| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BANK OF AMERICA CORP /DE/ | 0 | 1,033,692 | +1,033,692 | 0.00 | 0.00 | +0.00 | buy |
| CANTOR FITZGERALD, L. P. | 0 | 650,500 | +650,500 | 0.00 | 0.04 | +0.04 | buy |
| Kynam Capital Management, LP | 0 | 547,000 | +547,000 | 0.00 | 0.06 | +0.06 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 465,100 | +465,100 | 0.00 | 0.01 | +0.01 | buy |
| BlackRock, Inc. | 1,867,097 | 2,306,255 | +439,158 | 0.00 | 0.00 | -0.00 | buy |
| UBS Group AG | 0 | 415,355 | +415,355 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 68,600 | 372,300 | +303,700 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 0 | 291,796 | +291,796 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 23,514 | 237,710 | +214,196 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 111,700 | +111,700 | 0.00 | 0.00 | +0.00 | buy |
| Mariner, LLC | 0 | 98,289 | +98,289 | 0.00 | 0.00 | +0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 181,970 | 251,935 | +69,965 | 0.15 | 0.08 | -0.07 | buy |
| GOLDMAN SACHS GROUP INC | 59,046 | 125,304 | +66,258 | 0.00 | 0.00 | -0.00 | buy |
| SEGALL BRYANT & HAMILL, LLC | 58,411 | 123,956 | +65,545 | 0.00 | 0.00 | -0.00 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 33,824 | 98,160 | +64,336 | 0.15 | 0.16 | +0.00 | buy |
| STATE STREET CORP | 315,036 | 378,536 | +63,500 | 0.00 | 0.00 | -0.00 | buy |
| Walleye Capital LLC | 0 | 62,039 | +62,039 | 0.00 | 0.00 | +0.00 | buy |
| BAILARD, INC. | 0 | 56,800 | +56,800 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 43,893 | +43,893 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 30,845 | +30,845 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 292,611 | 313,838 | +21,227 | 0.00 | 0.00 | -0.00 | buy |
| SG Americas Securities, LLC | 11,715 | 30,988 | +19,273 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 0 | 16,748 | +16,748 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 10,370 | 25,181 | +14,811 | 0.00 | 0.00 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 0 | 14,254 | +14,254 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 13,701 | +13,701 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 0 | 13,563 | +13,563 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 0 | 11,733 | +11,733 | 0.00 | 0.00 | +0.00 | buy |
| Parkman Healthcare Partners LLC | 278,775 | 290,491 | +11,716 | 0.18 | 0.07 | -0.11 | buy |
| ProShare Advisors LLC | 0 | 11,469 | +11,469 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 38,859 | 49,804 | +10,945 | 0.00 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 651,297 | 660,831 | +9,534 | 0.00 | 0.00 | -0.00 | buy |
| Chicago Partners Investment Group LLC | 16,966 | 21,695 | +4,729 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 27,740 | 31,836 | +4,096 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 2,557 | 5,594 | +3,037 | 0.00 | 0.00 | -0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 0 | 2,240 | +2,240 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 21,417 | 22,731 | +1,314 | 0.00 | 0.00 | -0.00 | buy |
| Sterling Capital Management LLC | 112 | 941 | +829 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 16,064 | 16,832 | +768 | 0.00 | 0.00 | -0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 0 | 227 | +227 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 0 | 22 | +22 | 0.00 | 0.00 | 0.00 | buy |
