| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 18,599,195 | 14,729,555 | -3,869,640 | 0.02 | 0.01 | -0.00 | sell |
| Deep Track Capital, LP | 9,500,000 | 9,728,845 | +228,845 | 4.89 | 4.38 | -0.51 | buy |
| VANGUARD GROUP INC | 7,025,938 | 6,826,810 | -199,128 | 0.00 | 0.00 | -0.00 | sell |
| ARMISTICE CAPITAL, LLC | 5,200,000 | 5,836,000 | +636,000 | 3.15 | 2.95 | -0.20 | buy |
| BlackRock, Inc. | 5,848,285 | 5,738,236 | -110,049 | 0.00 | 0.00 | -0.00 | sell |
| BAKER BROS. ADVISORS LP | 5,457,881 | 5,457,881 | 0 | 0.85 | 0.64 | -0.21 | hold |
| T. Rowe Price Investment Management, Inc. | 6,878,956 | 5,164,698 | -1,714,258 | 0.07 | 0.05 | -0.02 | sell |
| Point72 Asset Management, L.P. | 3,336,250 | 3,442,078 | +105,828 | 0.13 | 0.12 | -0.01 | buy |
| STATE STREET CORP | 2,830,074 | 2,892,618 | +62,544 | 0.00 | 0.00 | -0.00 | buy |
| Two Seas Capital LP | 2,252,772 | 2,762,040 | +509,268 | 3.53 | 2.68 | -0.86 | buy |
| Alpine Global Management, LLC | 2,626,692 | 2,754,731 | +128,039 | 9.47 | 8.04 | -1.43 | buy |
| ADAR1 Capital Management, LLC | 535,066 | 2,241,753 | +1,706,687 | 1.39 | 3.58 | +2.19 | buy |
| MORGAN STANLEY | 2,309,061 | 1,959,026 | -350,035 | 0.00 | 0.00 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 1,825,602 | 1,801,649 | -23,953 | 0.00 | 0.00 | -0.00 | sell |
| STEMPOINT CAPITAL LP | 1,300,860 | 1,589,580 | +288,720 | 6.70 | 5.17 | -1.53 | buy |
| PERCEPTIVE ADVISORS LLC | 2,137,890 | 1,587,890 | -550,000 | 1.28 | 0.74 | -0.54 | sell |
| Woodline Partners LP | 1,498,725 | 1,498,725 | 0 | 0.13 | 0.11 | -0.01 | hold |
| GOLDMAN SACHS GROUP INC | 1,195,516 | 1,482,539 | +287,023 | 0.00 | 0.00 | +0.00 | buy |
| Aberdeen Group plc | 844,705 | 981,804 | +137,099 | 0.02 | 0.03 | +0.00 | buy |
| CITADEL ADVISORS LLC | 350,392 | 746,553 | +396,161 | 0.00 | 0.01 | +0.00 | buy |
| UBS Group AG | 671,284 | 726,173 | +54,889 | 0.00 | 0.00 | +0.00 | buy |
| Prosight Management, LP | 479,400 | 698,472 | +219,072 | 1.87 | 2.70 | +0.83 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 298,170 | 683,402 | +385,232 | 0.00 | 0.01 | +0.00 | buy |
| Pictet Asset Management Holding SA | 1,188,578 | 676,577 | -512,001 | 0.02 | 0.01 | -0.01 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 661,146 | 580,696 | -80,450 | 0.00 | 0.00 | -0.00 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 448,515 | 558,897 | +110,382 | 0.03 | 0.03 | +0.00 | buy |
| NORTHERN TRUST CORP | 575,383 | 555,915 | -19,468 | 0.00 | 0.00 | -0.00 | sell |
| GREAT POINT PARTNERS LLC | 262,176 | 500,000 | +237,824 | 2.73 | 3.37 | +0.64 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 197,569 | 448,051 | +250,482 | 0.01 | 0.01 | +0.01 | buy |
| MARSHALL WACE, LLP | 0 | 419,680 | +419,680 | 0.00 | 0.01 | +0.01 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 414,800 | 414,800 | 0 | 0.01 | 0.00 | -0.00 | hold |
