| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Deep Track Capital, LP | 9,728,845 | 11,526,971 | +1,798,126 | 4.38 | 6.68 | +2.31 | buy |
| Logos Global Management LP | 275,000 | 1,375,000 | +1,100,000 | 0.44 | 2.33 | +1.89 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 343,600 | 863,000 | +519,400 | 0.01 | 0.03 | +0.02 | buy |
| PERCEPTIVE ADVISORS LLC | 1,587,890 | 1,994,890 | +407,000 | 0.74 | 0.90 | +0.16 | buy |
| GREAT POINT PARTNERS LLC | 500,000 | 750,000 | +250,000 | 3.32 | 6.18 | +2.86 | buy |
| ADAR1 Capital Management, LLC | 2,241,753 | 2,480,968 | +239,215 | 3.58 | 4.72 | +1.14 | buy |
| Aberdeen Group plc | 981,804 | 1,184,122 | +202,318 | 0.03 | 0.05 | +0.02 | buy |
| Two Seas Capital LP | 2,762,040 | 2,866,962 | +104,922 | 2.68 | 4.27 | +1.59 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 558,897 | 467,469 | +91,428 | 0.03 | 0.03 | +0.00 | sell |
| TD ASSET MANAGEMENT INC | 135,754 | 224,960 | +89,206 | 0.00 | 0.00 | +0.00 | buy |
| Erste Asset Management GmbH | 52,500 | 128,500 | +76,000 | 0.01 | 0.03 | +0.02 | buy |
| Rafferty Asset Management, LLC | 101,863 | 132,346 | +30,483 | 0.01 | 0.01 | +0.01 | buy |
| PROFUND ADVISORS LLC | 22,266 | 49,076 | +26,810 | 0.01 | 0.04 | 0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 27,148 | 44,140 | +16,992 | 0.04 | 0.11 | 0.00 | buy |
| DYMON ASIA CAPITAL (SINGAPORE) PTE. LTD. | 17,905 | 29,205 | +11,300 | 0.03 | 0.07 | +0.04 | buy |
| DnB Asset Management AS | 12,408 | 18,109 | +5,701 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 7,138 | 10,069 | +2,931 | 0.03 | 0.07 | +0.04 | buy |
| FNY Investment Advisers, LLC | 2,000 | 4,000 | +2,000 | 0.01 | 0.03 | +0.02 | buy |
| BANQUE PICTET & CIE SA | 113,888 | 114,881 | +993 | 0.01 | 0.02 | +0.01 | buy |
| Empowered Funds, LLC | 13,565 | 14,175 | +610 | 0.00 | 0.01 | +0.00 | buy |
| ALTFEST L J & CO INC | 17,726 | 17,867 | +141 | 0.03 | 0.05 | +0.02 | buy |
| GF FUND MANAGEMENT CO. LTD. | 3,750 | 3,443 | -307 | 0.00 | 0.00 | +0.00 | sell |
| China Universal Asset Management Co., Ltd. | 30,555 | 28,561 | -1,994 | 0.04 | 0.06 | +0.02 | sell |
| PLATINUM INVESTMENT MANAGEMENT LTD | 195,727 | 181,774 | -13,953 | 0.20 | 1.07 | +0.86 | sell |
| TFG Asset Management GP Ltd | 188,379 | 166,187 | -22,192 | 0.41 | 0.89 | +0.48 | sell |
| Headlands Technologies LLC | 38,386 | 14,212 | -24,174 | 0.05 | 0.03 | -0.02 | sell |
| HighVista Strategies LLC | 253,127 | 221,883 | -31,244 | 1.00 | 1.45 | +0.45 | sell |
| Granahan Investment Management, LLC | 266,221 | 230,188 | -36,033 | 0.18 | 0.25 | +0.07 | sell |
| DAFNA Capital Management LLC | 191,493 | 150,524 | -40,969 | 0.76 | 0.89 | +0.13 | sell |
| SUPERSTRING CAPITAL MANAGEMENT LP | 341,348 | 288,677 | -52,671 | 5.42 | 3.93 | -1.49 | sell |
| ARMISTICE CAPITAL, LLC | 5,836,000 | 5,747,155 | -88,845 | 1.40 | 1.74 | +0.34 | sell |
| Affinity Asset Advisors, LLC | 300,000 | 200,000 | -100,000 | 0.45 | 0.37 | -0.08 | sell |
| T. Rowe Price Investment Management, Inc. | 5,164,698 | 5,060,399 | -104,299 | 0.05 | 0.08 | +0.03 | sell |
| Alpine Global Management, LLC | 2,754,731 | 2,626,692 | -128,039 | 9.00 | 14.39 | +5.39 | sell |
| Prosight Management, LP | 698,472 | 243,404 | -455,068 | 2.63 | 1.28 | -1.35 | sell |
| STEMPOINT CAPITAL LP | 1,589,580 | 644,959 | -944,621 | 5.17 | 2.81 | -2.35 | sell |