| Ameritas Investment Partners, Inc. | 2,981 | 2,981 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TD ASSET MANAGEMENT INC | 89,400 | 89,400 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 2,169 | 2,169 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 31,419,267 | 31,419,267 | 0 | 1.84 | 0.75 | -1.09 | hold |
| Bank of New York Mellon Corp | 64,914 | 64,914 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Samsara BioCapital, LLC | 2,609,114 | 2,609,114 | 0 | 2.55 | 0.64 | -1.91 | hold |
| Nan Fung Group Holdings Ltd | 463,654 | 463,654 | 0 | 2.03 | 0.71 | -1.32 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Legal & General Group Plc | 2,581 | 2,581 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 10,500 | 10,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| STRS OHIO | 5,300 | 5,300 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 70,093 | 70,093 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMALGAMATED BANK | 252 | 252 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BOOTHBAY FUND MANAGEMENT, LLC | 53,674 | 53,662 | -12 | 0.01 | 0.00 | -0.01 | sell |
| Ikarian Capital, LLC | 175,100 | 175,088 | -12 | 0.28 | 0.09 | -0.19 | sell |
| Russell Investments Group, Ltd. | 69 | 0 | -69 | 0.00 | 0.00 | -0.00 | sell |
| US BANCORP \DE\ | 141 | 0 | -141 | 0.00 | 0.00 | -0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 13,885 | 13,684 | -201 | 0.00 | 0.00 | -0.00 | sell |
| SIGNATUREFD, LLC | 333 | 0 | -333 | 0.00 | 0.00 | -0.00 | sell |
| QUADRANT CAPITAL GROUP LLC | 488 | 0 | -488 | 0.00 | 0.00 | -0.00 | sell |
| Corebridge Financial, Inc. | 15,733 | 14,629 | -1,104 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 49,524 | 38,900 | -10,624 | 0.00 | 0.00 | -0.00 | sell |
| Valence8 US LP | 12,045 | 0 | -12,045 | 0.03 | 0.00 | -0.03 | sell |
| WELLS FARGO & COMPANY/MN | 13,248 | 0 | -13,248 | 0.00 | 0.00 | -0.00 | sell |
| MetLife Investment Management, LLC | 17,769 | 0 | -17,769 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 18,280 | 0 | -18,280 | 0.00 | 0.00 | -0.00 | sell |
| VANGUARD GROUP INC | 1,524,868 | 1,506,257 | -18,611 | 0.00 | 0.00 | -0.00 | sell |
| WINTON GROUP Ltd | 27,551 | 0 | -27,551 | 0.01 | 0.00 | -0.01 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 672,566 | 628,650 | -43,916 | 0.00 | 0.00 | -0.00 | sell |
| Advantage Alpha Capital Partners LP | 48,169 | 0 | -48,169 | 0.06 | 0.00 | -0.06 | sell |
| ACUTA CAPITAL PARTNERS, LLC | 54,000 | 0 | -54,000 | 0.22 | 0.00 | -0.22 | sell |
| MILLENNIUM MANAGEMENT LLC | 111,137 | 0 | -111,137 | 0.00 | 0.00 | -0.00 | sell |
| ADAR1 Capital Management, LLC | 163,443 | 48,125 | -115,318 | 0.14 | 0.02 | -0.12 | sell |
| Monashee Investment Management LLC | 230,000 | 0 | -230,000 | 0.13 | 0.00 | -0.13 | sell |
| GREAT POINT PARTNERS LLC | 248,168 | 0 | -248,168 | 0.38 | 0.00 | -0.38 | sell |
| JANUS HENDERSON GROUP PLC | 3,606,495 | 3,184,200 | -422,295 | 0.01 | 0.00 | -0.01 | sell |
| Ally Bridge Group (NY) LLC | 1,229,292 | 760,225 | -469,067 | 3.35 | 1.17 | -2.18 | sell |
| Point72 Asset Management, L.P. | 590,946 | 0 | -590,946 | 0.01 | 0.00 | -0.01 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 612,387 | 0 | -612,387 | 0.03 | 0.00 | -0.03 | sell |
| Affinity Asset Advisors, LLC | 1,500,000 | 500,000 | -1,000,000 | 1.18 | 0.14 | -1.04 | sell |
| Deep Track Capital, LP | 2,169,143 | 1,040,115 | -1,129,028 | 0.35 | 0.07 | -0.28 | sell |