| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 10,483,883 | 12,537,571 | +2,053,688 | 0.02 | 0.02 | +0.00 | buy |
| T. Rowe Price Investment Management, Inc. | 1,625,220 | 3,331,017 | +1,705,797 | 0.03 | 0.06 | +0.03 | buy |
| Deep Track Capital, LP | 2,883,736 | 4,347,464 | +1,463,728 | 2.27 | 3.96 | +1.68 | buy |
| Hood River Capital Management LLC | 0 | 1,143,567 | +1,143,567 | 0.00 | 0.53 | +0.53 | buy |
| BAKER BROS. ADVISORS LP | 464,718 | 1,225,410 | +760,692 | 0.16 | 0.36 | +0.21 | buy |
| ADAR1 Capital Management, LLC | 476,543 | 1,131,707 | +655,164 | 2.53 | 5.41 | +2.88 | buy |
| Logos Global Management LP | 575,000 | 1,100,000 | +525,000 | 1.75 | 3.51 | +1.76 | buy |
| PERCEPTIVE ADVISORS LLC | 1,923,786 | 2,378,762 | +454,976 | 1.23 | 1.46 | +0.23 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 559,688 | 951,124 | +391,436 | 0.01 | 0.01 | +0.01 | buy |
| STATE STREET CORP | 2,718,956 | 3,022,342 | +303,386 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 140,317 | 324,165 | +183,848 | 0.00 | 0.01 | +0.01 | buy |
| FEDERATED HERMES, INC. | 0 | 154,192 | +154,192 | 0.00 | 0.01 | +0.01 | buy |
| ARMISTICE CAPITAL, LLC | 3,396,909 | 3,548,000 | +151,091 | 2.35 | 2.65 | +0.30 | buy |
| VANGUARD GROUP INC | 6,509,753 | 6,658,800 | +149,047 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 98,440 | 217,812 | +119,372 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 114,104 | +114,104 | 0.00 | 0.00 | +0.00 | buy |
| Rhenman & Partners Asset Management AB | 130,500 | 243,000 | +112,500 | 0.33 | 0.56 | +0.23 | buy |
| GOLDMAN SACHS GROUP INC | 411,918 | 521,673 | +109,755 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 0 | 109,390 | +109,390 | 0.00 | 0.01 | +0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 275,352 | 376,507 | +101,155 | 0.01 | 0.01 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,414,002 | 1,510,926 | +96,924 | 0.00 | 0.00 | +0.00 | buy |
| Caption Management, LLC | 27,436 | 122,711 | +95,275 | 0.08 | 0.38 | +0.30 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 461,171 | 552,430 | +91,259 | 0.00 | 0.00 | +0.00 | buy |
| BANQUE PICTET & CIE SA | 68,152 | 158,920 | +90,768 | 0.02 | 0.04 | +0.03 | buy |
| Aberdeen Group plc | 400,722 | 478,757 | +78,035 | 0.02 | 0.03 | +0.00 | buy |
| Russell Investments Group, Ltd. | 175,195 | 251,492 | +76,297 | 0.01 | 0.01 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 22,227 | 98,274 | +76,047 | 0.00 | 0.02 | +0.02 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 121,692 | 195,307 | +73,615 | 0.01 | 0.01 | +0.00 | buy |
| MACQUARIE GROUP LTD | 122,100 | 185,984 | +63,884 | 0.00 | 0.01 | +0.00 | buy |
| CITIGROUP INC | 31,595 | 93,338 | +61,743 | 0.00 | 0.00 | +0.00 | buy |
| Pictet Asset Management Holding SA | 1,174,816 | 1,230,309 | +55,493 | 0.04 | 0.04 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 36,800 | 85,000 | +48,200 | 0.00 | 0.00 | +0.00 | buy |
| Prosight Management, LP | 325,000 | 370,000 | +45,000 | 2.56 | 2.67 | +0.11 | buy |
| NORTHERN TRUST CORP | 463,721 | 506,990 | +43,269 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 0 | 38,915 | +38,915 | 0.00 | 0.00 | +0.00 | buy |
| Rock Springs Capital Management LP | 1,185,654 | 1,221,309 | +35,655 | 0.94 | 1.13 | +0.19 | buy |
| Nicholas Investment Partners, LP | 0 | 33,103 | +33,103 | 0.00 | 0.09 | +0.09 | buy |
| Invesco Ltd. | 570,898 | 594,242 | +23,344 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 312,370 | 335,360 | +22,990 | 0.01 | 0.01 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 21,825 | +21,825 | 0.00 | 0.01 | +0.01 | buy |
| UBS Group AG | 119,355 | 140,989 | +21,634 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 41,479 | 62,435 | +20,956 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 0 | 20,000 | +20,000 | 0.00 | 0.00 | +0.00 | buy |
| EFG Asset Management (North America) Corp. | 58,070 | 73,818 | +15,748 | 0.27 | 0.35 | +0.09 | buy |
| Advantage Alpha Capital Partners LP | 0 | 14,975 | +14,975 | 0.00 | 0.10 | +0.10 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 0 | 12,447 | +12,447 | 0.00 | 0.32 | +0.32 | buy |
| Rafferty Asset Management, LLC | 140,698 | 152,347 | +11,649 | 0.01 | 0.01 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 17,160 | 28,151 | +10,991 | 0.06 | 0.09 | +0.02 | buy |
