| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| CITIGROUP INC | 22,731 | 1,850,118 | +1,827,387 | 0.00 | 0.00 | +0.00 | buy |
| CANTOR FITZGERALD, L. P. | 650,500 | 1,999,415 | +1,348,915 | 0.04 | 0.09 | +0.05 | buy |
| TANG CAPITAL MANAGEMENT LLC | 0 | 1,000,000 | +1,000,000 | 0.00 | 0.07 | +0.07 | buy |
| Affinity Asset Advisors, LLC | 500,000 | 1,500,000 | +1,000,000 | 0.14 | 0.29 | +0.15 | buy |
| Peapod Lane Capital LLC | 0 | 553,816 | +553,816 | 0.00 | 0.76 | +0.76 | buy |
| Kynam Capital Management, LP | 547,000 | 1,047,000 | +500,000 | 0.06 | 0.11 | +0.04 | buy |
| DIADEMA PARTNERS LP | 374,423 | 669,803 | +295,380 | 0.76 | 0.65 | -0.11 | buy |
| Shay Capital LLC | 0 | 200,000 | +200,000 | 0.00 | 0.07 | +0.07 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 372,300 | 514,398 | +142,098 | 0.00 | 0.00 | -0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 0 | 134,300 | +134,300 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 48,125 | 119,320 | +71,195 | 0.02 | 0.03 | +0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 63,379 | +63,379 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 27,660 | +27,660 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 237,710 | 255,114 | +17,404 | 0.00 | 0.00 | -0.00 | buy |
| Vanguard Personalized Indexing Management, LLC | 0 | 15,225 | +15,225 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 291,796 | 306,424 | +14,628 | 0.00 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 660,831 | 673,811 | +12,980 | 0.00 | 0.00 | -0.00 | buy |
| BARCLAYS PLC | 49,804 | 58,730 | +8,926 | 0.00 | 0.00 | -0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 13,701 | 21,022 | +7,321 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 5,594 | 8,130 | +2,536 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 111,700 | 114,000 | +2,300 | 0.00 | 0.00 | -0.00 | buy |
| CWM, LLC | 22 | 2,006 | +1,984 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 38,900 | 40,125 | +1,225 | 0.00 | 0.00 | -0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 16,832 | 17,618 | +786 | 0.00 | 0.00 | -0.00 | buy |
| AMALGAMATED BANK | 252 | 1,016 | +764 | 0.00 | 0.00 | +0.00 | buy |
| COLDSTREAM CAPITAL MANAGEMENT INC | 0 | 336 | +336 | 0.00 | 0.00 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,412 | 1,616 | +204 | 0.00 | 0.00 | -0.00 | buy |
| True Wealth Design, LLC | 0 | 12 | +12 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 2,240 | 2,249 | +9 | 0.00 | 0.00 | -0.00 | buy |
| EverSource Wealth Advisors, LLC | 0 | 9 | +9 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 2,981 | 2,981 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TD ASSET MANAGEMENT INC | 89,400 | 89,400 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 2,169 | 2,169 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 31,419,267 | 31,419,267 | 0 | 0.75 | 0.64 | -0.11 | hold |
| Bank of New York Mellon Corp | 64,914 | 64,914 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BOOTHBAY FUND MANAGEMENT, LLC | 53,662 | 53,662 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Ikarian Capital, LLC | 175,088 | 175,088 | 0 | 0.09 | 0.07 | -0.02 | hold |
| Nan Fung Group Holdings Ltd | 463,654 | 463,654 | 0 | 0.71 | 0.46 | -0.25 | hold |
| Militia Capital Partners, LP | 1,700 | 1,700 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SBI Securities Co., Ltd. | 10 | 10 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Deep Track Capital, LP | 1,040,115 | 1,040,115 | 0 | 0.07 | 0.04 | -0.03 | hold |
| Allostery Investments LP | 244,988 | 244,988 | 0 | 0.87 | 0.43 | -0.43 | hold |
