| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 6,397 | 6,790,364 | +6,783,967 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 85,945 | 3,404,866 | +3,318,921 | 0.00 | 0.01 | +0.01 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 2,506,000 | +2,506,000 | 0.00 | 0.05 | +0.05 | buy |
| Cormorant Asset Management, LP | 0 | 2,106,000 | +2,106,000 | 0.00 | 1.41 | +1.41 | buy |
| BlackRock, Inc. | 401,649 | 2,354,872 | +1,953,223 | 0.00 | 0.00 | +0.00 | buy |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 0 | 1,939,019 | +1,939,019 | 0.00 | 0.24 | +0.24 | buy |
| Woodline Partners LP | 0 | 1,582,291 | +1,582,291 | 0.00 | 0.06 | +0.06 | buy |
| BRAIDWELL LP | 1,529,675 | 2,797,375 | +1,267,700 | 0.35 | 1.35 | +1.00 | buy |
| Redmile Group, LLC | 0 | 1,226,330 | +1,226,330 | 0.00 | 1.07 | +1.07 | buy |
| CITADEL ADVISORS LLC | 345,663 | 1,297,972 | +952,309 | 0.00 | 0.01 | +0.01 | buy |
| STEMPOINT CAPITAL LP | 0 | 742,745 | +742,745 | 0.00 | 1.68 | +1.68 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 657,971 | +657,971 | 0.00 | 0.00 | +0.00 | buy |
| Parkman Healthcare Partners LLC | 0 | 563,484 | +563,484 | 0.00 | 0.75 | +0.75 | buy |
| STATE STREET CORP | 132,000 | 686,772 | +554,772 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 312,999 | 782,199 | +469,200 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 0 | 373,445 | +373,445 | 0.00 | 0.00 | +0.00 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 199,209 | 521,082 | +321,873 | 0.97 | 4.29 | +3.32 | buy |
| Ikarian Capital, LLC | 0 | 300,000 | +300,000 | 0.00 | 0.64 | +0.64 | buy |
| Affinity Asset Advisors, LLC | 700,000 | 972,000 | +272,000 | 0.28 | 0.62 | +0.34 | buy |
| Ally Bridge Group (NY) LLC | 0 | 249,172 | +249,172 | 0.00 | 4.19 | +4.19 | buy |
| ADAR1 Capital Management, LLC | 597,662 | 822,649 | +224,987 | 0.25 | 0.50 | +0.26 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,916,968 | 2,127,281 | +210,313 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 127,904 | 330,290 | +202,386 | 0.00 | 0.00 | +0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 600,946 | 790,000 | +189,054 | 0.03 | 0.06 | +0.03 | buy |
| FIFTH THIRD BANCORP | 0 | 164,923 | +164,923 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 104,217 | 266,649 | +162,432 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 104,437 | 239,451 | +135,014 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 234,182 | 365,088 | +130,906 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 126,138 | +126,138 | 0.00 | 0.01 | +0.01 | buy |
| Bank of New York Mellon Corp | 0 | 123,658 | +123,658 | 0.00 | 0.00 | +0.00 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 104,634 | +104,634 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 96,807 | +96,807 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 92,297 | 182,645 | +90,348 | 0.01 | 0.04 | +0.03 | buy |
| Nuveen, LLC | 0 | 85,935 | +85,935 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 22,051 | 104,634 | +82,583 | 0.00 | 0.00 | +0.00 | buy |
| Cambria Investment Management, L.P. | 0 | 76,109 | +76,109 | 0.00 | 0.05 | +0.05 | buy |
| Informed Momentum Co LLC | 0 | 69,657 | +69,657 | 0.00 | 0.08 | +0.08 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 419,247 | 483,747 | +64,500 | 0.49 | 0.90 | +0.41 | buy |
| DeepCurrents Investment Group LLC | 0 | 64,286 | +64,286 | 0.00 | 0.03 | +0.03 | buy |
| ALPS ADVISORS INC | 0 | 58,121 | +58,121 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 0 | 49,456 | +49,456 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 0 | 47,250 | +47,250 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 0 | 44,544 | +44,544 | 0.00 | 0.00 | +0.00 | buy |
| OPPENHEIMER & CO INC | 0 | 41,498 | +41,498 | 0.00 | 0.01 | +0.01 | buy |
| DEUTSCHE BANK AG\ | 1 | 34,673 | +34,672 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 0 | 31,670 | +31,670 | 0.00 | 0.00 | +0.00 | buy |
| Integrated Quantitative Investments LLC | 0 | 31,406 | +31,406 | 0.00 | 0.07 | +0.07 | buy |
| WELLS FARGO & COMPANY/MN | 0 | 30,660 | +30,660 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 0 | 28,800 | +28,800 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 0 | 28,602 | +28,602 | 0.00 | 0.09 | +0.09 | buy |
