| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BRAIDWELL LP | 0 | 1,529,675 | +1,529,675 | 0.00 | 0.35 | +0.35 | buy |
| MILLENNIUM MANAGEMENT LLC | 296,314 | 1,276,260 | +979,946 | 0.00 | 0.01 | +0.01 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 684,908 | +684,908 | 0.00 | 0.55 | +0.55 | buy |
| MARSHALL WACE, LLP | 304,015 | 773,123 | +469,108 | 0.00 | 0.01 | +0.00 | buy |
| GREAT POINT PARTNERS LLC | 979,534 | 1,334,130 | +354,596 | 1.27 | 2.24 | +0.97 | buy |
| DIADEMA PARTNERS LP | 0 | 286,126 | +286,126 | 0.00 | 0.81 | +0.81 | buy |
| MORGAN STANLEY | 0 | 234,182 | +234,182 | 0.00 | 0.00 | +0.00 | buy |
| Longaeva Partners L.P. | 0 | 217,768 | +217,768 | 0.00 | 0.07 | +0.07 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 0 | 199,209 | +199,209 | 0.00 | 0.97 | +0.97 | buy |
| CITADEL ADVISORS LLC | 239,043 | 345,663 | +106,620 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 0 | 104,437 | +104,437 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 92,297 | +92,297 | 0.00 | 0.01 | +0.01 | buy |
| UBS Group AG | 0 | 85,945 | +85,945 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 34,596 | 104,217 | +69,621 | 0.00 | 0.00 | +0.00 | buy |
| Persistent Asset Partners Ltd | 9,228 | 72,325 | +63,097 | 0.02 | 0.19 | +0.17 | buy |
| LPL Financial LLC | 0 | 60,379 | +60,379 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 56,624 | +56,624 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 42,974 | +42,974 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 37,161 | +37,161 | 0.00 | 0.00 | +0.00 | buy |
| CANTOR FITZGERALD, L. P. | 0 | 30,000 | +30,000 | 0.00 | 0.01 | +0.01 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 513 | 29,128 | +28,615 | 0.00 | 0.00 | +0.00 | buy |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | 0 | 24,590 | +24,590 | 0.00 | 0.24 | +0.24 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0 | 22,051 | +22,051 | 0.00 | 0.00 | +0.00 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 19,287 | +19,287 | 0.00 | 0.02 | +0.02 | buy |
| RAYMOND JAMES FINANCIAL INC | 0 | 17,727 | +17,727 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 34,852 | 51,912 | +17,060 | 0.00 | 0.01 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 140,617 | 156,317 | +15,700 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 389,309 | 401,649 | +12,340 | 0.00 | 0.00 | +0.00 | buy |
| Diametric Capital, LP | 0 | 11,218 | +11,218 | 0.00 | 0.02 | +0.02 | buy |
| Susquehanna Portfolio Strategies, LLC | 0 | 11,056 | +11,056 | 0.00 | 0.00 | +0.00 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 11,293,828 | 11,300,939 | +7,111 | 0.80 | 0.82 | +0.02 | buy |
| Hudson Bay Capital Management LP | 48,736 | 54,460 | +5,724 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 246,200 | 250,102 | +3,902 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 124,670 | 127,904 | +3,234 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 128,900 | 132,000 | +3,100 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 3,357 | 5,836 | +2,479 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 310,756 | 312,999 | +2,243 | 0.00 | 0.00 | +0.00 | buy |
| Advisory Services Network, LLC | 0 | 2,032 | +2,032 | 0.00 | 0.00 | +0.00 | buy |
| BLAIR WILLIAM & CO/IL | 11,000 | 12,000 | +1,000 | 0.00 | 0.00 | +0.00 | buy |
| JONES FINANCIAL COMPANIES LLLP | 0 | 266 | +266 | 0.00 | 0.00 | +0.00 | buy |
