,767,350 | 0.01 | 0.01 | +0.00 | buy |
| Logos Global Management LP | 10,900,000 | 12,500,000 | +1,600,000 | 3.33 | 3.67 | +0.34 | buy |
| DIMENSIONAL FUND ADVISORS LP | 1,208,299 | 2,111,986 | +903,687 | 0.00 | 0.00 | +0.00 | buy |
| Atom Investors LP | 0 | 775,417 | +775,417 | 0.00 | 0.24 | +0.24 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 6,946,488 | 7,543,901 | +597,413 | 4.27 | 4.23 | -0.04 | buy |
| STATE STREET CORP | 6,027,620 | 6,609,481 | +581,861 | 0.00 | 0.00 | -0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 465,672 | +465,672 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 15,356,680 | 15,761,364 | +404,684 | 0.00 | 0.00 | -0.00 | buy |
| NORTHERN TRUST CORP | 1,537,949 | 1,717,109 | +179,160 | 0.00 | 0.00 | -0.00 | buy |
| IPG Investment Advisors LLC | 0 | 169,978 | +169,978 | 0.00 | 0.10 | +0.10 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 70,000 | 229,600 | +159,600 | 0.00 | 0.01 | +0.01 | buy |
| HighVista Strategies LLC | 0 | 135,667 | +135,667 | 0.00 | 0.13 | +0.13 | buy |
| CITIGROUP INC | 134,367 | 241,964 | +107,597 | 0.00 | 0.00 | +0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 502,915 | 602,915 | +100,000 | 0.10 | 0.10 | +0.00 | buy |
| Paradigm Biocapital Advisors LP | 10,668,141 | 10,752,354 | +84,213 | 1.02 | 0.94 | -0.08 | buy |
| DEUTSCHE BANK AG\ | 51,599 | 135,770 | +84,171 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 364,085 | 444,769 | +80,684 | 0.00 | 0.00 | +0.00 | buy |
| Cresset Asset Management, LLC | 0 | 79,913 | +79,913 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 284,206 | 363,571 | +79,365 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 4,502,698 | 4,569,819 | +67,121 | 0.00 | 0.00 | -0.00 | buy |
| Legal & General Group Plc | 122,251 | 186,825 | +64,574 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 59,499 | 115,501 | +56,002 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 55,361 | +55,361 | 0.00 | 0.01 | +0.01 | buy |
| Squarepoint Ops LLC | 0 | 50,308 | +50,308 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0 | 39,963 | +39,963 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,723,630 | 1,762,696 | +39,066 | 0.00 | 0.00 | -0.00 | buy |
| Bank of New York Mellon Corp | 509,551 | 544,819 | +35,268 | 0.00 | 0.00 | -0.00 | buy |
| AMERIPRISE FINANCIAL INC | 20,928 | 55,585 | +34,657 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 63,286 | 97,369 | +34,083 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 343,930 | 377,764 | +33,834 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 329,700 | 361,200 | +31,500 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 24,225 | +24,225 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 74,647 | 92,781 | +18,134 | 0.00 | 0.00 | -0.00 | buy |
| CIBC WORLD MARKETS CORP | 0 | 17,200 | +17,200 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 6,776 | 23,323 | +16,547 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 16,158 | +16,158 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 35,960 | 51,364 | +15,404 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 50,234 | 65,155 | +14,921 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 306,129 | 320,358 | +14,229 | 0.00 | 0.00 | -0.00 | buy |
| Neuberger Berman Group LLC | 0 | 13,158 | +13,158 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 64,946 | 77,545 | +12,599 | 0.00 | 0.00 | +0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 42,361 | 54,706 | +12,345 | 0.00 | 0.00 | -0.00 | buy |
| ALPS ADVISORS INC | 217,178 | 228,619 | +11,441 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 212,488 | 223,888 | +11,400 | 0.00 | 0.00 | -0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 160,436 | 171,821 | +11,385 | 0.00 | 0.00 | -0.00 | buy |
| Invesco Ltd. | 37,381 | 48,671 | +11,290 | 0.00 | 0.00 | +0.00 | buy |
| MACKENZIE FINANCIAL CORP | 0 | 11,141 | +11,141 | 0.00 | 0.00 | +0.00 | buy |
| MACKENZIE FINANCIAL CORP | 0 | 11,141 | +11,141 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 59,138 | 70,037 | +10,899 | 0.00 | 0.00 | +0.00 | buy |
