| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 7,655,945 | 10,483,883 | +2,827,938 | 0.02 | 0.02 | +0.00 | buy |
| Deep Track Capital, LP | 493,352 | 2,883,736 | +2,390,384 | 0.46 | 2.27 | +1.82 | buy |
| T. Rowe Price Investment Management, Inc. | 0 | 1,625,220 | +1,625,220 | 0.00 | 0.03 | +0.03 | buy |
| ARMISTICE CAPITAL, LLC | 2,164,000 | 3,396,909 | +1,232,909 | 1.86 | 2.35 | +0.48 | buy |
| Paradigm Biocapital Advisors LP | 799,054 | 1,362,827 | +563,773 | 0.91 | 1.38 | +0.47 | buy |
| Woodline Partners LP | 1,289,504 | 1,823,415 | +533,911 | 0.39 | 0.46 | +0.08 | buy |
| VIKING GLOBAL INVESTORS LP | 1,809,172 | 2,320,902 | +511,730 | 0.22 | 0.24 | +0.02 | buy |
| ADAR1 Capital Management, LLC | 60,763 | 476,543 | +415,780 | 0.54 | 2.53 | +2.00 | buy |
| Avidity Partners Management LP | 505,000 | 908,000 | +403,000 | 0.58 | 1.02 | +0.44 | buy |
| STEMPOINT CAPITAL LP | 627,228 | 1,011,879 | +384,651 | 5.41 | 7.86 | +2.44 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 100,000 | 420,000 | +320,000 | 0.01 | 0.02 | +0.01 | buy |
| FRANKLIN RESOURCES INC | 869,216 | 1,101,868 | +232,652 | 0.01 | 0.01 | +0.00 | buy |
| Aberdeen Group plc | 187,636 | 400,722 | +213,086 | 0.01 | 0.02 | +0.01 | buy |
| Assenagon Asset Management S.A. | 104,522 | 311,525 | +207,003 | 0.01 | 0.02 | +0.01 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 0 | 199,800 | +199,800 | 0.00 | 0.01 | +0.01 | buy |
| First Turn Management, LLC | 512,893 | 695,428 | +182,535 | 2.48 | 2.99 | +0.51 | buy |
| Tyro Capital Management LLC | 97,667 | 250,620 | +152,953 | 1.82 | 3.00 | +1.18 | buy |
| Two Seas Capital LP | 541,295 | 692,406 | +151,111 | 3.43 | 2.98 | -0.44 | buy |
| Prosight Management, LP | 195,000 | 325,000 | +130,000 | 1.75 | 2.56 | +0.81 | buy |
| CITADEL ADVISORS LLC | 228,499 | 343,512 | +115,013 | 0.01 | 0.01 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 206,031 | 320,508 | +114,477 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 0 | 113,931 | +113,931 | 0.00 | 0.02 | +0.02 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,316,827 | 1,414,002 | +97,175 | 0.00 | 0.00 | -0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 144,385 | 238,588 | +94,203 | 0.02 | 0.03 | +0.01 | buy |
| JANE STREET GROUP, LLC | 67,605 | 140,317 | +72,712 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 51,660 | 120,938 | +69,278 | 0.07 | 0.11 | +0.04 | buy |
| GOLDMAN SACHS GROUP INC | 349,177 | 411,918 | +62,741 | 0.00 | 0.00 | -0.00 | buy |
| Affinity Asset Advisors, LLC | 285,000 | 346,088 | +61,088 | 1.50 | 1.44 | -0.06 | buy |
| Rubric Capital Management LP | 0 | 58,624 | +58,624 | 0.00 | 0.04 | +0.04 | buy |
| ExodusPoint Capital Management, LP | 69,154 | 126,660 | +57,506 | 0.03 | 0.04 | +0.01 | buy |
| Jump Financial, LLC | 95,000 | 151,472 | +56,472 | 0.08 | 0.08 | -0.00 | buy |
