| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Frazier Life Sciences Management, L.P. | 19,391,687 | 19,391,687 | 0 | 2.12 | 2.02 | -0.10 | hold |
| T. Rowe Price Investment Management, Inc. | 16,830,856 | 16,710,347 | -120,509 | 0.03 | 0.03 | -0.00 | sell |
| VR Adviser, LLC | 16,216,216 | 16,216,216 | 0 | 2.32 | 2.79 | +0.47 | hold |
| BlackRock, Inc. | 15,356,680 | 15,761,364 | +404,684 | 0.00 | 0.00 | -0.00 | buy |
| VANGUARD GROUP INC | 13,288,740 | 12,673,900 | -614,840 | 0.00 | 0.00 | -0.00 | sell |
| Logos Global Management LP | 10,900,000 | 12,500,000 | +1,600,000 | 3.33 | 3.67 | +0.34 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 13,768,039 | 12,315,004 | -1,453,035 | 1.35 | 1.15 | -0.20 | sell |
| ARCH Venture Management, LLC | 11,055,554 | 11,055,554 | 0 | 11.58 | 12.05 | +0.47 | hold |
| Paradigm Biocapital Advisors LP | 10,668,141 | 10,752,354 | +84,213 | 1.02 | 0.94 | -0.08 | buy |
| Siren, L.L.C. | 8,857,179 | 8,857,179 | 0 | 1.21 | 0.98 | -0.23 | hold |
| SILVERARC CAPITAL MANAGEMENT, LLC | 6,946,488 | 7,543,901 | +597,413 | 4.27 | 4.23 | -0.04 | buy |
| Vivo Capital, LLC | 6,756,756 | 6,756,756 | 0 | 1.53 | 1.90 | +0.37 | hold |
| STATE STREET CORP | 6,027,620 | 6,609,481 | +581,861 | 0.00 | 0.00 | -0.00 | buy |
| 5AM Venture Management, LLC | 5,405,404 | 5,405,404 | 0 | 3.05 | 3.24 | +0.19 | hold |
| Octagon Capital Advisors LP | 0 | 5,136,795 | +5,136,795 | 0.00 | 2.19 | +2.19 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 4,502,698 | 4,569,819 | +67,121 | 0.00 | 0.00 | -0.00 | buy |
| PFM Health Sciences, LP | 4,876,911 | 4,390,427 | -486,484 | 0.76 | 0.84 | +0.08 | sell |
| CITADEL ADVISORS LLC | 4,315,673 | 4,288,369 | -27,304 | 0.01 | 0.01 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 2,410,550 | 4,177,900 | +1,767,350 | 0.01 | 0.01 | +0.00 | buy |
| Woodline Partners LP | 4,138,849 | 4,147,275 | +8,426 | 0.10 | 0.07 | -0.03 | buy |
| AH Capital Management, L.L.C. | 2,862,500 | 2,862,500 | 0 | 0.69 | 0.96 | +0.28 | hold |
| GOLDMAN SACHS GROUP INC | 3,230,356 | 2,801,630 | -428,726 | 0.00 | 0.00 | -0.00 | sell |
| Affinity Asset Advisors, LLC | 2,499,431 | 2,499,431 | 0 | 1.06 | 0.98 | -0.08 | hold |
| Soleus Capital Management, L.P. | 2,162,162 | 2,162,162 | 0 | 0.49 | 0.41 | -0.08 | hold |
| DIMENSIONAL FUND ADVISORS LP | 1,208,299 | 2,111,986 | +903,687 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 3,027,727 | 2,027,027 | -1,000,700 | 0.01 | 0.01 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 4,220,671 | 1,945,773 | -2,274,898 | 0.00 | 0.00 | -0.00 | sell |
| Sofinnova Investments, Inc. | 1,842,668 | 1,795,880 | -46,788 | 0.42 | 0.33 | -0.09 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,723,630 | 1,762,696 | +39,066 | 0.00 | 0.00 | -0.00 | buy |
| NORTHERN TRUST CORP | 1,537,949 | 1,717,109 | +179,160 | 0.00 | 0.00 | -0.00 | buy |
| JPMORGAN CHASE & CO | 2,024,514 | 1,474,585 | -549,929 | 0.00 | 0.00 | -0.00 | sell |
| Sio Capital Management, LLC | 2,219,186 | 1,356,186 | -863,000 | 2.71 | 0.96 | -1.76 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 1,291,000 | 1,133,000 | -158,000 | 0.01 | 0.00 | -0.00 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,000,000 | 1,000,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TWO SIGMA INVESTMENTS, LP | 1,344,913 | 958,245 | -386,668 | 0.01 | 0.01 | -0.00 | sell |
| Prosight Management, LP | 1,984,010 | 947,110 | -1,036,900 | 1.37 | 0.67 | -0.71 | sell |
| Atom Investors LP | 0 | 775,417 | +775,417 | 0.00 | 0.24 | +0.24 | buy |
| MORGAN STANLEY | 873,141 | 754,738 | -118,403 | 0.00 | 0.00 | -0.00 | sell |
| TANG CAPITAL MANAGEMENT LLC | 502,915 | 602,915 | +100,000 | 0.10 | 0.10 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 793,200 | 594,600 | -198,600 | 0.01 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 509,551 | 544,819 | +35,268 | 0.00 | 0.00 | -0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 465,672 | +465,672 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 364,085 | 444,769 | +80,684 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 343,930 | 377,764 | +33,834 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 483,826 | 369,254 | -114,572 | 0.00 | 0.00 | -0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 284,206 | 363,571 | +79,365 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 329,700 | 361,200 | +31,500 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 306,129 | 320,358 | +14,229 | 0.00 | 0.00 | -0.00 | buy |
