| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VIKING GLOBAL INVESTORS LP | 0 | 1,809,172 | +1,809,172 | 0.00 | 0.22 | +0.22 | buy |
| Paradigm Biocapital Advisors LP | 0 | 799,054 | +799,054 | 0.00 | 0.91 | +0.91 | buy |
| ARMISTICE CAPITAL, LLC | 1,436,000 | 2,164,000 | +728,000 | 1.61 | 1.86 | +0.26 | buy |
| VANGUARD GROUP INC | 5,827,798 | 6,478,304 | +650,506 | 0.01 | 0.00 | -0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 2,328,082 | 2,963,212 | +635,130 | 2.19 | 1.69 | -0.51 | buy |
| NORGES BANK | 38,441 | 656,100 | +617,659 | 0.00 | 0.00 | +0.00 | buy |
| Logos Global Management LP | 1,200,000 | 1,775,000 | +575,000 | 5.62 | 6.04 | +0.41 | buy |
| Woodline Partners LP | 750,266 | 1,289,504 | +539,238 | 0.34 | 0.39 | +0.04 | buy |
| Alpine Global Management, LLC | 1,398,372 | 1,882,704 | +484,332 | 16.09 | 11.78 | -4.31 | buy |
| STATE STREET CORP | 3,216,376 | 3,641,907 | +425,531 | 0.01 | 0.01 | -0.00 | buy |
| MORGAN STANLEY | 531,503 | 937,961 | +406,458 | 0.00 | 0.00 | +0.00 | buy |
| FRED ALGER MANAGEMENT, LLC | 884,872 | 1,271,762 | +386,890 | 0.20 | 0.20 | +0.00 | buy |
| Two Seas Capital LP | 198,752 | 541,295 | +342,543 | 2.06 | 3.43 | +1.36 | buy |
| FRANKLIN RESOURCES INC | 539,097 | 869,216 | +330,119 | 0.01 | 0.01 | -0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 18,300 | 339,700 | +321,400 | 0.00 | 0.02 | +0.02 | buy |
| STEMPOINT CAPITAL LP | 322,015 | 627,228 | +305,213 | 3.66 | 5.41 | +1.76 | buy |
| Avidity Partners Management LP | 245,000 | 505,000 | +260,000 | 0.39 | 0.58 | +0.19 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,602,562 | 1,862,043 | +259,481 | 0.01 | 0.01 | -0.00 | buy |
| Prosight Management, LP | 0 | 195,000 | +195,000 | 0.00 | 1.75 | +1.75 | buy |
| Qube Research & Technologies Ltd | 31,657 | 220,346 | +188,689 | 0.00 | 0.01 | +0.01 | buy |
| Rock Springs Capital Management LP | 983,301 | 1,150,123 | +166,822 | 1.02 | 0.94 | -0.08 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 440,115 | 582,721 | +142,606 | 0.01 | 0.01 | -0.00 | buy |
| Eversept Partners, LP | 113,793 | 255,526 | +141,733 | 0.47 | 0.62 | +0.15 | buy |
| CITIGROUP INC | 124,342 | 249,791 | +125,449 | 0.01 | 0.01 | +0.00 | buy |
| Caption Management, LLC | 0 | 113,477 | +113,477 | 0.00 | 0.40 | +0.40 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 295,020 | 407,654 | +112,634 | 0.00 | 0.00 | +0.00 | buy |
| Knott David M Jr | 1,485 | 85,300 | +83,815 | 0.02 | 0.97 | +0.95 | buy |
| CASTLEARK MANAGEMENT LLC | 0 | 80,440 | +80,440 | 0.00 | 0.11 | +0.11 | buy |
| Senator Investment Group LP | 175,000 | 250,000 | +75,000 | 0.32 | 0.37 | +0.05 | buy |
| Jump Financial, LLC | 29,072 | 95,000 | +65,928 | 0.04 | 0.08 | +0.04 | buy |
| MACQUARIE GROUP LTD | 40,626 | 103,100 | +62,474 | 0.00 | 0.00 | +0.00 | buy |