| FRANKLIN RESOURCES INC | 0 | 24,639 | +24,639 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 0 | 21,305 | +21,305 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 51,912 | 72,460 | +20,548 | 0.01 | 0.01 | +0.01 | buy |
| TD ASSET MANAGEMENT INC | 250,102 | 267,102 | +17,000 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0 | 16,153 | +16,153 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 0 | 15,300 | +15,300 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 0 | 14,650 | +14,650 | 0.00 | 0.00 | +0.00 | buy |
| State of Wyoming | 0 | 14,374 | +14,374 | 0.00 | 0.02 | +0.02 | buy |
| Spark Investment Management LLC | 0 | 13,600 | +13,600 | 0.00 | 0.35 | +0.35 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | 12,300 | +12,300 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 0 | 11,151 | +11,151 | 0.00 | 0.00 | +0.00 | buy |
| BAILARD, INC. | 0 | 10,900 | +10,900 | 0.00 | 0.00 | +0.00 | buy |
| SummitTX Capital, L.P. | 0 | 10,791 | +10,791 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 5,794 | 16,508 | +10,714 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 0 | 10,390 | +10,390 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 156,317 | 164,712 | +8,395 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 17,727 | 25,239 | +7,512 | 0.00 | 0.00 | +0.00 | buy |
| ArchPoint Investors | 121,400 | 128,900 | +7,500 | 0.20 | 0.36 | +0.16 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 4,533 | +4,533 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 0 | 3,419 | +3,419 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 0 | 3,197 | +3,197 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 0 | 3,120 | +3,120 | 0.00 | 0.00 | +0.00 | buy |
| Integrated Wealth Concepts LLC | 0 | 1,130 | +1,130 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 0 | 886 | +886 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 0 | 821 | +821 | 0.00 | 0.00 | +0.00 | buy |
| BLAIR WILLIAM & CO/IL | 12,000 | 12,700 | +700 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 0 | 485 | +485 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 0 | 452 | +452 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 74 | +74 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 0 | 47 | +47 | 0.00 | 0.00 | +0.00 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 11,300,939 | 11,300,939 | 0 | 0.82 | 1.28 | +0.46 | hold |
| Allworth Financial LP | 45 | 45 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Fortitude Family Office, LLC | 92 | 92 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Susquehanna Portfolio Strategies, LLC | 11,056 | 11,056 | 0 | 0.00 | 0.00 | +0.00 | hold |
| JONES FINANCIAL COMPANIES LLLP | 266 | 266 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 573 | 573 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Arax Advisory Partners | 51 | 0 | -51 | 0.00 | 0.00 | -0.00 | sell |
| Russell Investments Group, Ltd. | 79 | 0 | -79 | 0.00 | 0.00 | -0.00 | sell |
| Advisory Services Network, LLC | 2,032 | 0 | -2,032 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 5,836 | 2,240 | -3,596 | 0.00 | 0.00 | -0.00 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 134,300 | 130,300 | -4,000 | 0.02 | 0.03 | +0.01 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 6,959 | 0 | -6,959 | 0.00 | 0.00 | -0.00 | sell |
| LPL Financial LLC | 60,379 | 51,174 | -9,205 | 0.00 | 0.00 | +0.00 | sell |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | 24,590 | 15,241 | -9,349 | 0.24 | 0.06 | -0.19 | sell |
| Vanguard Personalized Indexing Management, LLC | 11,204 | 0 | -11,204 | 0.00 | 0.00 | -0.00 | sell |
| Diametric Capital, LP | 11,218 | 0 | -11,218 | 0.02 | 0.00 | -0.02 | sell |
| OMERS ADMINISTRATION Corp | 16,700 | 0 | -16,700 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 42,974 | 25,956 | -17,018 | 0.00 | 0.00 | +0.00 | sell |
| FOX RUN MANAGEMENT, L.L.C. | 19,287 | 0 | -19,287 | 0.02 | 0.00 | -0.02 | sell |
| BARCLAYS PLC | 48,936 | 26,924 | -22,012 | 0.00 | 0.00 | -0.00 | sell |