| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 17,241,035 | 18,599,195 | +1,358,160 | 0.02 | 0.02 | -0.00 | buy |
| Deep Track Capital, LP | 9,500,000 | 9,500,000 | 0 | 5.26 | 4.89 | -0.37 | hold |
| VANGUARD GROUP INC | 6,936,859 | 7,025,938 | +89,079 | 0.00 | 0.00 | -0.00 | buy |
| T. Rowe Price Investment Management, Inc. | 5,894,824 | 6,878,956 | +984,132 | 0.07 | 0.07 | +0.00 | buy |
| BlackRock, Inc. | 5,364,222 | 5,848,285 | +484,063 | 0.00 | 0.00 | -0.00 | buy |
| BAKER BROS. ADVISORS LP | 5,457,881 | 5,457,881 | 0 | 1.03 | 0.85 | -0.19 | hold |
| ARMISTICE CAPITAL, LLC | 4,500,000 | 5,200,000 | +700,000 | 2.06 | 3.15 | +1.10 | buy |
| Point72 Asset Management, L.P. | 801,927 | 3,336,250 | +2,534,323 | 0.04 | 0.13 | +0.09 | buy |
| STATE STREET CORP | 3,087,095 | 2,830,074 | -257,021 | 0.00 | 0.00 | -0.00 | sell |
| Alpine Global Management, LLC | 2,626,692 | 2,626,692 | 0 | 11.88 | 9.47 | -2.41 | hold |
| MORGAN STANLEY | 1,310,050 | 2,309,061 | +999,011 | 0.00 | 0.00 | +0.00 | buy |
| Two Seas Capital LP | 1,642,772 | 2,252,772 | +610,000 | 4.36 | 3.53 | -0.83 | buy |
| PERCEPTIVE ADVISORS LLC | 2,844,072 | 2,137,890 | -706,182 | 1.72 | 1.28 | -0.44 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 1,672,590 | 1,825,602 | +153,012 | 0.00 | 0.00 | -0.00 | buy |
| Woodline Partners LP | 1,497,869 | 1,498,725 | +856 | 0.17 | 0.13 | -0.04 | buy |
| STEMPOINT CAPITAL LP | 853,472 | 1,300,860 | +447,388 | 4.66 | 6.70 | +2.04 | buy |
| GOLDMAN SACHS GROUP INC | 1,007,700 | 1,195,516 | +187,816 | 0.00 | 0.00 | -0.00 | buy |
| Pictet Asset Management Holding SA | 1,188,578 | 1,188,578 | 0 | 0.02 | 0.02 | -0.00 | hold |
| Aberdeen Group plc | 819,477 | 844,705 | +25,228 | 0.03 | 0.02 | -0.00 | buy |
| NORGES BANK | 637,947 | 687,662 | +49,715 | 0.00 | 0.00 | -0.00 | buy |
| UBS Group AG | 731,853 | 671,284 | -60,569 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 626,612 | 661,146 | +34,534 | 0.00 | 0.00 | -0.00 | buy |
| NORTHERN TRUST CORP | 536,622 | 575,383 | +38,761 | 0.00 | 0.00 | -0.00 | buy |
| ADAR1 Capital Management, LLC | 968,866 | 535,066 | -433,800 | 3.19 | 1.39 | -1.80 | sell |
| Prosight Management, LP | 360,000 | 479,400 | +119,400 | 2.02 | 1.87 | -0.15 | buy |
| JPMORGAN CHASE & CO | 652,719 | 478,263 | -174,456 | 0.00 | 0.00 | -0.00 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 21,200 | 463,600 | +442,400 | 0.00 | 0.01 | +0.01 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 364,229 | 448,515 | +84,286 | 0.03 | 0.03 | -0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 471,961 | 421,726 | -50,235 | 0.00 | 0.00 | -0.00 | sell |
| CANADA PENSION PLAN INVESTMENT BOARD | 182,500 | 414,800 | +232,300 | 0.00 | 0.01 | +0.00 | buy |
| CITADEL ADVISORS LLC | 327,825 | 350,392 | +22,567 | 0.01 | 0.00 | -0.00 | buy |
| Jump Financial, LLC | 200,835 | 322,846 | +122,011 | 0.05 | 0.07 | +0.01 | buy |
| CITIGROUP INC | 289,329 | 317,882 | +28,553 | 0.00 | 0.00 | -0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 122,049 | 298,170 | +176,121 | 0.00 | 0.00 | +0.00 | buy |
| Logos Global Management LP | 275,000 | 275,000 | 0 | 0.84 | 0.59 | -0.25 | hold |
| BARCLAYS PLC | 151,541 | 271,350 | +119,809 | 0.00 | 0.00 | +0.00 | buy |
| GREAT POINT PARTNERS LLC | 375,000 | 262,176 | -112,824 | 3.48 | 2.73 | -0.76 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 194,638 | 256,743 | +62,105 | 0.82 | 1.07 | +0.25 | buy |
| ExodusPoint Capital Management, LP | 162,120 | 241,694 | +79,574 | 0.04 | 0.05 | +0.01 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 395,900 | 241,400 | -154,500 | 0.01 | 0.01 | -0.01 | sell |
| DIMENSIONAL FUND ADVISORS LP | 394,936 | 236,966 | -157,970 | 0.00 | 0.00 | -0.00 | sell |
| Nuveen, LLC | 233,985 | 225,099 | -8,886 | 0.00 | 0.00 | -0.00 | sell |
| Rock Springs Capital Management LP | 975,803 | 221,500 | -754,303 | 0.95 | 0.22 | -0.73 | sell |
| Granahan Investment Management, LLC | 172,316 | 213,088 | +40,772 | 0.15 | 0.14 | -0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 153,240 | 201,172 | +47,932 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 140,091 | 200,260 | +60,169 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 197,569 | +197,569 | 0.00 | 0.01 | +0.01 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 156,989 | 195,727 | +38,738 | 0.16 | 0.21 | +0.05 | buy |
| TD ASSET MANAGEMENT INC | 182,398 | 192,506 | +10,108 | 0.00 | 0.00 | -0.00 | buy |