| BANK OF AMERICA CORP /DE/ | 421,726 | 374,769 | -46,957 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 236,966 | 374,285 | +137,319 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 463,600 | 343,600 | -120,000 | 0.01 | 0.01 | -0.00 | sell |
| SUPERSTRING CAPITAL MANAGEMENT LP | 0 | 341,348 | +341,348 | 0.00 | 5.42 | +5.42 | buy |
| JANE STREET GROUP, LLC | 0 | 337,666 | +337,666 | 0.00 | 0.01 | +0.01 | buy |
| Affinity Asset Advisors, LLC | 0 | 300,000 | +300,000 | 0.00 | 0.45 | +0.45 | buy |
| Jump Financial, LLC | 322,846 | 296,260 | -26,586 | 0.07 | 0.07 | +0.01 | sell |
| Logos Global Management LP | 275,000 | 275,000 | 0 | 0.59 | 0.44 | -0.15 | hold |
| Granahan Investment Management, LLC | 213,088 | 266,221 | +53,133 | 0.14 | 0.18 | +0.04 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 256,743 | 256,743 | 0 | 1.07 | 0.98 | -0.09 | hold |
| HighVista Strategies LLC | 182,808 | 253,127 | +70,319 | 1.07 | 1.00 | -0.07 | buy |
| Cubist Systematic Strategies, LLC | 94,287 | 252,712 | +158,425 | 0.02 | 0.06 | +0.04 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 105,293 | 244,224 | +138,931 | 0.00 | 0.01 | +0.00 | buy |
| CITIGROUP INC | 317,882 | 242,022 | -75,860 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 271,350 | 226,357 | -44,993 | 0.00 | 0.00 | -0.00 | sell |
| Nuveen, LLC | 225,099 | 225,040 | -59 | 0.00 | 0.00 | -0.00 | sell |
| Assenagon Asset Management S.A. | 0 | 205,219 | +205,219 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 61,114 | 204,584 | +143,470 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 189,663 | 201,955 | +12,292 | 0.00 | 0.00 | +0.00 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 195,727 | 195,727 | 0 | 0.21 | 0.20 | -0.00 | hold |
| DAFNA Capital Management LLC | 191,493 | 191,493 | 0 | 0.85 | 0.76 | -0.08 | hold |
| Verition Fund Management LLC | 21,154 | 189,397 | +168,243 | 0.00 | 0.02 | +0.02 | buy |
| TFG Asset Management GP Ltd | 147,817 | 188,379 | +40,562 | 0.43 | 0.44 | +0.01 | buy |
| Exome Asset Management LLC | 0 | 158,622 | +158,622 | 0.00 | 1.69 | +1.69 | buy |
| TD ASSET MANAGEMENT INC | 192,506 | 135,754 | -56,752 | 0.00 | 0.00 | -0.00 | sell |
| Swiss National Bank | 129,800 | 132,600 | +2,800 | 0.00 | 0.00 | -0.00 | buy |
| MACQUARIE GROUP LTD | 122,100 | 122,100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Schonfeld Strategic Advisors LLC | 0 | 115,750 | +115,750 | 0.00 | 0.01 | +0.01 | buy |
| BANQUE PICTET & CIE SA | 125,952 | 113,888 | -12,064 | 0.02 | 0.02 | -0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 200,260 | 107,224 | -93,036 | 0.00 | 0.00 | -0.00 | sell |
| Rafferty Asset Management, LLC | 106,470 | 101,863 | -4,607 | 0.01 | 0.01 | -0.00 | sell |
| RHUMBLINE ADVISERS | 101,381 | 98,973 | -2,408 | 0.00 | 0.00 | -0.00 | sell |
| Hudson Bay Capital Management LP | 92,500 | 92,500 | 0 | 0.01 | 0.01 | -0.00 | hold |
| TUDOR INVESTMENT CORP ET AL | 0 | 90,766 | +90,766 | 0.00 | 0.01 | +0.01 | buy |
| Caption Management, LLC | 32,076 | 90,000 | +57,924 | 0.05 | 0.08 | +0.04 | buy |
