| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| T. Rowe Price Investment Management, Inc. | 1,625,220 | 3,331,017 | +1,705,797 | 0.03 | 0.06 | +0.03 | buy |
| Deep Track Capital, LP | 2,883,736 | 4,347,464 | +1,463,728 | 2.27 | 3.96 | +1.68 | buy |
| BAKER BROS. ADVISORS LP | 464,718 | 1,225,410 | +760,692 | 0.16 | 0.36 | +0.21 | buy |
| ADAR1 Capital Management, LLC | 476,543 | 1,131,707 | +655,164 | 2.53 | 5.41 | +2.88 | buy |
| Logos Global Management LP | 575,000 | 1,100,000 | +525,000 | 1.75 | 3.51 | +1.76 | buy |
| PERCEPTIVE ADVISORS LLC | 1,923,786 | 2,378,762 | +454,976 | 1.22 | 1.43 | +0.21 | buy |
| ARMISTICE CAPITAL, LLC | 3,396,909 | 3,548,000 | +151,091 | 1.13 | 1.62 | +0.49 | buy |
| Rhenman & Partners Asset Management AB | 130,500 | 243,000 | +112,500 | 0.33 | 0.56 | +0.23 | buy |
| BANQUE PICTET & CIE SA | 68,152 | 158,920 | +90,768 | 0.02 | 0.03 | +0.02 | buy |
| ALGERT GLOBAL LLC | 120,938 | 36,969 | +83,969 | 0.11 | 0.03 | 0.00 | sell |
| Aberdeen Group plc | 400,722 | 478,757 | +78,035 | 0.02 | 0.03 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 238,588 | 181,799 | +56,789 | 0.03 | 0.03 | -0.00 | sell |
| Prosight Management, LP | 325,000 | 370,000 | +45,000 | 2.56 | 2.60 | +0.03 | buy |
| Rock Springs Capital Management LP | 1,185,654 | 1,221,309 | +35,655 | 0.94 | 1.13 | +0.19 | buy |
| EFG Asset Management (North America) Corp. | 58,070 | 73,818 | +15,748 | 0.27 | 0.35 | +0.09 | buy |
| Rafferty Asset Management, LLC | 140,698 | 152,347 | +11,649 | 0.01 | 0.01 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 17,160 | 28,151 | +10,991 | 0.06 | 0.09 | +0.02 | buy |
| EntryPoint Capital, LLC | 470 | 8,738 | +8,268 | 0.02 | 0.14 | +0.12 | buy |
| Scientech Research LLC | 12,634 | 20,691 | +8,057 | 0.07 | 0.12 | +0.05 | buy |
| Erste Asset Management GmbH | 45,500 | 52,500 | +7,000 | 0.02 | 0.02 | +0.00 | buy |
| DAFNA Capital Management LLC | 47,916 | 51,996 | +4,080 | 0.30 | 0.35 | +0.05 | buy |
| PROFUND ADVISORS LLC | 26,140 | 30,031 | +3,891 | 0.03 | 0.03 | 0.00 | buy |
| Tyro Capital Management LLC | 250,620 | 252,149 | +1,529 | 3.00 | 3.69 | +0.69 | buy |
| E Fund Management Co., Ltd. | 8,545 | 9,789 | +1,244 | 0.01 | 0.01 | +0.00 | buy |
| Knott David M Jr | 91,500 | 92,000 | +500 | 0.96 | 0.92 | -0.04 | buy |
| DnB Asset Management AS | 10,290 | 10,487 | +197 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 3,403 | 3,462 | +59 | 0.04 | 0.05 | +0.00 | buy |
| BFSG, LLC | 600 | 565 | -35 | 0.00 | 0.00 | -0.00 | sell |
| ALPS ADVISORS INC | 113,931 | 112,895 | -1,036 | 0.02 | 0.02 | +0.00 | sell |
| WCM INVESTMENT MANAGEMENT, LLC | 175,542 | 173,984 | -1,558 | 0.01 | 0.01 | +0.00 | sell |
| Two Seas Capital LP | 692,406 | 676,614 | -15,792 | 2.98 | 3.26 | +0.28 | sell |
| EMERALD MUTUAL FUND ADVISERS TRUST | 201,087 | 183,621 | -17,466 | 0.28 | 0.27 | -0.01 | sell |
| BAMCO INC /NY/ | 55,000 | 30,000 | -25,000 | 0.00 | 0.00 | -0.00 | sell |
| AWM Investment Company, Inc. | 50,000 | 25,000 | -25,000 | 0.18 | 0.09 | -0.09 | sell |
| Alpine Global Management, LLC | 1,907,704 | 1,882,704 | -25,000 | 8.76 | 12.99 | +4.24 | sell |
| EMERALD ADVISERS, LLC | 288,564 | 250,039 | -38,525 | 0.32 | 0.28 | -0.04 | sell |
| Redmile Group, LLC | 720,177 | 642,229 | -77,948 | 1.15 | 1.08 | -0.07 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 420,000 | 300,000 | -120,000 | 0.02 | 0.02 | -0.01 | sell |
| Affinity Asset Advisors, LLC | 346,088 | 225,000 | -121,088 | 1.44 | 1.00 | -0.44 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,361,649 | 1,209,046 | -152,603 | 0.00 | 0.00 | -0.00 | sell |
| Skandinaviska Enskilda Banken AB (publ) | 277,022 | 88,468 | -188,554 | 100.00 | 18.18 | -81.82 | sell |
| Soleus Capital Management, L.P. | 251,900 | 9,678 | -242,222 | 0.59 | 0.02 | -0.56 | sell |
| STEMPOINT CAPITAL LP | 1,011,879 | 671,001 | -340,878 | 7.86 | 5.74 | -2.12 | sell |
| PFM Health Sciences, LP | 472,540 | 122,701 | -349,839 | 0.62 | 0.20 | -0.42 | sell |
| Woodline Partners LP | 1,823,415 | 1,414,977 | -408,438 | 0.46 | 0.34 | -0.12 | sell |
| Avidity Partners Management LP | 908,000 | 99,000 | -809,000 | 1.02 | 0.14 | -0.87 | sell |