| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 7,655,945 | 10,483,883 | +2,827,938 | 0.02 | 0.02 | +0.00 | buy |
| VANGUARD GROUP INC | 6,478,304 | 6,509,753 | +31,449 | 0.00 | 0.00 | -0.00 | buy |
| ARMISTICE CAPITAL, LLC | 2,164,000 | 3,396,909 | +1,232,909 | 1.86 | 2.35 | +0.48 | buy |
| Deep Track Capital, LP | 493,352 | 2,883,736 | +2,390,384 | 0.46 | 2.27 | +1.82 | buy |
| STATE STREET CORP | 3,641,907 | 2,718,956 | -922,951 | 0.01 | 0.00 | -0.00 | sell |
| VIKING GLOBAL INVESTORS LP | 1,809,172 | 2,320,902 | +511,730 | 0.22 | 0.24 | +0.02 | buy |
| PERCEPTIVE ADVISORS LLC | 2,963,212 | 1,923,786 | -1,039,426 | 1.69 | 1.23 | -0.46 | sell |
| Alpine Global Management, LLC | 1,882,704 | 1,907,704 | +25,000 | 11.78 | 8.76 | -3.02 | buy |
| Woodline Partners LP | 1,289,504 | 1,823,415 | +533,911 | 0.39 | 0.46 | +0.08 | buy |
| T. Rowe Price Investment Management, Inc. | 0 | 1,625,220 | +1,625,220 | 0.00 | 0.03 | +0.03 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,316,827 | 1,414,002 | +97,175 | 0.00 | 0.00 | -0.00 | buy |
| Paradigm Biocapital Advisors LP | 799,054 | 1,362,827 | +563,773 | 0.91 | 1.38 | +0.47 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,862,043 | 1,361,649 | -500,394 | 0.01 | 0.00 | -0.00 | sell |
| Rock Springs Capital Management LP | 1,150,123 | 1,185,654 | +35,531 | 0.94 | 0.94 | +0.00 | buy |
| Pictet Asset Management Holding SA | 1,265,298 | 1,174,816 | -90,482 | 0.04 | 0.04 | -0.01 | sell |
| FRANKLIN RESOURCES INC | 869,216 | 1,101,868 | +232,652 | 0.01 | 0.01 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 627,228 | 1,011,879 | +384,651 | 5.41 | 7.86 | +2.44 | buy |
| Capital Research Global Investors | 976,237 | 976,237 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Avidity Partners Management LP | 505,000 | 908,000 | +403,000 | 0.58 | 1.02 | +0.44 | buy |
| MORGAN STANLEY | 937,961 | 817,038 | -120,923 | 0.00 | 0.00 | -0.00 | sell |
| Commodore Capital LP | 750,990 | 750,990 | 0 | 1.62 | 1.35 | -0.27 | hold |
| Redmile Group, LLC | 969,621 | 720,177 | -249,444 | 1.15 | 1.15 | -0.00 | sell |
| First Turn Management, LLC | 512,893 | 695,428 | +182,535 | 2.48 | 2.99 | +0.51 | buy |
| Two Seas Capital LP | 541,295 | 692,406 | +151,111 | 3.43 | 2.98 | -0.44 | buy |
| FRED ALGER MANAGEMENT, LLC | 1,271,762 | 607,724 | -664,038 | 0.20 | 0.08 | -0.13 | sell |
| NORGES BANK | 656,100 | 601,861 | -54,239 | 0.00 | 0.00 | -0.00 | sell |
| Logos Global Management LP | 1,775,000 | 575,000 | -1,200,000 | 6.04 | 1.75 | -4.29 | sell |
| Invesco Ltd. | 526,233 | 570,898 | +44,665 | 0.00 | 0.00 | -0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 582,721 | 559,688 | -23,033 | 0.01 | 0.01 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 573,447 | 494,689 | -78,758 | 0.01 | 0.00 | -0.00 | sell |
| ADAR1 Capital Management, LLC | 60,763 | 476,543 | +415,780 | 0.54 | 2.53 | +2.00 | buy |
| PFM Health Sciences, LP | 472,540 | 472,540 | 0 | 0.76 | 0.68 | -0.08 | hold |