| Fortitude Family Office, LLC | 0 | 92 | +92 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 0 | 79 | +79 | 0.00 | 0.00 | +0.00 | buy |
| Vanguard Personalized Indexing Management, LLC | 11,127 | 11,204 | +77 | 0.00 | 0.00 | +0.00 | buy |
| Arax Advisory Partners | 0 | 51 | +51 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 6,349 | 6,397 | +48 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 0 | 45 | +45 | 0.00 | 0.00 | +0.00 | buy |
| ArchPoint Investors | 121,400 | 121,400 | 0 | 0.12 | 0.20 | +0.08 | hold |
| NISA INVESTMENT ADVISORS, LLC | 573 | 573 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 600,946 | 600,946 | 0 | 0.02 | 0.03 | +0.01 | hold |
| DEUTSCHE BANK AG\ | 1 | 1 | 0 | 0.00 | 0.00 | +0.00 | hold |
| HARBOUR INVESTMENTS, INC. | 2,000 | 0 | -2,000 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 10,331 | 5,794 | -4,537 | 0.00 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,923,639 | 1,916,968 | -6,671 | 0.00 | 0.00 | +0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 14,236 | 6,959 | -7,277 | 0.00 | 0.00 | -0.00 | sell |
| Scientech Research LLC | 10,428 | 0 | -10,428 | 0.03 | 0.00 | -0.03 | sell |
| Virtu Financial LLC | 10,655 | 0 | -10,655 | 0.00 | 0.00 | -0.00 | sell |
| Chicago Partners Investment Group LLC | 10,962 | 0 | -10,962 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 61,853 | 48,936 | -12,917 | 0.00 | 0.00 | +0.00 | sell |
| JANE STREET GROUP, LLC | 187,403 | 171,375 | -16,028 | 0.00 | 0.00 | +0.00 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 19,918 | 0 | -19,918 | 0.01 | 0.00 | -0.01 | sell |
| HSBC HOLDINGS PLC | 24,744 | 0 | -24,744 | 0.00 | 0.00 | -0.00 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 159,300 | 134,300 | -25,000 | 0.01 | 0.02 | +0.01 | sell |
| Kynam Capital Management, LP | 1,028,341 | 1,003,341 | -25,000 | 0.27 | 0.44 | +0.17 | sell |
| CITIZENS FINANCIAL GROUP INC/RI | 28,168 | 0 | -28,168 | 0.00 | 0.00 | -0.00 | sell |
| NAN FUNG TRINITY (HK) Ltd | 463,654 | 420,517 | -43,137 | 0.15 | 0.32 | +0.17 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 445,342 | 387,403 | -57,939 | 0.00 | 0.00 | +0.00 | sell |
| OMERS ADMINISTRATION Corp | 85,466 | 16,700 | -68,766 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 224,883 | 149,970 | -74,913 | 0.00 | 0.00 | +0.00 | sell |
| MPM BioImpact LLC | 2,671,480 | 2,593,439 | -78,041 | 1.22 | 1.37 | +0.15 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 320,600 | 217,300 | -103,300 | 0.00 | 0.00 | +0.00 | sell |
| 683 Capital Management, LLC | 201,652 | 90,000 | -111,652 | 0.07 | 0.06 | -0.01 | sell |
| TWO SIGMA ADVISERS, LP | 124,700 | 0 | -124,700 | 0.00 | 0.00 | -0.00 | sell |
| AMERIPRISE FINANCIAL INC | 139,529 | 0 | -139,529 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 566,712 | 310,606 | -256,106 | 0.00 | 0.00 | -0.00 | sell |
| Peapod Lane Capital LLC | 565,992 | 108,878 | -457,114 | 1.93 | 0.61 | -1.32 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 932,247 | 419,247 | -513,000 | 0.78 | 0.49 | -0.29 | sell |
| Affinity Asset Advisors, LLC | 1,300,000 | 700,000 | -600,000 | 0.37 | 0.28 | -0.09 | sell |
| Point72 Asset Management, L.P. | 716,680 | 59,090 | -657,590 | 0.00 | 0.00 | -0.00 | sell |
| ADAR1 Capital Management, LLC | 1,432,475 | 597,662 | -834,813 | 0.43 | 0.25 | -0.18 | sell |