| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 14,729,555 | 16,990,754 | +2,261,199 | 0.01 | 0.02 | +0.01 | buy |
| Deep Track Capital, LP | 9,728,845 | 11,526,971 | +1,798,126 | 4.38 | 6.68 | +2.31 | buy |
| VANGUARD GROUP INC | 6,826,810 | 7,779,314 | +952,504 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 5,738,236 | 6,058,216 | +319,980 | 0.00 | 0.00 | +0.00 | buy |
| ARMISTICE CAPITAL, LLC | 5,836,000 | 5,747,155 | -88,845 | 2.95 | 3.58 | +0.62 | sell |
| BAKER BROS. ADVISORS LP | 5,457,881 | 5,457,881 | 0 | 0.64 | 0.81 | +0.18 | hold |
| T. Rowe Price Investment Management, Inc. | 5,164,698 | 5,060,399 | -104,299 | 0.05 | 0.08 | +0.03 | sell |
| MORGAN STANLEY | 1,959,026 | 4,846,385 | +2,887,359 | 0.00 | 0.01 | +0.01 | buy |
| STATE STREET CORP | 2,892,618 | 3,786,926 | +894,308 | 0.00 | 0.00 | +0.00 | buy |
| RTW INVESTMENTS, LP | 0 | 3,177,850 | +3,177,850 | 0.00 | 0.81 | +0.81 | buy |
| Two Seas Capital LP | 2,762,040 | 2,866,962 | +104,922 | 2.68 | 4.27 | +1.59 | buy |
| Alpine Global Management, LLC | 2,754,731 | 2,626,692 | -128,039 | 8.04 | 14.85 | +6.80 | sell |
| ADAR1 Capital Management, LLC | 2,241,753 | 2,480,968 | +239,215 | 3.58 | 4.72 | +1.14 | buy |
| Point72 Asset Management, L.P. | 3,442,078 | 2,000,000 | -1,442,078 | 0.12 | 0.08 | -0.04 | sell |
| PERCEPTIVE ADVISORS LLC | 1,587,890 | 1,994,890 | +407,000 | 0.74 | 0.93 | +0.19 | buy |
| Woodline Partners LP | 1,498,725 | 1,975,869 | +477,144 | 0.11 | 0.19 | +0.08 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,801,649 | 1,857,532 | +55,883 | 0.00 | 0.00 | +0.00 | buy |
| TCG Crossover Management, LLC | 0 | 1,660,933 | +1,660,933 | 0.00 | 1.40 | +1.40 | buy |
| Logos Global Management LP | 275,000 | 1,375,000 | +1,100,000 | 0.44 | 2.33 | +1.89 | buy |
| GOLDMAN SACHS GROUP INC | 1,482,539 | 1,296,008 | -186,531 | 0.00 | 0.00 | +0.00 | sell |
| Aberdeen Group plc | 981,804 | 1,184,122 | +202,318 | 0.03 | 0.05 | +0.02 | buy |
| Soleus Capital Management, L.P. | 0 | 1,110,000 | +1,110,000 | 0.00 | 1.20 | +1.20 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 204,584 | 893,056 | +688,472 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 343,600 | 863,000 | +519,400 | 0.01 | 0.03 | +0.02 | buy |
| GREAT POINT PARTNERS LLC | 500,000 | 750,000 | +250,000 | 3.37 | 6.18 | +2.82 | buy |
| UBS Group AG | 726,173 | 732,386 | +6,213 | 0.00 | 0.00 | +0.00 | buy |
| JENNISON ASSOCIATES LLC | 0 | 700,464 | +700,464 | 0.00 | 0.01 | +0.01 | buy |
| Candriam S.C.A. | 0 | 680,372 | +680,372 | 0.00 | 0.09 | +0.09 | buy |
| STEMPOINT CAPITAL LP | 1,589,580 | 644,959 | -944,621 | 5.17 | 2.81 | -2.35 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 580,696 | 642,974 | +62,278 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 555,915 | 566,148 | +10,233 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 558,897 | 467,469 | -91,428 | 0.03 | 0.03 | +0.00 | sell |
| Pictet Asset Management Holding SA | 676,577 | 380,842 | -295,735 | 0.01 | 0.01 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 683,402 | 353,056 | -330,346 | 0.01 | 0.01 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 374,769 | 313,481 | -61,288 | 0.00 | 0.00 | +0.00 | sell |
| SUPERSTRING CAPITAL MANAGEMENT LP | 341,348 | 288,677 | -52,671 | 5.42 | 3.93 | -1.49 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 244,224 | 259,117 | +14,893 | 0.01 | 0.01 | +0.00 | buy |
| Prosight Management, LP | 698,472 | 243,404 | -455,068 | 2.70 | 1.28 | -1.42 | sell |
| BARCLAYS PLC | 226,357 | 232,326 | +5,969 | 0.00 | 0.00 | +0.00 | buy |
| Granahan Investment Management, LLC | 266,221 | 230,188 | -36,033 | 0.18 | 0.25 | +0.07 | sell |
| Nuveen, LLC | 225,040 | 226,489 | +1,449 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 135,754 | 224,960 | +89,206 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 253,127 | 221,883 | -31,244 | 1.00 | 1.45 | +0.45 | sell |
| Assenagon Asset Management S.A. | 205,219 | 205,219 | 0 | 0.00 | 0.01 | +0.00 | hold |
| Affinity Asset Advisors, LLC | 300,000 | 200,000 | -100,000 | 0.45 | 0.37 | -0.08 | sell |
| Bank of New York Mellon Corp | 201,955 | 199,364 | -2,591 | 0.00 | 0.00 | +0.00 | sell |
| PLATINUM INVESTMENT MANAGEMENT LTD | 195,727 | 181,774 | -13,953 | 0.20 | 1.07 | +0.86 | sell |
| MILLENNIUM MANAGEMENT LLC | 88,114 | 172,496 | +84,382 | 0.00 | 0.00 | +0.00 | buy |
| TFG Asset Management GP Ltd | 188,379 | 166,187 | -22,192 | 0.44 | 0.89 | +0.45 | sell |