| WCM INVESTMENT MANAGEMENT, LLC | 107,401 | 169,665 | +62,264 | 0.01 | 0.01 | +0.00 | buy |
| Rafferty Asset Management, LLC | 229,087 | 289,385 | +60,298 | 0.04 | 0.03 | -0.01 | buy |
| Trexquant Investment LP | 0 | 58,218 | +58,218 | 0.00 | 0.04 | +0.04 | buy |
| MARSHALL WACE, LLP | 0 | 53,533 | +53,533 | 0.00 | 0.00 | +0.00 | buy |
| Tyro Capital Management LLC | 45,000 | 97,667 | +52,667 | 1.34 | 1.82 | +0.49 | buy |
| Aquatic Capital Management LLC | 0 | 52,000 | +52,000 | 0.00 | 0.05 | +0.05 | buy |
| TUDOR INVESTMENT CORP ET AL | 38,342 | 87,397 | +49,055 | 0.02 | 0.03 | +0.01 | buy |
| UBS Group AG | 155,082 | 202,550 | +47,468 | 0.00 | 0.00 | -0.00 | buy |
| Squarepoint Ops LLC | 0 | 46,673 | +46,673 | 0.00 | 0.01 | +0.01 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 198,712 | 243,643 | +44,931 | 0.01 | 0.01 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,272,966 | 1,316,827 | +43,861 | 0.01 | 0.00 | -0.00 | buy |
| Ikarian Capital, LLC | 233,394 | 276,925 | +43,531 | 2.69 | 2.43 | -0.26 | buy |
| BARCLAYS PLC | 167,993 | 209,270 | +41,277 | 0.00 | 0.00 | -0.00 | buy |
| Atika Capital Management LLC | 120,000 | 160,000 | +40,000 | 0.72 | 0.58 | -0.14 | buy |
| Blue Owl Capital Holdings LP | 60,000 | 100,000 | +40,000 | 0.60 | 0.65 | +0.04 | buy |
| Polar Asset Management Partners Inc. | 12,100 | 51,500 | +39,400 | 0.01 | 0.04 | +0.03 | buy |
| Mirae Asset Global Investments Co., Ltd. | 36,199 | 71,788 | +35,589 | 0.00 | 0.00 | -0.00 | buy |
| Invesco Ltd. | 492,115 | 526,233 | +34,118 | 0.00 | 0.00 | -0.00 | buy |
| Monashee Investment Management LLC | 70,000 | 100,000 | +30,000 | 0.52 | 0.38 | -0.14 | buy |
| Pearl River Capital, LLC | 0 | 26,053 | +26,053 | 0.00 | 0.13 | +0.13 | buy |
| NOMURA HOLDINGS INC | 0 | 25,708 | +25,708 | 0.00 | 0.01 | +0.01 | buy |
| Allspring Global Investments Holdings, LLC | 42,865 | 65,091 | +22,226 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 48,905 | 69,154 | +20,249 | 0.03 | 0.03 | +0.00 | buy |
| EFG Asset Management (North America) Corp. | 27,005 | 47,070 | +20,065 | 0.22 | 0.26 | +0.05 | buy |
| AQR CAPITAL MANAGEMENT LLC | 68,964 | 88,598 | +19,634 | 0.01 | 0.00 | -0.00 | buy |
| Allianz Asset Management GmbH | 11,900 | 30,178 | +18,278 | 0.00 | 0.00 | +0.00 | buy |
| Dynamic Technology Lab Private Ltd | 0 | 17,670 | +17,670 | 0.00 | 0.06 | +0.06 | buy |
| CANTOR FITZGERALD, L. P. | 0 | 17,335 | +17,335 | 0.00 | 0.13 | +0.13 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 49,590 | 65,017 | +15,427 | 0.07 | 0.06 | -0.01 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 62,347 | 77,503 | +15,156 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 16,734 | 27,936 | +11,202 | 0.14 | 0.11 | -0.02 | buy |
| Walleye Capital LLC | 4,895 | 15,534 | +10,639 | 0.00 | 0.01 | +0.00 | buy |
