| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Vivo Capital, LLC | 1,137,015 | 1,789,916 | +652,901 | 0.56 | 0.63 | +0.07 | buy |
| Squarepoint Ops LLC | 0 | 117,327 | +117,327 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 58,786 | 125,727 | +66,941 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 605,953 | 658,878 | +52,925 | 0.00 | 0.00 | -0.00 | buy |
| GOLDMAN SACHS GROUP INC | 0 | 45,200 | +45,200 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 12,523 | 54,827 | +42,304 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 37,823 | +37,823 | 0.00 | 0.01 | +0.01 | buy |
| BlackRock, Inc. | 0 | 36,355 | +36,355 | 0.00 | 0.00 | +0.00 | buy |
| Chicago Partners Investment Group LLC | 0 | 26,961 | +26,961 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 0 | 23,947 | +23,947 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 10,787 | 32,699 | +21,912 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 0 | 6,692 | +6,692 | 0.00 | 0.00 | +0.00 | buy |
| Rockefeller Capital Management L.P. | 0 | 500 | +500 | 0.00 | 0.00 | +0.00 | buy |
| TFC Financial Management, Inc. | 0 | 300 | +300 | 0.00 | 0.00 | +0.00 | buy |
| Fortitude Family Office, LLC | 0 | 107 | +107 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 55 | +55 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 553 | 560 | +7 | 0.00 | 0.00 | -0.00 | buy |
| Logos Global Management LP | 473,562 | 473,563 | +1 | 0.30 | 0.20 | -0.10 | buy |
| GREAT POINT PARTNERS LLC | 796,558 | 796,558 | 0 | 2.47 | 1.45 | -1.02 | hold |
| Nantahala Capital Management, LLC | 939,202 | 939,202 | 0 | 0.32 | 0.25 | -0.07 | hold |
| Bogart Wealth, LLC | 6 | 6 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Octagon Capital Advisors LP | 1,000,000 | 1,000,000 | 0 | 1.05 | 0.68 | -0.37 | hold |
| BARCLAYS PLC | 80 | 80 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HARBOUR INVESTMENTS, INC. | 100 | 100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ACUTA CAPITAL PARTNERS, LLC | 62,899 | 59,985 | -2,914 | 0.42 | 0.27 | -0.15 | sell |
| LAZARD ASSET MANAGEMENT LLC | 11,575 | 0 | -11,575 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 11,790 | 0 | -11,790 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 21,709 | 0 | -21,709 | 0.00 | 0.00 | -0.00 | sell |