| Tejara Capital Ltd | 0 | 55,210 | +55,210 | 0.00 | 0.53 | +0.53 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 339,700 | 388,100 | +48,400 | 0.02 | 0.02 | +0.00 | buy |
| Invesco Ltd. | 526,233 | 570,898 | +44,665 | 0.00 | 0.00 | -0.00 | buy |
| BAKER BROS. ADVISORS LP | 425,009 | 464,718 | +39,709 | 0.17 | 0.16 | -0.02 | buy |
| Ensign Peak Advisors, Inc | 167,056 | 204,221 | +37,165 | 0.01 | 0.01 | -0.00 | buy |
| Rock Springs Capital Management LP | 1,150,123 | 1,185,654 | +35,531 | 0.94 | 0.94 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 208,630 | 243,334 | +34,704 | 0.00 | 0.00 | -0.00 | buy |
| SIMPLEX TRADING, LLC | 24,989 | 56,961 | +31,972 | 0.02 | 0.05 | +0.02 | buy |
| VANGUARD GROUP INC | 6,478,304 | 6,509,753 | +31,449 | 0.00 | 0.00 | -0.00 | buy |
| Bank of New York Mellon Corp | 222,379 | 250,339 | +27,960 | 0.00 | 0.00 | -0.00 | buy |
| GROUP ONE TRADING LLC | 31,908 | 59,007 | +27,099 | 0.04 | 0.05 | +0.01 | buy |
| SG Americas Securities, LLC | 4,156 | 30,702 | +26,546 | 0.00 | 0.01 | +0.00 | buy |
| Alpine Global Management, LLC | 1,882,704 | 1,907,704 | +25,000 | 11.78 | 8.76 | -3.02 | buy |
| Polar Asset Management Partners Inc. | 51,500 | 75,300 | +23,800 | 0.04 | 0.05 | +0.01 | buy |
| TWINBEECH CAPITAL LP | 7,401 | 30,859 | +23,458 | 0.00 | 0.02 | +0.01 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 22,227 | +22,227 | 0.00 | 0.00 | +0.00 | buy |
| WINTON GROUP Ltd | 0 | 20,675 | +20,675 | 0.00 | 0.04 | +0.04 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 51,401 | 71,745 | +20,344 | 0.00 | 0.01 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 442,084 | 461,171 | +19,087 | 0.00 | 0.00 | -0.00 | buy |
| MACQUARIE GROUP LTD | 103,100 | 122,100 | +19,000 | 0.00 | 0.00 | -0.00 | buy |
| DAFNA Capital Management LLC | 29,416 | 47,916 | +18,500 | 0.22 | 0.30 | +0.09 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 0 | 17,684 | +17,684 | 0.00 | 0.01 | +0.01 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 14,824 | +14,824 | 0.00 | 0.03 | +0.03 | buy |
| Tower Research Capital LLC (TRC) | 512 | 14,142 | +13,630 | 0.00 | 0.01 | +0.01 | buy |
| Engineers Gate Manager LP | 0 | 13,564 | +13,564 | 0.00 | 0.01 | +0.01 | buy |
| AIGEN INVESTMENT MANAGEMENT, LP | 0 | 13,323 | +13,323 | 0.00 | 0.07 | +0.07 | buy |
| Scientech Research LLC | 0 | 12,634 | +12,634 | 0.00 | 0.07 | +0.07 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 0 | 12,000 | +12,000 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 245,033 | 256,843 | +11,810 | 0.00 | 0.00 | -0.00 | buy |
| EFG Asset Management (North America) Corp. | 47,070 | 58,070 | +11,000 | 0.26 | 0.27 | +0.00 | buy |
| Harbour Capital Advisors, LLC | 0 | 9,400 | +9,400 | 0.00 | 0.06 | +0.06 | buy |
| RHUMBLINE ADVISERS | 76,169 | 83,532 | +7,363 | 0.00 | 0.00 | -0.00 | buy |
| Knott David M Jr | 85,300 | 91,500 | +6,200 | 0.97 | 0.96 | -0.01 | buy |