| BAKER BROS. ADVISORS LP | 425,009 | 464,718 | +39,709 | 0.17 | 0.16 | -0.02 | buy |
| NORTHERN TRUST CORP | 478,707 | 463,721 | -14,986 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 442,084 | 461,171 | +19,087 | 0.00 | 0.00 | -0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 100,000 | 420,000 | +320,000 | 0.01 | 0.02 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 349,177 | 411,918 | +62,741 | 0.00 | 0.00 | -0.00 | buy |
| Aberdeen Group plc | 187,636 | 400,722 | +213,086 | 0.01 | 0.02 | +0.01 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 339,700 | 388,100 | +48,400 | 0.02 | 0.02 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 285,000 | 346,088 | +61,088 | 1.50 | 1.44 | -0.06 | buy |
| CITADEL ADVISORS LLC | 228,499 | 343,512 | +115,013 | 0.01 | 0.01 | +0.00 | buy |
| Prosight Management, LP | 195,000 | 325,000 | +130,000 | 1.75 | 2.56 | +0.81 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 206,031 | 320,508 | +114,477 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 319,001 | 312,370 | -6,631 | 0.01 | 0.01 | -0.00 | sell |
| Assenagon Asset Management S.A. | 104,522 | 311,525 | +207,003 | 0.01 | 0.02 | +0.01 | buy |
| EMERALD ADVISERS, LLC | 302,789 | 288,564 | -14,225 | 0.39 | 0.32 | -0.07 | sell |
| Skandinaviska Enskilda Banken AB (publ) | 277,022 | 277,022 | 0 | 0.04 | 0.04 | -0.01 | hold |
| Ikarian Capital, LLC | 276,925 | 276,925 | 0 | 2.43 | 2.28 | -0.15 | hold |
| MILLENNIUM MANAGEMENT LLC | 459,027 | 275,352 | -183,675 | 0.01 | 0.01 | -0.01 | sell |
| JPMORGAN CHASE & CO | 245,033 | 256,843 | +11,810 | 0.00 | 0.00 | -0.00 | buy |
| Soleus Capital Management, L.P. | 264,650 | 251,900 | -12,750 | 0.75 | 0.59 | -0.16 | sell |
| Tyro Capital Management LLC | 97,667 | 250,620 | +152,953 | 1.82 | 3.00 | +1.18 | buy |
| Bank of New York Mellon Corp | 222,379 | 250,339 | +27,960 | 0.00 | 0.00 | -0.00 | buy |
| Senator Investment Group LP | 250,000 | 250,000 | 0 | 0.37 | 0.32 | -0.05 | hold |
| BANK OF AMERICA CORP /DE/ | 208,630 | 243,334 | +34,704 | 0.00 | 0.00 | -0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 144,385 | 238,588 | +94,203 | 0.02 | 0.03 | +0.01 | buy |
| Ensign Peak Advisors, Inc | 167,056 | 204,221 | +37,165 | 0.01 | 0.01 | -0.00 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 201,087 | 201,087 | 0 | 0.34 | 0.28 | -0.06 | hold |
| CANADA PENSION PLAN INVESTMENT BOARD | 0 | 199,800 | +199,800 | 0.00 | 0.01 | +0.01 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 190,656 | 192,242 | +1,586 | 0.25 | 0.21 | -0.04 | buy |
| WCM INVESTMENT MANAGEMENT, LLC | 169,665 | 175,542 | +5,877 | 0.01 | 0.01 | -0.00 | buy |
| Russell Investments Group, Ltd. | 176,346 | 175,195 | -1,151 | 0.01 | 0.01 | -0.00 | sell |
| Jump Financial, LLC | 95,000 | 151,472 | +56,472 | 0.08 | 0.08 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 145,425 | 142,974 | -2,451 | 0.00 | 0.00 | -0.00 | sell |
| Rafferty Asset Management, LLC | 289,385 | 140,698 | -148,687 | 0.03 | 0.01 | -0.02 | sell |
| JANE STREET GROUP, LLC | 67,605 | 140,317 | +72,712 | 0.00 | 0.00 | +0.00 | buy |
