| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BAKER BROS. ADVISORS LP | 1,707,881 | 5,457,881 | +3,750,000 | 0.45 | 1.03 | +0.58 | buy |
| Deep Track Capital, LP | 6,000,000 | 9,500,000 | +3,500,000 | 5.57 | 5.26 | -0.31 | buy |
| Woodline Partners LP | 642,726 | 1,497,869 | +855,143 | 0.11 | 0.17 | +0.06 | buy |
| T. Rowe Price Investment Management, Inc. | 5,117,234 | 5,894,824 | +777,590 | 0.08 | 0.07 | -0.01 | buy |
| PERCEPTIVE ADVISORS LLC | 2,139,199 | 2,844,072 | +704,873 | 1.46 | 1.72 | +0.26 | buy |
| ARMISTICE CAPITAL, LLC | 3,870,586 | 4,500,000 | +629,414 | 1.31 | 1.15 | -0.16 | buy |
| Alpine Global Management, LLC | 2,158,904 | 2,626,692 | +467,788 | 15.75 | 11.88 | -3.87 | buy |
| Affinity Asset Advisors, LLC | 100,000 | 430,000 | +330,000 | 0.39 | 1.15 | +0.76 | buy |
| Vestal Point Capital, LP | 45,000 | 350,000 | +305,000 | 0.07 | 0.43 | +0.36 | buy |
| Aberdeen Group plc | 532,110 | 819,477 | +287,367 | 0.02 | 0.03 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 787,478 | 968,866 | +181,388 | 4.02 | 3.19 | -0.83 | buy |
| Two Seas Capital LP | 1,511,614 | 1,642,772 | +131,158 | 4.42 | 4.36 | -0.06 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 235,884 | 364,229 | +128,345 | 0.03 | 0.03 | +0.00 | buy |
| TWINBEECH CAPITAL LP | 12,689 | 102,036 | +89,347 | 0.01 | 0.03 | +0.03 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 95,200 | 182,500 | +87,300 | 0.00 | 0.00 | 0.00 | buy |
| Rock Springs Capital Management LP | 909,103 | 975,803 | +66,700 | 0.86 | 0.95 | +0.10 | buy |
| DAFNA Capital Management LLC | 107,996 | 169,996 | +62,000 | 0.68 | 0.82 | +0.14 | buy |
| EFG Asset Management (North America) Corp. | 73,981 | 130,356 | +56,375 | 0.25 | 0.37 | +0.12 | buy |
| Prosight Management, LP | 305,523 | 360,000 | +54,477 | 2.09 | 2.02 | -0.07 | buy |
| Hood River Capital Management LLC | 1,145,618 | 1,175,863 | +30,245 | 0.42 | 0.34 | -0.08 | buy |
| TD ASSET MANAGEMENT INC | 152,246 | 182,398 | +30,152 | 0.00 | 0.00 | -0.00 | buy |
| Tyro Capital Management LLC | 151,456 | 177,107 | +25,651 | 1.60 | 1.13 | -0.48 | buy |
| Granahan Investment Management, LLC | 149,396 | 172,316 | +22,920 | 0.15 | 0.15 | -0.01 | buy |
| Rafferty Asset Management, LLC | 116,624 | 138,837 | +22,213 | 0.01 | 0.01 | -0.00 | buy |
| ABC ARBITRAGE SA | 29,639 | 37,449 | +7,810 | 0.11 | 0.12 | +0.01 | buy |
| PROFUND ADVISORS LLC | 22,710 | 28,560 | +5,850 | 0.02 | 0.02 | +0.00 | buy |
| E Fund Management Co., Ltd. | 8,250 | 12,975 | +4,725 | 0.01 | 0.01 | +0.00 | buy |
| DnB Asset Management AS | 10,421 | 14,356 | +3,935 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 31,124 | 34,071 | +2,947 | 0.07 | 0.05 | -0.02 | buy |
| BANQUE PICTET & CIE SA | 145,480 | 147,397 | +1,917 | 0.02 | 0.02 | -0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 3,082 | 3,758 | +676 | 0.00 | 0.00 | -0.00 | buy |
| Knights of Columbus Asset Advisors LLC | 24,873 | 25,547 | +674 | 0.04 | 0.03 | -0.01 | buy |
| WCM INVESTMENT MANAGEMENT, LLC | 159,525 | 155,937 | -3,588 | 0.01 | 0.01 | -0.00 | sell |
| J. Goldman & Co LP | 34,337 | 21,000 | -13,337 | 0.02 | 0.01 | -0.01 | sell |
| Logos Global Management LP | 300,000 | 275,000 | -25,000 | 0.87 | 0.84 | -0.03 | sell |
| PLATINUM INVESTMENT MANAGEMENT LTD | 202,323 | 156,989 | -45,334 | 0.29 | 0.16 | -0.14 | sell |
| Knott David M Jr | 92,000 | 22,443 | -69,557 | 0.82 | 0.18 | -0.64 | sell |
| Redmile Group, LLC | 571,824 | 490,394 | -81,430 | 0.99 | 0.79 | -0.19 | sell |
| Rhenman & Partners Asset Management AB | 145,000 | 25,924 | -119,076 | 0.37 | 0.05 | -0.32 | sell |
| EMERALD ADVISERS, LLC | 244,558 | 9,246 | -235,312 | 0.23 | 0.01 | -0.23 | sell |
| STEMPOINT CAPITAL LP | 1,118,508 | 853,472 | -265,036 | 6.95 | 4.66 | -2.29 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 300,000 | 21,200 | -278,800 | 0.01 | 0.00 | -0.01 | sell |
| VIKING GLOBAL INVESTORS LP | 1,407,290 | 1,114,827 | -292,463 | 0.11 | 0.06 | -0.05 | sell |