| CITIGROUP INC | 134,367 | 241,964 | +107,597 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 240,746 | 240,746 | 0 | 0.00 | 0.00 | -0.00 | hold |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 70,000 | 229,600 | +159,600 | 0.00 | 0.01 | +0.01 | buy |
| ALPS ADVISORS INC | 217,178 | 228,619 | +11,441 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 212,488 | 223,888 | +11,400 | 0.00 | 0.00 | -0.00 | buy |
| Rafferty Asset Management, LLC | 232,170 | 209,751 | -22,419 | 0.00 | 0.00 | -0.00 | sell |
| Polar Asset Management Partners Inc. | 200,300 | 200,300 | 0 | 0.01 | 0.01 | -0.01 | hold |
| UBS Group AG | 230,622 | 193,168 | -37,454 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 122,251 | 186,825 | +64,574 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 160,436 | 171,821 | +11,385 | 0.00 | 0.00 | -0.00 | buy |
| IPG Investment Advisors LLC | 0 | 169,978 | +169,978 | 0.00 | 0.10 | +0.10 | buy |
| ALLIANCEBERNSTEIN L.P. | 154,490 | 154,490 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Walleye Capital LLC | 949,557 | 138,708 | -810,849 | 0.03 | 0.00 | -0.02 | sell |
| DEUTSCHE BANK AG\ | 51,599 | 135,770 | +84,171 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 0 | 135,667 | +135,667 | 0.00 | 0.13 | +0.13 | buy |
| WELLS FARGO & COMPANY/MN | 206,639 | 133,377 | -73,262 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 59,499 | 115,501 | +56,002 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 103,686 | 112,725 | +9,039 | 0.00 | 0.00 | -0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 106,221 | 112,565 | +6,344 | 0.00 | 0.00 | -0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 63,286 | 97,369 | +34,083 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 74,647 | 92,781 | +18,134 | 0.00 | 0.00 | -0.00 | buy |
| Corebridge Financial, Inc. | 94,904 | 91,376 | -3,528 | 0.00 | 0.00 | -0.00 | sell |
| Cresset Asset Management, LLC | 0 | 79,913 | +79,913 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 64,946 | 77,545 | +12,599 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 4,109,548 | 73,200 | -4,036,348 | 0.01 | 0.00 | -0.01 | sell |
| THRIVENT FINANCIAL FOR LUTHERANS | 101,756 | 72,493 | -29,263 | 0.00 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 59,138 | 70,037 | +10,899 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 67,661 | 66,319 | -1,342 | 0.00 | 0.00 | -0.00 | sell |
| FRANKLIN RESOURCES INC | 65,872 | 65,872 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ProShare Advisors LLC | 50,234 | 65,155 | +14,921 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 54,335 | 59,949 | +5,614 | 0.02 | 0.01 | -0.00 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 59,384 | 59,384 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AQR CAPITAL MANAGEMENT LLC | 101,924 | 57,025 | -44,899 | 0.00 | 0.00 | -0.00 | sell |
| AMERIPRISE FINANCIAL INC | 20,928 | 55,585 | +34,657 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 55,361 | +55,361 | 0.00 | 0.01 | +0.01 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 42,361 | 54,706 | +12,345 | 0.00 | 0.00 | -0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 53,795 | 54,073 | +278 | 0.00 | 0.00 | -0.00 | buy |
| Arizona State Retirement System | 48,632 | 53,196 | +4,564 | 0.00 | 0.00 | -0.00 | buy |
| ALGERT GLOBAL LLC | 35,960 | 51,364 | +15,404 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 50,308 | +50,308 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 37,381 | 48,671 | +11,290 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 47,626 | 42,632 | -4,994 | 0.00 | 0.00 | -0.00 | sell |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0 | 39,963 | +39,963 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 18,256 | 28,714 | +10,458 | 0.00 | 0.00 | +0.00 | buy |
| Palumbo Wealth Management LLC | 39,723 | 28,600 | -11,123 | 0.04 | 0.03 | -0.02 | sell |
| Aaron Wealth Advisors LLC | 27,735 | 27,735 | 0 | 0.01 | 0.01 | -0.00 | hold |
| VIRTUS ADVISERS, LLC | 42,275 | 27,031 | -15,244 | 0.05 | 0.03 | -0.03 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 18,859 | 26,859 | +8,000 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 24,225 | +24,225 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 6,776 | 23,323 | +16,547 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 20,014 | 22,684 | +2,670 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 21,079 | 20,216 | -863 | 0.00 | 0.00 | -0.00 | sell |