| AXQ CAPITAL, LP | 0 | 10,681 | +10,681 | 0.00 | 0.01 | +0.01 | buy |
| HSBC HOLDINGS PLC | 18,256 | 28,714 | +10,458 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 103,686 | 112,725 | +9,039 | 0.00 | 0.00 | -0.00 | buy |
| Woodline Partners LP | 4,138,849 | 4,147,275 | +8,426 | 0.10 | 0.07 | -0.03 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 18,859 | 26,859 | +8,000 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 106,221 | 112,565 | +6,344 | 0.00 | 0.00 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 54,335 | 59,949 | +5,614 | 0.02 | 0.01 | -0.00 | buy |
| Sterling Capital Management LLC | 616 | 5,686 | +5,070 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 48,632 | 53,196 | +4,564 | 0.00 | 0.00 | -0.00 | buy |
| Creative Planning | 20,014 | 22,684 | +2,670 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 2,733 | 4,455 | +1,722 | 0.00 | 0.00 | +0.00 | buy |
| XPONANCE, INC. | 11,290 | 12,393 | +1,103 | 0.00 | 0.00 | -0.00 | buy |
| CLEAR STREET LLC | 0 | 1,100 | +1,100 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 17,665 | 18,412 | +747 | 0.00 | 0.00 | -0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 354 | 868 | +514 | 0.00 | 0.00 | +0.00 | buy |
| Aster Capital Management (DIFC) Ltd | 0 | 510 | +510 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 125 | 615 | +490 | 0.00 | 0.00 | +0.00 | buy |
| Amundi | 0 | 367 | +367 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 53,795 | 54,073 | +278 | 0.00 | 0.00 | -0.00 | buy |
| CoreCap Advisors, LLC | 0 | 100 | +100 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 0 | 6 | +6 | 0.00 | 0.00 | +0.00 | buy |
| IFP Advisors, Inc | 0 | 3 | +3 | 0.00 | 0.00 | +0.00 | buy |
| Covestor Ltd | 40 | 43 | +3 | 0.00 | 0.00 | 0.00 | buy |
| Ameritas Investment Partners, Inc. | 17,980 | 17,980 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TD ASSET MANAGEMENT INC | 240,746 | 240,746 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MassMutual Private Wealth & Trust, FSB | 333 | 333 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 154,490 | 154,490 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PRUDENTIAL FINANCIAL INC | 10,371 | 10,371 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,000,000 | 1,000,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SHELL ASSET MANAGEMENT CO | 52 | 52 | 0 | 0.00 | 0.00 | 0.00 | hold |
| ARCH Venture Management, LLC | 11,055,554 | 11,055,554 | 0 | 11.58 | 12.05 | +0.47 | hold |
| Polar Asset Management Partners Inc. | 200,300 | 200,300 | 0 | 0.01 | 0.01 | -0.01 | hold |
| EXCHANGE TRADED CONCEPTS, LLC | 59,384 | 59,384 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Daiwa Securities Group Inc. | 1,074 | 1,074 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AH Capital Management, L.L.C. | 2,862,500 | 2,862,500 | 0 | 0.69 | 0.96 | +0.28 | hold |
| VR Adviser, LLC | 16,216,216 | 16,216,216 | 0 | 2.32 | 2.79 | +0.47 | hold |
| Vivo Capital, LLC | 6,756,756 | 6,756,756 | 0 | 1.53 | 1.90 | +0.37 | hold |
| Affinity Asset Advisors, LLC | 2,499,431 | 2,499,431 | 0 | 1.06 | 0.98 | -0.08 | hold |
| 5AM Venture Management, LLC | 5,405,404 | 5,405,404 | 0 | 3.05 | 3.24 | +0.19 | hold |
| Soleus Capital Management, L.P. | 2,162,162 | 2,162,162 | 0 | 0.49 | 0.41 | -0.08 | hold |
| Aaron Wealth Advisors LLC | 27,735 | 27,735 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Frazier Life Sciences Management, L.P. | 19,391,687 | 19,391,687 | 0 | 2.12 | 2.02 | -0.10 | hold |
| Pictet Asset Management Holding SA | 17,302 | 17,302 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Siren, L.L.C. | 8,857,179 | 8,857,179 | 0 | 1.21 | 0.98 | -0.23 | hold |
| Smartleaf Asset Management LLC | 108 | 108 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO | 11,916 | 11,916 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SEI INVESTMENTS CO | 16,682 | 16,682 | 0 | 0.00 | 0.00 | -0.00 | hold |
| FRANKLIN RESOURCES INC | 65,872 | 65,872 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| COMERICA BANK | 2,861 | 2,861 | 0 | 0.00 | 0.00 | -0.00 | hold |