| Verition Fund Management LLC | 0 | 9,360 | +9,360 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 5,036 | 14,371 | +9,335 | 0.00 | 0.00 | +0.00 | buy |
| DnB Asset Management AS | 0 | 9,332 | +9,332 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 9,237 | +9,237 | 0.00 | 0.04 | +0.04 | buy |
| Corton Capital Inc. | 0 | 9,027 | +9,027 | 0.00 | 0.11 | +0.11 | buy |
| Hillsdale Investment Management Inc. | 92,000 | 100,200 | +8,200 | 0.32 | 0.26 | -0.06 | buy |
| PROFUND ADVISORS LLC | 37,460 | 45,004 | +7,544 | 0.07 | 0.06 | -0.01 | buy |
| TWINBEECH CAPITAL LP | 0 | 7,401 | +7,401 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 0 | 7,298 | +7,298 | 0.00 | 0.00 | +0.00 | buy |
| GUGGENHEIM CAPITAL LLC | 27,875 | 34,227 | +6,352 | 0.01 | 0.01 | -0.00 | buy |
| CANADA LIFE ASSURANCE Co | 5,987 | 12,331 | +6,344 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 13,650 | 19,401 | +5,751 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 38,931 | 43,936 | +5,005 | 0.00 | 0.00 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 437,080 | 442,084 | +5,004 | 0.00 | 0.00 | -0.00 | buy |
| TD ASSET MANAGEMENT INC | 66,308 | 69,042 | +2,734 | 0.00 | 0.00 | -0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 14,292 | 16,500 | +2,208 | 0.00 | 0.00 | -0.00 | buy |
| EntryPoint Capital, LLC | 749 | 2,912 | +2,163 | 0.03 | 0.08 | +0.05 | buy |
| SEI INVESTMENTS CO | 18,605 | 20,690 | +2,085 | 0.00 | 0.00 | -0.00 | buy |
| ALGERT GLOBAL LLC | 49,661 | 51,660 | +1,999 | 0.08 | 0.07 | -0.02 | buy |
| RHUMBLINE ADVISERS | 74,359 | 76,169 | +1,810 | 0.00 | 0.00 | -0.00 | buy |
| ProShare Advisors LLC | 18,174 | 19,877 | +1,703 | 0.00 | 0.00 | -0.00 | buy |
| CoreCap Advisors, LLC | 6,407 | 8,038 | +1,631 | 0.02 | 0.01 | -0.00 | buy |
| E Fund Management Co., Ltd. | 12,256 | 13,675 | +1,419 | 0.03 | 0.03 | -0.01 | buy |
| Nicholas Investment Partners, LP | 136,310 | 137,682 | +1,372 | 0.67 | 0.46 | -0.22 | buy |
| Pacer Advisors, Inc. | 0 | 1,343 | +1,343 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 16,471 | 17,662 | +1,191 | 0.00 | 0.00 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 144,393 | 145,425 | +1,032 | 0.00 | 0.00 | -0.00 | buy |
| BAMCO INC /NY/ | 59,000 | 60,000 | +1,000 | 0.01 | 0.01 | -0.00 | buy |
| AlphaQuest LLC | 1 | 824 | +823 | 0.00 | 0.00 | +0.00 | buy |
| OLD POINT TRUST & FINANCIAL SERVICES N A | 0 | 250 | +250 | 0.00 | 0.00 | +0.00 | buy |
| ASSETMARK, INC | 1,457 | 1,639 | +182 | 0.00 | 0.00 | -0.00 | buy |
| Creekmur Asset Management LLC | 510 | 644 | +134 | 0.01 | 0.01 | +0.00 | buy |
| CI INVESTMENTS INC. | 0 | 110 | +110 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 2 | 53 | +51 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 3,759 | 3,797 | +38 | 0.00 | 0.00 | -0.00 | buy |
| GAMMA Investing LLC | 79 | 110 | +31 | 0.00 | 0.00 | -0.00 | buy |
| AXA S.A. | 98,726 | 98,754 | +28 | 0.01 | 0.01 | -0.00 | buy |