| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Frazier Life Sciences Management, L.P. | 22,729,436 | 22,729,436 | 0 | 1.48 | 2.27 | +0.79 | hold |
| VR Adviser, LLC | 17,857,083 | 17,857,083 | 0 | 2.19 | 3.28 | +1.09 | hold |
| T. Rowe Price Investment Management, Inc. | 20,231,906 | 16,111,414 | -4,120,492 | 0.03 | 0.04 | +0.01 | sell |
| BlackRock, Inc. | 15,071,319 | 15,597,330 | +526,011 | 0.00 | 0.00 | +0.00 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 14,502,004 | 14,502,004 | 0 | 0.96 | 1.34 | +0.39 | hold |
| Paradigm Biocapital Advisors LP | 13,560,017 | 14,159,095 | +599,078 | 0.87 | 1.41 | +0.54 | buy |
| Logos Global Management LP | 15,150,000 | 13,000,000 | -2,150,000 | 3.26 | 3.22 | -0.04 | sell |
| VANGUARD GROUP INC | 12,811,832 | 12,812,156 | +324 | 0.00 | 0.00 | +0.00 | buy |
| ARCH Venture Management, LLC | 11,055,554 | 11,055,554 | 0 | 4.89 | 6.31 | +1.42 | hold |
| Vivo Capital, LLC | 9,273,428 | 9,273,428 | 0 | 1.63 | 2.23 | +0.60 | hold |
| Siren, L.L.C. | 8,757,249 | 8,757,249 | 0 | 0.75 | 0.97 | +0.22 | hold |
| STATE STREET CORP | 4,029,256 | 6,174,642 | +2,145,386 | 0.00 | 0.00 | +0.00 | buy |
| 5AM Venture Management, LLC | 5,405,404 | 5,405,404 | 0 | 4.32 | 6.32 | +2.01 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 4,848,563 | 4,926,335 | +77,772 | 0.00 | 0.00 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 4,285,787 | 3,900,000 | -385,787 | 0.87 | 1.04 | +0.17 | sell |
| GOLDMAN SACHS GROUP INC | 2,517,188 | 3,331,418 | +814,230 | 0.00 | 0.00 | +0.00 | buy |
| AH Capital Management, L.L.C. | 2,862,500 | 2,862,500 | 0 | 0.45 | 0.67 | +0.23 | hold |
| MILLENNIUM MANAGEMENT LLC | 2,914,819 | 2,237,951 | -676,868 | 0.01 | 0.01 | +0.00 | sell |
| Soleus Capital Management, L.P. | 2,162,162 | 2,162,162 | 0 | 0.25 | 0.34 | +0.09 | hold |
| Woodline Partners LP | 1,534,390 | 1,930,642 | +396,252 | 0.02 | 0.03 | +0.01 | buy |
| DIMENSIONAL FUND ADVISORS LP | 1,371,935 | 1,775,685 | +403,750 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,725,356 | 1,673,404 | -51,952 | 0.00 | 0.00 | +0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 1,534,274 | 1,611,850 | +77,576 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 1,490,967 | +1,490,967 | 0.00 | 0.06 | +0.06 | buy |
| NORTHERN TRUST CORP | 1,443,511 | 1,331,508 | -112,003 | 0.00 | 0.00 | +0.00 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 1,368,075 | 1,317,584 | -50,491 | 0.43 | 0.71 | +0.28 | sell |
| JPMORGAN CHASE & CO | 1,269,042 | 1,153,090 | -115,952 | 0.00 | 0.00 | +0.00 | sell |
| CITADEL ADVISORS LLC | 341,799 | 1,030,345 | +688,546 | 0.00 | 0.00 | +0.00 | buy |
| Rock Springs Capital Management LP | 0 | 951,710 | +951,710 | 0.00 | 0.18 | +0.18 | buy |
| JANE STREET GROUP, LLC | 386,069 | 912,519 | +526,450 | 0.00 | 0.00 | +0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 1,502,915 | 900,000 | -602,915 | 0.13 | 0.17 | +0.04 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 1,015,005 | 850,100 | -164,905 | 0.00 | 0.00 | +0.00 | sell |
| MORGAN STANLEY | 0 | 810,385 | +810,385 | 0.00 | 0.00 | +0.00 | buy |
| Ikarian Capital, LLC | 0 | 735,396 | +735,396 | 0.00 | 0.35 | +0.35 | buy |
| AQR CAPITAL MANAGEMENT LLC | 664,339 | 669,876 | +5,537 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 573,935 | 546,776 | -27,159 | 0.00 | 0.00 | +0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 600,580 | 543,196 | -57,384 | 0.00 | 0.00 | +0.00 | sell |
| HRT FINANCIAL LP | 0 | 536,909 | +536,909 | 0.00 | 0.01 | +0.01 | buy |
| FMR LLC | 419,554 | 521,455 | +101,901 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 450,056 | 424,713 | -25,343 | 0.00 | 0.00 | +0.00 | sell |
| BARCLAYS PLC | 268,252 | 402,796 | +134,544 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 350,314 | 381,695 | +31,381 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 111,337 | 346,072 | +234,735 | 0.01 | 0.04 | +0.03 | buy |
| Invesco Ltd. | 282,025 | 329,795 | +47,770 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 84,701 | 258,275 | +173,574 | 0.00 | 0.00 | +0.00 | buy |
| DAFNA Capital Management LLC | 350,000 | 254,436 | -95,564 | 0.19 | 0.22 | +0.03 | sell |
| TD ASSET MANAGEMENT INC | 256,032 | 229,840 | -26,192 | 0.00 | 0.00 | +0.00 | sell |
