| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ARMISTICE CAPITAL, LLC | 1,436,000 | 2,164,000 | +728,000 | 0.83 | 0.93 | +0.10 | buy |
| PERCEPTIVE ADVISORS LLC | 2,328,082 | 2,963,212 | +635,130 | 2.19 | 1.68 | -0.51 | buy |
| Logos Global Management LP | 1,200,000 | 1,775,000 | +575,000 | 5.62 | 6.04 | +0.41 | buy |
| Woodline Partners LP | 750,266 | 1,289,504 | +539,238 | 0.34 | 0.39 | +0.04 | buy |
| Alpine Global Management, LLC | 1,398,372 | 1,882,704 | +484,332 | 16.09 | 11.78 | -4.31 | buy |
| FRED ALGER MANAGEMENT, LLC | 884,872 | 1,271,762 | +386,890 | 0.20 | 0.20 | +0.00 | buy |
| Two Seas Capital LP | 198,752 | 541,295 | +342,543 | 2.06 | 3.43 | +1.36 | buy |
| STEMPOINT CAPITAL LP | 322,015 | 627,228 | +305,213 | 3.66 | 5.41 | +1.76 | buy |
| Avidity Partners Management LP | 245,000 | 505,000 | +260,000 | 0.39 | 0.58 | +0.19 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,602,562 | 1,862,043 | +259,481 | 0.01 | 0.01 | -0.00 | buy |
| Rock Springs Capital Management LP | 983,301 | 1,150,123 | +166,822 | 1.02 | 0.94 | -0.08 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 440,115 | 582,721 | +142,606 | 0.01 | 0.01 | 0.00 | buy |
| Eversept Partners, LP | 113,793 | 255,526 | +141,733 | 0.42 | 0.55 | +0.13 | buy |
| Knott David M Jr | 1,485 | 85,300 | +83,815 | 0.02 | 0.97 | +0.95 | buy |
| Senator Investment Group LP | 175,000 | 250,000 | +75,000 | 0.32 | 0.37 | +0.05 | buy |
| WCM INVESTMENT MANAGEMENT, LLC | 107,401 | 169,665 | +62,264 | 0.01 | 0.01 | +0.00 | buy |
| Rafferty Asset Management, LLC | 229,087 | 289,385 | +60,298 | 0.04 | 0.03 | -0.01 | buy |
| Tyro Capital Management LLC | 45,000 | 97,667 | +52,667 | 1.34 | 1.82 | +0.49 | buy |
| Ikarian Capital, LLC | 233,394 | 276,925 | +43,531 | 2.69 | 2.43 | -0.26 | buy |
| Blue Owl Capital Holdings LP | 60,000 | 100,000 | +40,000 | 0.60 | 0.65 | +0.04 | buy |
| Atika Capital Management LLC | 120,000 | 160,000 | +40,000 | 0.68 | 0.51 | -0.17 | buy |
| Monashee Investment Management LLC | 70,000 | 100,000 | +30,000 | 0.52 | 0.38 | -0.14 | buy |
| ExodusPoint Capital Management, LP | 48,905 | 69,154 | +20,249 | 0.03 | 0.03 | 0.00 | buy |
| EFG Asset Management (North America) Corp. | 27,005 | 47,070 | +20,065 | 0.22 | 0.26 | +0.05 | buy |
| China Universal Asset Management Co., Ltd. | 16,734 | 27,936 | +11,202 | 0.14 | 0.11 | -0.02 | buy |
| Hillsdale Investment Management Inc. | 92,000 | 100,200 | +8,200 | 0.32 | 0.26 | -0.06 | buy |
| PROFUND ADVISORS LLC | 37,460 | 45,004 | +7,544 | 0.07 | 0.06 | 0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 150,240 | 144,385 | +5,855 | 0.03 | 0.02 | -0.01 | sell |
| TD ASSET MANAGEMENT INC | 66,308 | 69,042 | +2,734 | 0.00 | 0.00 | -0.00 | buy |
| ALGERT GLOBAL LLC | 49,661 | 51,660 | +1,999 | 0.08 | 0.07 | 0.00 | buy |
| ProShare Advisors LLC | 18,174 | 19,877 | +1,703 | 0.00 | 0.00 | 0.00 | buy |
| E Fund Management Co., Ltd. | 12,256 | 13,675 | +1,419 | 0.03 | 0.03 | -0.01 | buy |
| Nicholas Investment Partners, LP | 136,310 | 137,682 | +1,372 | 0.67 | 0.46 | -0.22 | buy |
| BAMCO INC /NY/ | 59,000 | 60,000 | +1,000 | 0.01 | 0.01 | -0.00 | buy |
| Creekmur Asset Management LLC | 510 | 644 | +134 | 0.01 | 0.01 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 2,174 | 2,031 | -143 | 0.06 | 0.03 | -0.02 | sell |
| LORD, ABBETT & CO. LLC | 631,399 | 629,882 | -1,517 | 0.09 | 0.07 | -0.03 | sell |
| EMERALD MUTUAL FUND ADVISERS TRUST | 204,399 | 201,087 | -3,312 | 0.46 | 0.34 | -0.12 | sell |
| EMERALD ADVISERS, LLC | 306,265 | 302,789 | -3,476 | 0.55 | 0.39 | -0.16 | sell |
| ArrowMark Colorado Holdings LLC | 73,550 | 70,000 | -3,550 | 0.03 | 0.03 | -0.01 | sell |
| Cinctive Capital Management LP | 36,841 | 31,730 | -5,111 | 0.11 | 0.05 | -0.06 | sell |
| BANQUE PICTET & CIE SA | 77,031 | 70,309 | -6,722 | 0.03 | 0.02 | -0.01 | sell |
| Redmile Group, LLC | 977,072 | 969,621 | -7,451 | 1.47 | 1.15 | -0.32 | sell |
| DAFNA Capital Management LLC | 40,742 | 29,416 | -11,326 | 0.41 | 0.22 | -0.19 | sell |
| Rhenman & Partners Asset Management AB | 146,061 | 125,500 | -20,561 | 0.61 | 0.38 | -0.23 | sell |
| ACUTA CAPITAL PARTNERS, LLC | 119,489 | 92,346 | -27,143 | 2.83 | 1.94 | -0.90 | sell |
| PLATINUM INVESTMENT MANAGEMENT LTD | 228,765 | 190,656 | -38,109 | 0.39 | 0.25 | -0.14 | sell |
| Informed Momentum Co LLC | 110,929 | 69,241 | -41,688 | 0.83 | 0.35 | -0.48 | sell |
| Soleus Capital Management, L.P. | 317,050 | 264,650 | -52,400 | 1.48 | 0.75 | -0.73 | sell |
| Affinity Asset Advisors, LLC | 345,000 | 285,000 | -60,000 | 2.90 | 1.50 | -1.40 | sell |
| ADAR1 Capital Management, LLC | 134,125 | 60,763 | -73,362 | 2.53 | 0.54 | -1.99 | sell |
| Aberdeen Group plc | 327,706 | 187,636 | -140,070 | 0.03 | 0.01 | -0.02 | sell |
| Commodore Capital LP | 1,000,000 | 750,990 | -249,010 | 3.68 | 1.62 | -2.06 | sell |
| Skandinaviska Enskilda Banken AB (publ) | 681,935 | 277,022 | -404,913 | 0.17 | 0.04 | -0.12 | sell |
| Deep Track Capital, LP | 1,000,000 | 493,352 | -506,648 | 1.48 | 0.46 | -1.02 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,331,780 | 100,000 | -1,231,780 | 0.12 | 0.01 | -0.11 | sell |