| ALLIANCEBERNSTEIN L.P. | 83,960 | 89,623 | +5,663 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 201,172 | 88,114 | -113,058 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 77,296 | 87,077 | +9,781 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 66,750 | 76,602 | +9,852 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 478,263 | 75,330 | -402,933 | 0.00 | 0.00 | -0.00 | sell |
| Rock Springs Capital Management LP | 221,500 | 72,965 | -148,535 | 0.22 | 0.07 | -0.15 | sell |
| ArrowMark Colorado Holdings LLC | 70,000 | 70,000 | 0 | 0.02 | 0.02 | +0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 74,314 | 64,568 | -9,746 | 0.00 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 8,028 | 62,598 | +54,570 | 0.00 | 0.00 | +0.00 | buy |
| Quinn Opportunity Partners LLC | 51,108 | 61,108 | +10,000 | 0.07 | 0.07 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 59,818 | 56,700 | -3,118 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 48,771 | 54,785 | +6,014 | 0.00 | 0.00 | +0.00 | buy |
| Erste Asset Management GmbH | 52,500 | 52,500 | 0 | 0.01 | 0.01 | +0.00 | hold |
| STATE OF WISCONSIN INVESTMENT BOARD | 93,893 | 51,242 | -42,651 | 0.00 | 0.00 | -0.00 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 50,000 | +50,000 | 0.00 | 0.12 | +0.12 | buy |
| WELLS FARGO & COMPANY/MN | 36,273 | 44,937 | +8,664 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 41,683 | +41,683 | 0.00 | 0.05 | +0.05 | buy |
| MetLife Investment Management, LLC | 40,900 | 40,900 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GUGGENHEIM CAPITAL LLC | 41,501 | 39,445 | -2,056 | 0.01 | 0.00 | -0.00 | sell |
| Voleon Capital Management LP | 0 | 39,035 | +39,035 | 0.00 | 0.02 | +0.02 | buy |
| Creative Planning | 35,368 | 38,503 | +3,135 | 0.00 | 0.00 | -0.00 | buy |
| Headlands Technologies LLC | 64 | 38,386 | +38,322 | 0.00 | 0.05 | +0.05 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 42,641 | 36,951 | -5,690 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 36,124 | 35,893 | -231 | 0.00 | 0.00 | -0.00 | sell |
| CAPITAL FUND MANAGEMENT S.A. | 55,524 | 35,128 | -20,396 | 0.01 | 0.01 | -0.00 | sell |
| ALGERT GLOBAL LLC | 0 | 34,900 | +34,900 | 0.00 | 0.01 | +0.01 | buy |
| HighTower Advisors, LLC | 33,392 | 33,408 | +16 | 0.00 | 0.00 | -0.00 | buy |
| DekaBank Deutsche Girozentrale | 32,600 | 32,600 | 0 | 0.00 | 0.00 | -0.00 | hold |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 31,950 | +31,950 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 45,350 | 31,150 | -14,200 | 0.01 | 0.00 | -0.00 | sell |
| JANUS HENDERSON GROUP PLC | 30,731 | 30,731 | 0 | 0.00 | 0.00 | -0.00 | hold |
| China Universal Asset Management Co., Ltd. | 34,329 | 30,555 | -3,774 | 0.05 | 0.04 | -0.01 | sell |
| NOMURA HOLDINGS INC | 0 | 30,000 | +30,000 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 23,889 | 28,092 | +4,203 | 0.00 | 0.00 | +0.00 | buy |