| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| T. Rowe Price Investment Management, Inc. | 3,331,017 | 5,117,234 | +1,786,217 | 0.06 | 0.08 | +0.02 | buy |
| Deep Track Capital, LP | 4,347,464 | 6,000,000 | +1,652,536 | 3.96 | 5.57 | +1.62 | buy |
| Two Seas Capital LP | 676,614 | 1,511,614 | +835,000 | 3.26 | 4.42 | +1.16 | buy |
| BAKER BROS. ADVISORS LP | 1,225,410 | 1,707,881 | +482,471 | 0.36 | 0.45 | +0.09 | buy |
| STEMPOINT CAPITAL LP | 671,001 | 1,118,508 | +447,507 | 5.74 | 6.95 | +1.21 | buy |
| ARMISTICE CAPITAL, LLC | 3,548,000 | 3,870,586 | +322,586 | 1.62 | 1.31 | -0.31 | buy |
| Alpine Global Management, LLC | 1,882,704 | 2,158,904 | +276,200 | 12.99 | 15.75 | +2.76 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 951,124 | 791,863 | +159,261 | 0.02 | 0.01 | 0.00 | sell |
| TD ASSET MANAGEMENT INC | 85,000 | 152,246 | +67,246 | 0.00 | 0.00 | +0.00 | buy |
| DAFNA Capital Management LLC | 51,996 | 107,996 | +56,000 | 0.35 | 0.68 | +0.33 | buy |
| Hudson Bay Capital Management LP | 20,000 | 75,000 | +55,000 | 0.00 | 0.01 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 181,799 | 235,884 | +54,085 | 0.03 | 0.03 | +0.00 | buy |
| Aberdeen Group plc | 478,757 | 532,110 | +53,353 | 0.03 | 0.02 | -0.00 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 192,242 | 202,323 | +10,081 | 0.25 | 0.29 | +0.05 | buy |
| PROFUND ADVISORS LLC | 30,031 | 22,710 | +7,321 | 0.03 | 0.02 | 0.00 | sell |
| China Universal Asset Management Co., Ltd. | 28,151 | 31,124 | +2,973 | 0.09 | 0.07 | -0.02 | buy |
| Hood River Capital Management LLC | 1,143,567 | 1,145,618 | +2,051 | 0.53 | 0.42 | -0.11 | buy |
| EFG Asset Management (North America) Corp. | 73,818 | 73,981 | +163 | 0.35 | 0.25 | -0.10 | buy |
| DnB Asset Management AS | 10,487 | 10,421 | -66 | 0.00 | 0.00 | -0.00 | sell |
| VIRTUS ADVISERS, LLC | 3,462 | 2,577 | -885 | 0.05 | 0.03 | -0.02 | sell |
| Bank Pictet & Cie (Europe) AG | 9,168 | 8,089 | -1,079 | 0.01 | 0.00 | -0.00 | sell |
| E Fund Management Co., Ltd. | 9,789 | 8,250 | -1,539 | 0.01 | 0.01 | -0.00 | sell |
| EMERALD ADVISERS, LLC | 250,039 | 244,558 | -5,481 | 0.28 | 0.23 | -0.04 | sell |
| BANQUE PICTET & CIE SA | 158,920 | 145,480 | -13,440 | 0.03 | 0.02 | -0.01 | sell |
| WCM INVESTMENT MANAGEMENT, LLC | 173,984 | 159,525 | -14,459 | 0.01 | 0.01 | -0.00 | sell |
| EMERALD MUTUAL FUND ADVISERS TRUST | 183,621 | 156,097 | -27,524 | 0.27 | 0.24 | -0.04 | sell |
| Rafferty Asset Management, LLC | 152,347 | 116,624 | -35,723 | 0.01 | 0.01 | -0.00 | sell |
| Skandinaviska Enskilda Banken AB (publ) | 88,468 | 35,316 | -53,152 | 18.18 | 36.47 | +18.29 | sell |
| Prosight Management, LP | 370,000 | 305,523 | -64,477 | 2.60 | 2.09 | -0.50 | sell |
| Redmile Group, LLC | 642,229 | 571,824 | -70,405 | 1.08 | 0.99 | -0.09 | sell |
| Rhenman & Partners Asset Management AB | 243,000 | 145,000 | -98,000 | 0.56 | 0.37 | -0.19 | sell |
| Tyro Capital Management LLC | 252,149 | 151,456 | -100,693 | 3.69 | 1.60 | -2.09 | sell |
| Affinity Asset Advisors, LLC | 225,000 | 100,000 | -125,000 | 1.00 | 0.39 | -0.61 | sell |
| PERCEPTIVE ADVISORS LLC | 2,378,762 | 2,139,199 | -239,563 | 1.43 | 1.46 | +0.03 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,209,046 | 916,250 | -292,796 | 0.00 | 0.00 | -0.00 | sell |
| Rock Springs Capital Management LP | 1,221,309 | 909,103 | -312,206 | 1.13 | 0.86 | -0.28 | sell |
| ADAR1 Capital Management, LLC | 1,131,707 | 787,478 | -344,229 | 5.41 | 4.02 | -1.39 | sell |
| Woodline Partners LP | 1,414,977 | 642,726 | -772,251 | 0.34 | 0.11 | -0.23 | sell |
| Logos Global Management LP | 1,100,000 | 300,000 | -800,000 | 3.51 | 0.87 | -2.64 | sell |
| VIKING GLOBAL INVESTORS LP | 2,320,902 | 1,407,290 | -913,612 | 0.24 | 0.11 | -0.13 | sell |