| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Vivo Capital, LLC | 0 | 1,137,015 | +1,137,015 | 0.00 | 0.56 | +0.56 | buy |
| Octagon Capital Advisors LP | 0 | 1,000,000 | +1,000,000 | 0.00 | 1.05 | +1.05 | buy |
| Nantahala Capital Management, LLC | 0 | 939,202 | +939,202 | 0.00 | 0.32 | +0.32 | buy |
| GREAT POINT PARTNERS LLC | 0 | 796,558 | +796,558 | 0.00 | 2.47 | +2.47 | buy |
| VANGUARD GROUP INC | 0 | 605,953 | +605,953 | 0.00 | 0.00 | +0.00 | buy |
| Logos Global Management LP | 0 | 473,562 | +473,562 | 0.00 | 0.30 | +0.30 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 0 | 62,899 | +62,899 | 0.00 | 0.42 | +0.42 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 0 | 58,786 | +58,786 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 0 | 21,709 | +21,709 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 0 | 12,523 | +12,523 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 11,790 | +11,790 | 0.00 | 0.00 | +0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 0 | 11,575 | +11,575 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 0 | 10,787 | +10,787 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 0 | 553 | +553 | 0.00 | 0.00 | +0.00 | buy |
| HARBOUR INVESTMENTS, INC. | 0 | 100 | +100 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 0 | 80 | +80 | 0.00 | 0.00 | +0.00 | buy |
| Bogart Wealth, LLC | 0 | 6 | +6 | 0.00 | 0.00 | +0.00 | buy |