| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 12,537,571 | 13,097,915 | +560,344 | 0.02 | 0.02 | -0.00 | buy |
| VANGUARD GROUP INC | 6,658,800 | 6,679,414 | +20,614 | 0.00 | 0.00 | -0.00 | buy |
| Deep Track Capital, LP | 4,347,464 | 6,000,000 | +1,652,536 | 3.96 | 5.57 | +1.62 | buy |
| BlackRock, Inc. | 5,053,150 | 5,143,071 | +89,921 | 0.00 | 0.00 | -0.00 | buy |
| T. Rowe Price Investment Management, Inc. | 3,331,017 | 5,117,234 | +1,786,217 | 0.06 | 0.08 | +0.02 | buy |
| ARMISTICE CAPITAL, LLC | 3,548,000 | 3,870,586 | +322,586 | 2.65 | 2.23 | -0.42 | buy |
| STATE STREET CORP | 3,022,342 | 2,697,522 | -324,820 | 0.00 | 0.00 | -0.00 | sell |
| Alpine Global Management, LLC | 1,882,704 | 2,158,904 | +276,200 | 12.99 | 15.75 | +2.76 | buy |
| PERCEPTIVE ADVISORS LLC | 2,378,762 | 2,139,199 | -239,563 | 1.46 | 1.48 | +0.02 | sell |
| BAKER BROS. ADVISORS LP | 1,225,410 | 1,707,881 | +482,471 | 0.36 | 0.45 | +0.09 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,510,926 | 1,515,020 | +4,094 | 0.00 | 0.00 | -0.00 | buy |
| Two Seas Capital LP | 676,614 | 1,511,614 | +835,000 | 3.26 | 4.42 | +1.16 | buy |
| VIKING GLOBAL INVESTORS LP | 2,320,902 | 1,407,290 | -913,612 | 0.24 | 0.11 | -0.13 | sell |
| Pictet Asset Management Holding SA | 1,230,309 | 1,175,685 | -54,624 | 0.04 | 0.03 | -0.01 | sell |
| JPMORGAN CHASE & CO | 228,257 | 1,153,338 | +925,081 | 0.00 | 0.00 | +0.00 | buy |
| Hood River Capital Management LLC | 1,143,567 | 1,145,618 | +2,051 | 0.53 | 0.42 | -0.11 | buy |
| STEMPOINT CAPITAL LP | 671,001 | 1,118,508 | +447,507 | 5.74 | 6.95 | +1.21 | buy |
| MORGAN STANLEY | 817,742 | 1,010,624 | +192,882 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 1,049,679 | 984,063 | -65,616 | 0.01 | 0.01 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,209,046 | 916,250 | -292,796 | 0.00 | 0.00 | -0.00 | sell |
| Rock Springs Capital Management LP | 1,221,309 | 909,103 | -312,206 | 1.13 | 0.86 | -0.28 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 951,124 | 791,863 | -159,261 | 0.01 | 0.01 | -0.00 | sell |
| ADAR1 Capital Management, LLC | 1,131,707 | 787,478 | -344,229 | 5.41 | 4.02 | -1.39 | sell |
| GOLDMAN SACHS GROUP INC | 521,673 | 678,346 | +156,673 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 1,414,977 | 642,726 | -772,251 | 0.34 | 0.11 | -0.23 | sell |
| NORGES BANK | 563,694 | 637,947 | +74,253 | 0.00 | 0.00 | -0.00 | buy |
| UBS Group AG | 140,989 | 590,764 | +449,775 | 0.00 | 0.00 | +0.00 | buy |
| Redmile Group, LLC | 642,229 | 571,824 | -70,405 | 1.08 | 0.99 | -0.09 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 552,430 | 564,442 | +12,012 | 0.00 | 0.00 | -0.00 | buy |
| Aberdeen Group plc | 478,757 | 532,110 | +53,353 | 0.03 | 0.02 | -0.00 | buy |
| RTW INVESTMENTS, LP | 0 | 530,614 | +530,614 | 0.00 | 0.20 | +0.20 | buy |
| NORTHERN TRUST CORP | 506,990 | 527,367 | +20,377 | 0.00 | 0.00 | -0.00 | buy |
| JANE STREET GROUP, LLC | 324,165 | 505,591 | +181,426 | 0.01 | 0.02 | +0.01 | buy |