| WELLS FARGO & COMPANY/MN | 158,601 | 220,132 | +61,531 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 233,430 | 208,810 | -24,620 | 0.00 | 0.00 | +0.00 | sell |
| D. E. Shaw & Co., Inc. | 0 | 201,938 | +201,938 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 107,242 | 199,788 | +92,546 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 201,550 | 189,012 | -12,538 | 0.00 | 0.00 | +0.00 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 188,467 | +188,467 | 0.00 | 0.02 | +0.02 | buy |
| UBS Group AG | 0 | 170,531 | +170,531 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 35,454 | 165,359 | +129,905 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 0 | 158,020 | +158,020 | 0.00 | 0.00 | +0.00 | buy |
| RTW INVESTMENTS, LP | 0 | 146,651 | +146,651 | 0.00 | 0.01 | +0.01 | buy |
| Palumbo Wealth Management LLC | 124,533 | 139,385 | +14,852 | 0.09 | 0.13 | +0.04 | buy |
| Rafferty Asset Management, LLC | 0 | 131,019 | +131,019 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 165,895 | 121,977 | -43,918 | 0.00 | 0.00 | +0.00 | sell |
| PANAGORA ASSET MANAGEMENT INC | 102,379 | 118,218 | +15,839 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 93,580 | 103,503 | +9,923 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 100,459 | 98,073 | -2,386 | 0.00 | 0.00 | +0.00 | sell |
| CITIGROUP INC | 15,246 | 95,770 | +80,524 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 79,975 | 90,720 | +10,745 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 81,534 | 88,232 | +6,698 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 90,050 | 80,368 | -9,682 | 0.00 | 0.00 | +0.00 | sell |
| Cresset Asset Management, LLC | 79,913 | 79,913 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Virtus Investment Advisers, LLC | 74,371 | 73,896 | -475 | 0.05 | 0.07 | +0.03 | sell |
| Scientech Research LLC | 0 | 72,203 | +72,203 | 0.00 | 0.17 | +0.17 | buy |
| MARSHALL WACE, LLP | 526,009 | 61,960 | -464,049 | 0.00 | 0.00 | -0.00 | sell |
| Cerity Partners LLC | 61,415 | 61,536 | +121 | 0.00 | 0.00 | +0.00 | buy |
| IEQ CAPITAL, LLC | 63,214 | 60,346 | -2,868 | 0.00 | 0.00 | +0.00 | sell |
| Susquehanna Portfolio Strategies, LLC | 37,300 | 59,087 | +21,787 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 60,452 | 55,559 | -4,893 | 0.00 | 0.00 | +0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 61,801 | 54,769 | -7,032 | 0.00 | 0.00 | +0.00 | sell |
| TUDOR INVESTMENT CORP ET AL | 0 | 53,436 | +53,436 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 90,746 | 52,731 | -38,015 | 0.00 | 0.00 | +0.00 | sell |
| PROFUND ADVISORS LLC | 0 | 50,605 | +50,605 | 0.00 | 0.01 | +0.01 | buy |
| SG Americas Securities, LLC | 14,605 | 48,677 | +34,072 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 49,723 | 46,231 | -3,492 | 0.01 | 0.01 | +0.00 | sell |
| ProShare Advisors LLC | 39,786 | 44,216 | +4,430 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 59,153 | 44,030 | -15,123 | 0.00 | 0.00 | +0.00 | sell |
| Jain Global LLC | 0 | 42,336 | +42,336 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 347,767 | 38,024 | -309,743 | 0.00 | 0.00 | -0.00 | sell |
| BAILARD, INC. | 0 | 35,238 | +35,238 | 0.00 | 0.00 | +0.00 | buy |
| Vanguard Personalized Indexing Management, LLC | 34,802 | 34,659 | -143 | 0.00 | 0.00 | +0.00 | sell |
| CWM, LLC | 33,300 | 33,605 | +305 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 33,187 | 33,187 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 38,161 | 32,486 | -5,675 | 0.00 | 0.00 | +0.00 | sell |
| EP Wealth Advisors, LLC | 23,000 | 30,000 | +7,000 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 24,311 | +24,311 | 0.00 | 0.00 | +0.00 | buy |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 22,143 | 22,505 | +362 | 0.00 | 0.00 | +0.00 | buy |
| AXQ CAPITAL, LP | 0 | 20,459 | +20,459 | 0.00 | 0.02 | +0.02 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 18,532 | 18,391 | -141 | 0.00 | 0.00 | +0.00 | sell |
| CAPTRUST FINANCIAL ADVISORS | 22,901 | 17,606 | -5,295 | 0.00 | 0.00 | +0.00 | sell |
| QUADRANT CAPITAL GROUP LLC | 17,546 | 17,546 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SEI INVESTMENTS CO | 16,682 | 16,682 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Abel Hall, LLC | 0 | 15,682 | +15,682 | 0.00 | 0.01 | +0.01 | buy |
| Legal & General Group Plc | 15,428 | 15,428 | 0 | 0.00 | 0.00 | +0.00 | hold |