| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RTW INVESTMENTS, LP | 0 | 3,177,850 | +3,177,850 | 0.00 | 0.81 | +0.81 | buy |
| MORGAN STANLEY | 1,959,026 | 4,846,385 | +2,887,359 | 0.00 | 0.01 | +0.01 | buy |
| FMR LLC | 14,729,555 | 16,990,754 | +2,261,199 | 0.01 | 0.02 | +0.01 | buy |
| Deep Track Capital, LP | 9,728,845 | 11,526,971 | +1,798,126 | 4.38 | 6.68 | +2.31 | buy |
| TCG Crossover Management, LLC | 0 | 1,660,933 | +1,660,933 | 0.00 | 1.40 | +1.40 | buy |
| Soleus Capital Management, L.P. | 0 | 1,110,000 | +1,110,000 | 0.00 | 1.20 | +1.20 | buy |
| Logos Global Management LP | 275,000 | 1,375,000 | +1,100,000 | 0.44 | 2.33 | +1.89 | buy |
| VANGUARD GROUP INC | 6,826,810 | 7,779,314 | +952,504 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 2,892,618 | 3,786,926 | +894,308 | 0.00 | 0.00 | +0.00 | buy |
| JENNISON ASSOCIATES LLC | 0 | 700,464 | +700,464 | 0.00 | 0.01 | +0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 204,584 | 893,056 | +688,472 | 0.00 | 0.00 | +0.00 | buy |
| Candriam S.C.A. | 0 | 680,372 | +680,372 | 0.00 | 0.09 | +0.09 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 343,600 | 863,000 | +519,400 | 0.01 | 0.03 | +0.02 | buy |
| Woodline Partners LP | 1,498,725 | 1,975,869 | +477,144 | 0.11 | 0.19 | +0.08 | buy |
| PERCEPTIVE ADVISORS LLC | 1,587,890 | 1,994,890 | +407,000 | 0.74 | 0.93 | +0.19 | buy |
| BlackRock, Inc. | 5,738,236 | 6,058,216 | +319,980 | 0.00 | 0.00 | +0.00 | buy |
| GREAT POINT PARTNERS LLC | 500,000 | 750,000 | +250,000 | 3.37 | 6.18 | +2.82 | buy |
| ADAR1 Capital Management, LLC | 2,241,753 | 2,480,968 | +239,215 | 3.58 | 4.72 | +1.14 | buy |
| Aberdeen Group plc | 981,804 | 1,184,122 | +202,318 | 0.03 | 0.05 | +0.02 | buy |
| ExodusPoint Capital Management, LP | 0 | 126,621 | +126,621 | 0.00 | 0.04 | +0.04 | buy |
| Trexquant Investment LP | 0 | 114,995 | +114,995 | 0.00 | 0.03 | +0.03 | buy |
| Two Seas Capital LP | 2,762,040 | 2,866,962 | +104,922 | 2.68 | 4.27 | +1.59 | buy |
| TD ASSET MANAGEMENT INC | 135,754 | 224,960 | +89,206 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 84,840 | +84,840 | 0.00 | 0.01 | +0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 88,114 | 172,496 | +84,382 | 0.00 | 0.00 | +0.00 | buy |
| Blackstone Inc. | 0 | 79,673 | +79,673 | 0.00 | 0.01 | +0.01 | buy |
| Erste Asset Management GmbH | 52,500 | 128,500 | +76,000 | 0.01 | 0.03 | +0.02 | buy |
| Hennion & Walsh Asset Management, Inc. | 0 | 71,705 | +71,705 | 0.00 | 0.06 | +0.06 | buy |
| Amundi | 0 | 67,404 | +67,404 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 580,696 | 642,974 | +62,278 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 35,893 | 97,234 | +61,341 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,801,649 | 1,857,532 | +55,883 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 12,651 | 53,631 | +40,980 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 44,937 | 79,667 | +34,730 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 14,932 | 48,411 | +33,479 | 0.01 | 0.03 | +0.03 | buy |
| Rafferty Asset Management, LLC | 101,863 | 132,346 | +30,483 | 0.01 | 0.01 | +0.01 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 107,224 | 134,441 | +27,217 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 22,266 | 49,076 | +26,810 | 0.01 | 0.04 | +0.03 | buy |
| Swiss National Bank | 132,600 | 158,300 | +25,700 | 0.00 | 0.00 | +0.00 | buy |
| State of New Jersey Common Pension Fund D | 0 | 23,799 | +23,799 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 64,568 | 85,952 | +21,384 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 21,002 | +21,002 | 0.00 | 0.01 | +0.01 | buy |
| GSA CAPITAL PARTNERS LLP | 27,148 | 44,140 | +16,992 | 0.04 | 0.10 | +0.06 | buy |
| XTX Topco Ltd | 17,327 | 33,122 | +15,795 | 0.01 | 0.02 | +0.01 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 244,224 | 259,117 | +14,893 | 0.01 | 0.01 | +0.00 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 0 | 14,064 | +14,064 | 0.00 | 0.02 | +0.02 | buy |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | 0 | 13,714 | +13,714 | 0.00 | 0.05 | +0.05 | buy |