| Invesco Ltd. | 594,242 | 504,032 | -90,210 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 339,921 | 444,013 | +104,092 | 0.01 | 0.01 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 462,210 | 403,747 | -58,463 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 227,024 | 341,535 | +114,511 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 217,812 | 310,330 | +92,518 | 0.00 | 0.00 | +0.00 | buy |
| Prosight Management, LP | 370,000 | 305,523 | -64,477 | 2.67 | 2.12 | -0.55 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 300,000 | 300,000 | 0 | 0.02 | 0.01 | -0.00 | hold |
| Logos Global Management LP | 1,100,000 | 300,000 | -800,000 | 3.51 | 0.87 | -2.64 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 310,830 | 279,252 | -31,578 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 195,307 | 245,650 | +50,343 | 0.01 | 0.01 | -0.00 | buy |
| EMERALD ADVISERS, LLC | 250,039 | 244,558 | -5,481 | 0.28 | 0.23 | -0.04 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 181,799 | 235,884 | +54,085 | 0.03 | 0.03 | +0.00 | buy |
| Russell Investments Group, Ltd. | 251,492 | 222,806 | -28,686 | 0.01 | 0.01 | -0.00 | sell |
| Bank of New York Mellon Corp | 202,999 | 203,061 | +62 | 0.00 | 0.00 | -0.00 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 192,242 | 202,323 | +10,081 | 0.25 | 0.29 | +0.05 | buy |
| DEUTSCHE BANK AG\ | 149,569 | 166,472 | +16,903 | 0.00 | 0.00 | -0.00 | buy |
| WCM INVESTMENT MANAGEMENT, LLC | 173,984 | 159,525 | -14,459 | 0.01 | 0.01 | -0.00 | sell |
| EMERALD MUTUAL FUND ADVISERS TRUST | 183,621 | 156,097 | -27,524 | 0.27 | 0.24 | -0.04 | sell |
| TD ASSET MANAGEMENT INC | 85,000 | 152,246 | +67,246 | 0.00 | 0.00 | +0.00 | buy |
| Tyro Capital Management LLC | 252,149 | 151,456 | -100,693 | 3.69 | 1.60 | -2.09 | sell |
| Granahan Investment Management, LLC | 0 | 149,396 | +149,396 | 0.00 | 0.15 | +0.15 | buy |
| MILLENNIUM MANAGEMENT LLC | 376,507 | 147,097 | -229,410 | 0.01 | 0.00 | -0.01 | sell |
| BANQUE PICTET & CIE SA | 158,920 | 145,480 | -13,440 | 0.04 | 0.04 | -0.01 | sell |
| Rhenman & Partners Asset Management AB | 243,000 | 145,000 | -98,000 | 0.56 | 0.37 | -0.19 | sell |
| CITIGROUP INC | 93,338 | 142,318 | +48,980 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 61,356 | 129,668 | +68,312 | 0.04 | 0.07 | +0.03 | buy |
| MACQUARIE GROUP LTD | 185,984 | 122,100 | -63,884 | 0.01 | 0.00 | -0.00 | sell |
| Rafferty Asset Management, LLC | 152,347 | 116,624 | -35,723 | 0.01 | 0.01 | -0.00 | sell |
| DAFNA Capital Management LLC | 51,996 | 107,996 | +56,000 | 0.35 | 0.68 | +0.33 | buy |
| Swiss National Bank | 99,600 | 100,800 | +1,200 | 0.00 | 0.00 | -0.00 | buy |
| Affinity Asset Advisors, LLC | 225,000 | 100,000 | -125,000 | 1.00 | 0.39 | -0.61 | sell |
| AXA S.A. | 98,838 | 98,683 | -155 | 0.01 | 0.01 | -0.00 | sell |
| CANADA PENSION PLAN INVESTMENT BOARD | 1,200 | 95,200 | +94,000 | 0.00 | 0.00 | +0.00 | buy |
