| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 10,483,883 | 12,537,571 | +2,053,688 | 0.02 | 0.02 | +0.00 | buy |
| VANGUARD GROUP INC | 6,509,753 | 6,658,800 | +149,047 | 0.00 | 0.00 | +0.00 | buy |
| Deep Track Capital, LP | 2,883,736 | 4,347,464 | +1,463,728 | 2.27 | 3.96 | +1.68 | buy |
| ARMISTICE CAPITAL, LLC | 3,396,909 | 3,548,000 | +151,091 | 2.35 | 2.65 | +0.30 | buy |
| T. Rowe Price Investment Management, Inc. | 1,625,220 | 3,331,017 | +1,705,797 | 0.03 | 0.06 | +0.03 | buy |
| STATE STREET CORP | 2,718,956 | 3,022,342 | +303,386 | 0.00 | 0.00 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 1,923,786 | 2,378,762 | +454,976 | 1.23 | 1.46 | +0.23 | buy |
| VIKING GLOBAL INVESTORS LP | 2,320,902 | 2,320,902 | 0 | 0.24 | 0.24 | +0.01 | hold |
| Alpine Global Management, LLC | 1,907,704 | 1,882,704 | -25,000 | 8.76 | 12.99 | +4.24 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 1,414,002 | 1,510,926 | +96,924 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 1,823,415 | 1,414,977 | -408,438 | 0.46 | 0.34 | -0.12 | sell |
| Paradigm Biocapital Advisors LP | 1,362,827 | 1,362,827 | 0 | 1.38 | 1.36 | -0.02 | hold |
| Pictet Asset Management Holding SA | 1,174,816 | 1,230,309 | +55,493 | 0.04 | 0.04 | +0.00 | buy |
| BAKER BROS. ADVISORS LP | 464,718 | 1,225,410 | +760,692 | 0.16 | 0.36 | +0.21 | buy |
| Rock Springs Capital Management LP | 1,185,654 | 1,221,309 | +35,655 | 0.94 | 1.13 | +0.19 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,361,649 | 1,209,046 | -152,603 | 0.00 | 0.00 | -0.00 | sell |
| Hood River Capital Management LLC | 0 | 1,143,567 | +1,143,567 | 0.00 | 0.53 | +0.53 | buy |
| ADAR1 Capital Management, LLC | 476,543 | 1,131,707 | +655,164 | 2.53 | 5.41 | +2.88 | buy |
| Logos Global Management LP | 575,000 | 1,100,000 | +525,000 | 1.75 | 3.51 | +1.76 | buy |
| FRANKLIN RESOURCES INC | 1,101,868 | 1,049,679 | -52,189 | 0.01 | 0.01 | -0.00 | sell |
| Capital Research Global Investors | 976,237 | 976,237 | 0 | 0.01 | 0.01 | +0.00 | hold |
| PRINCIPAL FINANCIAL GROUP INC | 559,688 | 951,124 | +391,436 | 0.01 | 0.01 | +0.01 | buy |
| MORGAN STANLEY | 817,038 | 817,742 | +704 | 0.00 | 0.00 | +0.00 | buy |
| Two Seas Capital LP | 692,406 | 676,614 | -15,792 | 2.98 | 3.26 | +0.28 | sell |
| STEMPOINT CAPITAL LP | 1,011,879 | 671,001 | -340,878 | 7.86 | 5.74 | -2.12 | sell |
| Redmile Group, LLC | 720,177 | 642,229 | -77,948 | 1.15 | 1.08 | -0.07 | sell |
| Invesco Ltd. | 570,898 | 594,242 | +23,344 | 0.00 | 0.00 | +0.00 | buy |
| NORGES BANK | 601,861 | 563,694 | -38,167 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 461,171 | 552,430 | +91,259 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 411,918 | 521,673 | +109,755 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 463,721 | 506,990 | +43,269 | 0.00 | 0.00 | +0.00 | buy |