| Allianz Asset Management GmbH | 0 | 12,900 | +12,900 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 0 | 12,784 | +12,784 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 76,602 | 88,857 | +12,255 | 0.00 | 0.00 | +0.00 | buy |
| DYMON ASIA CAPITAL (SINGAPORE) PTE. LTD. | 17,905 | 29,205 | +11,300 | 0.12 | 0.16 | +0.05 | buy |
| NORTHERN TRUST CORP | 555,915 | 566,148 | +10,233 | 0.00 | 0.00 | +0.00 | buy |
| Kestra Advisory Services, LLC | 0 | 8,979 | +8,979 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 0 | 8,537 | +8,537 | 0.00 | 0.00 | +0.00 | buy |
| Handelsbanken Fonder AB | 23,800 | 32,300 | +8,500 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 54,785 | 62,458 | +7,673 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 726,173 | 732,386 | +6,213 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 226,357 | 232,326 | +5,969 | 0.00 | 0.00 | +0.00 | buy |
| DnB Asset Management AS | 12,408 | 18,109 | +5,701 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 87,077 | 92,714 | +5,637 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 0 | 4,549 | +4,549 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 75,330 | 79,866 | +4,536 | 0.00 | 0.00 | +0.00 | buy |
| KLP KAPITALFORVALTNING AS | 14,500 | 18,900 | +4,400 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 31,150 | 35,189 | +4,039 | 0.00 | 0.01 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 20,255 | 24,055 | +3,800 | 0.00 | 0.00 | +0.00 | buy |
| Quantbot Technologies LP | 0 | 3,600 | +3,600 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 36,951 | 40,305 | +3,354 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 30,731 | 33,731 | +3,000 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 38,503 | 41,501 | +2,998 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 7,138 | 10,069 | +2,931 | 0.03 | 0.07 | +0.04 | buy |
| Quantinno Capital Management LP | 11,488 | 14,243 | +2,755 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 17,893 | 20,553 | +2,660 | 0.00 | 0.00 | +0.00 | buy |
| FNY Investment Advisers, LLC | 2,000 | 4,000 | +2,000 | 0.01 | 0.03 | +0.02 | buy |
| Mirae Asset Global Investments Co., Ltd. | 6,739 | 8,517 | +1,778 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 1,539 | 3,000 | +1,461 | 0.01 | 0.01 | +0.01 | buy |
| Nuveen, LLC | 225,040 | 226,489 | +1,449 | 0.00 | 0.00 | +0.00 | buy |
| Geneos Wealth Management Inc. | 0 | 1,000 | +1,000 | 0.00 | 0.00 | +0.00 | buy |
| BANQUE PICTET & CIE SA | 113,888 | 114,881 | +993 | 0.02 | 0.03 | +0.01 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 28,092 | 28,847 | +755 | 0.00 | 0.00 | +0.00 | buy |
| Rockefeller Capital Management L.P. | 0 | 669 | +669 | 0.00 | 0.00 | +0.00 | buy |
| Empowered Funds, LLC | 13,565 | 14,175 | +610 | 0.00 | 0.00 | +0.00 | buy |
| Kemnay Advisory Services Inc. | 0 | 416 | +416 | 0.00 | 0.00 | +0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 474 | 825 | +351 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 2,499 | 2,819 | +320 | 0.00 | 0.00 | +0.00 | buy |
| JONES FINANCIAL COMPANIES LLLP | 53 | 373 | +320 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 304 | +304 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 166 | 454 | +288 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 45 | 287 | +242 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 2,010 | 2,203 | +193 | 0.00 | 0.00 | +0.00 | buy |
| MEEDER ASSET MANAGEMENT INC | 0 | 192 | +192 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 350 | 512 | +162 | 0.00 | 0.00 | +0.00 | buy |
| ALTFEST L J & CO INC | 17,726 | 17,867 | +141 | 0.03 | 0.05 | +0.02 | buy |
| AdvisorNet Financial, Inc | 437 | 572 | +135 | 0.00 | 0.00 | +0.00 | buy |
| QUADRANT CAPITAL GROUP LLC | 80 | 212 | +132 | 0.00 | 0.00 | +0.00 | buy |
| HUNTINGTON NATIONAL BANK | 0 | 116 | +116 | 0.00 | 0.00 | +0.00 | buy |
| Larson Financial Group LLC | 42 | 97 | +55 | 0.00 | 0.00 | +0.00 | buy |
| MassMutual Private Wealth & Trust, FSB | 144 | 184 | +40 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 55 | 86 | +31 | 0.00 | 0.00 | +0.00 | buy |
| Parallel Advisors, LLC | 82 | 108 | +26 | 0.00 | 0.00 | +0.00 | buy |
| Trust Co | 0 | 21 | +21 | 0.00 | 0.00 | +0.00 | buy |