| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 13,150,849 | 31,419,267 | +18,268,418 | 0.46 | 2.95 | +2.50 | buy |
| Deep Track Capital, LP | 0 | 3,904,785 | +3,904,785 | 0.00 | 0.83 | +0.83 | buy |
| Samsara BioCapital, LLC | 0 | 3,261,393 | +3,261,393 | 0.00 | 4.85 | +4.85 | buy |
| JANUS HENDERSON GROUP PLC | 0 | 3,253,988 | +3,253,988 | 0.00 | 0.01 | +0.01 | buy |
| Affinity Asset Advisors, LLC | 0 | 1,670,661 | +1,670,661 | 0.00 | 1.87 | +1.87 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 670,362 | +670,362 | 0.00 | 0.01 | +0.01 | buy |
| Ally Bridge Group (NY) LLC | 0 | 500,000 | +500,000 | 0.00 | 2.12 | +2.12 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 0 | 215,179 | +215,179 | 0.00 | 0.25 | +0.25 | buy |
| Walleye Capital LLC | 0 | 196,390 | +196,390 | 0.00 | 0.01 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 66,626 | 171,597 | +104,971 | 0.00 | 0.00 | +0.00 | buy |
| Ikarian Capital, LLC | 0 | 100,000 | +100,000 | 0.00 | 0.22 | +0.22 | buy |
| ADAR1 Capital Management, LLC | 0 | 97,695 | +97,695 | 0.00 | 0.14 | +0.14 | buy |
| STATE STREET CORP | 21,700 | 59,007 | +37,307 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 0 | 33,567 | +33,567 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 30,710 | +30,710 | 0.00 | 0.01 | +0.01 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 10,617 | 37,000 | +26,383 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 0 | 22,192 | +22,192 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 0 | 18,845 | +18,845 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0 | 17,128 | +17,128 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 310,486 | 326,381 | +15,895 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | 13,300 | +13,300 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 0 | 12,560 | +12,560 | 0.00 | 0.00 | +0.00 | buy |
| Polar Asset Management Partners Inc. | 0 | 10,781 | +10,781 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA SECURITIES, LLC | 0 | 10,619 | +10,619 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 0 | 8,233 | +8,233 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 0 | 5,300 | +5,300 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 0 | 2,543 | +2,543 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 43,468 | 45,677 | +2,209 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 0 | 1,632 | +1,632 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 0 | 714 | +714 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 0 | 631 | +631 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 0 | 528 | +528 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 0 | 252 | +252 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 55,223 | 55,223 | 0 | 0.00 | 0.01 | +0.01 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Tower Research Capital LLC (TRC) | 3,606 | 3,020 | -586 | 0.00 | 0.00 | +0.00 | sell |
| Qube Research & Technologies Ltd | 981 | 0 | -981 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 20,106 | 11,397 | -8,709 | 0.00 | 0.00 | +0.00 | sell |
| Chicago Partners Investment Group LLC | 12,104 | 0 | -12,104 | 0.00 | 0.00 | -0.00 | sell |
| TUDOR INVESTMENT CORP ET AL | 29,466 | 0 | -29,466 | 0.00 | 0.00 | -0.00 | sell |
| Atom Investors LP | 78,276 | 0 | -78,276 | 0.03 | 0.00 | -0.03 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 811,680 | 696,057 | -115,623 | 0.02 | 0.05 | +0.03 | sell |
| BML Capital Management, LLC | 2,193,742 | 0 | -2,193,742 | 4.02 | 0.00 | -4.02 | sell |