| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| PERCEPTIVE ADVISORS LLC | 2,523,783 | 3,814,691 | +1,290,908 | 1.39 | 4.92 | +3.53 | buy |
| FRED ALGER MANAGEMENT, LLC | 19,102 | 1,186,031 | +1,166,929 | 0.00 | 0.26 | +0.26 | buy |
| Cormorant Asset Management, LP | 550,000 | 1,225,000 | +675,000 | 0.59 | 2.74 | +2.15 | buy |
| TWO SIGMA INVESTMENTS, LP | 1,009,483 | 346,396 | +663,087 | 0.05 | 0.04 | 0.00 | sell |
| Woodline Partners LP | 635,091 | 964,083 | +328,992 | 0.14 | 0.43 | +0.29 | buy |
| Soleus Capital Management, L.P. | 173,599 | 399,599 | +226,000 | 0.37 | 1.55 | +1.18 | buy |
| Skandinaviska Enskilda Banken AB (publ) | 521,084 | 681,935 | +160,851 | 0.06 | 0.17 | +0.11 | buy |
| Commodore Capital LP | 900,000 | 1,000,000 | +100,000 | 1.92 | 4.49 | +2.57 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 147,804 | 247,182 | +99,378 | 0.01 | 0.05 | +0.04 | buy |
| PFM Health Sciences, LP | 388,918 | 472,540 | +83,622 | 0.30 | 0.87 | +0.57 | buy |
| Rhenman & Partners Asset Management AB | 100,000 | 166,061 | +66,061 | 0.20 | 0.69 | +0.49 | buy |
| Informed Momentum Co LLC | 39,796 | 102,520 | +62,724 | 0.14 | 0.76 | +0.62 | buy |
| Rafferty Asset Management, LLC | 251,621 | 296,832 | +45,211 | 0.03 | 0.07 | +0.04 | buy |
| Affinity Asset Advisors, LLC | 260,000 | 300,000 | +40,000 | 1.94 | 3.76 | +1.82 | buy |
| ALGERT GLOBAL LLC | 79,659 | 63,469 | +16,190 | 0.07 | 0.11 | 0.00 | sell |
| PROFUND ADVISORS LLC | 45,754 | 49,869 | +4,115 | 0.05 | 0.11 | +0.06 | buy |
| NEW YORK LIFE INVESTMENT MANAGEMENT LLC | 26,572 | 22,920 | +3,652 | 0.01 | 0.01 | 0.00 | sell |
| E Fund Management Co., Ltd. | 13,530 | 15,245 | +1,715 | 0.02 | 0.04 | +0.02 | buy |
| China Universal Asset Management Co., Ltd. | 1,709 | 3,360 | +1,651 | 0.01 | 0.04 | +0.03 | buy |
| ALPS ADVISORS INC | 95,856 | 96,434 | +578 | 0.02 | 0.03 | +0.01 | buy |
| Polar Asset Management Partners Inc. | 155,000 | 155,500 | +500 | 0.06 | 0.14 | +0.09 | buy |
| VIRTUS ADVISERS, LLC | 5,107 | 4,647 | -460 | 0.06 | 0.11 | +0.05 | sell |
| CoreCap Advisors, LLC | 15,412 | 5,760 | -9,652 | 0.02 | 0.02 | -0.00 | sell |
| ACUTA CAPITAL PARTNERS, LLC | 141,755 | 129,000 | -12,755 | 1.82 | 3.60 | +1.78 | sell |
| Hillsdale Investment Management Inc. | 138,100 | 116,300 | -21,800 | 0.24 | 0.41 | +0.17 | sell |
| Hennion & Walsh Asset Management, Inc. | 171,328 | 143,080 | -28,248 | 0.19 | 0.35 | +0.16 | sell |
| HighVista Strategies LLC | 180,320 | 106,908 | -73,412 | 1.57 | 1.90 | +0.33 | sell |
| PLATINUM INVESTMENT MANAGEMENT LTD | 328,842 | 225,939 | -102,903 | 0.22 | 0.34 | +0.12 | sell |
| Alpine Global Management, LLC | 1,439,544 | 1,252,474 | -187,070 | 7.52 | 11.09 | +3.57 | sell |
| TCG Crossover Management, LLC | 654,853 | 334,853 | -320,000 | 2.04 | 1.89 | -0.14 | sell |
| Logos Global Management LP | 2,250,000 | 1,600,000 | -650,000 | 5.90 | 8.76 | +2.87 | sell |
| Redmile Group, LLC | 1,921,152 | 1,102,514 | -818,638 | 1.40 | 2.01 | +0.62 | sell |
| Avidity Partners Management LP | 2,085,000 | 1,173,662 | -911,338 | 1.38 | 1.81 | +0.43 | sell |
| Deep Track Capital, LP | 5,421,330 | 2,797,955 | -2,623,375 | 4.80 | 4.17 | -0.64 | sell |