| Knott David M Jr | 92,000 | 92,000 | 0 | 0.92 | 0.82 | -0.10 | hold |
| SIMPLEX TRADING, LLC | 48,191 | 86,847 | +38,656 | 0.05 | 0.06 | +0.01 | buy |
| Caption Management, LLC | 122,711 | 86,760 | -35,951 | 0.38 | 0.09 | -0.29 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 85,201 | +85,201 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 84,708 | +84,708 | 0.00 | 0.07 | +0.07 | buy |
| RHUMBLINE ADVISERS | 79,744 | 80,932 | +1,188 | 0.00 | 0.00 | -0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 189,000 | 80,900 | -108,100 | 0.01 | 0.00 | -0.01 | sell |
| Verition Fund Management LLC | 0 | 80,073 | +80,073 | 0.00 | 0.01 | +0.01 | buy |
| ORBIMED ADVISORS LLC | 0 | 78,500 | +78,500 | 0.00 | 0.04 | +0.04 | buy |
| Hudson Bay Capital Management LP | 20,000 | 75,000 | +55,000 | 0.00 | 0.01 | +0.01 | buy |
| ALLIANCEBERNSTEIN L.P. | 70,650 | 74,850 | +4,200 | 0.00 | 0.00 | -0.00 | buy |
| EFG Asset Management (North America) Corp. | 73,818 | 73,981 | +163 | 0.35 | 0.25 | -0.10 | buy |
| ArrowMark Colorado Holdings LLC | 70,000 | 70,000 | 0 | 0.03 | 0.02 | -0.00 | hold |
| D. E. Shaw & Co., Inc. | 62,435 | 67,669 | +5,234 | 0.00 | 0.00 | -0.00 | buy |
| Legal & General Group Plc | 55,394 | 58,990 | +3,596 | 0.00 | 0.00 | -0.00 | buy |
| Erste Asset Management GmbH | 52,500 | 52,500 | 0 | 0.02 | 0.02 | -0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 48,909 | 48,400 | -509 | 0.00 | 0.00 | -0.00 | sell |
| Aquatic Capital Management LLC | 0 | 47,648 | +47,648 | 0.00 | 0.03 | +0.03 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 335,360 | 45,100 | -290,260 | 0.01 | 0.00 | -0.01 | sell |
| Vestal Point Capital, LP | 0 | 45,000 | +45,000 | 0.00 | 0.07 | +0.07 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 68,593 | 42,174 | -26,419 | 0.00 | 0.00 | -0.00 | sell |
| SEI INVESTMENTS CO | 38,915 | 40,456 | +1,541 | 0.00 | 0.00 | -0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 37,766 | 37,623 | -143 | 0.00 | 0.00 | -0.00 | sell |
| GUGGENHEIM CAPITAL LLC | 36,729 | 36,917 | +188 | 0.01 | 0.01 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 36,680 | 35,908 | -772 | 0.00 | 0.00 | -0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 37,186 | 35,861 | -1,325 | 0.00 | 0.00 | -0.00 | sell |
| Engineers Gate Manager LP | 0 | 35,737 | +35,737 | 0.00 | 0.02 | +0.02 | buy |
| MetLife Investment Management, LLC | 33,608 | 35,648 | +2,040 | 0.01 | 0.00 | -0.00 | buy |
| Skandinaviska Enskilda Banken AB (publ) | 88,468 | 35,316 | -53,152 | 0.01 | 0.00 | -0.01 | sell |
| OCCUDO QUANTITATIVE STRATEGIES LP | 0 | 34,731 | +34,731 | 0.00 | 0.16 | +0.16 | buy |
| J. Goldman & Co LP | 0 | 34,337 | +34,337 | 0.00 | 0.03 | +0.03 | buy |
| HighTower Advisors, LLC | 33,224 | 33,035 | -189 | 0.00 | 0.00 | -0.00 | sell |
| DekaBank Deutsche Girozentrale | 32,600 | 32,600 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HSBC HOLDINGS PLC | 0 | 31,896 | +31,896 | 0.00 | 0.00 | +0.00 | buy |