| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 16,947,888 | 16,186,469 | -761,419 | 0.02 | 0.03 | +0.00 | sell |
| Deep Track Capital, LP | 11,526,971 | 9,341,151 | -2,185,820 | 5.91 | 5.30 | -0.61 | sell |
| BlackRock, Inc. | 6,574,497 | 7,180,897 | +606,400 | 0.00 | 0.00 | +0.00 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 1,546,000 | 5,805,000 | +4,259,000 | 0.23 | 1.31 | +1.08 | buy |
| BAKER BROS. ADVISORS LP | 5,457,881 | 5,435,220 | -22,661 | 0.78 | 1.05 | +0.27 | sell |
| STATE STREET CORP | 4,537,929 | 4,617,005 | +79,076 | 0.00 | 0.01 | +0.00 | buy |
| MORGAN STANLEY | 3,876,877 | 4,534,833 | +657,956 | 0.01 | 0.01 | +0.00 | buy |
| TCG Crossover Management, LLC | 4,457,988 | 4,457,988 | 0 | 3.17 | 4.13 | +0.96 | hold |
| JENNISON ASSOCIATES LLC | 3,196,705 | 3,310,238 | +113,533 | 0.05 | 0.08 | +0.02 | buy |
| RTW INVESTMENTS, LP | 3,177,849 | 3,177,849 | 0 | 0.79 | 1.05 | +0.26 | hold |
| Two Seas Capital LP | 3,201,962 | 3,148,505 | -53,457 | 3.67 | 4.63 | +0.96 | sell |
| ADAR1 Capital Management, LLC | 2,679,010 | 2,330,716 | -348,294 | 4.00 | 4.22 | +0.22 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 2,092,102 | 2,234,602 | +142,500 | 0.00 | 0.00 | +0.00 | buy |
| T. Rowe Price Investment Management, Inc. | 3,612,860 | 2,222,101 | -1,390,759 | 0.06 | 0.06 | -0.01 | sell |
| Woodline Partners LP | 1,975,869 | 1,975,869 | 0 | 0.19 | 0.24 | +0.05 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 339,607 | 1,829,210 | +1,489,603 | 0.00 | 0.01 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 1,785,107 | 1,751,183 | -33,924 | 0.01 | 0.01 | +0.00 | sell |
| ARMISTICE CAPITAL, LLC | 3,564,916 | 1,736,000 | -1,828,916 | 2.92 | 1.85 | -1.07 | sell |
| Alpine Global Management, LLC | 2,636,925 | 1,375,000 | -1,261,925 | 9.96 | 8.69 | -1.27 | sell |
| PERCEPTIVE ADVISORS LLC | 1,597,383 | 1,357,383 | -240,000 | 0.78 | 0.81 | +0.03 | sell |
| D. E. Shaw & Co., Inc. | 0 | 1,240,654 | +1,240,654 | 0.00 | 0.03 | +0.03 | buy |
| BANK OF AMERICA CORP /DE/ | 893,678 | 1,181,452 | +287,774 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 617,807 | 1,022,513 | +404,706 | 0.02 | 0.03 | +0.02 | buy |
| Aberdeen Group plc | 1,160,762 | 857,030 | -303,732 | 0.05 | 0.05 | -0.00 | sell |
| NORTHERN TRUST CORP | 672,774 | 794,004 | +121,230 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 192,500 | 726,800 | +534,300 | 0.01 | 0.04 | +0.03 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 680,592 | +680,592 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 660,438 | 680,592 | +20,154 | 0.00 | 0.00 | +0.00 | buy |
| Logos Global Management LP | 1,075,000 | 665,000 | -410,000 | 1.38 | 1.10 | -0.27 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 414,236 | 619,096 | +204,860 | 1.21 | 2.65 | +1.44 | buy |
| Nuveen, LLC | 241,195 | 602,046 | +360,851 | 0.00 | 0.01 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 503,673 | 473,984 | -29,689 | 0.03 | 0.03 | +0.01 | sell |
| UBS Group AG | 684,551 | 472,122 | -212,429 | 0.00 | 0.00 | -0.00 | sell |
| Pictet Asset Management Holding SA | 472,381 | 462,359 | -10,022 | 0.01 | 0.02 | +0.00 | sell |
| HRT FINANCIAL LP | 66,485 | 331,920 | +265,435 | 0.00 | 0.02 | +0.02 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 328,678 | +328,678 | 0.00 | 0.01 | +0.01 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 334,557 | 320,071 | -14,486 | 0.01 | 0.01 | +0.00 | sell |
| Bank of New York Mellon Corp | 216,225 | 295,791 | +79,566 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 225,139 | 277,873 | +52,734 | 1.54 | 2.44 | +0.90 | buy |
| STEMPOINT CAPITAL LP | 746,494 | 276,527 | -469,967 | 3.56 | 1.84 | -1.72 | sell |
| TFG Asset Management GP Ltd | 218,507 | 255,934 | +37,427 | 1.07 | 1.61 | +0.54 | buy |
| Soleus Capital Management, L.P. | 230,000 | 252,000 | +22,000 | 0.23 | 0.33 | +0.10 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 357,606 | 208,368 | -149,238 | 6.35 | 5.07 | -1.28 | sell |
| Granahan Investment Management, LLC | 244,430 | 206,372 | -38,058 | 0.29 | 0.28 | -0.01 | sell |
| CITADEL ADVISORS LLC | 144,398 | 160,123 | +15,725 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 105,770 | 159,840 | +54,070 | 0.04 | 0.07 | +0.03 | buy |
| DAFNA Capital Management LLC | 150,524 | 149,524 | -1,000 | 0.85 | 1.10 | +0.25 | sell |
