| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| T. Rowe Price Investment Management, Inc. | 5,894,824 | 6,878,956 | +984,132 | 0.07 | 0.07 | +0.00 | buy |
| ARMISTICE CAPITAL, LLC | 4,500,000 | 5,200,000 | +700,000 | 1.15 | 1.44 | +0.28 | buy |
| Two Seas Capital LP | 1,642,772 | 2,252,772 | +610,000 | 4.36 | 3.53 | -0.83 | buy |
| STEMPOINT CAPITAL LP | 853,472 | 1,300,860 | +447,388 | 4.66 | 6.70 | +2.04 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 21,200 | 463,600 | +442,400 | 0.00 | 0.01 | +0.01 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 182,500 | 414,800 | +232,300 | 0.00 | 0.01 | 0.00 | buy |
| Prosight Management, LP | 360,000 | 479,400 | +119,400 | 2.02 | 1.87 | -0.15 | buy |
| HighVista Strategies LLC | 95,648 | 182,808 | +87,160 | 0.63 | 1.07 | +0.44 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 364,229 | 448,515 | +84,286 | 0.03 | 0.03 | -0.00 | buy |
| ExodusPoint Capital Management, LP | 162,120 | 241,694 | +79,574 | 0.04 | 0.05 | 0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 194,638 | 256,743 | +62,105 | 0.77 | 0.96 | +0.20 | buy |
| Granahan Investment Management, LLC | 172,316 | 213,088 | +40,772 | 0.15 | 0.14 | -0.01 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 156,989 | 195,727 | +38,738 | 0.16 | 0.21 | +0.05 | buy |
| Fieldview Capital Management, LLC | 10,779 | 45,101 | +34,322 | 0.03 | 0.11 | +0.08 | buy |
| Tejara Capital Ltd | 53,790 | 84,394 | +30,604 | 0.45 | 0.63 | +0.17 | buy |
| Aberdeen Group plc | 819,477 | 844,705 | +25,228 | 0.03 | 0.02 | -0.00 | buy |
| DAFNA Capital Management LLC | 169,996 | 191,493 | +21,497 | 0.82 | 0.85 | +0.02 | buy |
| TFG Asset Management GP Ltd | 131,167 | 147,817 | +16,650 | 0.51 | 0.38 | -0.13 | buy |
| Quinn Opportunity Partners LLC | 35,100 | 51,108 | +16,008 | 0.04 | 0.07 | +0.03 | buy |
| TD ASSET MANAGEMENT INC | 182,398 | 192,506 | +10,108 | 0.00 | 0.00 | -0.00 | buy |
| Woodline Partners LP | 1,497,869 | 1,498,725 | +856 | 0.17 | 0.13 | -0.04 | buy |
| China Universal Asset Management Co., Ltd. | 34,071 | 34,329 | +258 | 0.05 | 0.05 | -0.00 | buy |
| Virtus Investment Advisers, LLC | 5,953 | 5,899 | -54 | 0.03 | 0.03 | +0.00 | sell |
| E Fund Management Co., Ltd. | 12,975 | 11,854 | -1,121 | 0.01 | 0.01 | -0.00 | sell |
| DnB Asset Management AS | 14,356 | 12,904 | -1,452 | 0.00 | 0.00 | -0.00 | sell |
| PROFUND ADVISORS LLC | 28,560 | 22,436 | -6,124 | 0.02 | 0.01 | -0.01 | sell |
| Bridgefront Capital, LLC | 36,059 | 20,721 | -15,338 | 0.18 | 0.09 | -0.09 | sell |
| BANQUE PICTET & CIE SA | 147,397 | 125,952 | -21,445 | 0.02 | 0.01 | -0.01 | sell |
| Rafferty Asset Management, LLC | 138,837 | 106,470 | -32,367 | 0.01 | 0.01 | -0.00 | sell |
| GREAT POINT PARTNERS LLC | 375,000 | 262,176 | -112,824 | 3.39 | 2.73 | -0.67 | sell |
| ADAR1 Capital Management, LLC | 968,866 | 535,066 | -433,800 | 3.19 | 1.39 | -1.80 | sell |
| PERCEPTIVE ADVISORS LLC | 2,844,072 | 2,137,890 | -706,182 | 1.72 | 1.27 | -0.45 | sell |
| Rock Springs Capital Management LP | 975,803 | 221,500 | -754,303 | 0.95 | 0.22 | -0.73 | sell |
| Hood River Capital Management LLC | 1,175,863 | 100 | -1,175,763 | 0.34 | 0.00 | -0.34 | sell |