| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 16,990,754 | 16,947,888 | -42,866 | 0.02 | 0.02 | +0.00 | sell |
| Deep Track Capital, LP | 11,526,971 | 11,526,971 | 0 | 6.68 | 5.91 | -0.78 | hold |
| BlackRock, Inc. | 6,058,216 | 6,574,497 | +516,281 | 0.00 | 0.00 | +0.00 | buy |
| BAKER BROS. ADVISORS LP | 5,457,881 | 5,457,881 | 0 | 0.81 | 0.78 | -0.03 | hold |
| STATE STREET CORP | 3,786,926 | 4,537,929 | +751,003 | 0.00 | 0.00 | +0.00 | buy |
| TCG Crossover Management, LLC | 1,660,933 | 4,457,988 | +2,797,055 | 1.40 | 3.17 | +1.77 | buy |
| MORGAN STANLEY | 4,846,385 | 3,876,877 | -969,508 | 0.01 | 0.01 | -0.00 | sell |
| T. Rowe Price Investment Management, Inc. | 5,060,399 | 3,612,860 | -1,447,539 | 0.08 | 0.06 | -0.02 | sell |
| ARMISTICE CAPITAL, LLC | 5,747,155 | 3,564,916 | -2,182,239 | 3.58 | 2.92 | -0.65 | sell |
| Two Seas Capital LP | 2,866,962 | 3,201,962 | +335,000 | 4.27 | 3.67 | -0.60 | buy |
| JENNISON ASSOCIATES LLC | 700,464 | 3,196,705 | +2,496,241 | 0.01 | 0.05 | +0.04 | buy |
| RTW INVESTMENTS, LP | 3,177,850 | 3,177,849 | -1 | 0.81 | 0.79 | -0.02 | sell |
| ADAR1 Capital Management, LLC | 2,480,968 | 2,679,010 | +198,042 | 4.72 | 4.00 | -0.72 | buy |
| Alpine Global Management, LLC | 2,626,692 | 2,636,925 | +10,233 | 14.85 | 9.96 | -4.89 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,857,532 | 2,092,102 | +234,570 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 1,975,869 | 1,975,869 | 0 | 0.19 | 0.19 | -0.01 | hold |
| GOLDMAN SACHS GROUP INC | 1,296,008 | 1,785,107 | +489,099 | 0.00 | 0.01 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 1,994,890 | 1,597,383 | -397,507 | 0.93 | 0.78 | -0.15 | sell |
| FARALLON CAPITAL MANAGEMENT LLC | 12,000 | 1,546,000 | +1,534,000 | 0.00 | 0.23 | +0.23 | buy |
| Aberdeen Group plc | 1,184,122 | 1,160,762 | -23,360 | 0.05 | 0.05 | -0.00 | sell |
| Logos Global Management LP | 1,375,000 | 1,075,000 | -300,000 | 2.33 | 1.38 | -0.95 | sell |
| BANK OF AMERICA CORP /DE/ | 313,481 | 893,678 | +580,197 | 0.00 | 0.00 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 644,959 | 746,494 | +101,535 | 2.81 | 3.56 | +0.75 | buy |
| UBS Group AG | 732,386 | 684,551 | -47,835 | 0.00 | 0.00 | -0.00 | sell |
| Candriam S.C.A. | 680,372 | 680,372 | 0 | 0.09 | 0.09 | +0.00 | hold |
| NORTHERN TRUST CORP | 566,148 | 672,774 | +106,626 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 642,974 | 660,438 | +17,464 | 0.00 | 0.00 | -0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 259,117 | 617,807 | +358,690 | 0.01 | 0.02 | +0.01 | buy |
| GREAT POINT PARTNERS LLC | 750,000 | 545,625 | -204,375 | 6.18 | 3.32 | -2.86 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 467,469 | 503,673 | +36,204 | 0.03 | 0.03 | -0.00 | buy |
| Pictet Asset Management Holding SA | 380,842 | 472,381 | +91,539 | 0.01 | 0.01 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 414,236 | +414,236 | 0.00 | 1.21 | +1.21 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 863,000 | 413,000 | -450,000 | 0.03 | 0.02 | -0.02 | sell |
| SUPERSTRING CAPITAL MANAGEMENT LP | 288,677 | 357,606 | +68,929 | 3.93 | 6.35 | +2.42 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 893,056 | 339,607 | -553,449 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 353,056 | 334,557 | -18,499 | 0.01 | 0.01 | -0.00 | sell |
| Granahan Investment Management, LLC | 230,188 | 244,430 | +14,242 | 0.25 | 0.29 | +0.04 | buy |
| Nuveen, LLC | 226,489 | 241,195 | +14,706 | 0.00 | 0.00 | +0.00 | buy |
| Soleus Capital Management, L.P. | 1,110,000 | 230,000 | -880,000 | 1.20 | 0.23 | -0.97 | sell |
| HighVista Strategies LLC | 221,883 | 225,139 | +3,256 | 1.45 | 1.54 | +0.09 | buy |
| TFG Asset Management GP Ltd | 166,187 | 218,507 | +52,320 | 0.89 | 1.07 | +0.18 | buy |
| Bank of New York Mellon Corp | 199,364 | 216,225 | +16,861 | 0.00 | 0.00 | +0.00 | buy |
| Assenagon Asset Management S.A. | 205,219 | 205,219 | 0 | 0.01 | 0.01 | +0.00 | hold |
| XTX Topco Ltd | 33,122 | 203,029 | +169,907 | 0.02 | 0.09 | +0.07 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 192,500 | +192,500 | 0.00 | 0.01 | +0.01 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 181,774 | 181,774 | 0 | 1.07 | 1.14 | +0.07 | hold |
| Prosight Management, LP | 243,404 | 175,825 | -67,579 | 1.28 | 0.72 | -0.56 | sell |
| MARSHALL WACE, LLP | 0 | 165,300 | +165,300 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 158,300 | 159,400 | +1,100 | 0.00 | 0.00 | -0.00 | buy |
