| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| SPHERA FUNDS MANAGEMENT LTD. | 209,837 | 434,837 | +225,000 | 0.07 | 0.21 | +0.14 | buy |
| MARSHALL WACE, LLP | 36,738 | 229,889 | +193,151 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 142,450 | +142,450 | 0.00 | 0.00 | +0.00 | buy |
| BLUEFIN CAPITAL MANAGEMENT, LLC | 0 | 59,985 | +59,985 | 0.00 | 0.05 | +0.05 | buy |
| CITIZENS FINANCIAL GROUP INC/RI | 0 | 46,000 | +46,000 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 495,500 | 537,100 | +41,600 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 40,718 | +40,718 | 0.00 | 0.01 | +0.01 | buy |
| XTX Topco Ltd | 0 | 29,184 | +29,184 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 382,482 | 405,404 | +22,922 | 0.00 | 0.00 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 0 | 18,272 | +18,272 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 0 | 15,000 | +15,000 | 0.00 | 0.00 | +0.00 | buy |
| Vanguard Personalized Indexing Management, LLC | 0 | 14,546 | +14,546 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 119,320 | 133,530 | +14,210 | 0.02 | 0.03 | +0.00 | buy |
| Peapod Lane Capital LLC | 555,667 | 561,866 | +6,199 | 0.69 | 1.01 | +0.32 | buy |
| FEDERATED HERMES, INC. | 0 | 4,420 | +4,420 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 34,310 | 36,602 | +2,292 | 0.00 | 0.00 | +0.00 | buy |
| HARBOUR INVESTMENTS, INC. | 0 | 2,000 | +2,000 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 51 | 224 | +173 | 0.00 | 0.00 | +0.00 | buy |
| Arax Advisory Partners | 0 | 53 | +53 | 0.00 | 0.00 | +0.00 | buy |
| Advisory Services Network, LLC | 0 | 32 | +32 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 2,610 | 2,620 | +10 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 12 | 13 | +1 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 89,400 | 89,400 | 0 | 0.00 | 0.00 | +0.00 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 311,721 | 311,721 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TANG CAPITAL MANAGEMENT LLC | 1,000,000 | 1,000,000 | 0 | 0.06 | 0.08 | +0.01 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 31,419,267 | 31,419,267 | 0 | 0.66 | 0.78 | +0.12 | hold |
| Alyeska Investment Group, L.P. | 485,364 | 485,364 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NAN FUNG TRINITY (HK) Ltd | 463,654 | 463,654 | 0 | 0.07 | 0.09 | +0.02 | hold |
| Kynam Capital Management, LP | 1,028,341 | 1,028,341 | 0 | 0.14 | 0.15 | +0.02 | hold |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 38,900 | 38,900 | 0 | 0.00 | 0.00 | +0.00 | hold |
| STATE STREET CORP | 103,100 | 103,100 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 573 | 573 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Clearstead Advisors, LLC | 11 | 0 | -11 | 0.00 | 0.00 | -0.00 | sell |
| True Wealth Design, LLC | 19 | 0 | -19 | 0.00 | 0.00 | -0.00 | sell |
| GF FUND MANAGEMENT CO. LTD. | 1,616 | 1,458 | -158 | 0.00 | 0.00 | +0.00 | sell |
| Point72 (DIFC) Ltd | 421 | 0 | -421 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 7,627 | 7,142 | -485 | 0.00 | 0.00 | +0.00 | sell |
| Tower Research Capital LLC (TRC) | 14,102 | 13,244 | -858 | 0.00 | 0.00 | +0.00 | sell |
| HSBC HOLDINGS PLC | 13,296 | 11,944 | -1,352 | 0.00 | 0.00 | +0.00 | sell |
| China Universal Asset Management Co., Ltd. | 13,572 | 11,878 | -1,694 | 0.00 | 0.00 | +0.00 | sell |
| Squarepoint Ops LLC | 19,640 | 17,699 | -1,941 | 0.00 | 0.00 | +0.00 | sell |
| CWM, LLC | 2,393 | 0 | -2,393 | 0.00 | 0.00 | -0.00 | sell |
| Chicago Partners Investment Group LLC | 12,842 | 10,332 | -2,510 | 0.00 | 0.00 | +0.00 | sell |
| Point72 Asia (Singapore) Pte. Ltd. | 14,085 | 10,952 | -3,133 | 0.00 | 0.00 | +0.00 | sell |
| BARCLAYS PLC | 29,377 | 24,753 | -4,624 | 0.00 | 0.00 | +0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 7,669 | 1,854 | -5,815 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 480,078 | 471,704 | -8,374 | 0.00 | 0.00 | +0.00 | sell |
| DEUTSCHE BANK AG\ | 12,382 | 1 | -12,381 | 0.00 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 13,818 | 0 | -13,818 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 94,900 | 80,900 | -14,000 | 0.00 | 0.00 | +0.00 | sell |
| VANGUARD GROUP INC | 1,331,250 | 1,315,811 | -15,439 | 0.00 | 0.00 | +0.00 | sell |
| NORTHERN TRUST CORP | 141,424 | 125,423 | -16,001 | 0.00 | 0.00 | +0.00 | sell |
| HRT FINANCIAL LP | 18,529 | 0 | -18,529 | 0.00 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 547,965 | 526,917 | -21,048 | 0.00 | 0.00 | +0.00 | sell |
| Cubist Systematic Strategies, LLC | 62,176 | 38,591 | -23,585 | 0.00 | 0.00 | +0.00 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 134,300 | 109,300 | -25,000 | 0.00 | 0.00 | +0.00 | sell |
| Jain Global LLC | 25,693 | 0 | -25,693 | 0.00 | 0.00 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 28,890 | 0 | -28,890 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 179,591 | 112,681 | -66,910 | 0.00 | 0.00 | -0.00 | sell |
| Stonepine Capital Management, LLC | 116,147 | 0 | -116,147 | 0.14 | 0.00 | -0.14 | sell |
| Persistent Asset Partners Ltd | 145,179 | 28,221 | -116,958 | 0.16 | 0.04 | -0.12 | sell |
| GOLDMAN SACHS GROUP INC | 201,312 | 73,715 | -127,597 | 0.00 | 0.00 | -0.00 | sell |
| Y-Intercept (Hong Kong) Ltd | 127,952 | 0 | -127,952 | 0.00 | 0.00 | -0.00 | sell |
| BlackRock, Inc. | 877,969 | 735,503 | -142,466 | 0.00 | 0.00 | +0.00 | sell |
| JANE STREET GROUP, LLC | 148,180 | 0 | -148,180 | 0.00 | 0.00 | -0.00 | sell |
| Affinity Asset Advisors, LLC | 1,500,000 | 1,300,000 | -200,000 | 0.28 | 0.24 | -0.03 | sell |
| JPMORGAN CHASE & CO | 210,122 | 0 | -210,122 | 0.00 | 0.00 | -0.00 | sell |
| Shay Capital LLC | 415,000 | 150,000 | -265,000 | 0.12 | 0.05 | -0.06 | sell |
| Deep Track Capital, LP | 1,040,115 | 509,789 | -530,326 | 0.04 | 0.03 | -0.01 | sell |
| DIADEMA PARTNERS LP | 702,135 | 136,488 | -565,647 | 0.54 | 0.19 | -0.35 | sell |
| CITIGROUP INC | 1,611,887 | 329,548 | -1,282,339 | 0.00 | 0.00 | -0.00 | sell |
| CANTOR FITZGERALD, L. P. | 2,502,531 | 547,173 | -1,955,358 | 0.08 | 0.02 | -0.05 | sell |