| WELLS FARGO & COMPANY/MN | 33,222 | 146,639 | +113,417 | 0.00 | 0.00 | +0.00 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 181,774 | 144,671 | -37,103 | 1.14 | 1.37 | +0.23 | sell |
| Erste Asset Management GmbH | 144,500 | 144,500 | 0 | 0.03 | 0.04 | +0.01 | hold |
| MARSHALL WACE, LLP | 165,300 | 142,488 | -22,812 | 0.00 | 0.00 | +0.00 | sell |
| Man Group plc | 0 | 140,116 | +140,116 | 0.00 | 0.01 | +0.01 | buy |
| Swiss National Bank | 159,400 | 132,700 | -26,700 | 0.00 | 0.00 | +0.00 | sell |
| Informed Momentum Co LLC | 0 | 127,273 | +127,273 | 0.00 | 0.44 | +0.44 | buy |
| Jump Financial, LLC | 44,202 | 124,987 | +80,785 | 0.02 | 0.04 | +0.03 | buy |
| Hennion & Walsh Asset Management, Inc. | 91,009 | 120,686 | +29,677 | 0.08 | 0.13 | +0.06 | buy |
| ALLIANCEBERNSTEIN L.P. | 90,410 | 116,860 | +26,450 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 25,350 | 116,145 | +90,795 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 141,728 | 115,102 | -26,626 | 0.00 | 0.00 | +0.00 | sell |
| RHUMBLINE ADVISERS | 97,493 | 107,146 | +9,653 | 0.00 | 0.00 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 100,000 | 100,000 | 0 | 0.15 | 0.19 | +0.04 | hold |
| DEUTSCHE BANK AG\ | 79,000 | 98,595 | +19,595 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 93,894 | 94,351 | +457 | 0.00 | 0.00 | -0.00 | buy |
| DME Capital Management, LP | 93,520 | 93,520 | 0 | 0.07 | 0.09 | +0.02 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 94,286 | 91,690 | -2,596 | 0.00 | 0.00 | +0.00 | sell |
| XTX Topco Ltd | 203,029 | 90,758 | -112,271 | 0.09 | 0.05 | -0.04 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 54,286 | 87,993 | +33,707 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 25,692 | 79,920 | +54,228 | 0.00 | 0.02 | +0.01 | buy |
| Squarepoint Ops LLC | 0 | 77,769 | +77,769 | 0.00 | 0.01 | +0.01 | buy |
| TD ASSET MANAGEMENT INC | 131,352 | 76,540 | -54,812 | 0.00 | 0.00 | -0.00 | sell |
| Atom Investors LP | 0 | 74,171 | +74,171 | 0.00 | 0.25 | +0.25 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 71,801 | 72,169 | +368 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 136,619 | 71,430 | -65,189 | 0.01 | 0.01 | -0.01 | sell |
| Amundi | 66,848 | 70,948 | +4,100 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 74,456 | 67,717 | -6,739 | 0.00 | 0.00 | +0.00 | sell |
| JPMORGAN CHASE & CO | 96,882 | 66,186 | -30,696 | 0.00 | 0.00 | +0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 72,820 | 65,267 | -7,553 | 0.11 | 0.16 | +0.05 | sell |
| Creative Planning | 45,729 | 57,326 | +11,597 | 0.00 | 0.00 | +0.00 | buy |
| BANQUE PICTET & CIE SA | 88,660 | 57,190 | -31,470 | 0.03 | 0.02 | -0.00 | sell |
| TUDOR INVESTMENT CORP ET AL | 0 | 57,145 | +57,145 | 0.00 | 0.01 | +0.01 | buy |
| HighTower Advisors, LLC | 56,744 | 56,104 | -640 | 0.00 | 0.00 | +0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 57,086 | 55,528 | -1,558 | 0.00 | 0.00 | +0.00 | sell |
| CAPITAL FUND MANAGEMENT S.A. | 0 | 51,448 | +51,448 | 0.00 | 0.01 | +0.01 | buy |
| SIMPLEX TRADING, LLC | 50,276 | 51,080 | +804 | 0.04 | 0.05 | +0.01 | buy |
| DYMON ASIA CAPITAL (SINGAPORE) PTE. LTD. | 23,805 | 49,805 | +26,000 | 0.13 | 0.31 | +0.18 | buy |
| MetLife Investment Management, LLC | 44,461 | 49,677 | +5,216 | 0.01 | 0.01 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 51,421 | 48,570 | -2,851 | 0.00 | 0.00 | +0.00 | sell |
| Quantinno Capital Management LP | 40,030 | 46,005 | +5,975 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 8,145 | 42,554 | +34,409 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 51,022 | 40,803 | -10,219 | 0.00 | 0.00 | +0.00 | sell |
| BARCLAYS PLC | 14,900 | 39,471 | +24,571 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 0 | 36,545 | +36,545 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 61,008 | 36,510 | -24,498 | 0.06 | 0.04 | -0.02 | sell |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 34,827 | +34,827 | 0.00 | 0.22 | +0.22 | buy |
| Handelsbanken Fonder AB | 32,300 | 34,500 | +2,200 | 0.00 | 0.00 | +0.00 | buy |
| Cinctive Capital Management LP | 0 | 34,435 | +34,435 | 0.00 | 0.05 | +0.05 | buy |
| China Universal Asset Management Co., Ltd. | 37,718 | 33,925 | -3,793 | 0.07 | 0.08 | +0.01 | sell |
| STRS OHIO | 0 | 32,800 | +32,800 | 0.00 | 0.00 | +0.00 | buy |
| DekaBank Deutsche Girozentrale | 32,600 | 32,600 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 33,173 | 30,893 | -2,280 | 0.00 | 0.00 | +0.00 | sell |