| DAFNA Capital Management LLC | 150,524 | 150,524 | 0 | 0.89 | 0.85 | -0.04 | hold |
| Erste Asset Management GmbH | 128,500 | 144,500 | +16,000 | 0.03 | 0.03 | +0.00 | buy |
| CITADEL ADVISORS LLC | 154,507 | 144,398 | -10,109 | 0.00 | 0.00 | -0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 134,441 | 141,728 | +7,287 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 132,346 | 136,619 | +4,273 | 0.01 | 0.01 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 224,960 | 131,352 | -93,608 | 0.00 | 0.00 | -0.00 | sell |
| Blackstone Inc. | 79,673 | 107,297 | +27,624 | 0.01 | 0.01 | +0.00 | buy |
| ALGERT GLOBAL LLC | 0 | 105,770 | +105,770 | 0.00 | 0.04 | +0.04 | buy |
| Affinity Asset Advisors, LLC | 200,000 | 100,000 | -100,000 | 0.37 | 0.15 | -0.22 | sell |
| RHUMBLINE ADVISERS | 86,847 | 97,493 | +10,646 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 79,866 | 96,882 | +17,016 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 85,952 | 94,286 | +8,334 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 88,857 | 93,894 | +5,037 | 0.00 | 0.00 | +0.00 | buy |
| DME Capital Management, LP | 0 | 93,520 | +93,520 | 0.00 | 0.07 | +0.07 | buy |
| Hennion & Walsh Asset Management, Inc. | 71,705 | 91,009 | +19,304 | 0.06 | 0.08 | +0.01 | buy |
| ALLIANCEBERNSTEIN L.P. | 89,160 | 90,410 | +1,250 | 0.00 | 0.00 | +0.00 | buy |
| BANQUE PICTET & CIE SA | 114,881 | 88,660 | -26,221 | 0.03 | 0.03 | -0.00 | sell |
| JANE STREET GROUP, LLC | 0 | 84,312 | +84,312 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 62,458 | 79,000 | +16,542 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 92,714 | 74,456 | -18,258 | 0.00 | 0.00 | -0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 44,140 | 72,820 | +28,680 | 0.10 | 0.11 | +0.02 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 40,305 | 71,801 | +31,496 | 0.00 | 0.00 | +0.00 | buy |
| ArrowMark Colorado Holdings LLC | 70,000 | 70,000 | 0 | 0.04 | 0.05 | +0.01 | hold |
| Amundi | 67,404 | 66,848 | -556 | 0.00 | 0.00 | -0.00 | sell |
| HRT FINANCIAL LP | 84,840 | 66,485 | -18,355 | 0.01 | 0.00 | -0.00 | sell |
| PROFUND ADVISORS LLC | 49,076 | 61,008 | +11,932 | 0.04 | 0.06 | +0.02 | buy |
| DIMENSIONAL FUND ADVISORS LP | 160,442 | 57,086 | -103,356 | 0.00 | 0.00 | -0.00 | sell |
| HighTower Advisors, LLC | 33,408 | 56,744 | +23,336 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 53,631 | 54,286 | +655 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 97,234 | 51,421 | -45,813 | 0.00 | 0.00 | -0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 38,919 | 51,022 | +12,103 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 48,411 | 50,276 | +1,865 | 0.03 | 0.04 | +0.00 | buy |
| Creative Planning | 41,501 | 45,729 | +4,228 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 39,036 | 44,461 | +5,425 | 0.00 | 0.01 | +0.00 | buy |
| Jump Financial, LLC | 104,602 | 44,202 | -60,400 | 0.03 | 0.02 | -0.02 | sell |
| Quantinno Capital Management LP | 14,243 | 40,030 | +25,787 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 28,561 | 37,718 | +9,157 | 0.06 | 0.07 | +0.02 | buy |
| Quinn Opportunity Partners LLC | 61,108 | 37,500 | -23,608 | 0.07 | 0.05 | -0.02 | sell |
| JANUS HENDERSON GROUP PLC | 33,731 | 33,731 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Schonfeld Strategic Advisors LLC | 0 | 33,553 | +33,553 | 0.00 | 0.01 | +0.01 | buy |
| WELLS FARGO & COMPANY/MN | 79,667 | 33,222 | -46,445 | 0.00 | 0.00 | -0.00 | sell |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 0 | 33,173 | +33,173 | 0.00 | 0.00 | +0.00 | buy |
| DekaBank Deutsche Girozentrale | 32,600 | 32,600 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Handelsbanken Fonder AB | 32,300 | 32,300 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Ellsworth Advisors, LLC | 0 | 32,280 | +32,280 | 0.00 | 0.15 | +0.15 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 35,189 | 29,979 | -5,210 | 0.01 | 0.01 | -0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 28,847 | 28,525 | -322 | 0.00 | 0.00 | +0.00 | sell |
| Bridgefront Capital, LLC | 0 | 27,809 | +27,809 | 0.00 | 0.17 | +0.17 | buy |
| State of New Jersey Common Pension Fund D | 23,799 | 27,542 | +3,743 | 0.00 | 0.00 | +0.00 | buy |
| LMR Partners LLP | 25,067 | 26,045 | +978 | 0.01 | 0.01 | -0.00 | buy |
| Trexquant Investment LP | 114,995 | 25,692 | -89,303 | 0.03 | 0.00 | -0.02 | sell |