| GSA CAPITAL PARTNERS LLP | 14,824 | 24,634 | +9,810 | 0.03 | 0.05 | +0.03 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 17,684 | 27,122 | +9,438 | 0.01 | 0.02 | +0.01 | buy |
| Bank Pictet & Cie (Europe) AG | 0 | 9,168 | +9,168 | 0.00 | 0.01 | +0.01 | buy |
| EntryPoint Capital, LLC | 470 | 8,738 | +8,268 | 0.01 | 0.14 | +0.14 | buy |
| Scientech Research LLC | 12,634 | 20,691 | +8,057 | 0.07 | 0.12 | +0.05 | buy |
| WOLVERINE TRADING, LLC | 0 | 7,372 | +7,372 | 0.00 | 0.01 | +0.01 | buy |
| HighTower Advisors, LLC | 25,965 | 33,224 | +7,259 | 0.00 | 0.00 | +0.00 | buy |
| Erste Asset Management GmbH | 45,500 | 52,500 | +7,000 | 0.02 | 0.02 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 142,974 | 149,569 | +6,595 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 32,956 | 37,766 | +4,810 | 0.00 | 0.00 | +0.00 | buy |
| Handelsbanken Fonder AB | 16,200 | 20,900 | +4,700 | 0.00 | 0.00 | +0.00 | buy |
| DAFNA Capital Management LLC | 47,916 | 51,996 | +4,080 | 0.30 | 0.35 | +0.05 | buy |
| PROFUND ADVISORS LLC | 26,140 | 30,031 | +3,891 | 0.03 | 0.03 | +0.01 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 3,397 | +3,397 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 16,244 | 19,619 | +3,375 | 0.00 | 0.00 | +0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 11,167 | 12,830 | +1,663 | 0.00 | 0.00 | +0.00 | buy |
| Tyro Capital Management LLC | 250,620 | 252,149 | +1,529 | 3.00 | 3.69 | +0.69 | buy |
| Legal & General Group Plc | 53,984 | 55,394 | +1,410 | 0.00 | 0.00 | +0.00 | buy |
| E Fund Management Co., Ltd. | 8,545 | 9,789 | +1,244 | 0.01 | 0.01 | +0.00 | buy |
| ASSETMARK, INC | 1,663 | 2,891 | +1,228 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 4,360 | 5,294 | +934 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 817,038 | 817,742 | +704 | 0.00 | 0.00 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 1,585 | 2,263 | +678 | 0.00 | 0.00 | +0.00 | buy |
| KBC Group NV | 1,324 | 1,936 | +612 | 0.00 | 0.00 | +0.00 | buy |
| Knott David M Jr | 91,500 | 92,000 | +500 | 0.96 | 0.92 | -0.04 | buy |
| Arizona State Retirement System | 14,235 | 14,733 | +498 | 0.00 | 0.00 | +0.00 | buy |
| Covestor Ltd | 2,507 | 2,824 | +317 | 0.04 | 0.05 | +0.01 | buy |
| DnB Asset Management AS | 10,290 | 10,487 | +197 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 315 | 417 | +102 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 3,403 | 3,462 | +59 | 0.04 | 0.05 | +0.00 | buy |
| BESSEMER GROUP INC | 0 | 50 | +50 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 3,838 | 3,882 | +44 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 25 | 60 | +35 | 0.00 | 0.00 | +0.00 | buy |
| AXA S.A. | 98,810 | 98,838 | +28 | 0.01 | 0.01 | +0.00 | buy |
| Wilmington Savings Fund Society, FSB | 0 | 24 | +24 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 78 | 92 | +14 | 0.00 | 0.00 | -0.00 | buy |
| Smartleaf Asset Management LLC | 113 | 120 | +7 | 0.00 | 0.00 | -0.00 | buy |
| Farther Finance Advisors, LLC | 2 | 8 | +6 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 282 | 286 | +4 | 0.00 | 0.00 | +0.00 | buy |
| EARNED WEALTH ADVISORS, LLC | 0 | 3 | +3 | 0.00 | 0.00 | +0.00 | buy |
| FOURPATH CAPITAL MANAGEMENT, LLC | 0 | 1 | +1 | 0.00 | 0.00 | +0.00 | buy |
| NOMURA ASSET MANAGEMENT CO LTD | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Ameritas Investment Partners, Inc. | 5,585 | 5,585 | 0 | 0.01 | 0.01 | +0.00 | hold |
| VIKING GLOBAL INVESTORS LP | 2,320,902 | 2,320,902 | 0 | 0.24 | 0.24 | +0.01 | hold |
| PLATINUM INVESTMENT MANAGEMENT LTD | 192,242 | 192,242 | 0 | 0.21 | 0.25 | +0.04 | hold |
| JANUS HENDERSON GROUP PLC | 25,231 | 25,231 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 7,925 | 7,925 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Capital Research Global Investors | 976,237 | 976,237 | 0 | 0.01 | 0.01 | +0.00 | hold |
| DekaBank Deutsche Girozentrale | 32,600 | 32,600 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Daiwa Securities Group Inc. | 537 | 537 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ArrowMark Colorado Holdings LLC | 70,000 | 70,000 | 0 | 0.02 | 0.03 | +0.00 | hold |
| MetLife Investment Management, LLC | 33,608 | 33,608 | 0 | 0.01 | 0.01 | +0.00 | hold |