| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 13,097,915 | 17,241,035 | +4,143,120 | 0.02 | 0.02 | -0.00 | buy |
| BAKER BROS. ADVISORS LP | 1,707,881 | 5,457,881 | +3,750,000 | 0.45 | 1.03 | +0.58 | buy |
| Deep Track Capital, LP | 6,000,000 | 9,500,000 | +3,500,000 | 5.57 | 5.26 | -0.31 | buy |
| Woodline Partners LP | 642,726 | 1,497,869 | +855,143 | 0.11 | 0.17 | +0.06 | buy |
| Point72 Asset Management, L.P. | 0 | 801,927 | +801,927 | 0.00 | 0.04 | +0.04 | buy |
| T. Rowe Price Investment Management, Inc. | 5,117,234 | 5,894,824 | +777,590 | 0.08 | 0.07 | -0.01 | buy |
| PERCEPTIVE ADVISORS LLC | 2,139,199 | 2,844,072 | +704,873 | 1.48 | 1.72 | +0.25 | buy |
| ARMISTICE CAPITAL, LLC | 3,870,586 | 4,500,000 | +629,414 | 2.23 | 2.06 | -0.17 | buy |
| Alpine Global Management, LLC | 2,158,904 | 2,626,692 | +467,788 | 15.75 | 11.88 | -3.87 | buy |
| STATE STREET CORP | 2,697,522 | 3,087,095 | +389,573 | 0.00 | 0.00 | -0.00 | buy |
| GREAT POINT PARTNERS LLC | 0 | 375,000 | +375,000 | 0.00 | 3.48 | +3.48 | buy |
| Affinity Asset Advisors, LLC | 100,000 | 430,000 | +330,000 | 0.39 | 1.15 | +0.76 | buy |
| GOLDMAN SACHS GROUP INC | 678,346 | 1,007,700 | +329,354 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 80,900 | 395,900 | +315,000 | 0.00 | 0.01 | +0.01 | buy |
| Vestal Point Capital, LP | 45,000 | 350,000 | +305,000 | 0.07 | 0.43 | +0.36 | buy |
| MORGAN STANLEY | 1,010,624 | 1,310,050 | +299,426 | 0.00 | 0.00 | -0.00 | buy |
| Aberdeen Group plc | 532,110 | 819,477 | +287,367 | 0.02 | 0.03 | +0.00 | buy |
| VANGUARD GROUP INC | 6,679,414 | 6,936,859 | +257,445 | 0.00 | 0.00 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 166,472 | 411,509 | +245,037 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 5,143,071 | 5,364,222 | +221,151 | 0.00 | 0.00 | -0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 0 | 194,638 | +194,638 | 0.00 | 0.82 | +0.82 | buy |
| ADAR1 Capital Management, LLC | 787,478 | 968,866 | +181,388 | 4.02 | 3.19 | -0.83 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,515,020 | 1,672,590 | +157,570 | 0.00 | 0.00 | -0.00 | buy |
| CITIGROUP INC | 142,318 | 289,329 | +147,011 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 590,764 | 731,853 | +141,089 | 0.00 | 0.00 | -0.00 | buy |
| MARSHALL WACE, LLP | 0 | 138,477 | +138,477 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 29,233 | 162,120 | +132,887 | 0.01 | 0.04 | +0.03 | buy |
| TFG Asset Management GP Ltd | 0 | 131,167 | +131,167 | 0.00 | 0.72 | +0.72 | buy |
| Two Seas Capital LP | 1,511,614 | 1,642,772 | +131,158 | 4.42 | 4.36 | -0.06 | buy |
| BANK OF AMERICA CORP /DE/ | 341,535 | 471,961 | +130,426 | 0.00 | 0.00 | -0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 235,884 | 364,229 | +128,345 | 0.03 | 0.03 | +0.00 | buy |
| HighVista Strategies LLC | 0 | 95,648 | +95,648 | 0.00 | 0.63 | +0.63 | buy |