| DIMENSIONAL FUND ADVISORS LP | 374,285 | 160,442 | -213,843 | 0.00 | 0.00 | -0.00 | sell |
| Exome Asset Management LLC | 158,622 | 158,622 | 0 | 1.69 | 1.99 | +0.30 | hold |
| Swiss National Bank | 132,600 | 158,300 | +25,700 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 746,553 | 154,507 | -592,046 | 0.01 | 0.00 | -0.01 | sell |
| DAFNA Capital Management LLC | 191,493 | 150,524 | -40,969 | 0.76 | 0.89 | +0.13 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 107,224 | 134,441 | +27,217 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 101,863 | 132,346 | +30,483 | 0.01 | 0.01 | +0.01 | buy |
| Erste Asset Management GmbH | 52,500 | 128,500 | +76,000 | 0.01 | 0.03 | +0.02 | buy |
| ExodusPoint Capital Management, LP | 0 | 126,621 | +126,621 | 0.00 | 0.04 | +0.04 | buy |
| Trexquant Investment LP | 0 | 114,995 | +114,995 | 0.00 | 0.03 | +0.03 | buy |
| BANQUE PICTET & CIE SA | 113,888 | 114,881 | +993 | 0.02 | 0.03 | +0.01 | buy |
| Jump Financial, LLC | 296,260 | 104,602 | -191,658 | 0.07 | 0.03 | -0.04 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 35,893 | 97,234 | +61,341 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 87,077 | 92,714 | +5,637 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 89,623 | 89,160 | -463 | 0.00 | 0.00 | +0.00 | sell |
| Invesco Ltd. | 76,602 | 88,857 | +12,255 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 98,973 | 86,847 | -12,126 | 0.00 | 0.00 | +0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 64,568 | 85,952 | +21,384 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 84,840 | +84,840 | 0.00 | 0.01 | +0.01 | buy |
| Verition Fund Management LLC | 189,397 | 80,794 | -108,603 | 0.02 | 0.01 | -0.01 | sell |
| JPMORGAN CHASE & CO | 75,330 | 79,866 | +4,536 | 0.00 | 0.00 | +0.00 | buy |
| Blackstone Inc. | 0 | 79,673 | +79,673 | 0.00 | 0.01 | +0.01 | buy |
| WELLS FARGO & COMPANY/MN | 44,937 | 79,667 | +34,730 | 0.00 | 0.00 | +0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 0 | 71,705 | +71,705 | 0.00 | 0.06 | +0.06 | buy |
| ArrowMark Colorado Holdings LLC | 70,000 | 70,000 | 0 | 0.02 | 0.04 | +0.02 | hold |
| Amundi | 0 | 67,404 | +67,404 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 54,785 | 62,458 | +7,673 | 0.00 | 0.00 | +0.00 | buy |
| Quinn Opportunity Partners LLC | 61,108 | 61,108 | 0 | 0.07 | 0.07 | -0.00 | hold |
| VOYA INVESTMENT MANAGEMENT LLC | 12,651 | 53,631 | +40,980 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 22,266 | 49,076 | +26,810 | 0.01 | 0.04 | +0.03 | buy |
| SIMPLEX TRADING, LLC | 14,932 | 48,411 | +33,479 | 0.01 | 0.03 | +0.03 | buy |
| SG Americas Securities, LLC | 62,598 | 45,648 | -16,950 | 0.00 | 0.00 | -0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 27,148 | 44,140 | +16,992 | 0.04 | 0.10 | +0.06 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 41,683 | 41,683 | 0 | 0.05 | 0.08 | +0.03 | hold |
| Creative Planning | 38,503 | 41,501 | +2,998 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 36,951 | 40,305 | +3,354 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 40,900 | 39,036 | -1,864 | 0.00 | 0.00 | +0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 51,242 | 38,919 | -12,323 | 0.00 | 0.00 | +0.00 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 31,150 | 35,189 | +4,039 | 0.00 | 0.01 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 30,731 | 33,731 | +3,000 | 0.00 | 0.00 | +0.00 | buy |
| HighTower Advisors, LLC | 33,408 | 33,408 | 0 | 0.00 | 0.00 | +0.00 | hold |
| XTX Topco Ltd | 17,327 | 33,122 | +15,795 | 0.01 | 0.02 | +0.01 | buy |
| DekaBank Deutsche Girozentrale | 32,600 | 32,600 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Handelsbanken Fonder AB | 23,800 | 32,300 | +8,500 | 0.00 | 0.00 | +0.00 | buy |
| DYMON ASIA CAPITAL (SINGAPORE) PTE. LTD. | 17,905 | 29,205 | +11,300 | 0.12 | 0.16 | +0.05 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 28,092 | 28,847 | +755 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 30,555 | 28,561 | -1,994 | 0.04 | 0.06 | +0.02 | sell |
| TUDOR INVESTMENT CORP ET AL | 90,766 | 25,600 | -65,166 | 0.01 | 0.00 | -0.01 | sell |
| LMR Partners LLP | 25,067 | 25,067 | 0 | 0.01 | 0.01 | +0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 20,255 | 24,055 | +3,800 | 0.00 | 0.00 | +0.00 | buy |
| State of New Jersey Common Pension Fund D | 0 | 23,799 | +23,799 | 0.00 | 0.00 | +0.00 | buy |