| Aberdeen Group plc | 400,722 | 478,757 | +78,035 | 0.02 | 0.03 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 494,689 | 462,210 | -32,479 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 275,352 | 376,507 | +101,155 | 0.01 | 0.01 | +0.00 | buy |
| Prosight Management, LP | 325,000 | 370,000 | +45,000 | 2.56 | 2.67 | +0.11 | buy |
| CITADEL ADVISORS LLC | 343,512 | 339,921 | -3,591 | 0.01 | 0.01 | +0.00 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 312,370 | 335,360 | +22,990 | 0.01 | 0.01 | +0.00 | buy |
| JANE STREET GROUP, LLC | 140,317 | 324,165 | +183,848 | 0.00 | 0.01 | +0.01 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 320,508 | 310,830 | -9,678 | 0.00 | 0.00 | -0.00 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 420,000 | 300,000 | -120,000 | 0.02 | 0.02 | -0.01 | sell |
| Tyro Capital Management LLC | 250,620 | 252,149 | +1,529 | 3.00 | 3.69 | +0.69 | buy |
| Russell Investments Group, Ltd. | 175,195 | 251,492 | +76,297 | 0.01 | 0.01 | +0.00 | buy |
| EMERALD ADVISERS, LLC | 288,564 | 250,039 | -38,525 | 0.32 | 0.28 | -0.04 | sell |
| Rhenman & Partners Asset Management AB | 130,500 | 243,000 | +112,500 | 0.33 | 0.56 | +0.23 | buy |
| JPMORGAN CHASE & CO | 256,843 | 228,257 | -28,586 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 243,334 | 227,024 | -16,310 | 0.00 | 0.00 | -0.00 | sell |
| Affinity Asset Advisors, LLC | 346,088 | 225,000 | -121,088 | 1.44 | 1.00 | -0.44 | sell |
| BARCLAYS PLC | 98,440 | 217,812 | +119,372 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 250,339 | 202,999 | -47,340 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 121,692 | 195,307 | +73,615 | 0.01 | 0.01 | +0.00 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 192,242 | 192,242 | 0 | 0.21 | 0.25 | +0.04 | hold |
| RENAISSANCE TECHNOLOGIES LLC | 388,100 | 189,000 | -199,100 | 0.02 | 0.01 | -0.01 | sell |
| MACQUARIE GROUP LTD | 122,100 | 185,984 | +63,884 | 0.00 | 0.01 | +0.00 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 201,087 | 183,621 | -17,466 | 0.28 | 0.27 | -0.01 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 238,588 | 181,799 | -56,789 | 0.03 | 0.03 | -0.00 | sell |
| WCM INVESTMENT MANAGEMENT, LLC | 175,542 | 173,984 | -1,558 | 0.01 | 0.01 | +0.00 | sell |
| BANQUE PICTET & CIE SA | 68,152 | 158,920 | +90,768 | 0.02 | 0.04 | +0.03 | buy |
| Ensign Peak Advisors, Inc | 204,221 | 158,621 | -45,600 | 0.01 | 0.01 | -0.00 | sell |
| FEDERATED HERMES, INC. | 0 | 154,192 | +154,192 | 0.00 | 0.01 | +0.01 | buy |
| Rafferty Asset Management, LLC | 140,698 | 152,347 | +11,649 | 0.01 | 0.01 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 142,974 | 149,569 | +6,595 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 119,355 | 140,989 | +21,634 | 0.00 | 0.00 | +0.00 | buy |
| Caption Management, LLC | 27,436 | 122,711 | +95,275 | 0.08 | 0.38 | +0.30 | buy |
| PFM Health Sciences, LP | 472,540 | 122,701 | -349,839 | 0.68 | 0.20 | -0.48 | sell |
| MARSHALL WACE, LLP | 0 | 114,104 | +114,104 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 113,931 | 112,895 | -1,036 | 0.02 | 0.02 | +0.00 | sell |