| DAFNA Capital Management LLC | 169,996 | 191,493 | +21,497 | 0.82 | 0.85 | +0.02 | buy |
| Bank of New York Mellon Corp | 201,911 | 189,663 | -12,248 | 0.00 | 0.00 | -0.00 | sell |
| HighVista Strategies LLC | 95,648 | 182,808 | +87,160 | 0.63 | 1.07 | +0.44 | buy |
| TFG Asset Management GP Ltd | 131,167 | 147,817 | +16,650 | 0.72 | 0.43 | -0.29 | buy |
| Aquatic Capital Management LLC | 92,991 | 136,522 | +43,531 | 0.04 | 0.04 | +0.00 | buy |
| Swiss National Bank | 131,600 | 129,800 | -1,800 | 0.00 | 0.00 | -0.00 | sell |
| BANQUE PICTET & CIE SA | 147,397 | 125,952 | -21,445 | 0.03 | 0.02 | -0.01 | sell |
| MACQUARIE GROUP LTD | 122,100 | 122,100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Rafferty Asset Management, LLC | 138,837 | 106,470 | -32,367 | 0.01 | 0.01 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 87,527 | 105,293 | +17,766 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 83,555 | 101,381 | +17,826 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 58,122 | 94,287 | +36,165 | 0.01 | 0.02 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 55,713 | 93,893 | +38,180 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 161,660 | 92,500 | -69,160 | 0.02 | 0.01 | -0.01 | sell |
| Squarepoint Ops LLC | 10,425 | 84,919 | +74,494 | 0.00 | 0.00 | +0.00 | buy |
| Tejara Capital Ltd | 53,790 | 84,394 | +30,604 | 0.45 | 0.63 | +0.17 | buy |
| ALLIANCEBERNSTEIN L.P. | 74,850 | 83,960 | +9,110 | 0.00 | 0.00 | -0.00 | buy |
| XTX Topco Ltd | 0 | 81,188 | +81,188 | 0.00 | 0.05 | +0.05 | buy |
| Legal & General Group Plc | 72,286 | 77,296 | +5,010 | 0.00 | 0.00 | -0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 74,314 | 74,314 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ArrowMark Colorado Holdings LLC | 70,000 | 70,000 | 0 | 0.02 | 0.02 | +0.00 | hold |
| Invesco Ltd. | 55,312 | 66,750 | +11,438 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 744,544 | 61,114 | -683,430 | 0.00 | 0.00 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 50,534 | 59,818 | +9,284 | 0.00 | 0.00 | -0.00 | buy |
| CAPITAL FUND MANAGEMENT S.A. | 0 | 55,524 | +55,524 | 0.00 | 0.01 | +0.01 | buy |
| Erste Asset Management GmbH | 52,500 | 52,500 | 0 | 0.01 | 0.01 | -0.01 | hold |
| Quinn Opportunity Partners LLC | 35,100 | 51,108 | +16,008 | 0.04 | 0.07 | +0.03 | buy |
| DEUTSCHE BANK AG\ | 411,509 | 48,771 | -362,738 | 0.00 | 0.00 | -0.00 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 45,975 | 45,350 | -625 | 0.01 | 0.01 | -0.00 | sell |
| Fieldview Capital Management, LLC | 10,779 | 45,101 | +34,322 | 0.03 | 0.11 | +0.08 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 40,971 | 42,641 | +1,670 | 0.00 | 0.00 | -0.00 | buy |
| GUGGENHEIM CAPITAL LLC | 41,972 | 41,501 | -471 | 0.01 | 0.01 | -0.00 | sell |
| MetLife Investment Management, LLC | 35,095 | 40,900 | +5,805 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 28,793 | 36,273 | +7,480 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 35,224 | 36,124 | +900 | 0.00 | 0.00 | -0.00 | buy |
| Creative Planning | 29,193 | 35,368 | +6,175 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 34,071 | 34,329 | +258 | 0.05 | 0.05 | -0.00 | buy |
| HighTower Advisors, LLC | 33,273 | 33,392 | +119 | 0.00 | 0.00 | -0.00 | buy |
| DekaBank Deutsche Girozentrale | 32,600 | 32,600 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Caption Management, LLC | 0 | 32,076 | +32,076 | 0.00 | 0.05 | +0.05 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 0 | 31,507 | +31,507 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 30,731 | 30,731 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Ensign Peak Advisors, Inc | 28,406 | 28,406 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Jain Global LLC | 0 | 26,636 | +26,636 | 0.00 | 0.01 | +0.01 | buy |
| LMR Partners LLP | 0 | 25,067 | +25,067 | 0.00 | 0.01 | +0.01 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 25,030 | 23,889 | -1,141 | 0.00 | 0.00 | -0.00 | sell |
| Handelsbanken Fonder AB | 20,900 | 23,800 | +2,900 | 0.00 | 0.00 | -0.00 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 23,553 | +23,553 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 28,560 | 22,436 | -6,124 | 0.02 | 0.01 | -0.01 | sell |
| Verition Fund Management LLC | 139,317 | 21,154 | -118,163 | 0.01 | 0.00 | -0.01 | sell |
| Bridgefront Capital, LLC | 36,059 | 20,721 | -15,338 | 0.18 | 0.09 | -0.09 | sell |