| Rhenman & Partners Asset Management AB | 125,500 | 130,500 | +5,000 | 0.38 | 0.33 | -0.05 | buy |
| ExodusPoint Capital Management, LP | 69,154 | 126,660 | +57,506 | 0.03 | 0.04 | +0.01 | buy |
| MACQUARIE GROUP LTD | 103,100 | 122,100 | +19,000 | 0.00 | 0.00 | -0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 243,643 | 121,692 | -121,951 | 0.01 | 0.01 | -0.01 | sell |
| ALGERT GLOBAL LLC | 51,660 | 120,938 | +69,278 | 0.07 | 0.11 | +0.04 | buy |
| UBS Group AG | 202,550 | 119,355 | -83,195 | 0.00 | 0.00 | -0.00 | sell |
| ALPS ADVISORS INC | 0 | 113,931 | +113,931 | 0.00 | 0.02 | +0.02 | buy |
| Swiss National Bank | 99,600 | 99,600 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AXA S.A. | 98,754 | 98,810 | +56 | 0.01 | 0.01 | -0.00 | buy |
| BARCLAYS PLC | 209,270 | 98,440 | -110,830 | 0.00 | 0.00 | -0.00 | sell |
| Eversept Partners, LP | 255,526 | 92,909 | -162,617 | 0.62 | 0.19 | -0.43 | sell |
| Knott David M Jr | 85,300 | 91,500 | +6,200 | 0.97 | 0.96 | -0.01 | buy |
| AQR CAPITAL MANAGEMENT LLC | 88,598 | 86,283 | -2,315 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 76,169 | 83,532 | +7,363 | 0.00 | 0.00 | -0.00 | buy |
| Blue Owl Capital Holdings LP | 100,000 | 80,000 | -20,000 | 0.65 | 0.59 | -0.06 | sell |
| Polar Asset Management Partners Inc. | 51,500 | 75,300 | +23,800 | 0.04 | 0.05 | +0.01 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 51,401 | 71,745 | +20,344 | 0.00 | 0.01 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 67,150 | 71,450 | +4,300 | 0.00 | 0.00 | -0.00 | buy |
| ArrowMark Colorado Holdings LLC | 70,000 | 70,000 | 0 | 0.03 | 0.02 | -0.00 | hold |
| BANQUE PICTET & CIE SA | 70,309 | 68,152 | -2,157 | 0.02 | 0.02 | -0.01 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 80,910 | 65,046 | -15,864 | 0.00 | 0.00 | -0.00 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 65,017 | 64,796 | -221 | 0.06 | 0.05 | -0.01 | sell |
| Allspring Global Investments Holdings, LLC | 65,091 | 60,947 | -4,144 | 0.00 | 0.00 | -0.00 | sell |
| GROUP ONE TRADING LLC | 31,908 | 59,007 | +27,099 | 0.04 | 0.05 | +0.01 | buy |
| Rubric Capital Management LP | 0 | 58,624 | +58,624 | 0.00 | 0.04 | +0.04 | buy |
| EFG Asset Management (North America) Corp. | 47,070 | 58,070 | +11,000 | 0.26 | 0.27 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 24,989 | 56,961 | +31,972 | 0.02 | 0.05 | +0.02 | buy |
| Tejara Capital Ltd | 0 | 55,210 | +55,210 | 0.00 | 0.53 | +0.53 | buy |
| BAMCO INC /NY/ | 60,000 | 55,000 | -5,000 | 0.01 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 53,266 | 53,984 | +718 | 0.00 | 0.00 | -0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 50,959 | 50,235 | -724 | 0.00 | 0.00 | -0.00 | sell |
| AWM Investment Company, Inc. | 70,000 | 50,000 | -20,000 | 0.30 | 0.18 | -0.12 | sell |
| Squarepoint Ops LLC | 46,673 | 49,288 | +2,615 | 0.01 | 0.00 | -0.00 | buy |
| DAFNA Capital Management LLC | 29,416 | 47,916 | +18,500 | 0.22 | 0.30 | +0.09 | buy |