| WCM INVESTMENT MANAGEMENT, LLC | 169,665 | 175,542 | +5,877 | 0.01 | 0.01 | -0.00 | buy |
| MetLife Investment Management, LLC | 28,477 | 33,608 | +5,131 | 0.01 | 0.01 | -0.00 | buy |
| Rhenman & Partners Asset Management AB | 125,500 | 130,500 | +5,000 | 0.38 | 0.33 | -0.05 | buy |
| Handelsbanken Fonder AB | 11,800 | 16,200 | +4,400 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 67,150 | 71,450 | +4,300 | 0.00 | 0.00 | -0.00 | buy |
| GUGGENHEIM CAPITAL LLC | 34,227 | 37,538 | +3,311 | 0.01 | 0.01 | -0.00 | buy |
| CANADA LIFE ASSURANCE Co | 12,331 | 15,403 | +3,072 | 0.00 | 0.00 | -0.00 | buy |
| Headlands Technologies LLC | 0 | 2,927 | +2,927 | 0.00 | 0.01 | +0.01 | buy |
| Squarepoint Ops LLC | 46,673 | 49,288 | +2,615 | 0.01 | 0.00 | -0.00 | buy |
| Covestor Ltd | 253 | 2,507 | +2,254 | 0.01 | 0.04 | +0.04 | buy |
| Twin Tree Management, LP | 0 | 2,201 | +2,201 | 0.00 | 0.00 | +0.00 | buy |
| Catalyst Funds Management Pty Ltd | 0 | 2,200 | +2,200 | 0.00 | 0.02 | +0.02 | buy |
| ROYAL BANK OF CANADA | 18,497 | 20,342 | +1,845 | 0.00 | 0.00 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 17,662 | 19,487 | +1,825 | 0.00 | 0.00 | -0.00 | buy |
| STRS OHIO | 15,700 | 17,500 | +1,800 | 0.00 | 0.00 | -0.00 | buy |
| AlphaQuest LLC | 824 | 2,610 | +1,786 | 0.00 | 0.01 | +0.00 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 14,134 | 15,774 | +1,640 | 0.00 | 0.00 | +0.00 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 190,656 | 192,242 | +1,586 | 0.25 | 0.21 | -0.04 | buy |
| VIRTUS ADVISERS, LLC | 2,031 | 3,403 | +1,372 | 0.03 | 0.04 | +0.01 | buy |
| DnB Asset Management AS | 9,332 | 10,290 | +958 | 0.00 | 0.00 | -0.00 | buy |
| Legal & General Group Plc | 53,266 | 53,984 | +718 | 0.00 | 0.00 | -0.00 | buy |
| BFSG, LLC | 0 | 600 | +600 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 8,313 | 8,848 | +535 | 0.00 | 0.00 | -0.00 | buy |
| Arizona State Retirement System | 13,915 | 14,235 | +320 | 0.00 | 0.00 | -0.00 | buy |
| CWM, LLC | 53 | 315 | +262 | 0.00 | 0.00 | +0.00 | buy |
| Blue Trust, Inc. | 0 | 155 | +155 | 0.00 | 0.00 | +0.00 | buy |
| Smartleaf Asset Management LLC | 0 | 113 | +113 | 0.00 | 0.00 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 1,521 | 1,585 | +64 | 0.00 | 0.00 | -0.00 | buy |
| INNEALTA CAPITAL, LLC | 0 | 59 | +59 | 0.00 | 0.00 | +0.00 | buy |
| COMERICA BANK | 524 | 583 | +59 | 0.00 | 0.00 | -0.00 | buy |
| AXA S.A. | 98,754 | 98,810 | +56 | 0.01 | 0.01 | -0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 3,797 | 3,838 | +41 | 0.00 | 0.00 | -0.00 | buy |
| ASSETMARK, INC | 1,639 | 1,663 | +24 | 0.00 | 0.00 | -0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 5 | 25 | +20 | 0.00 | 0.00 | +0.00 | buy |
| CIBC Private Wealth Group LLC | 0 | 17 | +17 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 3 | 14 | +11 | 0.00 | 0.00 | +0.00 | buy |