| Police & Firemen's Retirement System of New Jersey | 5,869 | 5,869 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Persistent Asset Partners Ltd | 145,760 | 145,760 | 0 | 0.24 | 0.16 | -0.08 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Legal & General Group Plc | 2,581 | 2,581 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 10,500 | 10,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| STRS OHIO | 5,300 | 5,300 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 70,093 | 70,093 | 0 | 0.00 | 0.00 | -0.00 | hold |
| STATE STREET CORP | 378,536 | 378,536 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HSBC HOLDINGS PLC | 16,748 | 16,726 | -22 | 0.00 | 0.00 | -0.00 | sell |
| Corebridge Financial, Inc. | 14,629 | 14,416 | -213 | 0.00 | 0.00 | -0.00 | sell |
| NISA INVESTMENT ADVISORS, LLC | 227 | 0 | -227 | 0.00 | 0.00 | -0.00 | sell |
| Sterling Capital Management LLC | 941 | 479 | -462 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 14,254 | 13,484 | -770 | 0.00 | 0.00 | -0.00 | sell |
| R Squared Ltd | 1,330 | 0 | -1,330 | 0.00 | 0.00 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 25,181 | 21,808 | -3,373 | 0.00 | 0.00 | -0.00 | sell |
| VANGUARD GROUP INC | 1,506,257 | 1,502,556 | -3,701 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 125,304 | 120,742 | -4,562 | 0.00 | 0.00 | -0.00 | sell |
| Chicago Partners Investment Group LLC | 21,695 | 14,958 | -6,737 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 31,836 | 24,782 | -7,054 | 0.00 | 0.00 | -0.00 | sell |
| BlackRock, Inc. | 2,306,255 | 2,296,424 | -9,831 | 0.00 | 0.00 | -0.00 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 251,935 | 241,935 | -10,000 | 0.08 | 0.07 | -0.01 | sell |
| FMR LLC | 13,563 | 2,650 | -10,913 | 0.00 | 0.00 | -0.00 | sell |
| ProShare Advisors LLC | 11,469 | 0 | -11,469 | 0.00 | 0.00 | -0.00 | sell |
| Virtu Financial LLC | 11,733 | 0 | -11,733 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 313,838 | 300,886 | -12,952 | 0.00 | 0.00 | -0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 13,684 | 0 | -13,684 | 0.00 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 30,988 | 14,811 | -16,177 | 0.00 | 0.00 | -0.00 | sell |
| Schonfeld Strategic Advisors LLC | 465,100 | 442,661 | -22,439 | 0.01 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 30,845 | 0 | -30,845 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 415,355 | 382,225 | -33,130 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 43,893 | 5,763 | -38,130 | 0.00 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 628,650 | 585,728 | -42,922 | 0.00 | 0.00 | -0.00 | sell |
| BAILARD, INC. | 56,800 | 0 | -56,800 | 0.00 | 0.00 | -0.00 | sell |
| Walleye Capital LLC | 62,039 | 0 | -62,039 | 0.00 | 0.00 | -0.00 | sell |
| Mariner, LLC | 98,289 | 17,187 | -81,102 | 0.00 | 0.00 | -0.00 | sell |
| SUPERSTRING CAPITAL MANAGEMENT LP | 98,160 | 0 | -98,160 | 0.16 | 0.00 | -0.16 | sell |
| SEGALL BRYANT & HAMILL, LLC | 123,956 | 0 | -123,956 | 0.00 | 0.00 | -0.00 | sell |
| Parkman Healthcare Partners LLC | 290,491 | 0 | -290,491 | 0.07 | 0.00 | -0.07 | sell |
| Ally Bridge Group (NY) LLC | 760,225 | 0 | -760,225 | 1.17 | 0.00 | -1.17 | sell |
| BANK OF AMERICA CORP /DE/ | 1,033,692 | 0 | -1,033,692 | 0.00 | 0.00 | -0.00 | sell |
| Boxer Capital Management, LLC | 2,603,190 | 145,000 | -2,458,190 | 0.40 | 0.05 | -0.35 | sell |
| Samsara BioCapital, LLC | 2,609,114 | 0 | -2,609,114 | 0.64 | 0.00 | -0.64 | sell |
| JANUS HENDERSON GROUP PLC | 3,184,200 | 0 | -3,184,200 | 0.00 | 0.00 | -0.00 | sell |