| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VANGUARD GROUP INC | 326,381 | 1,524,868 | +1,198,487 | 0.00 | 0.00 | +0.00 | buy |
| Ally Bridge Group (NY) LLC | 500,000 | 1,229,292 | +729,292 | 2.12 | 3.35 | +1.23 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0 | 672,566 | +672,566 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 0 | 590,946 | +590,946 | 0.00 | 0.01 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 171,597 | 651,297 | +479,700 | 0.00 | 0.00 | +0.00 | buy |
| Nan Fung Group Holdings Ltd | 0 | 463,654 | +463,654 | 0.00 | 2.03 | +2.03 | buy |
| JANUS HENDERSON GROUP PLC | 3,253,988 | 3,606,495 | +352,507 | 0.01 | 0.01 | -0.00 | buy |
| Parkman Healthcare Partners LLC | 0 | 278,775 | +278,775 | 0.00 | 0.18 | +0.18 | buy |
| STATE STREET CORP | 59,007 | 315,036 | +256,029 | 0.00 | 0.00 | +0.00 | buy |
| GREAT POINT PARTNERS LLC | 0 | 248,168 | +248,168 | 0.00 | 0.38 | +0.38 | buy |
| NORTHERN TRUST CORP | 45,677 | 292,611 | +246,934 | 0.00 | 0.00 | +0.00 | buy |
| Monashee Investment Management LLC | 0 | 230,000 | +230,000 | 0.00 | 0.13 | +0.13 | buy |
| MILLENNIUM MANAGEMENT LLC | 11,397 | 111,137 | +99,740 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 0 | 89,400 | +89,400 | 0.00 | 0.00 | +0.00 | buy |
| Ikarian Capital, LLC | 100,000 | 175,100 | +75,100 | 0.22 | 0.28 | +0.05 | buy |
| ADAR1 Capital Management, LLC | 97,695 | 163,443 | +65,748 | 0.14 | 0.14 | -0.00 | buy |
| GOLDMAN SACHS GROUP INC | 0 | 59,046 | +59,046 | 0.00 | 0.00 | +0.00 | buy |
| SEGALL BRYANT & HAMILL, LLC | 0 | 58,411 | +58,411 | 0.00 | 0.00 | +0.00 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 0 | 54,000 | +54,000 | 0.00 | 0.22 | +0.22 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 17,128 | 70,093 | +52,965 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 49,524 | +49,524 | 0.00 | 0.00 | +0.00 | buy |
| Advantage Alpha Capital Partners LP | 0 | 48,169 | +48,169 | 0.00 | 0.06 | +0.06 | buy |
| Bank of New York Mellon Corp | 18,845 | 64,914 | +46,069 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 2,543 | 38,859 | +36,316 | 0.00 | 0.00 | +0.00 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 0 | 33,824 | +33,824 | 0.00 | 0.15 | +0.15 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 37,000 | 68,600 | +31,600 | 0.00 | 0.00 | +0.00 | buy |
| WINTON GROUP Ltd | 0 | 27,551 | +27,551 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 23,514 | +23,514 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 30,710 | 53,674 | +22,964 | 0.01 | 0.01 | +0.00 | buy |
| CITIGROUP INC | 1,632 | 21,417 | +19,785 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 8,233 | 27,740 | +19,507 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 0 | 17,769 | +17,769 | 0.00 | 0.00 | +0.00 | buy |
| Chicago Partners Investment Group LLC | 0 | 16,966 | +16,966 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0 | 16,064 | +16,064 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 0 | 13,885 | +13,885 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 0 | 13,248 | +13,248 | 0.00 | 0.00 | +0.00 | buy |
| Valence8 US LP | 0 | 12,045 | +12,045 | 0.00 | 0.03 | +0.03 | buy |
| Corebridge Financial, Inc. | 3,918 | 15,733 | +11,815 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 11,715 | +11,715 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 0 | 10,370 | +10,370 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 12,560 | 18,280 | +5,720 | 0.00 | 0.00 | -0.00 | buy |
| Ameritas Investment Partners, Inc. | 714 | 2,981 | +2,267 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 631 | 2,581 | +1,950 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 528 | 2,169 | +1,641 | 0.00 | 0.00 | +0.00 | buy |
| QUADRANT CAPITAL GROUP LLC | 0 | 488 | +488 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 0 | 333 | +333 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 0 | 141 | +141 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 0 | 69 | +69 | 0.00 | 0.00 | +0.00 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 31,419,267 | 31,419,267 | 0 | 2.95 | 1.84 | -1.11 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| STRS OHIO | 5,300 | 5,300 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMALGAMATED BANK | 252 | 252 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Tower Research Capital LLC (TRC) | 3,020 | 2,557 | -463 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 13,300 | 10,500 | -2,800 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA SECURITIES, LLC | 10,619 | 0 | -10,619 | 0.00 | 0.00 | -0.00 | sell |
| Polar Asset Management Partners Inc. | 10,781 | 0 | -10,781 | 0.00 | 0.00 | -0.00 | sell |
| Woodline Partners LP | 22,192 | 0 | -22,192 | 0.00 | 0.00 | -0.00 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 215,179 | 181,970 | -33,209 | 0.25 | 0.15 | -0.10 | sell |
| Man Group plc | 33,567 | 0 | -33,567 | 0.00 | 0.00 | -0.00 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 55,223 | 0 | -55,223 | 0.01 | 0.00 | -0.01 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 696,057 | 612,387 | -83,670 | 0.05 | 0.03 | -0.02 | sell |
| Affinity Asset Advisors, LLC | 1,670,661 | 1,500,000 | -170,661 | 1.87 | 1.18 | -0.69 | sell |
| Walleye Capital LLC | 196,390 | 0 | -196,390 | 0.01 | 0.00 | -0.01 | sell |
| Samsara BioCapital, LLC | 3,261,393 | 2,609,114 | -652,279 | 4.85 | 2.55 | -2.30 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 670,362 | 0 | -670,362 | 0.01 | 0.00 | -0.01 | sell |
| Deep Track Capital, LP | 3,904,785 | 2,169,143 | -1,735,642 | 0.83 | 0.35 | -0.48 | sell |