| TWINBEECH CAPITAL LP | 12,689 | 102,036 | +89,347 | 0.01 | 0.03 | +0.03 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 95,200 | 182,500 | +87,300 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 75,000 | 161,660 | +86,660 | 0.01 | 0.02 | +0.01 | buy |
| Privium Fund Management B.V. | 0 | 72,000 | +72,000 | 0.00 | 0.32 | +0.32 | buy |
| Jump Financial, LLC | 129,668 | 200,835 | +71,167 | 0.07 | 0.05 | -0.01 | buy |
| Rock Springs Capital Management LP | 909,103 | 975,803 | +66,700 | 0.86 | 0.95 | +0.10 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 564,442 | 626,612 | +62,170 | 0.00 | 0.00 | -0.00 | buy |
| DAFNA Capital Management LLC | 107,996 | 169,996 | +62,000 | 0.68 | 0.82 | +0.14 | buy |
| Verition Fund Management LLC | 80,073 | 139,317 | +59,244 | 0.01 | 0.01 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 0 | 58,122 | +58,122 | 0.00 | 0.01 | +0.01 | buy |
| EFG Asset Management (North America) Corp. | 73,981 | 130,356 | +56,375 | 0.25 | 0.37 | +0.12 | buy |
| Prosight Management, LP | 305,523 | 360,000 | +54,477 | 2.12 | 2.02 | -0.10 | buy |
| Tejara Capital Ltd | 0 | 53,790 | +53,790 | 0.00 | 0.45 | +0.45 | buy |
| OMERS ADMINISTRATION Corp | 0 | 48,300 | +48,300 | 0.00 | 0.01 | +0.01 | buy |
| Aquatic Capital Management LLC | 47,648 | 92,991 | +45,343 | 0.03 | 0.04 | +0.01 | buy |
| RAYMOND JAMES FINANCIAL INC | 20,382 | 59,674 | +39,292 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 85,201 | 122,049 | +36,848 | 0.00 | 0.00 | -0.00 | buy |
| Bridgefront Capital, LLC | 0 | 36,059 | +36,059 | 0.00 | 0.18 | +0.18 | buy |
| Quinn Opportunity Partners LLC | 0 | 35,100 | +35,100 | 0.00 | 0.04 | +0.04 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 0 | 31,726 | +31,726 | 0.00 | 0.02 | +0.02 | buy |
| Swiss National Bank | 100,800 | 131,600 | +30,800 | 0.00 | 0.00 | -0.00 | buy |
| Hood River Capital Management LLC | 1,145,618 | 1,175,863 | +30,245 | 0.42 | 0.34 | -0.08 | buy |
| TD ASSET MANAGEMENT INC | 152,246 | 182,398 | +30,152 | 0.00 | 0.00 | -0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 48,400 | 74,314 | +25,914 | 0.00 | 0.00 | +0.00 | buy |
| Tyro Capital Management LLC | 151,456 | 177,107 | +25,651 | 1.60 | 1.13 | -0.48 | buy |
| Granahan Investment Management, LLC | 149,396 | 172,316 | +22,920 | 0.15 | 0.15 | -0.01 | buy |
| Rafferty Asset Management, LLC | 116,624 | 138,837 | +22,213 | 0.01 | 0.01 | -0.00 | buy |
| Creative Planning | 13,121 | 29,193 | +16,072 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 31,439 | 45,975 | +14,536 | 0.01 | 0.01 | +0.00 | buy |
| Quadrature Capital Ltd | 0 | 14,498 | +14,498 | 0.00 | 0.01 | +0.01 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 42,174 | 55,713 | +13,539 | 0.00 | 0.00 | -0.00 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 13,428 | +13,428 | 0.00 | 0.04 | +0.04 | buy |
| Legal & General Group Plc | 58,990 | 72,286 | +13,296 | 0.00 | 0.00 | -0.00 | buy |
| Pictet Asset Management Holding SA | 1,175,685 | 1,188,578 | +12,893 | 0.03 | 0.02 | -0.01 | buy |
