| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Deep Track Capital, LP | 493,352 | 2,883,736 | +2,390,384 | 0.46 | 2.27 | +1.82 | buy |
| ARMISTICE CAPITAL, LLC | 2,164,000 | 3,396,909 | +1,232,909 | 0.93 | 1.13 | +0.20 | buy |
| Paradigm Biocapital Advisors LP | 799,054 | 1,362,827 | +563,773 | 0.91 | 1.38 | +0.47 | buy |
| Woodline Partners LP | 1,289,504 | 1,823,415 | +533,911 | 0.39 | 0.46 | +0.08 | buy |
| VIKING GLOBAL INVESTORS LP | 1,809,172 | 2,320,902 | +511,730 | 0.22 | 0.24 | +0.02 | buy |
| ADAR1 Capital Management, LLC | 60,763 | 476,543 | +415,780 | 0.54 | 2.53 | +2.00 | buy |
| Avidity Partners Management LP | 505,000 | 908,000 | +403,000 | 0.58 | 1.02 | +0.44 | buy |
| STEMPOINT CAPITAL LP | 627,228 | 1,011,879 | +384,651 | 5.41 | 7.86 | +2.44 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 100,000 | 420,000 | +320,000 | 0.01 | 0.02 | +0.01 | buy |
| Aberdeen Group plc | 187,636 | 400,722 | +213,086 | 0.01 | 0.02 | +0.01 | buy |
| First Turn Management, LLC | 512,893 | 695,428 | +182,535 | 2.48 | 2.99 | +0.51 | buy |
| Tyro Capital Management LLC | 97,667 | 250,620 | +152,953 | 1.82 | 3.00 | +1.18 | buy |
| Two Seas Capital LP | 541,295 | 692,406 | +151,111 | 3.43 | 2.98 | -0.44 | buy |
| Prosight Management, LP | 195,000 | 325,000 | +130,000 | 1.75 | 2.56 | +0.81 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 144,385 | 238,588 | +94,203 | 0.02 | 0.03 | +0.01 | buy |
| ALGERT GLOBAL LLC | 51,660 | 120,938 | +69,278 | 0.07 | 0.11 | 0.00 | buy |
| Affinity Asset Advisors, LLC | 285,000 | 346,088 | +61,088 | 1.50 | 1.44 | -0.06 | buy |
| ExodusPoint Capital Management, LP | 69,154 | 126,660 | +57,506 | 0.03 | 0.04 | 0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 339,700 | 388,100 | +48,400 | 0.02 | 0.02 | -0.00 | buy |
| BAKER BROS. ADVISORS LP | 425,009 | 464,718 | +39,709 | 0.17 | 0.16 | -0.02 | buy |
| Rock Springs Capital Management LP | 1,150,123 | 1,185,654 | +35,531 | 0.94 | 0.94 | -0.00 | buy |
| Alpine Global Management, LLC | 1,882,704 | 1,907,704 | +25,000 | 11.78 | 8.76 | -3.02 | buy |
| Polar Asset Management Partners Inc. | 51,500 | 75,300 | +23,800 | 0.03 | 0.04 | +0.01 | buy |
| TWINBEECH CAPITAL LP | 7,401 | 30,859 | +23,458 | 0.00 | 0.02 | +0.01 | buy |
| PROFUND ADVISORS LLC | 45,004 | 26,140 | +18,864 | 0.06 | 0.03 | 0.00 | sell |
| DAFNA Capital Management LLC | 29,416 | 47,916 | +18,500 | 0.22 | 0.30 | +0.09 | buy |
| EFG Asset Management (North America) Corp. | 47,070 | 58,070 | +11,000 | 0.26 | 0.27 | +0.00 | buy |
| Knott David M Jr | 85,300 | 91,500 | +6,200 | 0.97 | 0.96 | -0.01 | buy |
| WCM INVESTMENT MANAGEMENT, LLC | 169,665 | 175,542 | +5,877 | 0.01 | 0.01 | -0.00 | buy |
| Rhenman & Partners Asset Management AB | 125,500 | 130,500 | +5,000 | 0.38 | 0.33 | -0.05 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 190,656 | 192,242 | +1,586 | 0.25 | 0.21 | -0.04 | buy |
| VIRTUS ADVISERS, LLC | 2,031 | 3,403 | +1,372 | 0.03 | 0.04 | +0.01 | buy |
| DnB Asset Management AS | 9,332 | 10,290 | +958 | 0.00 | 0.00 | -0.00 | buy |
| BANQUE PICTET & CIE SA | 70,309 | 68,152 | -2,157 | 0.02 | 0.02 | -0.01 | sell |
| EntryPoint Capital, LLC | 2,912 | 470 | -2,442 | 0.08 | 0.02 | -0.07 | sell |
| BAMCO INC /NY/ | 60,000 | 55,000 | -5,000 | 0.01 | 0.00 | -0.00 | sell |
| E Fund Management Co., Ltd. | 13,675 | 8,545 | -5,130 | 0.03 | 0.01 | -0.01 | sell |
| China Universal Asset Management Co., Ltd. | 27,936 | 17,160 | -10,776 | 0.11 | 0.06 | -0.05 | sell |
| Soleus Capital Management, L.P. | 264,650 | 251,900 | -12,750 | 0.75 | 0.59 | -0.16 | sell |
| EMERALD ADVISERS, LLC | 302,789 | 288,564 | -14,225 | 0.39 | 0.32 | -0.07 | sell |
| Blue Owl Capital Holdings LP | 100,000 | 80,000 | -20,000 | 0.65 | 0.59 | -0.06 | sell |
| AWM Investment Company, Inc. | 70,000 | 50,000 | -20,000 | 0.30 | 0.18 | -0.12 | sell |
| CASTLEARK MANAGEMENT LLC | 80,440 | 5,190 | -75,250 | 0.11 | 0.01 | -0.10 | sell |
| Rafferty Asset Management, LLC | 289,385 | 140,698 | -148,687 | 0.03 | 0.01 | -0.02 | sell |
| Eversept Partners, LP | 255,526 | 92,909 | -162,617 | 0.55 | 0.17 | -0.38 | sell |
| Redmile Group, LLC | 969,621 | 720,177 | -249,444 | 1.15 | 1.15 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,862,043 | 1,361,649 | -500,394 | 0.01 | 0.00 | -0.00 | sell |
| FRED ALGER MANAGEMENT, LLC | 1,271,762 | 607,724 | -664,038 | 0.20 | 0.08 | -0.13 | sell |
| PERCEPTIVE ADVISORS LLC | 2,963,212 | 1,923,786 | -1,039,426 | 1.68 | 1.22 | -0.45 | sell |
| Logos Global Management LP | 1,775,000 | 575,000 | -1,200,000 | 6.04 | 1.75 | -4.29 | sell |