| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 434,500 | 1,331,780 | +897,280 | 0.04 | 0.12 | +0.08 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 730,042 | 1,602,562 | +872,520 | 0.00 | 0.01 | +0.00 | buy |
| ARMISTICE CAPITAL, LLC | 1,035,877 | 1,436,000 | +400,123 | 0.61 | 0.83 | +0.22 | buy |
| Rock Springs Capital Management LP | 644,344 | 983,301 | +338,957 | 0.66 | 1.02 | +0.36 | buy |
| Capital Research Global Investors | 750,000 | 976,237 | +226,237 | 0.01 | 0.01 | +0.00 | buy |
| Alpine Global Management, LLC | 1,252,474 | 1,398,372 | +145,898 | 11.09 | 16.09 | +5.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 247,182 | 150,240 | +96,942 | 0.05 | 0.03 | -0.02 | sell |
| Sofinnova Investments, Inc. | 139,885 | 222,553 | +82,668 | 0.34 | 0.52 | +0.19 | buy |
| SOROS FUND MANAGEMENT LLC | 75,000 | 140,000 | +65,000 | 0.04 | 0.08 | +0.04 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 372,771 | 325,534 | +47,237 | 0.02 | 0.01 | -0.00 | sell |
| Affinity Asset Advisors, LLC | 300,000 | 345,000 | +45,000 | 3.76 | 2.90 | -0.86 | buy |
| AWM Investment Company, Inc. | 50,000 | 70,000 | +20,000 | 0.28 | 0.39 | +0.10 | buy |
| DAFNA Capital Management LLC | 22,500 | 40,742 | +18,242 | 0.27 | 0.41 | +0.14 | buy |
| HighVista Strategies LLC | 106,908 | 121,287 | +14,379 | 1.90 | 1.85 | -0.05 | buy |
| ALGERT GLOBAL LLC | 63,469 | 49,661 | +13,808 | 0.11 | 0.08 | 0.00 | sell |
| China Universal Asset Management Co., Ltd. | 3,360 | 16,734 | +13,374 | 0.04 | 0.14 | +0.10 | buy |
| Y-Intercept (Hong Kong) Ltd | 22,060 | 9,241 | +12,819 | 0.08 | 0.04 | 0.00 | sell |
| PROFUND ADVISORS LLC | 49,869 | 37,460 | +12,409 | 0.11 | 0.07 | 0.00 | sell |
| Informed Momentum Co LLC | 102,520 | 110,929 | +8,409 | 0.76 | 0.83 | +0.07 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 225,939 | 228,765 | +2,826 | 0.34 | 0.39 | +0.05 | buy |
| ProShare Advisors LLC | 15,554 | 18,174 | +2,620 | 0.00 | 0.00 | 0.00 | buy |
| CoreCap Advisors, LLC | 5,760 | 6,407 | +647 | 0.02 | 0.02 | +0.00 | buy |
| NEW YORK LIFE INVESTMENT MANAGEMENT LLC | 22,920 | 22,438 | +482 | 0.01 | 0.01 | 0.00 | sell |
| JENNISON ASSOCIATES LLC | 313,191 | 313,205 | +14 | 0.01 | 0.01 | -0.00 | buy |
| Red Tortoise LLC | 350 | 242 | -108 | 0.01 | 0.01 | -0.00 | sell |
| VIRTUS ADVISERS, LLC | 4,647 | 2,174 | -2,473 | 0.11 | 0.06 | -0.05 | sell |
| E Fund Management Co., Ltd. | 15,245 | 12,256 | -2,989 | 0.04 | 0.03 | -0.01 | sell |
| ACUTA CAPITAL PARTNERS, LLC | 129,000 | 119,489 | -9,511 | 3.32 | 2.83 | -0.49 | sell |
| Rhenman & Partners Asset Management AB | 166,061 | 146,061 | -20,000 | 0.69 | 0.61 | -0.07 | sell |
| Hillsdale Investment Management Inc. | 116,300 | 92,000 | -24,300 | 0.41 | 0.32 | -0.09 | sell |
| Cormorant Asset Management, LP | 1,225,000 | 1,165,000 | -60,000 | 2.74 | 2.34 | -0.40 | sell |
| Ikarian Capital, LLC | 297,794 | 233,394 | -64,400 | 4.24 | 2.69 | -1.55 | sell |
| Rafferty Asset Management, LLC | 296,832 | 229,087 | -67,745 | 0.07 | 0.04 | -0.03 | sell |
| Soleus Capital Management, L.P. | 399,599 | 317,050 | -82,549 | 1.55 | 1.48 | -0.06 | sell |
| Atika Capital Management LLC | 209,000 | 120,000 | -89,000 | 1.05 | 0.68 | -0.38 | sell |
| Monashee Investment Management LLC | 170,000 | 70,000 | -100,000 | 2.73 | 0.52 | -2.21 | sell |
| Redmile Group, LLC | 1,102,514 | 977,072 | -125,442 | 2.01 | 1.47 | -0.54 | sell |
| Woodline Partners LP | 964,083 | 750,266 | -213,817 | 0.43 | 0.34 | -0.09 | sell |
| Two Seas Capital LP | 427,256 | 198,752 | -228,504 | 3.32 | 2.06 | -1.26 | sell |
| Nicholas Investment Partners, LP | 378,155 | 136,310 | -241,845 | 1.08 | 0.67 | -0.41 | sell |
| FRED ALGER MANAGEMENT, LLC | 1,186,031 | 884,872 | -301,159 | 0.26 | 0.20 | -0.06 | sell |
| Logos Global Management LP | 1,600,000 | 1,200,000 | -400,000 | 8.76 | 5.62 | -3.14 | sell |
| Avidity Partners Management LP | 1,173,662 | 245,000 | -928,662 | 1.81 | 0.39 | -1.42 | sell |
| PERCEPTIVE ADVISORS LLC | 3,814,691 | 2,328,082 | -1,486,609 | 4.88 | 2.19 | -2.70 | sell |
| Deep Track Capital, LP | 2,797,955 | 1,000,000 | -1,797,955 | 4.17 | 1.48 | -2.69 | sell |