| CIBC WORLD MARKETS CORP | 0 | 12,880 | +12,880 | 0.00 | 0.00 | +0.00 | buy |
| AXQ CAPITAL, LP | 0 | 11,453 | +11,453 | 0.00 | 0.08 | +0.08 | buy |
| Fieldview Capital Management, LLC | 0 | 10,779 | +10,779 | 0.00 | 0.03 | +0.03 | buy |
| SIH Partners, LLLP | 0 | 10,705 | +10,705 | 0.00 | 0.02 | +0.02 | buy |
| Squarepoint Ops LLC | 0 | 10,425 | +10,425 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 527,367 | 536,622 | +9,255 | 0.00 | 0.00 | -0.00 | buy |
| Ensign Peak Advisors, Inc | 19,706 | 28,406 | +8,700 | 0.00 | 0.00 | +0.00 | buy |
| KLP KAPITALFORVALTNING AS | 10,800 | 18,700 | +7,900 | 0.00 | 0.00 | +0.00 | buy |
| ABC ARBITRAGE SA | 29,639 | 37,449 | +7,810 | 0.11 | 0.12 | +0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 147,097 | 153,240 | +6,143 | 0.00 | 0.00 | -0.00 | buy |
| Virtus Investment Advisers, LLC | 0 | 5,953 | +5,953 | 0.00 | 0.03 | +0.03 | buy |
| PROFUND ADVISORS LLC | 22,710 | 28,560 | +5,850 | 0.02 | 0.02 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 25,231 | 30,731 | +5,500 | 0.00 | 0.00 | -0.00 | buy |
| AlphaQuest LLC | 354 | 5,700 | +5,346 | 0.00 | 0.01 | +0.01 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 7,844 | 13,044 | +5,200 | 0.00 | 0.00 | +0.00 | buy |
| GUGGENHEIM CAPITAL LLC | 36,917 | 41,972 | +5,055 | 0.01 | 0.01 | -0.00 | buy |
| E Fund Management Co., Ltd. | 8,250 | 12,975 | +4,725 | 0.01 | 0.01 | +0.00 | buy |
| Arizona State Retirement System | 14,854 | 19,468 | +4,614 | 0.00 | 0.00 | -0.00 | buy |
| Point72 Hong Kong Ltd | 0 | 4,416 | +4,416 | 0.00 | 0.01 | +0.01 | buy |
| DnB Asset Management AS | 10,421 | 14,356 | +3,935 | 0.00 | 0.00 | +0.00 | buy |
| Point72 (DIFC) Ltd | 0 | 3,923 | +3,923 | 0.00 | 0.01 | +0.01 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 37,623 | 40,971 | +3,348 | 0.00 | 0.00 | -0.00 | buy |
| Headlands Technologies LLC | 0 | 2,961 | +2,961 | 0.00 | 0.01 | +0.01 | buy |
| China Universal Asset Management Co., Ltd. | 31,124 | 34,071 | +2,947 | 0.07 | 0.05 | -0.02 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 15,203 | 18,122 | +2,919 | 0.00 | 0.00 | -0.00 | buy |
| Caitong International Asset Management Co., Ltd | 1,116 | 3,979 | +2,863 | 0.03 | 0.05 | +0.02 | buy |
| RHUMBLINE ADVISERS | 80,932 | 83,555 | +2,623 | 0.00 | 0.00 | -0.00 | buy |
| Covestor Ltd | 1,309 | 3,764 | +2,455 | 0.02 | 0.04 | +0.02 | buy |
| CoreCap Advisors, LLC | 3,433 | 5,834 | +2,401 | 0.00 | 0.00 | +0.00 | buy |
| BI Asset Management Fondsmaeglerselskab A/S | 0 | 2,181 | +2,181 | 0.00 | 0.00 | +0.00 | buy |
| FNY Investment Advisers, LLC | 0 | 2,000 | +2,000 | 0.00 | 0.02 | +0.02 | buy |
| BANQUE PICTET & CIE SA | 145,480 | 147,397 | +1,917 | 0.04 | 0.03 | -0.01 | buy |
| Mirae Asset Global Investments Co., Ltd. | 4,891 | 5,928 | +1,037 | 0.00 | 0.00 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 28,063 | 28,793 | +730 | 0.00 | 0.00 | -0.00 | buy |