| Man Group plc | 0 | 109,390 | +109,390 | 0.00 | 0.01 | +0.01 | buy |
| Swiss National Bank | 99,600 | 99,600 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Avidity Partners Management LP | 908,000 | 99,000 | -809,000 | 1.02 | 0.14 | -0.87 | sell |
| AXA S.A. | 98,810 | 98,838 | +28 | 0.01 | 0.01 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 22,227 | 98,274 | +76,047 | 0.00 | 0.02 | +0.02 | buy |
| CITIGROUP INC | 31,595 | 93,338 | +61,743 | 0.00 | 0.00 | +0.00 | buy |
| Knott David M Jr | 91,500 | 92,000 | +500 | 0.96 | 0.92 | -0.04 | buy |
| Skandinaviska Enskilda Banken AB (publ) | 277,022 | 88,468 | -188,554 | 0.04 | 0.01 | -0.02 | sell |
| TD ASSET MANAGEMENT INC | 36,800 | 85,000 | +48,200 | 0.00 | 0.00 | +0.00 | buy |
| Blue Owl Capital Holdings LP | 80,000 | 80,000 | 0 | 0.59 | 0.44 | -0.15 | hold |
| RHUMBLINE ADVISERS | 83,532 | 79,744 | -3,788 | 0.00 | 0.00 | -0.00 | sell |
| EFG Asset Management (North America) Corp. | 58,070 | 73,818 | +15,748 | 0.27 | 0.35 | +0.09 | buy |
| ALLIANCEBERNSTEIN L.P. | 71,450 | 70,650 | -800 | 0.00 | 0.00 | +0.00 | sell |
| ArrowMark Colorado Holdings LLC | 70,000 | 70,000 | 0 | 0.02 | 0.03 | +0.00 | hold |
| STATE OF WISCONSIN INVESTMENT BOARD | 71,745 | 68,593 | -3,152 | 0.01 | 0.00 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 41,479 | 62,435 | +20,956 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 151,472 | 61,356 | -90,116 | 0.08 | 0.04 | -0.04 | sell |
| Legal & General Group Plc | 53,984 | 55,394 | +1,410 | 0.00 | 0.00 | +0.00 | buy |
| Erste Asset Management GmbH | 45,500 | 52,500 | +7,000 | 0.02 | 0.02 | +0.00 | buy |
| DAFNA Capital Management LLC | 47,916 | 51,996 | +4,080 | 0.30 | 0.35 | +0.05 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 50,235 | 48,909 | -1,326 | 0.00 | 0.00 | +0.00 | sell |
| SIMPLEX TRADING, LLC | 56,961 | 48,191 | -8,770 | 0.05 | 0.05 | -0.00 | sell |
| SEI INVESTMENTS CO | 0 | 38,915 | +38,915 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 32,956 | 37,766 | +4,810 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 65,046 | 37,186 | -27,860 | 0.00 | 0.00 | -0.00 | sell |
| ALGERT GLOBAL LLC | 120,938 | 36,969 | -83,969 | 0.11 | 0.03 | -0.08 | sell |
| GUGGENHEIM CAPITAL LLC | 37,538 | 36,729 | -809 | 0.01 | 0.01 | +0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 37,626 | 36,680 | -946 | 0.00 | 0.00 | -0.00 | sell |
| MetLife Investment Management, LLC | 33,608 | 33,608 | 0 | 0.01 | 0.01 | +0.00 | hold |
| HighTower Advisors, LLC | 25,965 | 33,224 | +7,259 | 0.00 | 0.00 | +0.00 | buy |
| Nicholas Investment Partners, LP | 0 | 33,103 | +33,103 | 0.00 | 0.09 | +0.09 | buy |
| DekaBank Deutsche Girozentrale | 32,600 | 32,600 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Corebridge Financial, Inc. | 31,228 | 31,037 | -191 | 0.00 | 0.00 | +0.00 | sell |
| PROFUND ADVISORS LLC | 26,140 | 30,031 | +3,891 | 0.03 | 0.03 | +0.01 | buy |