| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Paradigm Biocapital Advisors LP | 13,560,017 | 14,159,095 | +599,078 | 0.87 | 1.41 | +0.54 | buy |
| Susquehanna Portfolio Strategies, LLC | 37,300 | 59,087 | +21,787 | 0.00 | 0.00 | +0.00 | buy |
| Palumbo Wealth Management LLC | 124,533 | 139,385 | +14,852 | 0.09 | 0.13 | +0.04 | buy |
| SUMMIT SECURITIES GROUP LLC | 1,072 | 1,762 | +690 | 0.00 | 0.00 | +0.00 | buy |
| Pallas Capital Advisors LLC | 13,884 | 13,925 | +41 | 0.00 | 0.00 | +0.00 | buy |
| Hughes Financial Services, LLC | 490 | 213 | -277 | 0.00 | 0.00 | -0.00 | sell |
| GF FUND MANAGEMENT CO. LTD. | 6,033 | 5,574 | -459 | 0.00 | 0.00 | +0.00 | sell |
| Virtus Investment Advisers, LLC | 74,371 | 73,896 | -475 | 0.05 | 0.07 | +0.03 | sell |
| China Universal Asset Management Co., Ltd. | 49,723 | 46,231 | -3,492 | 0.01 | 0.01 | +0.00 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 1,368,075 | 1,317,584 | -50,491 | 0.43 | 0.71 | +0.28 | sell |
| DAFNA Capital Management LLC | 350,000 | 254,436 | -95,564 | 0.19 | 0.22 | +0.03 | sell |
| Affinity Asset Advisors, LLC | 4,285,787 | 3,900,000 | -385,787 | 0.87 | 1.04 | +0.17 | sell |
| TANG CAPITAL MANAGEMENT LLC | 1,502,915 | 900,000 | -602,915 | 0.13 | 0.17 | +0.04 | sell |
| Logos Global Management LP | 15,150,000 | 13,000,000 | -2,150,000 | 3.26 | 3.22 | -0.04 | sell |
| T. Rowe Price Investment Management, Inc. | 20,231,906 | 16,111,414 | -4,120,492 | 0.03 | 0.04 | +0.01 | sell |